Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy

BMC Cell Biology

Volumn 10, Issue , 2009, Pages

  Pearce, Claire ^a   Hayden, Rachel E ^a   Bunce, Christopher M ^a   Khanim, Farhat L ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLADENINE; BAFILOMYCIN A1; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA TRANSDUCIN REPEAT CONTAINING PROTEIN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 4; COP9 SIGNALOSOME; COP9 SIGNALOSOME 2; COP9 SIGNALOSOME 5; CULLIN; F BOX PROTEIN; MESSENGER RNA; S PHASE KINASE ASSOCIATED PROTEIN 2; UNCLASSIFIED DRUG; CASEIN; COPS5 PROTEIN, HUMAN; PEPTIDE HYDROLASE; PROTEIN SUBUNIT; SIGNAL PEPTIDE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL DEATH; CELL GROWTH; CELL KINETICS; CELL STRAIN K 562; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; MITOSIS; MYELOID PROGENITOR CELL; PHENOTYPE; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN FUNCTION; PROTEIN STABILITY; TRANSCRIPTION REGULATION; CELL CYCLE; CELL LINE; CELL PROLIFERATION; GENE SILENCING; GENETICS; METABOLISM;

AUTOPHAGY; CASEINS; CELL CYCLE; CELL LINE; CELL PROLIFERATION; F-BOX PROTEINS; GENE KNOCKDOWN TECHNIQUES; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; PEPTIDE HYDROLASES; PROTEIN SUBUNITS;

EID: 66749097742     PISSN: None     EISSN: 14712121     Source Type: Journal    
DOI: 10.1186/1471-2121-10-31     Document Type: Article

References (56)

