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Volumn 8, Issue 4, 2009, Pages 779-785

Growth inhibition of human cancer cells by 5-aza-2′-deoxycytidine does not correlate with its effects on INK4a/ARF expression or initial promoter methylation status

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; ARF PROTEIN; PROTEIN P14; PROTEIN P16; SMALL INTERFERING RNA; ANTINEOPLASTIC ANTIMETABOLITE; AZACITIDINE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DRUG DERIVATIVE; MESSENGER RNA;

EID: 66449127105     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-0926     Document Type: Article
Times cited : (9)

References (46)
  • 1
    • 0031964055 scopus 로고    scopus 로고
    • Inhibition of DNA methylation by 5-Aza-2'-deoxycytidine suppresses the growth of human tumor cell lines
    • Bender CM, Pao MM, Jones PA. Inhibition of DNA methylation by 5- aza-2′-deoxycytidine suppresses the growth of human tumor cell lines. Cancer Res 1998;58:95-101. (Pubitemid 28027723)
    • (1998) Cancer Research , vol.58 , Issue.1 , pp. 95-101
    • Bender, C.M.1    Pao, M.M.2    Jones, P.A.3
  • 2
    • 0032585651 scopus 로고    scopus 로고
    • Re-expression of endogenous p16(ink4a) in oral squamous cell carcinoma lines by 5-aza-2'-deoxycytidine treatment induces a senescence-like state
    • Timmermann S, Hinds PW, Munger K. Re-expression of endogenous p16INK4a in oral squamous cell carcinoma lines by 5-aza-2′-deoxycytidine treatment induces a senescence-like state. Oncogene 1998;17: 3445-3453 (Pubitemid 29050679)
    • (1998) Oncogene , vol.17 , Issue.26 , pp. 3445-3453
    • Timmermann, S.1    Hinds, P.W.2    Munger, K.3
  • 3
    • 12444327285 scopus 로고    scopus 로고
    • Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2′-deoxycytidine treatment is associated with activation of the Interferon signalling pathway
    • DOI 10.1038/sj.onc.1208018
    • Missiaglia E, Donadelli M, Palmieri M, et al. Growth delay of human pancreatic cancer cells by methylase inhibitor 5-aza-2′-deoxycytidine treatment is associated with activation of the interferon signalling pathway. Oncogene 2005;24:199-211. (Pubitemid 40143879)
    • (2005) Oncogene , vol.24 , Issue.1 , pp. 199-211
    • Missiaglia, E.1    Donadelli, M.2    Palmieri, M.3    Crnogorac-Jurcevic, T.4    Scarpa, A.5    Lemoine, N.R.6
  • 4
    • 38349083449 scopus 로고    scopus 로고
    • Regulation of the p14ARF promoter by DNA methylation
    • Badal V, Menendez S, Coomber D, et al. Regulation of the p14ARF promoter by DNA methylation. Cell Cycle 2008;7:112-119
    • (2008) Cell Cycle , vol.7 , pp. 112-119
    • Badal, V.1    Menendez, S.2    Coomber, D.3
  • 5
    • 0035487104 scopus 로고    scopus 로고
    • The INK4a/ARF network in tumour suppression
    • DOI 10.1038/35096061
    • Sherr CJ. The INK4a/ARF network in tumour suppression. Nat Rev Mol Cell Biol 2001;2:731-737 (Pubitemid 33679835)
    • (2001) Nature Reviews Molecular Cell Biology , vol.2 , Issue.10 , pp. 731-737
    • Sherr, C.J.1
  • 6
    • 0028845142 scopus 로고
    • Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers
    • Herman JG, Merlo A, Mao L, et al. Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res 1995;55:4525-4530
    • (1995) Cancer Res , vol.55 , pp. 4525-4530
    • Herman, J.G.1    Merlo, A.2    Mao, L.3
  • 7
    • 0033985151 scopus 로고    scopus 로고
    • Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status
    • Esteller M, Tortola S, Toyota M, et al. Hypermethylation-associated inactivation of p14(ARF) is independent of p16(INK4a) methylation and p53 mutational status. Cancer Res 2000;60:129-133 (Pubitemid 30058742)
