Intestinal Anion Absorption

Physiology of the Gastrointestinal Tract

Volumn 2, Issue , 2006, Pages 1881-1915

  Dudeja, Pradeep K ^a   Ramaswamy, K ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 66749154912     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088394-3/50077-5     Document Type: Chapter

References (310)

1. Mulder G Sulfate availability in vivo 1981, CRC Press, Boca Raton, FL.
2. Mulder G, Jakoby W Sulfation 1990, Taylor and Francis, London.
3. Wolffram S, Grenacher B, Scharrer E Transport of selenate and sulphate across the intestinal brush-border membrane of pig jejunum by two common mechanism. Q J Exp Physiol 1988, 73:103-111.
4. Markovich D Physiological roles and regulation of mammalian sulfate transporters. Physiol Rev 2001, 81:1499-1533.
5. Lucke H, Stange G, Murer H Sulfate-sodium cotransport by brush-border membrane vesicles isolated from rat ileum. Gastroenterology 1981, 80:22-30.
6. -4 trans-port by rabbit ileal brush border membrane vesicles. J Membr Biol 1984, 78:177-186.
7. 4/- OH exchange. Am J Physiol 1985, 249:G607-G613.
8. Alrefai WA, Tyagi S, Mansour F, Saksena S, Syed I, Ramaswamy K, Dudeja PK Sulfate and chloride transport in Caco-2 cells: differential regulation by thyroxine and the possible role of DRA gene. Am J Physiol Gastwintest Liver Physiol 2001, 280:G603-G613.
9. Tyagi S, Kavilaveettil RJ, Alrefai WA, Alsafwah S, Ramaswamy K, Dudeja PK Evidence for the existence of a distinct SO (4) (-) -OH (-) exchange mechanism in the human proximal colonic apical membrane vesicles and its possible role in chloride transport. Exp Biol Med (Maywood) 2001, 226:912-918.
10. Hagenbuch B, Stange G, Murer H Transport of sulphate in rat jejunal and rat proximal tubular basolateral membrane vesicles. Pflugers Arch 1985, 405:202-208.
11. 4 exchange in rabbit ileal basolateral membrane vesicles. Am J Physiol 1987, 253:G404-G410.
12. 4/-2 cotransporter. Pflugers Arch 1994, 428(3-4):217-223.
13. 4 (2-) transport protein NaSi-1. J Biol Chem 1994, 269:12407-12409.
14. Mount DB, Romero MF The SLC26 gene family of multifunctional anion exchangers. Pflugers Arch 2004, 447:710-721.
15. - exchange and mechanism of coupling. Am J Physiol 1985, 249:G236-G245.
16. Binder HJ, Stange G, Murer H, Steiger B, Hauri HP Sodium proton exchange in colon brush-border membranes. Am J Physiol 1986, 251:G382-G390.
17. Alrefai WA, Ramaswamy K, Dudeja PK Mechanism (s) of chloride transport in human distal colonie apical membrane vesicles. Dig Dis Sci 2001, 46:2209-2218.
18. Binder HJ, Sandle GI Electrolyte transport in the mammalian colon. Physiology of the gastrointestinal tract 1994, 2133-2171. Raven Press, New York. 3rd ed. L.R. Johnson (Ed.).
19. + transport in human proximal colonie apical membrane vesicles. Gastroenterology 1994, 106:125-133.
20. Mahajan RJ, Baldwin ML, Harig JM, Ramaswamy K, Dudeja PK Chloride transport in human proximal colonie apical membrane vesicles. Biochim BiophysActa 1996, 1280:12-18.
21. - antiport systems in human ileal brush border membrane vesicles. NY Acad Sci 1989, 574:128-130.
22. - conductance. Am J Physiol 1982, 242:G272-G280.
23. Payne JA, Forbush B Molecular characterization of the epithelial Na-K-Cl cotransporter isoforms. Curr Opin Cell Biol 1995, 7:493-503.
24. Musch MW, Orellana SA, Kimberg LS, Field M, Halm DR, Krasny EJJ, Frizzel RA Na+-K+-Cl-cotransport in the intestine of a marine teleost. Nature (London) 1982, 300:351-353.
25. Montrose MH, Keely SJ, Barrett KE Electrolyte secretion and absorption: small intestine and colon. Textbook of gastroenterology 1999, 320-355. Lippincott Williams & Wilkins, Philadelphia. 3rd ed. T. Yamada, D.H. Alpers, L. Laine, C. Owyang, D.W. Powell (Eds.).
26. Reuss L Basolateral KC1 co-transport in a NaCl-absorbing epithelium. Nature 1983, 305:723-726.
27. 3 exchange in basolateral membrane of rat distal colon. Am J Physiol Cell Physiol 2003, 285:C912-C921.
28. Alrefai WA, Tyagi S, Nazir TM, Barakat J, Anwar SS, Hadjiagapiou C, Bavishi D, Sahi J, Malik P, Goldstein J, Layden TJ, Ramaswamy K, Dudeja PK Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization. Biochim Biophys Acta 2001, 1511:17-27.
29. + exchange: a cause of congenital secretary diarrhea. Lancet 1985, 1:10669.
30. Makela S, Kere J, Holmberg C, Hoglund P SLC26A3 mutations in congenital chloride diarrhea. Hum Mutat 2002, 20:425-438.
31. + diarrhea: a new type of secretory diar-rhea. J Pediatr 1985, 106:56-60.
32. Holmberg C, Perheentupa J, Launiala K Colonic electrolyte transport in health and in congenital chloride diarrhea. J Clin Invest 1975, 56:302-310.
33. Bieberdorf FA, Gordon P, Fordtran JS Pathogenesis of congenital alka-losis with diarrhea: implications for the physiology of normal ileal electrolyte absorption and secretion. J Clin Invest 1972, 51:1958-1968.
34. Frizzell RA, Koch MJ, Schultz SG Ion transport by rabbit colon. I. Active and passive components. J Membr Biol 1976, 27:297-316.
35. Frizzel RA, Turnheim K Ion transport by rabbit colon. II. Unidirectional sodium influx and the effects of amphoterecin B and amiloride. J Membr Biol 1978, 40:193-211.
36. Schultz SG A cellular model for active sodium absorption by mammalian colon. Annu Rev Physiol 1984, 46:435-451.
37. Sellin JH, De Soignie R Ion transport in human colon in vitro. Gastroenterology 1987, 93:441-448.
38. Sellin JH, De Soignie R Regulation of Na-Cl absorption in rabbit proximal colon in vitro. Am J Physiol 1987, 252:G45-G51.
39. Rajendran VM, Binder HJ C1-HCO3 and Cl-OH exchanges mediate Cl uptake in apical membrane vesicles of rat distal colon. Am J Physiol 1993, 264:G874-G879.
40. Rajendran VM, Binder HJ Distribution and regulation of apical Cl/anion exchanges in surface and crypt cells of rat distal colon. Am J Physiol 1999, 276:G132-G137. 1 pt 1.
41. - and SITS in rat intestinal epithelium. Biochim Biophys Acta 1988, 939:305-314.
42. Knickelbein RG, Aronson PS, Dobbins JW Membrane distribution of sodium-hydrogen and chloride-bicarbonate exchangers in crypt and villus cell membranes from rabbit ileum. J Clin Invest 1988, 82:2158-2163.
43. 3 exchange in the basolateral membrane domain of rat jejunal enterocyte. J Membr Biol 1991, 124:13-19.
44. Busche R, Bartels J, Kirschberger S, von Engelhardt W Intracellular pH regulation in guinea-pig caecal and colonic enterocytes during and after loading with short-chain fatty acids and ammonia. Pflugers Arch 2002, 444:785-794.
45. - exchange process in the human colonie basolateral membrane vesicles. Gastroenterology 1996, 110:A369.
46. Diener M, Scharrer E Effects of short-chain fatty acids on cell volume regulation and chloride transport in the rat distal colon. Comp Biochem Physiol A Physiol 1997, 118:375-379.
47. Potter GD Bile acid diarrhea. Dig Dis 1998, 16:118-124.
48. Freel RW, Hatch M, Earnest DL, Goldner AM Dihydroxy bile salt-induced alterations in NaCl transport across the rabbit colon. Am J Physiol 1983, 245:G808-G815.
