메뉴 건너뛰기




Volumn 18, Issue 5, 2007, Pages 1129-1137

Decreased expression of hMLH1 correlates with reduced 5-fluorouracil- mediated apoptosis in colon cancer cells

Author keywords

5 fluorouracil; Apoptosis; Chemosensitivity; Colorectal cancer; hMLH1

Indexed keywords

ANTINEOPLASTIC ANTIMETABOLITE; FLUOROURACIL; MESSENGER RNA; MLH1 PROTEIN, HUMAN; NUCLEAR PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; UNCLASSIFIED DRUG;

EID: 38449105001     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (15)

References (39)
  • 4
    • 0031017268 scopus 로고    scopus 로고
    • Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines
    • Kane MF, Loda M, Gaida GM, et al: Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines. Cancer Res 57: 808-811, 1997. (Pubitemid 27097998)
    • (1997) Cancer Research , vol.57 , Issue.5 , pp. 808-811
    • Kane, M.F.1    Loda, M.2    Gaida, G.M.3    Lipman, J.4    Mishra, R.5    Goldman, H.6    Jessup, J.M.7    Kolodner, R.8
  • 6
    • 0027314411 scopus 로고
    • Microsatellite instability in cancer of the proximal colon
    • Thibodeau SN, Bren G, Schaid D: Microsatellite instability in cancer of the proximal colon. Science 260: 816-819, 1993. (Pubitemid 23167612)
    • (1993) Science , vol.260 , Issue.5109 , pp. 816-819
    • Thibodeau, S.N.1    Bren, G.2    Schaid, D.3
  • 7
    • 0033946039 scopus 로고    scopus 로고
    • DNA mismatch repair genes and colorectal cancer
    • DOI 10.1136/gut.47.1.148
    • Wheeler JM, Bodmer WF, Mortensen NJ: DNA mismatch repair genes and colorectal cancer. Gut 47: 148-153, 2000. (Pubitemid 30430425)
    • (2000) Gut , vol.47 , Issue.1 , pp. 148-153
    • Wheeler, J.M.D.1    Bodmer, W.F.2    Wheeler, J.M.D.3    McC, M.N.J.4
  • 8
    • 0029066689 scopus 로고
    • Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability
    • Markowitz S, Wang J, Myeroff L, et al: Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science 268: 1336-1338, 1995.
    • (1995) Science , vol.268 , pp. 1336-1338
    • Markowitz, S.1    Wang, J.2    Myeroff, L.3
  • 9
    • 16144368515 scopus 로고    scopus 로고
    • Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours
    • Souza RF, Appel R, Yin J, et al: Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. Nat Genet 14: 255-257, 1996.
    • (1996) Nat Genet , vol.14 , pp. 255-257
    • Souza, R.F.1    Appel, R.2    Yin, J.3
  • 10
    • 0031018674 scopus 로고    scopus 로고
    • Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype
    • DOI 10.1126/science.275.5302.967
    • Rampino N, Yamamoto H, Ionov Y, et al: Somatic frameshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype. Science 275: 967-969, 1997. (Pubitemid 27087710)
    • (1997) Science , vol.275 , Issue.5302 , pp. 967-969
    • Rampino, N.1    Yamamoto, H.2    Ionov, Y.3    Li, Y.4    Sawai, H.5    Reed, J.C.6    Perucho, M.7
  • 16
    • 0033831989 scopus 로고    scopus 로고
    • Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer
    • Wright CM, Dent OF, Barker M, et al: Prognostic significance of extensive microsatellite instability in sporadic clinicopathological stage C colorectal cancer. Br J Surg 87: 1197-1202, 2000.
    • (2000) Br J Surg , vol.87 , pp. 1197-1202
    • Wright, C.M.1    Dent, O.F.2    Barker, M.3
  • 20
    • 0027936057 scopus 로고
    • Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation
    • Koi M, Umar A, Chauhan DP, et al: Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res 54: 4308-4312, 1994.
    • (1994) Cancer Res , vol.54 , pp. 4308-4312
    • Koi, M.1    Umar, A.2    Chauhan, D.P.3