1. Wei N Deng XW Characterization and purification of the mammalian COP9 complex, a conserved nuclear regulator initially identified as a repressor of photomorphogenesis in higher plants Photochemistry and photobiology 1998, 68(2):237-241. 10.1111/j.1751-1097.1998.tb02495.x
2. Mundt KE Porte J Murray JM Brikos C Christensen PU Caspari T Hagan IM Millar JB Simanis V Hofmann K et al The COP9/signalosome complex is conserved in fission yeast and has a role in S phase Curr Biol 1999, 9(23):1427-1430. 10.1016/S0960-9822(00)80091-3 10607571
3. Doronkin S Djagaeva I Beckendorf SK The COP9 signalosome promotes degradation of Cyclin E during early Drosophila oogenesis Developmental cell 2003, 4(5):699-710. 10.1016/S1534-5807(03)00121-7 12737805
4. Pintard L Kurz T Glaser S Willis JH Peter M Bowerman B Neddylation and deneddylation of CUL-3 is required to target MEI-1/Katanin for degradation at the meiosis-to-mitosis transition in C. elegans Curr Biol 2003, 13(11):911-921. 10.1016/S0960-9822(03)00336-1 12781129
5. Rosel D Kimmel AR The COP9 signalosome regulates cell proliferation of Dictyostelium discoideum European journal of cell biology 2006, 85(9-10):1023-1034. 10.1016/j.ejcb.2006.04.006 16781008
6. Chamovitz DA Wei N Osterlund MT von Arnim AG Staub JM Matsui M Deng XW The COP9 complex, a novel multisubunit nuclear regulator involved in light control of a plant developmental switch Cell 1996, 86(1):115-121. 10.1016/S0092-8674(00)80082-3 8689678
7. Cope GA Deshaies RJ COP9 signalosome: A multifunctional regulator of SCF and other cullin-based ubiquitin ligases Cell 2003, 114(6):663-671. 10.1016/S0092-8674(03)00722-0 14505567
8. Nielsen O COP9 signalosome: A provider of DNA building blocks Curr Biol 2003, 13(14):R565-567. 10.1016/S0960-9822(03)00475-5 12867051
9. Groisman R Polanowska J Kuraoka I Sawada J Saijo M Drapkin R Kisselev AF Tanaka K Nakatani Y The ubiquitin ligase activity in the DDB2 and CSA complexes is differentially regulated by the COP9 signalosome in response to DNA damage Cell 2003, 113(3):357-367. 10.1016/ S0092-8674(03)00316-7 12732143
10. Hough R Pratt G Rechsteiner M Ubiquitin-lysozyme conjugates. Identification and characterization of an ATP-dependent protease from rabbit reticulocyte lysates The Journal of biological chemistry 1986, 261(5):2400-2408. 3003114
11. Peters JM Proteasomes: Protein degradation machines of the cell Trends in biochemical sciences 1994, 19(9):377-382. 10.1016/ 0968-0004(94)90115-5 7985232
12. Rubin DM Finley D Proteolysis. The proteasome: A protein-degrading organelle? Curr Biol 1995, 5(8):854-858. 10.1016/S0960-9822(95)00172-2 7583140
13. Voges D Zwickl P Baumeister W The 26S proteasome: A molecular machine designed for controlled proteolysis Annual review of biochemistry 1999, 68:1015-1068. 10.1146/annurev.biochem.68.1.1015 10872471
14. Chau V Tobias JW Bachmair A Marriott D Ecker DJ Gonda DK Varshavsky A A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein Science 1989, 243(4898):1576-1583. 10.1126/ science.2538923 2538923
15. Hershko A Heller H Elias S Ciechanover A Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown The Journal of biological chemistry 1983, 258(13):8206-8214. 6305978
16. Petroski MD Deshaies RJ Function and regulation of cullin-RING ubiquitin ligases Nature reviews 2005, 6(1):9-20. 15688063
17. Bai C Sen P Hofmann K Ma L Goebl M Harper JW Elledge SJ SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box Cell 1996, 86(2):263-274. 10.1016/ S0092-8674(00)80098-7 8706131
18. Skowyra D Craig KL Tyers M Elledge SJ Harper JW F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex Cell 1997, 91(2):209-219. 10.1016/ S0092-8674(00)80403-1 9346238
19. Ho MS Tsai PI Chien CT F-box proteins: The key to protein degradation Journal of biomedical science 2006, 13(2):181-191. 10.1007/ s11373-005-9058-2 16463014