49. Volpe BT, Binder HJ Bile salt alteration of ion transport across jejunal mucosa. Biochim Biophys Acta 1975, 394:597-604.
50. Mekjian HS, Phillips SF, Hofmann AF Colonie secretion of water and electrolytes induced by bile acids: perfusion studies in man. J Clin Invest 1971, 50:1569-1577.
51. Potter GD, Sellin JH, Burlingame SM Bile acid stimulation of cyclic AMP and ion transport in developing rabbit colon. J Pediatr Gastroenterol Nutr 1991, 13:335-341.
52. Devor DC, Sekar MC, Frizzell RA, Duffey ME Taurodeoxycholate activates potassium and chloride conductances via an IP3-mediated release of calcium from intracellular stores in a colonie cell line (T84). J Clin Invest 1993, 92:2173-2181.
53. Dharmsathaphorn K, Huott PA, Vongkovit P, Beuerlein G, Pandol SJ, Ammon HV Cl secretion induced by bile salts. A study of the mecha-nism of action based on a cultured colonie epithelial cell line. J Clin Invest 1989, 84:945-953.
54. Pongracz J, Clark P, Neoptolemos JP, Lord JM Expression of protein kinase C isoenzymes in colorectal cancer tissue and their differential activation by different bile acids. Int J Cancer 1995, 61:35-39.
55. Gelbmann CM, Schteingart CD, Thompson SM, Hofmann AF, Barrett KE Mast cells and histamine contribute to bile acid-stimulated secretion in the mouse colon. J Clin Invest 1995, 95:2831-2839.
56. - exchange activity by bile acids in Caco2 cells. Digestive Diseases and Science 2006, (In press).
57. Gill RK, Saksena S, Syed IA, Tyagi S, Alrefai WA, Malakooti J, Ramaswamy K, Dudeja PK Regulation of NHE3 by nitric oxide in Caco-2 cells. Am J Physiol Gastrointest Liver Physiol 2002, 283:G747-G756.
58. Saksena S, Gill RK, Syed IA, Tyagi S, Alrefai WA, Ramaswamy K, Dudeja PK Modulation of C1-/OH-exchange activity in Caco-2 cells by nitric oxide. Am J Physiol Gastrointest Liver Physiol 2002, 283:G626-G633.
59. Alrefai WA, Scaglione-Sewell B, Tyagi S, Wartman L, Brasitus TA, Ramaswamy K, Dudeja PK Differential regulation of the expression of Na (+)/H (+) exchanger isoform NHE3 by PKC-alpha in Caco-2 cells. Am J Physiol Cell Physiol 2001, 281:C1551-C1558.
60. Alrefai WA, Tyagi S, Gill R, Saksena S, Hadjiagapiou C, Mansour F, Ramaswamy K, Dudeja PK Regulation of butyrate uptake in Caco-2 cells by phorbol 12-myristate 13-acetate. Am J Physiol Gastrointest Liver Physiol 1904, 286:G197-G203.
61. Said HM, Ortiz A, Ma TY A carrier-mediated mechanism for pyridox-ine uptake by human intestinal epithelial Caco-2 cells: regulation by a PKA-mediated pathway. Am J Physiol Cell Physiol 2003, 285:C1219-C1225.
62. Turner JR, Black ED NHE3-dependent cytoplasmic alkalinization is triggered by Na (+) -glucose cotransport in intestinal epithelia. Am J Physiol Cell Physiol 2001, 281:C1533-C1541.
63. Sundaram U, West AB Effect of chronic inflammation on electrolyte transport in rabbit ileal villus and crypt cells. Am J Physiol 1997, 272:G732-G741. 4 pt l.
64. Wilson KT, Xie Y, Musch MW, Chang EB Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon. J Pharmacol Exp Ther 1993, 266:224-230.
65. Mourad FH, Turvill JL, Farthing MJ Role of nitric oxide in intestinal water and electrolyte transport. Gut 1999, 44:143-147.
66. Izzo AA, Mascolo N, Capasso F Nitric oxide as a modulator of intes-tinal water and electrolyte transport. Dig Dis Sci 1998, 43:1605-1620.
67. - exchangers by constitutive nitric oxide in rabbit small intestine. Am J Physiol Gastrointest Liver Physiol 2003, 285:G1084-G1090.
68. Field M Intestinal ion transport and the pathophysiology of diarrhea. J Clin Invest 2003, 111:931-943.
69. Racusen LC, Binder HJ Mechanism(s) of intestinal secretion 1979, 201-205. Liss, New York.
70. Chang EB, Field M, Miller RJ alpha2-Adrenergic receptor regulation of ion transport in rabbit ileum. Am J Physiol 1982, 242:G237-G242.
71. Field M, McColl I Ion transport in rabbit ileal mucosa. 3. Effects of catecholamines. Am J Physiol 1973, 225:852-857.
72. Hubel KA Intestinal ion transport: effect of norepinephrine, pilocarpine, and atropine. Am J Physiol 1976, 231:252-257.
73. +-activated adenosine triphosphatase intestinal electrolyte transport. Effect of adrenal steroids. J Clin Invest 1975, 56:653-660.
74. Bastl CP, Schulman G, Cragoe EJ Low-dose glucocorticoids stimulate electroneutral NaCl absorption in rat colon. Am J Physiol 1989, 257:F1027-F1038. 6 pt 2.
75. Berant M, Diamond E, Mabriki W, Ben-Yitzhak O Effects of hypothy-roidism on jejunal mucosal function: study by in situ luminal perfusion in rats. Pediatr Res 1993, 34:79-83.
76. Okuno M, Nakanishi T, Shinomura Y, Kiyohara T, Ishikawa H, Tarui S Peptide YY enhances NaCl and water absorption in the rat colon in vivo. Experientia 1992, 48:47-50.
77. Liu CD, Newton TR, Zinner MJ, Ashley SW, McFadden DW Intraluminal peptide YY induces colonie absorption in vivo. Dis Colon Rectum 1997, 40:478-482.
78. Donowitz M, Tai YH, Asarkof N Effect of serotonin on active elec-trolyte transport in rabbit ileum, gallbladder, and colon. Am J Physiol 1980, 239:G463-G472.
79. Hardcastle J, Hardcastle PT, Redfern JS Action of 5-hydroxytrypta-mine on intestinal ion transport in the rat. J Physiol 1981, 320:41-55.
80. Siriwardena AK, Budhoo MR, Smith EP, Kellum JM A 5-HT3 receptor agonist induces neurally mediated chloride transport in rat distal colon. J Surg Res 1993, 55:55-59.
81. Ikuma M, Kashgarian M, Binder HJ, Rajendran VM Differential regu-lation of NHE isoforms by sodium depletion in proximal and distal segments of rat colon. Am J Physiol 1999, 276:G539-G549. 2 pt 1.
82. Turnamian SG, Binder HJ Aldosterone and glucocorticoid receptor-specific agonists regulate ion transport in rat proximal colon. Am J Physiol 1990, 258:G492-G498. 3 pt 1.
83. Rajendran VM, Black J, Ardito TA, Sangan P, Alper SL, Schweinfest C, Kashgarian M, Binder HJ Regulation of DRA and AE1 in rat colon by dietary Na depletion. Am J Physiol Gastwintest Liver Physiol 2000, 279:G931-G942.
84. Rajendran VM, Binder HJ Characterization and molecular localiza-tion of anion transporters in colonic epithelial cells. Ann NY Acad Sci 2000, 915:15-29.
85. Saksena S, Gill RK, Tyagi S, Alrefai WA, Sarwar Z, Ramaswamy K, Dudeja PK Involvement of c-Src and protein kinase Cdelta in the inhibition of Cl (-)/OH-exchange activity in Caco-2 cells by sero-tonin. JBiol Chem 2005, 280:11859-11868.
86. + exchange activity via 5-HT4 receptors and activation of PKCalpha in human intestinal epithelial cells. Gastroenterology 2005, 128:962-974.
87. + exchange isoform activities by enteropathogenic E. coli in human intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 2004, 287:G370-G378.
88. Hecht G, Gill R, Saksena S, Tyagi S, Hodges K, Ramaswamy K, Dudeja PK, Enteropathogenic E coli inhibits Cl (-)/(OH-) exchange activity in Caco-2 cells. Gastroenterology 2003, 124:194.
