Iron responses in hepatic, intestinal and macrophage/monocyte cell lines under different culture conditions

Blood Cells, Molecules, and Diseases

Volumn 41, Issue 1, 2008, Pages 100-108

  Jacolot, Sandrine ^a   Férec, Claude ^a,b   Mura, Catherine ^a,b  

^a INSERM   (France)

^b FACULTÉ DE MÉDECINE ET DES SCIENCES DE LA SANTÉ   (France)

Author keywords

Cell culture conditions; Holo transferrin; Iron responses; NTBI; Quantitative RT PCR

Indexed keywords

CYTOKINE; FERROPORTIN; HEPCIDIN; INTERLEUKIN 6; IRON; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HIF;

ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; INTESTINE CELL; IRON DEPLETION; IRON METABOLISM; LIVER CELL; MACROPHAGE; MONOCYTE; PRIORITY JOURNAL; PROTEIN DEGRADATION; UPREGULATION;

ANTIMICROBIAL CATIONIC PEPTIDES; CACO-2 CELLS; CELL LINE, TUMOR; CULTURE MEDIA, CONDITIONED; ENTEROCYTES; HEPATOCYTES; HOMEOSTASIS; HUMANS; INTERLEUKIN-6; IRON; MACROPHAGES; MONOCYTES; RNA, MESSENGER; TRANSFERRIN;

EID: 44449124500     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2008.01.006     Document Type: Article

References (35)