  • 22
  • 25
    • 0037869289 scopus 로고    scopus 로고
    • Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines
    • DOI 10.1002/ijc.11176
    • Arnold CN, Goel A, Boland CR: Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer 106: 66-73, 2003. (Pubitemid 36750389)
    • (2003) International Journal of Cancer , vol.106 , Issue.1 , pp. 66-73
    • Arnold, C.N.1    Goel, A.2    Boland, C.R.3
  • 27
    • 0642374238 scopus 로고    scopus 로고
    • A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage
    • Meyers M, Hwang A, Wagner MW, et al: A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage. Oncogene 22: 7376-7388, 2003.
    • (2003) Oncogene , vol.22 , pp. 7376-7388
    • Meyers, M.1    Hwang, A.2    Wagner, M.W.3
  • 29
    • 0035392965 scopus 로고    scopus 로고
    • Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine- mediated cell death and cell cycle responses
    • Meyers M, Wagner MW, Hwang HS, Kinsella TJ, Boothman DA: Role of the hMLH1 DNA mismatch repair protein in fluoropyrimidine-mediated cell death and cell cycle responses. Cancer Res 61: 5193-5201, 2001. (Pubitemid 32681553)
    • (2001) Cancer Research , vol.61 , Issue.13 , pp. 5193-5201
    • Meyers, M.1    Wagner, M.W.2    Hwang, H.-S.3    Kinsella, T.J.4    Boothman, D.A.5
  • 32
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
    • Miyashita T and Reed JC: Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Cell 80: 293-299, 1995.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 33
    • 0032701521 scopus 로고    scopus 로고
    • Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    • Bunz F, Hwang PM, Torrance C, et al: Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 104: 263-269, 1999.
    • (1999) J Clin Invest , vol.104 , pp. 263-269
    • Bunz, F.1    Hwang, P.M.2    Torrance, C.3
  • 35
    • 1642327569 scopus 로고    scopus 로고
    • Characterization of p53 Wild-Type and Null Isogenic Colorectal Cancer Cell Lines Resistant to 5-Fluorouracil, Oxaliplatin, and Irinotecan
    • DOI 10.1158/1078-0432.CCR-03-0362
    • Boyer J, McLean EG, Aroori S, et al: Characterization of p53 wild-type and null isogenic colorectal cancer cell lines resistant to 5-fluorouracil, oxaliplatin, and irinotecan. Clin Cancer Res 10: 2158-2167, 2004. (Pubitemid 38375578)
    • (2004) Clinical Cancer Research , vol.10 , Issue.6 , pp. 2158-2167
    • Boyer, J.1    McLean, E.G.2    Aroori, S.3    Wilson, P.4    McCulla, A.5    Carey, P.D.6    Longley, D.B.7    Johnston, P.G.8
  • 36
    • 0036466874 scopus 로고    scopus 로고
    • P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection
    • Liang JT, Huang KC, Cheng YM, et al: P53 overexpression predicts poor chemosensitivity to high-dose 5-fluorouracil plus leucovorin chemotherapy for stage IV colorectal cancers after palliative bowel resection. Int J Cancer 97: 451-457, 2002.
    • (2002) Int J Cancer , vol.97 , pp. 451-457
    • Liang, J.T.1    Huang, K.C.2    Cheng, Y.M.3
  • 37
    • 0034895979 scopus 로고    scopus 로고
    • p53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma
    • Elsaleh H, Powell B, McCaul K, et al: P53 alteration and microsatellite instability have predictive value for survival benefit from chemotherapy in stage III colorectal carcinoma. Clin Cancer Res 7: 1343-1349, 2001. (Pubitemid 32708690)
    • (2001) Clinical Cancer Research , vol.7 , Issue.5 , pp. 1343-1349
    • Elsaleh, H.1    Powell, B.2    McCaul, K.3    Grieu, F.4    Grant, R.5    Joseph, D.6    Iacopetta, B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.