89. Hecht G Microbes microbial toxins: paradigms for microbial-mucosal interactions. VII. Enteropathogenic Escherichia coli: physio-logical alterations from an extracellu. Am J Physiol Gastrointest Liver Physiol 2001, 281:G1-G7.
90. Donowitz M, Cheng HY, Sharp GW Effects of phorbol esters on sodium and chloride transport in rat colon. Am J Physiol 1986, 251:G509-G517. (4 pt l).
91. Saksena S, Gill RK, Syed IA, Tyagi S, Alrefai WA, Ramaswamy K, Dudeja PK Inhibition of apical Cl (-)/OH (-) exchange activity in Caco-2 cells by phorbol esters is mediated by PKCepsilon. Am J Physiol Cell Physiol 2002, 283:C1492-C1500.
92. Grisham MB, Granger DN Neutrophil-mediated mucosal injury. Role of reactive oxygen metabolites. Dig Dis Sci 1988, 33(3 suppl):6S-15S.
93. Pavlick KP, Laroux FS, Fuseler J, Wolf RE, Gray L, Hoffman J, Grisham MB Role of reactive metabolites of oxygen and nitrogen in inflammatory bowel disease. Free Radic Biol Med 2002, 33:311-322.
94. Grisham MB, Pavlick KP, Laroux FS, Hoffman J, Bharwani S, Wolf RE Nitric oxide and chronic gut inflammation: controversies in inflamma-tory bowel disease. J Investig Med 2002, 50:272-283.
95. Saksena S, Gill RK, Tyagi S, Alrefai WA, Ramaswamy K, Dudeja PK Hydrogen peroxide inhibits C1-/OH-exchange activity in Caco-2 Cells. Gastroenterology 2003, 124:A143.
96. Gill RK, Alrefai WA, Ramaswamy A, Dudeja PK Mechanisms and regulation of NaCl absorption in the human intestine. Recent Res Develop Physiol 2003, 643-677. Research Signpost Press.
97. - transporters. Pflugers Arch 2004, 447:495-509.
98. 3/- exchangers. J Nephrol 2002, 15(suppl 5):S41-S53.
99. 3/- cotransporter, NBC. Jop 2001, 2(4 suppl):182-191.
100. - exchangers by pH. JOP 2001, 2(4 suppl):171-175.
101. Choi I, Aalkjaer C, Boulpaep EL, Boron WF An electroneutral sodium/bicarbonate cotransporter NBCnl and associated sodium channel. Nature 2000, 405:571-575.
102. +-driven anion exchanger (NDAE1). A new bicarbonate transporter. J Biol Chem 2000, 275:24552-24559.
103. Tsuganezawa H, Kobayashi K, Iyori M, Araki T, Koizumi A, Watanabe S, Kaneko A, Fukao T, Monkawa T, Yoshida T, Kim DK, Kanai Y, Endou H, Hayashi M, Saruta T A new member of the HCO[in3} (-) transporter superfamily is an apical anion exchanger of betaintercalated cells in the kidney. J Biol Chem 2001, 276:8180-8189.
104. Xu J, Barone S, Petrovic S, Wang Z, Seidler U, Riederer B, Ramaswamy K, Dudeja PK, Shull GE, Soleimani M Identification of an apical C1-/HCO3-exchanger in gastric surface mucous and duodenal villus cells. Am J Physiol Gastrointest Liver Physiol 2003, 285:G1225-G1234.
105. Ko SB, Luo X, Hager H, Rojek A, Choi JY, Licht C, Suzuki M, Muallem S, Nielsen S, Ishibashi K AE4 is a DIDS-sensitive Cl (-)/HCO (-) (3) exchanger in the basolateral membrane of the renal CCD and the SMG duct. Am J Physiol Cell Physiol 2002, 283:C1206-C1218.
106. Parker MD, Ourmozdi EP, Tanner MJ Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney. Biochem Biophys Res Commun 2001, 282:1103-1109.
107. Praetorius J, Hager H, Nielsen S, Aalkjaer C, Friis UG, Ainsworth MA, Johansen T Molecular and functional evidence for electrogenic and electroneutral Na (+) -HCO (3) (-) cotransporters in murine duodenum. Am J Physiol Gastrointest Liver Physiol 2001, 280:G332-G343.
108. van Adelsberg JS, Edwards JC, al-Awqati Q The apical C1/HCO3 exchanger of beta intercalated cells. J Biol Chem 1993, 268:11283-11289.
109. Sabolic I, Brown D, Gluck SL, Alper SL Regulation of AE1 anion exchanger and H (+) -ATPase in rat cortex by acute metabolic acidosis and alkalosis. Kidney Int 1997, 51:125-137.
110. Charney AN, Egnor RW, Steinbrecher KA, Cohen MB Effect of secretagogues and pH on intestinal transport in guanylin-deficient mice. Biochim Biophys Acta 1904, 1671(l-3):79-86.
111. Alper SL The band 3-related AE anion exchanger gene family. Cell Physiol Biochem 1994, 4:265-281.
112. Stuart-Tilley A, Sardet C, Pouyssegur J, Schwartz MA, Brown D, Alper SL Immunolocalization of anion exchanger AE2 and cation exchanger NHE-1 in distinct adjacent cells of gastric mucosa. Am J Physiol 1994, C559-C568.
113. Stuart-Tilley AK, Shmukler BE, Brown D, Alper SL Immuno-localization and tissue-specific splicing of AE2 anion exchanger in mouse kidney. J Am Soc Nephrol 1998, 9:946-959.
114. Alper SL, Rossmann H, Wilhelm S, Stuart-Tilley AK, Shmukler BE, Seidler U Expression of AE2 anion exchanger in mouse intestine. Am J Physiol 1999, 277(2):G321-G332. pt 1.
115. Kopito RR, Lee BS, Simmons DM, Lindsey AE, Morgans CW, Schneider K Regulation of Intracellular pH by a neuronal homolog of the erythrocyte anion exchanger. Cell 1989, 59:927-937.
116. 3/- exchanger. J Biol Chem 1990, 265:462-471.
117. Kobayashi S, Morgans CW, Casey JR, Kopito RR AE3 anion exchanger isoforms in the vertebrate retina: developmental regulation and differential expression in neurons and glia. J Neurosci 1994, 14:6266-6279.
118. Yannoukakos D, Tilley AS, Fernandez HA, Fey P, Duyk G, Alper SL Molecular cloning, expression, and chromosomal localization of two isoforms of the AE3 anion exchanger from human heart. Circ Res 1994, 75:603-614.
119. Brosius FC, Pisoni RL, Cao X, Deshmukh G, Yannoukakos D, Stuart-Tilley AK, Haller C, Alper SL AE anion exchanger mRNA and protein expression in vascular smooth muscle cells, aorta, and renal microvessels. Am J Physiol 1997, 273:F1039-F1047. 6 pt 2.
120. 3/- cotransporter in mammalian and amphibian kidney. Am J Physiol 1999, 276:F27-F38. 1 pt 2.
121. Marino CR, Jeanes V, Boron WF, Schmitt BM Expression and distribution of the Na (+) -HCO (-) (3) cotransporter in human pancreas. Am J Physiol 1999, 277:G487-G494. 2 pt 1.
122. Jensen LJ, Schmitt BM, Berger UV, Nsumu NN, Boron WF, Hediger MA, Brown D, Breton S Localization of sodium bicarbonate cotransporter (NBC) protein and messenger ribonucleic acid in rat epididymis. Biol Reprod 1999, 60:573-579.
123. Schmitt BM, Berger UV, Douglas RM, Bevensee MO, Hediger MA, Haddad GG, Boron WE Na/HCO3 cotransporters in rat brain: expression in glia, neurons, and choroid plexus. J Neurosci 2000, 20:6839-6848.
124. Bok D, Schibler MJ, Pushkin A, Sassani P, Abuladze N, Naser Z, Kurtz I Immunolocalization of electrogenic sodium-bicarbonate cotransporters pNBCl and kNBCl in the rat eye. Am J Physiol Renal Physiol 2001, 281:F920-F935.
125. +-ATPase subunit are PDZ motifs involved in their interaction. Am J Physiol Cell Physiol 2003, 284:C667-C673.