20. Bosu DR Kipreos ET Cullin-RING ubiquitin ligases: Global regulation and activation cycles Cell division 2008, 3:7. 2266742 18282298 10.1186/ 1747-1028-3-7
21. Hori T Osaka F Chiba T Miyamoto C Okabayashi K Shimbara N Kato S Tanaka K Covalent modification of all members of human cullin family proteins by NEDD8 Oncogene 1999, 18(48):6829-6834. 10.1038/sj.onc.1203093 10597293
22. Ohh M Kim WY Moslehi JJ Chen Y Chau V Read MA Kaelin WG Jr An intact NEDD8 pathway is required for Cullin-dependent ubiquitylation in mammalian cells EMBO reports 2002, 3(2):177-182. 1083969 11818338 10.1093/embo-reports/kvf028
23. Kawakami T Chiba T Suzuki T Iwai K Yamanaka K Minato N Suzuki H Shimbara N Hidaka Y Osaka F et al NEDD8 recruits E2-ubiquitin to SCF E3 ligase The EMBO journal 2001, 20(15):4003-4012. 149148 11483504 10.1093/emboj/ 20.15.4003
24. Sakata E Yamaguchi Y Miyauchi Y Iwai K Chiba T Saeki Y Matsuda N Tanaka K Kato K Direct interactions between NEDD8 and ubiquitin E2 conjugating enzymes upregulate cullin-based E3 ligase activity Nature structural & molecular biology 2007, 14(2):167-168. 10.1038/nsmb1191 17206147
25. Lyapina S Cope G Shevchenko A Serino G Tsuge T Zhou C Wolf DA Wei N Shevchenko A Deshaies RJ Promotion of NEDD-CUL1 conjugate cleavage by COP9 signalosome Science 2001, 292(5520):1382-1385. 10.1126/ science.1059780 11337588
26. Cope GA Suh GS Aravind L Schwarz SE Zipursky SL Koonin EV Deshaies RJ Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 Science 2002, 298(5593):608-611. 10.1126/science.1075901 12183637
27. Wu JT Chan YR Chien CT Protection of cullin-RING E3 ligases by CSN-UBP12 Trends in cell biology 2006, 16(7):362-369. 10.1016/j.tcb.2006.05.001 16762551
28. Cope GA Deshaies RJ Targeted silencing of Jab1/Csn5 in human cells downregulates SCF activity through reduction of F-box protein levels BMC biochemistry 2006, 7:1. 1360668 16401342 10.1186/1471-2091-7-1
29. Wee S Geyer RK Toda T Wolf DA CSN facilitates Cullin-RING ubiquitin ligase function by counteracting autocatalytic adapter instability Nature cell biology 2005, 7(4):387-391. 10.1038/ncb1241 15793566
30. Peng H Du ZW Zhang JW Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells Leukemia 2006, 20(6):1109-1116. 10.1038/sj.leu.2404212 16628192
31. Jacquel A Herrant M Defamie V Belhacene N Colosetti P Marchetti S Legros L Deckert M Mari B Cassuto JP et al A survey of the signaling pathways involved in megakaryocytic differentiation of the human K562 leukemia cell line by molecular and c-DNA array analysis Oncogene 2006, 25(5):781-794. 10.1038/sj.onc.1209119 16186797
32. Su H Huang W Wang X The COP9 signalosome negatively regulates proteasome proteolytic function and is essential to transcription The international journal of biochemistry & cell biology 2009, 41(3):615-624. 10.1016/ j.biocel.2008.07.008 18706515
33. Denti S Fernandez-Sanchez ME Rogge L Bianchi E The COP9 signalosome regulates Skp2 levels and proliferation of human cells The Journal of biological chemistry 2006, 281(43):32188-32196. 10.1074/jbc.M604746200 16943200
34. Tsvetkov LM Yeh KH Lee SJ Sun H Zhang H p27(Kip1) ubiquitination and degradation is regulated by the SCF(Skp2) complex through phosphorylated Thr187 in p27 Curr Biol 1999, 9(12):661-664. 10.1016/ S0960-9822(99)80290-5 10375532
35. Biederbick A Kern HF Elsasser HP Monodansylcadaverine (MDC) is a specific in vivo marker for autophagic vacuoles European journal of cell biology 1995, 66(1):3-14. 7750517
36. Kabeya Y Mizushima N Ueno T Yamamoto A Kirisako T Noda T Kominami E Ohsumi Y Yoshimori T LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing The EMBO journal 2000, 19(21):5720-5728. 305793 11060023 10.1093/emboj/19.21.5720
37. Mizushima N Yoshimori T How to interpret LC3 immunoblotting Autophagy 2007, 3(6):542-545. 17611390
38. Schwechheimer C The COP9 signalosome (CSN): An evolutionary conserved proteolysis regulator in eukaryotic development Biochimica et biophysica acta 2004, 1695(1-3):45-54. 15571808