1. Pigeon C., Ilyn G., Courselaud B., Leroye P., Turlin B., Brissot P., and Loréal O. A new mouse-liver specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276 (2001) 7811-7819
2. Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., Beaumont C., Kahn A., and Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110 (2002) 1037-1044
3. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Mc Vey Ward D., Ganz T., and Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
4. Nemeth E., Valore E.V., Territo M., Schiller G., Lichtenstein A., and Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 101 (2003) 2461-2463
5. Weinstein D.A., Roy C.N., Fleming M.D., Loda F., Wolfsdorf J.I., and Andrews N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 100 (2002) 3776-3781
6. Nemeth E., Rivera S., Gabayan V., Keller C., Taudof S., Pedersen B.K., and Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J. Clin. Invest. 113 (2004) 1271-1276
7. Lee P., Peng H., Gelbart T., Wang L., and Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 1906-1910
8. Peyssonnaux C., Zinkernagel A.S., Schuepbach R.A., Rankin E., Vaulont S., Hase V.H., Nizet V., and Johnson R.S. Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs). J. Clin. Invest. 117 (2007) 1926-1932
9. Theil E.C., and Eisenstein R.S. Combinatorial mRNA regulation: iron regulatory proteins and iron-responsive elements (Iso-IREs). J. Biol. Chem. 275 (2000) 40659-40662
10. Klausner R.D., Rouault T.A., and Harford J.B. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 72 (1993) 19-28
11. Gunshin H., Mackenzie B., Berger U.V., Gunshin Y., Romero M.F., Boron W.F., Nussberger S., Gollan W.F., and Hediger M.A. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388 (1997) 482-488
12. Canonne-Hergaux F., Gruenheid S., Ponka P., and Gros P. Cellular and subcellular localization of the NRAMP2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93 (1999) 4406-4417
13. Roetto A., Papanikolaou G., Politou M., Alberti F., Girelli D., Christakis J., Loukopoulos D., and Camaschella C. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat. Genet. 33 (2002) 21-22
14. Njajou O.T., Vaessen N., Joosse M., Berhuis B., van Dongen J.W.F., Breuning M.H., Snijders P.J.L.M., Rutten W.P.F., Sandkuijl L.A., Oostra B.A., van Dujin C.M., and Heutink P. A mutation in SLC11A3 is associated with autosomal dominant hemochromatosis. Nat. Genet. 28 (2001) 213-214
15. Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., Basava A., Dormishian F., Domingo R., Ellis M.C., Fullan A., Hinton L.M., Jones N.L., Kimmel B.E., Kronmal G.S., Lauer P., Lee V.K., Loeb D.B., Mapa F.A., McClelland E., Meyer N.C., Mintier G.A., Moeller N., Moore T., Morikang E., Prass C.E., Quintana L., Starnes S.M., Schatzman R.C., Brunke K.J., Drayna D.T., Rish N.J., Bacon B.R., and Wolff R.K. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13 (1996) 399-408
16. Parkkila S., Waheed A., Britton R.S., Bacon B.R., Zhou X.Y., Tomatsu S., Fleming R.E., and Sly W.S. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 13198-13202
17. Gross C.N., Irrinki A., Feder J.N., and Enns C.A. Co-trafficking of HFE, a nonclassical major histocompatibility complex class I protein, with the transferrin receptor implies a role in intracellular iron regulation. J. Biol. Chem. 273 (1998) 22068-22074
18. Goswami T., and Andrews N.C. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J. Biol. Chem. 28 (2006) 28494-28498
19. Kawabata H., Germain R.S., Ikezoe T., Tong X., Green E.M., Gombart A.F., and Koeffler H.P. Regulation of expression of murine transferrin receptor 2. Blood 98 (2001) 1949-1954
20. Robb A., and Wessling-Resnick M. Regulation of transferrin receptor 2 protein levels by transferrin. Blood 104 (2004) 4294-4299
21. Johnson M.B., and Enns C.A. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 104 (2004) 4287-4293
22. Wallace D.F., Sumerville L., Lusby P.E., and Subramaniam V.N. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54 (2005) 980-986
23. Wilkins S.J., Frazer D.M., Millard K.N., Mc Laren G.D., and Anderson G.J. Iron metabolism in the hemoglobin-deficit mouse: correlation of diferric transferrin with hepcidin expression. Blood 4 (2006) 1659-1664
24. Camaschella C., Roetto A., Cali A., De Gobbi M., Garozzo G., Carella M., Majorano N., Totaro A., and Gasparini P. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat. Genet. 25 (2000) 14-15
25. Papanikolaou G., Samuels M.E., Ludwig E.H., MacDonald M.L.E., Franchini P.L., Dubé M.P., Andres L., MacFarlane J., Sakellaropoulos N., Politou M., Nemeth E., Thompson J., Risler J.K., Zaborowska C., Babakaiff R., Radomski C.C., Pape D., Davidas O., Christakis J., Brissot P., Lockitch G., Gantz T., Hayden M.R., and Goldberg P. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 36 (2004) 77-82
26. Lin L., Goldberg Y.P., and Gantz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 306 (2004) 2090-2093
27. Bridle K.R., Frazer D.M., Wilkins S.J., Dixon J.L., Purdie D.M., Crawford D.H.G., Subramaniam V.N., Powell L.W., Anderson G.J., and Ramm G.A. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis. Lancet 361 (2003) 669-673
28. Nemeth E., Roetto A., Garozzo G., Ganz T., and Camaschella C. Hepcidin is decreased in TfR2 hemochromatosis. Blood 105 (2005) 1803-1806
29. Whatling C., Björk H., Gredmark S., Hamsten A., and Eriksson P. Effect of macrophage differentiation and exposure to mildly oxidized LDL on the proteolytic repertoire of THP-1 monocytes. J. Lipid Res. 45 (2004) 1768-1776
30. Smith J.L., Rangaraj K., Simpson R., Maclean D.J., Nathanson L.K., Stuart K.A., Scott S.P., Ramm G.A., and de Jersey J. Quantitative analysis of the expression of ACAT genes in human tissues by real time PCR. J. Lipid Res. 45 (2004) 686-696
31. Makui H., Soares R.J., Jiang W., Constante M., and Santos M.M. Contribution of Hfe expression in macrophages to the regulation of hepatic hepcidin levels and iron loading. Blood 106 (2005) 2189-2195
32. Gehrke S.G., Kulaksiz H., Hermann T., Riedel H.D., Bentz K., Veltkamp C., and Stremmel W. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 102 (2003) 371-376
33. Stadnyk A.W. Intestinal epithelial cells as a source of inflammatory cytokines and chemokines. Can. J. Gastroenterol 16 (2002) 241-246
34. Hosoi T., Hirose R., Saegusa S., Ametani A., Kiuchi K., and Kaminogawa S. Cytokine responses of human intestinal epithelial-like Caco-2 cells to the nonpathogenic bacterium Bacillus subtilis (natto). Intl. J. Food Microbiol. 82 (2003) 255-264
35. Canonne-Hergaux F., Levy J.E., Fleming M.D., Montross L.K., Andrews N.C., and Gros P. Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. Blood 97 (2001) 1138-1140