126. Pushkin A, Abuladze N, Newman D, Lee I, Xu G, Kurtz I Cloning, characterization and chromosomal assignment of NBC4, a new member of the sodium bicarbonate cotransporter family. Biochim Biophys Acta 2000, 1493(l-2):215-218.
127. 3/- exchanger. Cloning, tissue distribution, and functional characterization. J Biol Chem 2000, 275:35486-35490.
128. Low PS, Zhang D, Bolin JT Localization of mutations leading to altered cell shape and anion transport in the crystal structure of the cytoplasmic domain of band 3. Blood Cells Mol Dis 2001, 27:81-84.
129. Morgans CW, Kopito RR Association of the brain anion exchanger, AE3, with the repeat domain of ankyrin. J Cell Sci 1993, 105:1137-1142. pt 4.
130. Zhu Q, Lee DW, Casey JR Novel topology in C-terminal region of the human plasma membrane anion exchanger, AE1. J Biol Chem 2003, 278:3112-3120.
131. Stewart AK, Chernova MN, Shmukler BE, Wilhelm S, Alper SL Regulation of AE2-mediated Cl-transport by intracellular or by extra-cellular pH requires highly conserved amino acid residues of the AE2 NH2-terminal cytopla. J Gen Physiol 2002, 120:707-722.
132. Alper SL, Chernova MN, Stewart AK How pH regulates a pH regulator: a regulatory hot spot in the N-terminal cytoplasmic domain of the AE2 anion exchanger. Cell Biochem Biophys 2002, 36(2-3):123-136.
133. Chernova MN, Stewart AK, Jiang L, Friedman DJ, Kunes YZ, Alper SL Structure-function relationships of AE2 regulation by Ca (i) (2+) -sensitive stimulators NH (4+) and hypertonicity. Am J Physiol Cell Physiol 2003, 284:C1235-C1246.
134. Sterling D, Alvarez BV, Casey JR The extracellular component of a transport metabolon Extracellular loop 4 of the human AE1 C1-/HCO3-exchanger binds carbonic anhydrase IV. J Biol Chem 2002, 277:25239-25246.
135. Sterling D, Reithmeier RA, Casey JR A transport metabolon. Functional interaction of carbonic anhydrase II and chloride/bicarbonate exchangers. J Biol Chem 2001, 276:47886-47894.
136. Pushkin AV, Tsuprun VL, Abuladze NK, Newman D, Kurtz I Oligomeric structure of bAE3 protein. IUBMB Life 2000, 50:397-401.
137. Zolotarev AS, Shmukler BE, Alper SL AE2 anion exchanger polypeptide is a homooligomer in pig gastric membranes: a chemical cross-linking study. Biochemistry 1999, 38:8521-8531.
138. Medina JF, Lecanda J, Acin A, Ciesielczyk P, Prieto J Tissue-specific N-terminal isoforms from overlapping alternate promoters of the human AE2 anion exchanger gene. Biochem Biophys Res Commun 2000, 267:228-235.
139. Morgans CW, Kopito RR Generation of truncated brain AE3 isoforms by alternate mRNA processing J. Cell Sci 1993, 106:1275-1282. pt 4.
140. Kopito RR, Lodish HF Primary structure and transmembrane orientation of the murine anion exchange protein. Nature 1985, 316:234-238.
141. Schofield AE, Martin PG, Spillett D, Tanner MJ The structure of the human red blood cell anion exchanger (EPB3, AE1, band 3) gene. Blood 1994, 84:2000-2012.
142. Jennings ML, Gosselink PG Anion exchange protein in Southeast Asian ovalocytes: heterodimer formation between normal and variant subunits. Biochemistry 1995, 34:3588-3595.
143. Jarolim P, Murray JL, Rubin HL, Taylor WM, Prchal JT, Ballas SK, Snyder LM, Chrobak L, Melrose WD, Brabec V, Palek J Characterization of 13 novel band 3 gene defects in hereditary sphe-rocytosis with band 3 deficiency. Blood 1996, 88:4366-4374.
144. Southgate CD, Chishti AH, Mitchell B, Yi SJ, Palek J Targeted disruption of the murine erythroid band 3 gene results in spherocytosis and severe haemolytic anaemia despite a normal membrane skeleton. Nat Genet 1996, 14:227-230.
145. Bruce LJ, Wrong O, Toye AM, Young MT, Ogle G, Ismail Z, Sinha AK, McMaster P, Hwaihwanje I, Nash GB, Hart S, Lavu E, Palmer R, Othman A, Unwin RJ, Tanner MJ Band 3 mutations, renal tubular acidosis and South-East Asian ovalocytosis in Malaysia and Papua New Guinea: loss of up to 95% band 3 transport in red cells. Biochem J 2000, 350:41-51. (pt 1).
146. Karet FE, Gainza FJ, Gyory AZ, Unwin RJ, Wrong O, Tanner MJ, Nayir A, Alpay H, Santos F, Hulton SA, Bakkaloglu A, Ozen S, Cunningham MJ, di Pietro A, Walker WG, Lifton RP Mutations in the chloride-bicarbonate exchanger gene AE1 cause autosomal dominant but not autosomal recessive distal renal tubular acidosis. Proc Natl Acad Sci U S A 1998, 95:6337-6342.
147. Timmer RT, Gunn RB Inducible expression of erythrocyte band 3 protein. Am J Physiol 1999, 276:C66-C75. (1 pt 1).
148. Sekler I, Lo RS, Mastrocola T, Kopito RR Sulfate transport mediated by the mammalian anion exchangers in reconstituted proteoliposomes. J Biol Chem 1995, 270:11251-11256.
149. Sekler I, Lo RS, Kopito RR A conserved glutamate is responsible for ion selectivity and pH dependence of the mammalian anion exchangers AE1 and AE2. J Biol Chem 1995, 270:28751-28758.
150. Charney AN, Egnor RW, Henner D, Rashid H, Cassai N, Sidhu GS Acid-base effects on intestinal Cl-absorption and vesicular trafficking. Am J Physiol Cell Physiol 2004, 286:C1062-C1070.
151. Alper SL, Kopito RR, Libresco SM, Lodish HF Cloning and charac-terization of a murine band 3-related cDNA from kidney and from a lymphoid cell line. J Biol Chem 1988, 263:17092-17099.
152. Medina J, Acin A, Prieto J Molecular cloning and characterization of the human AE2 anion exchanger (SLC4A2) gene. Genomics 1997, 39:74-85.
153. Gawenis LR, Ledoussal C, Judd LM, Prasad V, Alper SL, Stuart-Tilley A, Woo AL, Grisham C, Sanford LP, Doetschman T, Miller ML, Shull GE Mice with a targeted disruption of the AE2 C1-/HCO3-exchanger are achlorhydric. J Biol Chem 2004, 279:30531-30539.
154. Rossmann H, Bachmann O, Wang Z, Shull GE, Obermaier B, Stuart-Tilley A, Alper SL, Seidler U Differential expression and regulation of AE2 anion exchanger subtypes in rabbit parietal and mucous cells. JPhysiol 2001, 534:837-848. (pt 30).
155. Aranda V, Martinez I, Melero S, Lecanda J, Banales JM, Prieto J, Medina JF Shared apical sorting of anion exchanger isoforms AE2a, AE2bl, and AE2b2 in primary hepatocytes. Biochem Biophys Res Commun 2004, 319:1040-1046.
156. Rossmann H, Nader M, Seidler U, Classen M, Alper S Basolateral membrane localization of the AE-2 isoform of the anion exchanger family in both stomach and ileum. Gastroenterology 1995, 108:A319.
157. 3/- exchanger PAT1 and gastric H-K-ATPase in stomach parietal cells. Am J Physiol Gastrointest Liver Physiol 2002, 283:G1207-G1216.
158. Medina JF, Recalde S, Prieto J, Lecanda J, Saez E, Funk CD, Vecino P, van Roon MA, OttenhoffR, Bosma PJ, Bakker CT, Elferink RP Anion exchanger 2 is essential for spermiogenesis in mice. Proc Natl Acad Sci USA 2003, 100:15847-15852.
159. Linn SC, Kudrycki KE, Shull GE The predicted translation product of a cardiac AE3 mRNA contains an N terminus distinct from that of the brain AE3 C1-/HCO3-exchanger. Cloning of a cardiac AE organization of the AE3 gene, and identification of an alternative transcription initiation site. J Biol Chem 1992, 267:7927-7935.