39. Oren-Giladi P Krieger O Edgar BA Chamovitz DA Segal D Cop9 signalosome subunit 8 (CSN8) is essential for Drosophila development Genes Cells 2008, 13(3):221-231. 10.1111/j.1365-2443.2008.01164.x 18298797
40. Peth A Berndt C Henke W Dubiel W Downregulation of COP9 signalosome subunits differentially affects the CSN complex and target protein stability BMC biochemistry 2007, 8:27. 2225408 18093314 10.1186/ 1471-2091-8-27
41. Bech-Otschir D Seeger M Dubiel W The COP9 signalosome: At the interface between signal transduction and ubiquitin-dependent proteolysis Journal of cell science 2002, 115(Pt 3):467-473. 11861754
42. Ullah Z Buckley MS Arnosti DN Henry RW Retinoblastoma protein regulation by the COP9 signalosome Molecular biology of the cell 2007, 18(4):1179-1186. 1838975 17251548 10.1091/mbc.E06-09-0790
43. Fukumoto A Tomoda K Yoneda-Kato N Nakajima Y Kato JY Depletion of Jab1 inhibits proliferation of pancreatic cancer cell lines FEBS letters 2006, 580(25):5836-5844. 10.1016/j.febslet.2006.09.042 17027978
44. Panattoni M Sanvito F Basso V Doglioni C Casorati G Montini E Bender JR Mondino A Pardi R Targeted inactivation of the COP9 signalosome impairs multiple stages of T cell development The Journal of experimental medicine 2008, 205(2):465-477. 2271025 18268034 10.1084/jem.20070725
45. Dohmann EM Levesque MP De Veylder L Reichardt I Jurgens G Schmid M Schwechheimer C The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability Development (Cambridge, England) 2008, 135(11):2013-2022. 18434413
46. Peth A Boettcher JP Dubiel W Ubiquitin-dependent proteolysis of the microtubule end-binding protein 1, EB1, is controlled by the COP9 signalosome: Possible consequences for microtubule filament stability Journal of molecular biology 2007, 368(2):550-563. 10.1016/ j.jmb.2007.02.052 17350042
47. Sun L Gao J Dong X Liu M Li D Shi X Dong JT Lu X Liu C Zhou J EB1 promotes Aurora-B kinase activity through blocking its inactivation by protein phosphatase 2A Proceedings of the National Academy of Sciences of the United States of America 2008, 105(20):7153-7158. 2438220 18477699 10.1073/pnas.0710018105
48. Sumara I Quadroni M Frei C Olma MH Sumara G Ricci R Peter M A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells Developmental cell 2007, 12(6):887-900. 10.1016/j.devcel.2007.03.019 17543862
49. Chamovitz DA Segal D JAB1/CSN5 and the COP9 signalosome. A complex situation EMBO reports 2001, 2(2):96-101. 1083824 11258719 10.1093/ embo-reports/kve028
50. Claret FX Hibi M Dhut S Toda T Karin M A new group of conserved coactivators that increase the specificity of AP-1 transcription factors Nature 1996, 383(6599):453-457. 10.1038/383453a0 8837781
51. Lee JW Choi HS Gyuris J Brent R Moore DD Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor Molecular endocrinology (Baltimore, Md 1995, 9(2):243-254. 10.1210/me.9.2.243 7776974
52. Papaioannou M Melle C Baniahmad A The coregulator Alien Nuclear receptor signaling 2007, 5:e008. 2121318 18174916
53. Tanguy G Drevillon L Arous N Hasnain A Hinzpeter A Fritsch J Goossens M Fanen P CSN5 binds to misfolded CFTR and promotes its degradation Biochimica et biophysica acta 2008, 1783(6):1189-1199. 18267124
54. Wei N Serino G Deng XW The COP9 signalosome: More than a protease Trends in biochemical sciences 2008, 33(12):592-600. 10.1016/j.tibs.2008.09.004 18926707
55. Tomoda K Kato JY Tatsumi E Takahashi T Matsuo Y Yoneda-Kato N The Jab1/ COP9 signalosome subcomplex is a downstream mediator of Bcr-Abl kinase activity and facilitates cell-cycle progression Blood 2005, 105(2):775-783. 10.1182/blood-2004-04-1242 15353483
56. Kunath T Gish G Lickert H Jones N Pawson T Rossant J Transgenic RNA interference in ES cell-derived embryos recapitulates a genetic null phenotype Nature biotechnology 2003, 21(5):559-561. 10.1038/nbt813 12679785