    • (2000) Cancer Research , vol.60 , Issue.1 , pp. 129-133
    • Esteller, M.1    Tortola, S.2    Toyota, M.3    Capella, G.4    Peinado, M.A.5    Baylin, S.B.6    Herman, J.G.7
  • 8
    • 0035835493 scopus 로고    scopus 로고
    • Ink4a tumor suppressor gene 5′-CpG island in breast cancer
    • DOI 10.1016/S0304-3835(00)00674-1, PII S0304383500006741
    • Nielsen NH, Roos G, Emdin SO, et al. Methylation of the p16(INK4a) tumor suppressor gene 5′-CpG island in breast cancer. Cancer Lett 2001;163:59-69. (Pubitemid 32121831)
    • (2001) Cancer Letters , vol.163 , Issue.1 , pp. 59-69
    • Nielsen, N.H.1    Roos, G.2    Emdin, S.O.3    Landberg, G.4
  • 9
    • 11844264545 scopus 로고    scopus 로고
    • Induction of gene expression by 5-Aza-2′-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms
    • DOI 10.1038/sj.leu.2403552
    • Schmelz K, Sattler N, Wagner M, et al. Induction of gene expression by 5-aza-2′-deoxycytidine in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) but not epithelial cells by DNA-methylation-dependent and -independent mechanisms. Leukemia 2005;19:103-111 (Pubitemid 40090084)
    • (2005) Leukemia , vol.19 , Issue.1 , pp. 103-111
    • Schmelz, K.1    Sattler, N.2    Wagner, M.3    Lubbert, M.4    Dorken, B.5    Tamm, I.6
  • 12
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R. Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci U S A 1994;91:11797-11801 (Pubitemid 24985095)
    • (1994) Proceedings of the National Academy of Sciences of the United States of America , vol.91 , Issue.25 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 14
    • 0023035969 scopus 로고
    • Differences in DNA damage produced by incorporation of 5-Aza-2'-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells
    • Covey JM, D'Incalci M, Tilchen EJ, et al. Differences in DNA damage produced by incorporation of 5-aza-2′-deoxycytidine or 5,6-dihydro-5-azacytidine into DNA of mammalian cells. Cancer Res 1986;46:5511-5517 (Pubitemid 17177937)
    • (1986) Cancer Research , vol.46 , Issue.11 , pp. 5511-5517
    • Covey, J.M.1    D'Incalci, M.2    Tilchen, E.J.3
  • 15
    • 37849026412 scopus 로고    scopus 로고
    • DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3b
    • Palii SS, Van Emburgh BO, Sankpal UT, et al. DNA methylation inhibitor 5-aza-2′-deoxycytidine induces reversible genome-wide DNA damage that is distinctly influenced by DNA methyltransferases 1 and 3b. Mol Cell Biol 2008;28:752-771
    • (2008) Mol Cell Biol , vol.28 , pp. 752-771
    • Palii, S.S.1    Van Emburgh, B.O.2    Sankpal, U.T.3
  • 17
    • 0033737604 scopus 로고    scopus 로고
    • Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors
    • Zheng S, Chen P, McMillan A, et al. Correlations of partial and extensive methylation at the p14(ARF) locus with reduced mRNA expression in colorectal cancer cell lines and clinicopathological features in primary tumors. Carcinogenesis 2000;21:2057-2064
    • (2000) Carcinogenesis , vol.21 , pp. 2057-2064
    • Zheng, S.1    Chen, P.2    McMillan, A.3
  • 22
    • 0030612166 scopus 로고    scopus 로고
    • Mammalian G1 and G2 phase checkpoints
    • O'Connor PM. Mammalian G1 and G2 phase checkpoints. Cancer Surv 1997;29:151-182
    • (1997) Cancer Surv , vol.29 , pp. 151-182
    • O'Connor, P.M.1
  • 23
    • 40449123006 scopus 로고    scopus 로고
    • DNA damage-dependent translocation of B23 and p19 ARF is regulated by the Jun N-terminal kinase pathway