160. Lee BS, Gunn RB, Kopito RR Functional differences among nonerythroid anion exchangers expressed in a transfected human cell line. J Biol Chem 1991, 266:11448-11454.
161. Charney AN, Egnor RW NaCl absorption in the rabbit ileum: effect of acid base variables. Gastroenterology 1991, 100:403-409.
162. 3/- exchanger during intestinal development. Am J Physiol 1996, 271:G330-G337.
163. Riedel BD, Ghishan FK Maturation of chloride-bicarbonate exchange in rat ileal brush border membrane vesicles. Pediatr Res 1989, 25:189-193.
164. Sterling D, Casey JR Transport activity of AE3 chloride/bicarbonate anion-exchange proteins and their regulation by intracellular pH. Biochem J 1999, 344:221-229. (pt l).
165. 2terminal cytoplasmic domain. J Biol Chem 2004, 279:52664-52676.
166. Humphreys BD, Chernova MN, Jiang L, Zhang Y, Alper SL NH4C1 activates AE2 anion exchanger in Xenopus oocytes at acidic pHi. Am J Physiol 1997, 272:C1232-C1240. (4 pt l).
167. Minetti G, Seppi C, Ciana A, Balduini C, Low PS, Brovelli A Characterization of the hypertonically induced tyrosine phosphorylation of erythrocyte band 3. Biochem J 1998, 335:305-311. (pt 2).
168. Alvarez BV, Fujinaga J, Casey JR Molecular basis for angiotensin II-induced increase of chloride/bicarbonate exchange in the myocardium. Circ Res 2001, 89:1246-1253.
169. Lohi H, Kujala M, Kerkela E, Saarialho-Kere U, Kestila M, Kere J Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger. Genomics 2000, 70:102-112.
170. Everett LA, Green ED A family of mammalian anion transporters and their involvement in human genetic diseases. Hum Mol Genet 1999, 8:1883-1891.
171. Bissig M, Hagenbuch B, Stieger B, Koller T, Meier PJ Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes. J Biol Chem 1994, 269:3017-3021.
172. Schweinfest CW, Henderson KW, Suster S, Kondoh N, Papas TS Identification of a colon mucosa gene that is down-regulated in adenomas and adenocarcinomas. Proc Natl Acad Sci U S A 1993, 90:4166-4170.
173. Melvin JE, Park K, Richardson L, Schultheis PJ, Shull GE Mouse down-regulated in adenoma (DRA) is an intestinal Cl (-)/HCO (3) (-) exchanger and is up-regulated in colon of mice lacking the NHE3 Na (+)/H (+) excha. J Biol Chem 1999, 274:22855-22861.
174. Moseley RH, Hoglund P, Wu GD, Silberg DG, Haila S, Chapelle ADL, Holmberg C, Fere J Downregulated in adenoma gene encodes a chlo-ride transporter defective in congenital chloride diarrhea. Am J Physiol 1999, 267:G185-G192.
175. Chernova MN, Jiang L, Shmukler BE, Schweinfest CW, Blanco P, Freedman SD, Stewart AK, Alper SL Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytes. J Physiol 2003, 549:3-19. (pt 1).
176. Haila S, Saarialho-Kere U, Karjalainen-Lindsberg ML, Lohi H, Airola K, Holmberg C, Hastbacka J, Kere J, Hoglund P The congenital chloride diarrhea gene is expressed in seminal vesicle, sweat gland, inflammatory colon epithelium, and in some dysplastic colon cells. Histochem Cell Biol 2000, 113:279-286.
177. Scott DA, Wang R, Kreman TM, Sheffield VC, Karniski LP The Pendred syndrome gene encodes a chloride-iodide transport protein. Nat Genet 1999, 21:440-443.
178. Royaux IE, Suzuki K, Mori A, Katoh R, Everett LA, Kohn LD, Green ED Pendrin, the protein encoded by the Pendred syndrome gene (PDS), is an apical porter of iodide in the thyroid and is regulated by thyroglobulin in FRTL-5 cel. Endocrinology 2000, 141:839-845.
179. Soleimani M, Greeley T, Petrovic S, Wang Z, Amlal H, Kopp P, Burnham CE Pendrin: an apical C1-/OH-/HCO3-exchanger in the kidney cortex. Am J Physiol Renal Physiol 2001, 280:F356-F364.
180. Oliver D, He DZ, Klocker N, Ludwig J, Schulte U, Waldegger S, Ruppersberg JP, Dallos P, Fakler B Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein. Science 2001, 292:2340-2343.
181. Zheng J, Long KB, Matsuda KB, Madison LD, Ryan AD, Dallos PD Genomic characterization and expression of mouse prestin, the motor protein of outer hair cells. Mamm Genome 2003, 14:87-96.
182. Saksena S, Gill R, Tyagi S, Alrefai WA, Ramaswamy K, Dudeja PK Expression and membrane localization of PAT-1 in human intestine. Gastroenterology 2004, 126:A298.
183. 3/- exchanger pendrin in rat cortical collecting duct in metabolic acidosis. Am J Physiol Renal Physiol 2003, 284:F103-F112.
184. 3/- exchanger specific to intercalated cells of the outer medullary collecting duct. Am J Physiol Renal Physiol 2004, 286:F161-F169.
185. Lohi H, Kujala M, Makela S, Lehtonen E, Kestila M, Saarialho-Kere U, Markovich D, Kere J Functional characterization of three novel tissue-specific anion exchangers SLC26A7,-A8, and-A9. J Biol Chem 2002, 277:14246-14254.
186. Toure A, Morin L, Pineau C, Becq F, Dorseuil O, Gacon G Tatl, a novel sulfate transporter specifically expressed in human male germ cells and potentially linked to RhoGTPase signaling. J Biol Chem 2001, 276:20309-20315.
187. Vincourt JB, Jullien D, Kossida S, Amalric F, Girard JP Molecular cloning of SLC26A7, a novel member of the SLC26 sulfate/anion transporter family, from high endothelial venules and kidney. Genomics 2002, 79:249-256.
188. Hastbacka J, de la Chapelle A, Mahtani MM, Clines G, Reeve-Daly MP, Daly M, Hamilton BA, Kusumi K, Trivedi B, Weaver A, Coloma A, Lovett M, Buckler A, Kaitila I, Lander E The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell 1994, 78:1073-1087.
189. Hoglund P, Haila S, Socha J, Tomaszewski L, Saarialho-kere U, Lindsberg MLK, Chapelle A, Kere J Mutations of the down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. Nat Genet 1996, 14:316-319.
190. Everett LA, Glaser B, Beck JC, Idol JR, Buchs A, Heyman M, Adawi F, Hazani E, Nassir E, Baxevanis AD, Sheffield VC, Green ED Pendred syndrome is caused by mutations in a putative sulphate transporter gene (PDS). Nat Genet 1997, 17:411-422.
191. Scott DA, Karniski LP Human pendrin expressed in Xenopus laevis oocytes mediates chloride/formate exchange. Am J Physiol Cell Physiol 2000, 278:C207-C211.
192. Saier MH, Eng BH, Fard S, Garg J, Haggerty DA, Hutchinson WJ, Jack DL, Lai EC, Liu HJ, Nusinew DP, Omar AM, Pao SS, Paulsen IT, Quan JA, Sliwinski M, Tseng TT, Wachi S, Young GB Phylogenetic characterization of novel transport protein families revealed by genome analyses. Biochim Biophys Acta 1999, 1422:1-56.
193. Aravind L, Koonin EV The STAS domain: a link between anion trans-porters and antisigma-factor antagonists. Curr Biol 2000, 10:R53-R55.
194. Ko SB, Zeng W, Dorwart MR, Luo X, Kim KH, Millen L, Goto H, Naruse S, Soyombo A, Thomas PJ, Muallem S Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol 2004, 6:343-350.
195. Hoglund P Positional candidate genes for congenital chloride diarrhea suggested by high resolution physical mapping in chromosome region 7q31. Genome Res 1996, 6:202-210.
196. Holmberg C, Perheentupa J, Launiala K, Hallman N Congenital chloride diarrhoea. Clinical analysis of 21 Finnish patients. Arch Dis Child 1977, 52:255-267.
