Postreceptoral adipocyte insulin resistance induced by nelfinavir is caused by insensitivity of PKB/Akt to phosphatidylinositol-3,4,5-trisphosphate

Endocrinology

Volumn 150, Issue 6, 2009, Pages 2618-2626

  Kachko, Ilana ^a   Maissel, Adva ^a   Mazor, Livnat ^a   Ben Romano, Ronit ^a   Watson, Robert T ^b   Hou, June C ^b   Pessin, Jeffrey E ^c   Bashan, Nava ^a   Rudich, Assaf ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b STONY BROOK UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER 4; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEIN; INSULIN RECEPTOR SUBSTRATE 1; MYC PROTEIN; NELFINAVIR; PHOSPHATIDYLINOSITIDE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PLECKSTRIN; PROTEIN KINASE B; PROTEINASE INHIBITOR;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME SUBUNIT; GLUCOSE TRANSPORT; IN VITRO STUDY; INSULIN RESISTANCE; LIPODYSTROPHY; MEMBRANE FUSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

3T3-L1 CELLS; ADIPOCYTES; ANIMALS; CELL MEMBRANE; DISEASE MODELS, ANIMAL; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GREEN FLUORESCENT PROTEINS; HIV PROTEASE INHIBITORS; INSULIN; INSULIN RESISTANCE; MICE; NELFINAVIR; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

EID: 66649126365     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2008-1205     Document Type: Article

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