    • Yogev O, Saadon K, Anzi S, et al. DNA damage-dependent translocation of B23 and p19 ARF is regulated by the Jun N-terminal kinase pathway. Cancer Res 2008;68:1398-1406
    • (2008) Cancer Res , vol.68 , pp. 1398-1406
    • Yogev, O.1    Saadon, K.2    Anzi, S.3
  • 24
    • 0037013154 scopus 로고    scopus 로고
    • INK4a contributes to the outcome of cancer therapy
    • DOI 10.1016/S0092-8674(02)00734-1
    • Schmitt CA, Fridman JS, Yang M, et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 2002;109:335-346 (Pubitemid 34606876)
    • (2002) Cell , vol.109 , Issue.3 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3    Lee, S.4    Baranov, E.5    Hoffman, R.M.6    Lowe, S.W.7
  • 26
    • 33748872289 scopus 로고    scopus 로고
    • Down-regulation of Jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells
    • DOI 10.1002/ijc.22077
    • Zhang Y, Wang Z, Ahmed F, et al. Down-regulation of jagged-1 induces cell growth inhibition and S phase arrest in prostate cancer cells. Int J Cancer 2006;119:2071-2077 (Pubitemid 44423663)
    • (2006) International Journal of Cancer , vol.119 , Issue.9 , pp. 2071-2077
    • Zhang, Y.1    Wang, Z.2    Ahmed, F.3    Banerjee, S.4    Li, Y.5    Sarkar, F.H.6
  • 27
    • 33644818947 scopus 로고    scopus 로고
    • 5-Aza-2′-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines
    • Kanda T, Tada M, Imazeki F, et al. 5-Aza-2′-deoxycytidine sensitizes hepatoma and pancreatic cancer cell lines. Oncol Rep 2005;14:975-979
    • (2005) Oncol Rep , vol.14 , pp. 975-979
    • Kanda, T.1    Tada, M.2    Imazeki, F.3
  • 29
    • 14844313747 scopus 로고    scopus 로고
    • WAF expression by demethylation of p73 leading to p53-independent apoptosis in myeloid leukemia
    • DOI 10.1002/ijc.20797
    • Schmelz K, Wagner M, Dorken B, et al. 5-Aza-2′-deoxycytidine induces p21WAF expression by demethylation of p73 leading to p53- independent apoptosis in myeloid leukemia. Int J Cancer 2005;114: 683-695 (Pubitemid 40344429)
    • (2005) International Journal of Cancer , vol.114 , Issue.5 , pp. 683-695
    • Schmelz, K.1    Wagner, M.2    Dorken, B.3    Tamm, I.4
  • 33
    • 35348832560 scopus 로고    scopus 로고
    • The synergistic effect of 5-aza-2′-deoxycytidine and 5-fluorouracil on drug-resistant tumors
    • Morita S, Iida S, Kato K, et al. The synergistic effect of 5-aza-2′-deoxycytidine and 5-fluorouracil on drug-resistant tumors. Oncology 2006;71: 437-445
    • (2006) Oncology , vol.71 , pp. 437-445
    • Morita, S.1    Iida, S.2    Kato, K.3
  • 34
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the HMHL1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, et al. Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the HMHL1 gene promoter. Cancer Res 2000;60:6039-6044
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3
  • 35
    • 0037869289 scopus 로고    scopus 로고
    • Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines
    • DOI 10.1002/ijc.11176
    • Arnold CN, Goel A, Boland CR. Role of HMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer 2003;106:66-73. (Pubitemid 36750389)
    • (2003) International Journal of Cancer , vol.106 , Issue.1 , pp. 66-73
    • Arnold, C.N.1    Goel, A.2    Boland, C.R.3
  • 36
    • 38449105001 scopus 로고    scopus 로고
    • Decreased expression of HMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells
    • Fujita H, Kato J, Horii J, et al. Decreased expression of HMLH1 correlates with reduced 5-fluorouracil-mediated apoptosis in colon cancer cells. Oncol Rep 2007;18:1129-1137