197. Holmberg C Congenital chloride diarrhea. Clin Gastroenterol 1986, 15:583-588.
198. Kere J, Lohi H, Hoglund P Genetic disorder of membrane transport III. Congenital chloride diarrhea. Am J Physiol 1999, 276:G7-G13.
199. Kirkinen P, Jouppila P Prenatal ultrasonic findings in congenital chloride diarrhoea. Prenat Diagn 1984, 4:457-461.
200. Kagalwalla AF Congenital chloride diarrhea. A study in Arab children. J Clin Gastroenterol 1994, 19:36-40.
201. Turnberg L, Fordtran J, Carter N, Rector F Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunum. J Clin Invest 1970, 49:548-556.
202. Dudeja PK, Gill R, Ramaswamy K Absorption-secretion and epithelial cell function. Colonic Diseases 2003, Humana Press, Totowa, NJ. T. Koch (Ed.).
203. Canani RB, Terrin G, Cirillo P, Castaldo G, Salvatore F, Cardillo G, Coruzzo A, Troncone R Butyrate as an effective treatment of congenital chloride diarrhea. Gastroenterology 2004, 127:630-634.
204. Kere J, Sistonen P, Holmberg C, Chapelle A The gene for congenital chloride diarrhea maps close to but is distinct from the gene for cystic fibrosis transmembrane conductance regulator. Proc Natl Acad Sci USA 1993, 90:10686-10689.
205. Hoglund P, Sistonen P, Norio R, Holmberg C, Dimberg A, Gustavson KH, Chapelle A, Kere J Fine mapping of the congenital chloride diarrhea gene by linkage disequilibrium. Am J Hum Genet 1995, 57:95-102.
206. Haila S, Hoglund P, Scherer SW, Lee JR, Kristo P, Coyle B, Trembath R, Holmberg C, de la Chapelle A, Kere J Genomic structure of the human congenital chloride diarrhea (CLD) gene. Gene 1998, 214(1-2):87-93.
207. Hoglund P, Sormaala M, Haila S, Socha J, Rajaram U, Scheurlen W, Sinaasappel M, de Jonge H, Holmberg C, Yoshikawa H, Kere J Identification of seven novel mutations including the first two genomic rearrangements in SLC26A3 mutated in congenital chloride diarrhea. Hum Mutat 2001, 18:233-242.
208. Montrose M, Kere J Anion absorption in the intestine: anion transporters, short-chain fatty acids, and role of the DRA gene product. Current Topics in Membranes 2001, Vol. 50:301-328. Academic Press.
209. Byeon MK, Westerman MA, Maroulakou IG, Henderson KW, Suster S, Zhang XK, Papas TS, Vesely J, Willingham MC, Green JE, Schweinfest CW The down-regulated in adenoma (DRA) gene encodes an intestine-specific membrane glycoprotein. Oncogene 1996, 12:387-396.
210. Silberg DG, Wang W, Moseley RH, Traber PG The down-regulated in adenoma (DRA) gene encodes an intestine-specific membrane sulfate transport protein. J Biol Chem 1995, 270:11897-11902.
211. Lamprecht G, Baisch S, Schoenleber E, Gregor M Transport properties of the human intestinal anion exchanger DRA (down-regulated in adenoma) in transfected HEK293 cells. Pflugers Arch 2005, 449:479-490.
212. Chapman JM, Knoepp SM, Byeon MK, Henderson KW, Schweinfest CW The colon anion transporter, down-regulated in adenoma, induces growth suppression that is abrogated by ElA. Cancer Res 2002, 62:5083-5088.
213. Byeon MK, Frankel A, Papas TS, Henderson KW, Schweinfest CW Human DRA functions as a sulfate transporter in Sf9 insect cells. Protein Expr Purif 1998, 12:67-74.
214. Yang H, Jiang W, Furth EE, Wen X, Katz JP, Sellon RK, Silberg DG, Antalis TM, Schweinfest CW, Wu GD Intestinal inflammation reduces expression of DRA, a transporter responsible for congenital chloride diarrhea. Am J Physiol 1998, 275:G1445-G1453. (6 pt 1).
215. Jacob P, Rossmann H, Lamprecht G, Kretz A, NeffC, Lin-Wu E, Gregor M, Groneberg DA, Kere J, Seidler U Down-regulated in adenoma mediates apical C1-/HCO3-exchange in rabbit, rat, and human duodenum. Gastroenterology 2002, 122:709-724.
216. Greeley T, Shumaker H, Wang Z, Schweinfest CW, Soleimani M Downregulated in adenoma and putative anion transporter are regulated by CFTR in cultured pancreatic duct cells. Am J Physiol Gastrointest Liver Physiol 2001, 281:G1301-G1308.
217. Hemminki A, Hoglund P, Pukkala E, Salovaara R, Jarvinen H, Norio R, Aaltonen LA Intestinal cancer in patients with a germline mutation in the down-regulated in adenoma (DRA) gene. Oncogene 1998, 16:681-684.
218. Lamprecht G, Heil A, Baisch S, Lin-Wu E, Yun CC, Kaibacher H, Gregor M, Seidler U The down regulated in adenoma (dra) gene prod-uct binds to the second PDZ domain of the NHE3 kinase A regulatory protein (E3KARP), potentially linking intest C1-/HCO3-exchange to Na+/H+ exchange. Biochemistry 2002, 41:12336-12342.
219. Sterling D, Brown NJ, Supuran CT, Casey JR The functional and physical relationship between the DRA bicarbonate transporter and carbonic anhydrase II. Am J Physiol Cell Physiol 2002, 283:C1522-C1529.
220. 3/- anion exchanger binding site to the amino-terminal region of carbonic anhydrase II. Biochemistry 2000, 39:13344-13349.
221. Waldegger S, Moschen I, Ramirez A, Smith RJ, Ayadi H, Lang F, Kubisch C Cloning and characterization of slc26a6, a novel member of the solute carrier 26 gene family. Genomics 2001, 72:43-50.
222. Lohi H, Lamprecht G, Markovich D, Heil A, Kujala M, Seidler U, Kere J Isoforms of SLC26A6 mediate anion transport and have functional PDZ interaction domains. Am J Physiol Cell Physiol 2003, 284:C769-C779.
223. Xie Q, Welch R, Mercado A, Romero MF, Mount DB Molecular char-acterization of the murine Slc26a6 anion exchanger: functional compar-ison with Slc26al. Am J Physiol Renal Physiol 2002, 283:F826-F838.
224. Knauf F, Yang CL, Thomson RB, Mentone SA, Giebisch G, Aronson PS Identification of a chloride-formate exchanger expressed on the brush border membrane of renal proximal tubule cells. Proc Natl Acad Sci U S A 2001, 98:9425-9430.
225. Wang Z, Petrovic S, Mann E, Soleimani M Identification of an apical Cl (-)/HCO3 (-) exchanger in the small intestine. Am J Physiol Gastrointest Liver Physiol 2002, 282:G573-G579.
226. Jiang Z, Grichtchenko II, Boron WF, Aronson PS Specificity of anion exchange mediated by mouse Slc26a6. J Biol Chem 2002, 277:33963-33967.
227. Ko SB, Shcheynikov N, Choi JY, Luo X, Ishibashi K, Thomas PJ, Kim JY, Kim KH, Lee MG, Naruse S, Muallem S A molecular mech-anism for aberrant CFTR-dependent HCO (3) (-) transport in cystic fibrosis. EMBO J 2002, ,21:5662-5672.
228. Knickelbein RG, Aronson PS, Dobbins JW Oxalate transport by anion exchange across rabbit ileal brush border. J Clin Invest 1985, 77:170-175.
229. Holmes RP, Goodman HO, Assimos DG Contribution of dietary oxalate to urinary oxalate excretion. Kidney Int 2001, 59:270-276.
230. Karlstedt E, Kaitila I, Pirinen S Phenotypic features of dentition in diastrophic dysplasia. J Craniofac Genet Dev Biol 1996, 16:164-173.
231. Karlstedt E, Kovero O, Kaitila I, Pirinen S Transverse facial morphol-ogy in patients with diastrophic dysplasia. J Craniofac Genet Dev Biol 1997, 17:178-183.
232. Karlstedt E, Kaitila I, Pirinen S Craniofacial structure in diastrophic dysplasia: a cephalometric study. Am J Med Genet 1997, 72:266-274.
233. Hastbacka J, Superti-Furga A, Wilcox WR, Rimoin DL, Cohn DH, Lander ES Sulfate transport in chondrodysplasia. Ann NY Acad Sci 1996, 785:131-136.
234. Superti-Furga A, Hastbacka J, Rossi A, van der Harten JJ, Wilcox WR, Cohn DH, Rimoin DL, Steinmann B, Lander ES, Gitzelmann R A family of chondrodysplasias caused by mutations in the diastrophic dysplasia sulfate transporter gene and associated with impaired sulfation of proteoglycan. Ann NY Acad Sci 1996, 785:195-201.
235. Clines GA, Lovett M The full length sequence, genomic structure and identification of a novel splice junction within diastrophic dyspla-sia sulfate transporter gene. Am J Hum Genet 1996, 59:A148. suppl, (Abstract).
236. Hastbacka J, Kerrebrock A, Mokkala K, Clines G, Lovett M, Kaitila I, de la Chapelle A, Lander ES Identification of the Finnish founder mutation for diastrophic dysplasia (DTD). Eur J Hum Genet 1999, 7:664-670.
237. Satoh H, Susaki M, Shukunami C, Iyama K, Negoro T, Hiraki Y Functional analysis of diastrophic dysplasia sulfate transporter. Its involvement in growth regulation of chondrocytes mediated by sulfated proteoglycans. J Biol Chem 1998, 273:12307-12315.
238. Haila S, Hastbacka J, Bohling T, Karjalainen-Lindsberg ML, Kere J, Saarialho-Kere U SLC26A2 (diastrophic dysplasia sulfate trans-porter) is expressed in developing and mature cartilage but also in other tissues and cell types. J Histochem Cytochem 1901, 49:973-982.
239. Esko JD, Elgavish A, Prasthofer T, Taylor WH, Weinke JL Sulfate transport-deficient mutants of Chinese hamster ovary cells. Sulfation of glycosaminoglycans dependent on cysteine. J Biol Chem 1986, 261:15725-15733.
240. Paradiso AM, Townsley MC, Wenzl E, Machen TE Regulation of intracellular pH in resting and in stimulated parietal cells. Am J Physiol 1989, 257:C554-C561. (3 pt 1).
241. Jons T, Warrings B, Jons A, Drenckhahn D Basolateral localization of anion exchanger 2 (AE2) and actin in acid-secreting (parietal) cells of the human stomach. Histochemistry 1994, 102:255-263.
242. Humphreys BD, Jiang L, Chernova MN, Alper SL Functional charac-terization and regulation of murine AE2 anion exchanger expressed in Xenopus oocytes. Am J Physiol 1994, 267:C1295-C1307.
243. Seidler U, Hubner M, Roithmaier S, Classen M pHi and HCO3-dependence of proton extrusion and Cl (-) -base exchange rates in isolated rabbit parietal cells. Am J Physiol 1994, 266:G759-G766. (5 pt 1).
244. Seidler U, Roithmaier S, Classen M, Silen W Influence of acid secretory state on Cl (-) -base and Na (+) -H+ exchange and pHi in isolated rabbit parietal cells. Am J Physiol 1992, 262:G81-G91. (1 pt 1).
245. Zhang Y, Chernova N, Stuart-Tilley AK, Jiang L, Alper SL The cytoplasmic and transmembrane domains of AE2 both contribute to regulation of anion exchange by pH. J Biol Chem 1996, 271:5741-5749.
246. Lohi H, Makela S, Pulkkinen K, Hoglund P, Karjalainen-Lindsberg ML, Puolakkainen P, Kere J Upregulation of CFTR expression but not SLC26A3 and SLC9A3 in ulcerative colitis. Am J Physiol Gastrointest Liver Physiol 1902, 283:G567-G575.
247. Rosenstein BJ, Zeitlin PL Cystic fibrosis. Lancet 1998, 351:277-282.
248. Lee MG, Wigley WC, Zeng W, Noel LE, Marino CR, Thomas PJ, Muallem S Regulation of C1-/HCO3-exchange by cystic fibrosis transmembrane conductance regulator expressed in NIH 3T3 and HEK 293 cells. J Biol Chem 1999, 274:3414-3421.
249. Bugaut M Occurrence, absorption and metabolism of short chain fatty acids in the digestive tract of mammals. Comp Biochem Physiol 1987, 86B:439-472.
250. Topping DL, Clifton PM Short-chain fatty acids and human colonie function: roles of resistant starch and nonstarch polysaccharides. Physiol Rev 2001, 81:1031-1064.
251. McNeil NI, Cummings JH, James WR Rectal absorption of short chain fatty acids in the absence of chloride. Gut 1979, 20:400-403.
252. Argenzio RA, Southworth M, Lowe JE, Stevens CE Interrelationship of Na, HCO3, and volatile fatty acid transport by equine large intes-tine. Am J Physiol 1977, 233:E469-E478.
253. Argenzio RA, Whipp SC Inter-relationship of sodium, chloride, bicarbonate and acetate transport by the colon of the pig J. Physiol (London) 1979, 295:365-381.
254. Ash RW, Dobson A The effect of absorption on the acidity of rumen contents. J Physiol 1963, 169:39-61.
255. Umesaki Y, Yajima T, Yokokura T, Mutai M Effect of organic acid absorption on bicarbonate transport in rat colon. Pflugers Arch 1979, 379:43-47.
256. Schmitt MG, Soergel KH, Wood CM Absorption of short chain fatty acids from the human jejunum. Gastroenterology 1976, 70:211-215.
257. Schmitt MG, Soergel KH, Wood CM, SteffJJ Absorption of short-chain fatty acids from the human ileum. Am J Dig Dis 1977, 22:340-347.
258. Ruppin H, Bar-Meir S, Soergel KH, Wood CM, Schmitt MG Absorption of short-chain fatty acids by the colon. Gastroenterology 1980, 78:1500-1507.
259. Sellin JH, DeSoignie R Short-chain fatty acid absorption in rabbit colon in vitro. Gastroenterology 1990, 99:676-683.
260. von Engelhardt W, Rechkemmer G Segmental differences of short-chain fatty acid transport across guinea-pig large intestine. Exp Physiol 1992, 77:491-499.
261. von Engelhardt W, Busche R, Burmester M, Hansen K, Becker G Transport of propionate across the distal colonic epithelium of guinea pig in the presence and absence of bicarbonate and of chloride. Zentralbl Veterinarmed A 1997, 44:73-78.
262. Ronnau K, Guth D, von Engelhardt W Absorption of dissociated and undissociated short-chain fatty acids across the colonic epithelium of guinea-pig. Q J Exp Physiol 1989, 74:511-519.
263. Rechkemmer G, Ronnau K, von Engelhardt W Fermentation of polysaccharides and absorption of short chain fatty acids in the mammalian hindgut. Comp Biochem Physiol A 1988, 90:563-568.
264. Hatch M Short-chain fatty acid transport and its effects on ion trans-port by rabbit cecum. Am J Physiol 1987, 253:G171-G178. (2 pt 1).
265. Rubsamen K, von Engelhardt W Absorption of Na, H ions and short chain fatty acids from the sheep colon. Pflugers Arch 1981, 391:141-146.
266. + transport in human jejunal brush-border membrane vesicles. Am J Physiol 1988, 255:G206-G211.
267. Ramaswamy K, Harig JM, Kleinman JG, Harris MS, Barry JA Sodium-proton exchange in human ileal brush border membrane vesicles. Biochem Biophys Acta 1989, 981:193-199.
268. Murer H, Hopfer U, Kinne R Sodium/proton antiport in brush border membrane vesicles isolated from rat small intestine and kidney. Biochem J 1976, 154:597-604.
269. + exchange. Biochem Biophys Res Commun 1990, 167:438-443.
270. + antiporter of rat colonie basolateral membrane vesicles. Am J Physiol 1989, 257:G624-G632.
271. + transport in human distal colonie apical membrane vesicles. Biochim Biophys Acta 1994, 1193:67-76.
272. Harig JM, Ng EK, Dudeja PK, Brasitus TA, Ramaswamy K Transport of n-butyrate into human colonie luminal membrane vesicles. Am J Physiol 1996, 271:G415-G422.
273. Harig JM, Soergel KH, Barry JA, Ramaswamy K Transport of propi-onate by human ileal brush-border membrane vesicles. Am J Physiol 1991, 260:G776-G782.