    • (2007) Oncol Rep , vol.18 , pp. 1129-1137
    • Fujita, H.1    Kato, J.2    Horii, J.3
  • 37
    • 0041524111 scopus 로고    scopus 로고
    • CpG island methylator phenotype is an independent predictor of survival benefit from 5-fluorouracil in stage III colorectal cancer
    • Van Rijnsoever M, Elsaleh H, Joseph D, et al. CpG island methylator phenotype is an independent predictor of survival benefit from5-fluorouracil in stage III colorectal cancer. Clin Cancer Res 2003;9:2898-2903 (Pubitemid 36993247)
    • (2003) Clinical Cancer Research , vol.9 , Issue.8 , pp. 2898-2903
    • Van Rijnsoever, M.1    Elsaleh, H.2    Joseph, D.3    McCaul, K.4    Iacopetta, B.5
  • 38
    • 3042774430 scopus 로고    scopus 로고
    • The acquisition of hMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients
    • DOI 10.1158/1078-0432.CCR-03-0732
    • Gifford G, Paul J, Vasey PA, et al. The acquisition of HMLH1 methylation in plasma DNA after chemotherapy predicts poor survival for ovarian cancer patients. Clin Cancer Res 2004;10:4420-4426 (Pubitemid 38878884)
    • (2004) Clinical Cancer Research , vol.10 , Issue.13 , pp. 4420-4426
    • Gifford, G.1    Paul, J.2    Vasey, P.A.3    Kaye, S.B.4    Brown, R.5
  • 39
    • 44449147948 scopus 로고    scopus 로고
    • Role of mismatch repair and mgmt in response to anticancer therapies
    • Casorelli I, Russo MT, Bignami M. Role of mismatch repair and mgmt in response to anticancer therapies. Anticancer Agents Med Chem2008; 8:368-380
    • (2008) Anticancer Agents Med Chem , vol.8 , pp. 368-380
    • Casorelli, I.1    Russo, M.T.2    Bignami, M.3
  • 40
    • 41449118765 scopus 로고    scopus 로고
    • An ATM- And Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21WAF1/CIP1 in response to 5-aza-2′-deoxycytidine treatment
    • Wang H, Zhao Y, Li L, et al. An ATM- and Rad3-related (ATR) signaling pathway and a phosphorylation-acetylation cascade are involved in activation of p53/p21WAF1/CIP1 in response to 5-aza-2′-deoxycytidine treatment. J Biol Chem 2008;283:2564-2574
    • (2008) J Biol Chem , vol.283 , pp. 2564-2574
    • Wang, H.1    Zhao, Y.2    Li, L.3
  • 41
    • 0035057219 scopus 로고    scopus 로고
    • Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-Aza-2′-deoxycytidine
    • Karpf AR, Moore BC, Ririe TO, et al. Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza- 2′-deoxycytidine. Mol Pharmacol 2001;59:751-757 (Pubitemid 32274003)
    • (2001) Molecular Pharmacology , vol.59 , Issue.4 , pp. 751-757
    • Karpf, A.R.1    Moore, B.C.2    Ririe, T.O.3    Jones, D.A.4
  • 45
    • 44849104826 scopus 로고    scopus 로고
    • p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage
    • Jiemjit A, Fandy TE, Carraway H, et al. p21(WAF1/CIP1) induction by 5-azacytosine nucleosides requires DNA damage. Oncogene 2008;27: 3615-3623
    • (2008) Oncogene , vol.27 , pp. 3615-3623
    • Jiemjit, A.1    Fandy, T.E.2    Carraway, H.3
  • 46
    • 1242272932 scopus 로고    scopus 로고
    • The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine
    • DOI 10.1038/sj.onc.1207175
    • Nieto M, Samper E, Fraga MF, et al. The absence of p53 is critical for the induction of apoptosis by 5-aza-2′-deoxycytidine. Oncogene 2004;23:735-743 (Pubitemid 38241274)
    • (2004) Oncogene , vol.23 , Issue.3 , pp. 735-743
    • Nieto, M.1    Samper, E.2    Fraga, M.F.3    Gonzalez De Buitrago, G.4    Esteller, M.5    Serrano, M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.