274. Tyagi S, Venugopalakrishnan J, Ramaswamy K, Dudeja PK Mechanism of n-butyrate uptake in the human proximal colonie basolateral membranes. Am J Physiol Gastrointest Liver Physiol 2002, 282:G676-G682.
275. Mascolo N, Rajendran VM, Binder HJ Mechanism of short chain fatty acid uptake by apical membrane vesicles of rat distal colon. Gastroenterology 1991, 101:331-338.
276. Reynolds DA, Rajendran VM, Binder HJ Bicarbonate-stimulated [14C]butyrate uptake in basolateral membrane vesicles of rat distal colon. Gastroenterology 1993, 105:725-732.
277. Hadjiagapiou C, Schmidt L, Dudeja PK, Layden TJ, Ramaswamy K Mechanism (s) of butyrate transport in Caco-2 cells: role of monocar-boxylate transporter 1. Am J Physiol Gastrointest Liver Physiol 2000, 279:G775-G780.
278. CuffMA, Lambert DW, Shirazi-Beechey SP Substrate-induced regulation of the human colonic monocarboxylate transporter, MCT1. J Physiol 2002, 539:361-371. pt 2.
279. Rajendran VM, Binder HJ Apical membrane Cl-butyrate exchange: mechanism of short chain fatty acid stimulation of active chloride absorption in rat distal colon. J Membr Biol 1994, 141:51-58.
280. Sellin JH, DeSoignie R, Burlingame S Segmental differences in short-chain fatty acid transport in rabbit colon: effect of pH and Na. J Membr Biol 1993, 136:147-158.
281. Mortensen PB, Clausen MR Short-chain fatty acids in the human colon: relation to gastrointestinal health and disease. Scand J Gastroenterol Suppl 1996, 216:132-148.
282. Charney AN, Micic L, Egnor RW Nonionic diffusion of short-chain fatty acids across rat colon. Am J Physiol 1998, 274:G518-G524. (3pt 1).
283. Chu S, Montrose MH Non-ionic diffusion and carrier-mediated transport drive extracellular pH regulation of mouse colonie crypts. J Physiol (Lond) 1996, 494:783-793. (pt 3).
284. DeSoignie R, Sellin JH Propionate-initiated changes in intracellular pH in rabbit colonocytes. Gastroenterology 1994, 107:347-356.
285. Ritzhaupt A, Wood IS, Ellis A, Hosie KB, Shirazi-Beechey SP Identification and characterization of a monocarboxylate transporter (MCT1) in pig and human colon: its potential to transport L-lactate as well as butyrate. J Physiol (Lond) 1998, 513:719-732. (pt 3).
286. Tamai I, Takanaga H, Maeda H, Sai Y, Ogihara T, Higashida H, Tsuji A Participation of a proton-cotransporter, MCT1, in the intestinal transport of monocarboxylic acids. Biochem Biophys Res Commun 1995, 214:482-489.
287. Garcia CK, Goldstein JL, Pathak RK, Anderson RG, Brown MS Molecular characterization of a membrane transporter for lactate, pyruvate, and other monocarboxylates: implications for the Cori cycle. Cell 1994, 76:865-873.
288. Halestrap AP, Price NT The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 1999, 343:281-299. (pt2).
289. Halestrap AP, Meredith D The SLC16 gene family-from monocar-boxylate transporters (MCTs) to aromatic amino acid transporters and beyond. Pflugers Arch 2004, 447:619-628.
290. Buyse M, Sitaraman SV, Liu X, Bado A, Merlin D Luminal leptin enhances CD 147/MCT-l-mediated uptake of butyrate in the human intestinal cell line Caco2-BBE. J Biol Chem 2002, 277:28182-28190.
291. Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H Expression cloning of a Na+-independent aromatic amino acid trans-porter with structural similarity to H+/monocarboxylate transporters. J Biol Chem 2001, 276:17221-17228.
292. Garcia CK, Li X, Luna J, Francke U cDNA cloning of the human monocarboxylate transporter 1 chromosomal localization of the SLC16A1 locus to 1pl3.2-pl2. Genomics 1994, 23:500-503.
293. Garcia CK, Brown MS, Pathak RK, Goldstein JL cDNA cloning of MCT2, a second monocarboxylate transporter expressed in different cells than MCT1. J Biol Chem 1995, 270:1843-1849.
294. Grollman EF, Philp NJ, McPhie P, Ward RD, Sauer B Determination of transport kinetics of chick MCT3 monocarboxylate transporter from retinal pigment epithelium by expression in genetically modified yeast. Biochemistry 2000, 39:9351-9357.
295. Price NT, Jackson VN, Halestrap AP Cloning and sequencing of four new mammalian monocarboxylate transporter (MCT) homologues confirms the existence of a transporter family with an ancient past. Biochem J 1998, 329:321-328. (pt 2).
296. Lafreniere RG, Carrel L, Willard HE A novel transmembrane trans-porter encoded by the XPCT gene in Xq13.2. Hum Mol Genet 1994, 3:1133-1139.
297. Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J 1998, 333:167-174. (pt 1).
298. Broer S, Rahman B, Pellegri G, Pellerin L, Martin JL, Verleysdonk S, Hamprecht B, Magistretti PJ Comparison of lactate transport in astroglial cells monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monoc transporters in astroglial cells and neurons. J Biol Chem 1997, 272:30096-30102.
299. Poole RC, Sansom CE, Halestrap AP Studies of the membrane topology of the rat erythrocyte H+/lactate cotransporter (MCT1). Biochem J 1996, 320:817-824. (pt3).
300. Rahman B, Schneider HP, Broer A, Deitmer JW, Broer S Helix 8 and helix 10 are involved in substrate recognition in the rat monocarboxylate transporter MCT1. Biochemistry 1999, 38:11577-11584.
301. Kirk P, Wilson MC, Heddle C, Brown MH, Barclay AN, Halestrap AP CD147 is tightly associated with lactate transporters MCT1 and MCT4 and facilitates their cell surface expression. EMBO J 2000, 19:3896-3904.
302. Tamai I, Sai Y, Ono A, Kido Y, Yabuuchi H, Takanaga H, Satoh E, Ogihara T, Amano O, Izeki S, Tsuji A Immunohistochemical and functional characterization of pH-dependent intestinal absorption of weak organic acids by the monocarboxylic acid transporter MCT1. J Pharm Pharmacol 1999, 51:113-1121.
303. Gill R, Hadjiagapiou C, Alrefai WA, Saksena S, Carrol R, Goldstein J, Ramaswamy K, Dudeja PK Expression and membrane localization of MCT isoforms along the length of the human intestine. Am J Physiol Cell Physiol 1905, 289(4):C846-C852.
304. Lambert DW, Wood IS, Ellis A, Shirazi-Beechey SP Molecular changes in the expression of human colonic nutrient transporters during the transition from normality to malignancy. Br J Cancer 2002, 86:1262-1269.
305. Enerson BE, Drewes LR Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J Pharm Sci 2003, 92:1531-1544.
306. CuffMA, Shirazi-Beechey SP The human monocarboxylate transporter, MCT1: genomic organization and promoter analysis. Biochem Biophys Res Commun 2002, 292:1048-1056.
307. Hadjiagapiou C, Borthakur A, Dahdal RY, Gill RK, Malakooti J, Ramaswamy K, Dudeja PK Role of USF1 and USF2 as potential repressor proteins for human intestinal monocarboxylate transporter 1 (MCT1). Am JPhysiol 2005, 288(6):G1118-G1126.
308. Saksena S, Gill RK, Tyagi S, Alrefai WA, Borthakur A, Ramaswamy K, Dudeja PK PKC activation stimulates MCT1 promoter activity in Caco-2 cells. Gastroenterology 2004, 126:A-295.
309. Gill R, Saksena S, Alrefai WA, Tyagi S, Ramaswamy K, Dudeja PK Serotonin inhibits MCT1 activity by retrieval of the transporter from the apical membranes in Caco-2 cells. Gastroenterology 2004, 126:A145.
310. Chernova MN, Jiang L, Freidman DJ, Darman RB, Lohi H, Kere J, Vandorpe DH, Alper SL Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differ-ences in anion selectivity, regulation, and electrogeni. J Biol Chem 1905, 280(9):8564-8580.