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Volumn 71, Issue 5-6, 2007, Pages 437-445

The synergistic effect of 5-aza-2′-deoxycytidine and 5-fluorouracil on drug-resistant tumors

Author keywords

5 Aza 2 deoxycytidine; 5 Fluorouracil; Chemosensitivity; CpG island; Methylation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DEATH ASSOCIATED PROTEIN KINASE; FLUOROURACIL; PROTEIN P14; PROTEIN P16;

EID: 35348832560     PISSN: 00302414     EISSN: None     Source Type: Journal    
DOI: 10.1159/000107110     Document Type: Article
Times cited : (28)

References (38)
  • 2
    • 0035253051 scopus 로고    scopus 로고
    • p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells
    • Bartke T, Siegmund D, Peters N, Reichwein M, Henkler F, Scheurich P, Wajant H: p53 upregulates cFLIP, inhibits transcription of NF-κB-regulated genes and induces caspase-8-independent cell death in DLD-1 cells. Oncogene 2001;20:571-580.
    • (2001) Oncogene , vol.20 , pp. 571-580
    • Bartke, T.1    Siegmund, D.2    Peters, N.3    Reichwein, M.4    Henkler, F.5    Scheurich, P.6    Wajant, H.7
  • 4
    • 0038387494 scopus 로고    scopus 로고
    • 5-fluorouracil: Mechanism of action and clinical strategies
    • Longley DB, Harkin DP, Johnston PG: 5-fluorouracil: mechanism of action and clinical strategies. Nat Rev Cancer 2003;3:330-338.
    • (2003) Nat Rev Cancer , vol.3 , pp. 330-338
    • Longley, D.B.1    Harkin, D.P.2    Johnston, P.G.3
  • 5
    • 0033044686 scopus 로고    scopus 로고
    • A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells
    • Tillman DM, Petak I, Houghton JA: A Fas-dependent component in 5-fluorouracil/leucovorin-induced cytotoxicity in colon carcinoma cells. Clin Cancer Res 1999;5:425-430.
    • (1999) Clin Cancer Res , vol.5 , pp. 425-430
    • Tillman, D.M.1    Petak, I.2    Houghton, J.A.3
  • 6
    • 0033449456 scopus 로고    scopus 로고
    • Apoptosis of colorectal adenocarcinoma induced by 5-FU and/or IFN-γ through caspase 3 and caspase 8
    • Adachi Y, Taketani S, Oyaizu H, Ikebukuro K, Tokunaga R, Ikehara S: Apoptosis of colorectal adenocarcinoma induced by 5-FU and/or IFN-γ through caspase 3 and caspase 8. Int J Oncol 1999;6:1191-1196.
    • (1999) Int J Oncol , vol.6 , pp. 1191-1196
    • Adachi, Y.1    Taketani, S.2    Oyaizu, H.3    Ikebukuro, K.4    Tokunaga, R.5    Ikehara, S.6
  • 7
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB: The fundamental role of epigenetic events in cancer. Nat Rev Genet 2002;3:415-428.
    • (2002) Nat Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 8
    • 0034807280 scopus 로고    scopus 로고
    • Methylation and colorectal cancer
    • Jubb AM, Bell SM, Quirke P: Methylation and colorectal cancer. J Pathol 2001;195:111-134.
    • (2001) J Pathol , vol.195 , pp. 111-134
    • Jubb, A.M.1    Bell, S.M.2    Quirke, P.3
  • 9
    • 0036145156 scopus 로고    scopus 로고
    • Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumors
    • Esteller M, Herman JG: Cancer as an epigenetic disease: DNA methylation and chromatin alterations in human tumors. J Pathol 2002;196:1-7.
    • (2002) J Pathol , vol.196 , pp. 1-7
    • Esteller, M.1    Herman, J.G.2
  • 10
    • 0037068312 scopus 로고    scopus 로고
    • CpG island hypermethylation and tumor suppressor genes: A booming present, a brighter future
    • Esteller M: CpG island hypermethylation and tumor suppressor genes: a booming present, a brighter future. Oncogene 2002;21:5427-5740.
    • (2002) Oncogene , vol.21 , pp. 5427-5740
    • Esteller, M.1
  • 11
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger G, Liang G, Aparicio A, Jones PA: Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004;429:457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 12
    • 0018860957 scopus 로고
    • Cellular differentiation, cytidine analogs and DNA methylation
    • Jones PA, Taylor SM: Cellular differentiation, cytidine analogs and DNA methylation. Cell 1980;20:85-93.
    • (1980) Cell , vol.20 , pp. 85-93
    • Jones, P.A.1    Taylor, S.M.2
  • 13
    • 0028151343 scopus 로고
    • Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation
    • Juttermann R, Li E, Jaenisch R: Toxicity of 5-aza-2′-deoxycytidine to mammalian cells is mediated primarily by covalent trapping of DNA methyltransferase rather than DNA demethylation. Proc Natl Acad Sci USA 1994;91:11797-11801.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 11797-11801
    • Juttermann, R.1    Li, E.2    Jaenisch, R.3
  • 14
    • 0037068379 scopus 로고    scopus 로고
    • 5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
    • Christman JK: 5-azacytidine and 5-aza-2′-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy. Oncogene 2002;21:5483-5495.
    • (2002) Oncogene , vol.21 , pp. 5483-5495
    • Christman, J.K.1
  • 15
    • 0023573963 scopus 로고
    • The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas
    • Abele R, Clavel M, Dodion P, Bruntsch U, Gundersen S, Smyth J, Renard J, van Glabbeke M, Pinedo HM: The EORTC Early Clinical Trials Cooperative Group experience with 5-aza-2′-deoxycytidine (NSC 127716) in patients with colo-rectal, head and neck, renal carcinomas and malignant melanomas. Eur J Cancer Clin Oncol 1987:23:1921-1924.
    • (1987) Eur J Cancer Clin Oncol , vol.23 , pp. 1921-1924
    • Abele, R.1    Clavel, M.2    Dodion, P.3    Bruntsch, U.4    Gundersen, S.5    Smyth, J.6    Renard, J.7    van Glabbeke, M.8    Pinedo, H.M.9
  • 16
    • 0026572102 scopus 로고
    • 5-aza-2′-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer: Phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group
    • Clavel M, Monfardini S, Fossa S, Smyth J, Renard J, Kaye SB: 5-aza-2′-deoxycytidine (NSC 127716) in non-seminomatous testicular cancer: phase II from the EORTC Early Clinical Trials Cooperative Group and Genito-Urinary Group. Ann Oncol 1992:3:399-400.
    • (1992) Ann Oncol , vol.3 , pp. 399-400
    • Clavel, M.1    Monfardini, S.2    Fossa, S.3    Smyth, J.4    Renard, J.5    Kaye, S.B.6
  • 17
    • 0030965033 scopus 로고    scopus 로고
    • A randomized phase II study on the effects of 5-aza-2′-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: An EORTC Leukemia Cooperative Group phase II study (06893)
    • Willemze R, Suciu S, Archimbaud E, Muus P, Stryckmans P, Louwagie EA, Berneman Z, Tjean M, Wijermans P, Dohner H, Jehn U, Labar B, et al: A randomized phase II study on the effects of 5-aza-2′-deoxycytidine combined with either amsacrine or idarubicin in patients with relapsed acute leukemia: an EORTC Leukemia Cooperative Group phase II study (06893). Leukemia 1997;11(suppl 1):S24-S27.
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 1
    • Willemze, R.1    Suciu, S.2    Archimbaud, E.3    Muus, P.4    Stryckmans, P.5    Louwagie, E.A.6    Berneman, Z.7    Tjean, M.8    Wijermans, P.9    Dohner, H.10    Jehn, U.11    Labar, B.12
  • 18
    • 0030990163 scopus 로고    scopus 로고
    • Decitabine (5-aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: Preliminary observations
    • Schwartsmann G, Fernandes MS, Schaan MD, Moschen M, Gerhardt LM, Di Leone L, Loitzembauer B, Kalakun L: Decitabine (5-aza-2′-deoxycytidine; DAC) plus daunorubicin as a first line treatment in patients with acute myeloid leukemia: preliminary observations. Leukemia 1997;11(suppl 1):S28-S31.
    • (1997) Leukemia , vol.11 , Issue.SUPPL. 1
    • Schwartsmann, G.1    Fernandes, M.S.2    Schaan, M.D.3    Moschen, M.4    Gerhardt, L.M.5    Di Leone, L.6    Loitzembauer, B.7    Kalakun, L.8
  • 19
    • 17444452612 scopus 로고    scopus 로고
    • Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: A multicenter phase II study in elderly patients
    • Wijermans P, Lubbert M, Verhoef G, Bosly A, Ravoet C, Andre M, Ferrant A: Low-dose 5-aza-2′-deoxycytidine, a DNA hypomethylating agent, for the treatment of high-risk myelodysplastic syndrome: a multicenter phase II study in elderly patients. J Clin Oncol 2000;18:956-962.
    • (2000) J Clin Oncol , vol.18 , pp. 956-962
    • Wijermans, P.1    Lubbert, M.2    Verhoef, G.3    Bosly, A.4    Ravoet, C.5    Andre, M.6    Ferrant, A.7
  • 23
    • 0035799382 scopus 로고    scopus 로고
    • Changes in DNA methylation in neoplasia: Pathophysiology and therapeutic implications
    • Santini V, Kantarjian HM, Issa JP: Changes in DNA methylation in neoplasia: pathophysiology and therapeutic implications. Ann Intern Med 2001;134:573-586.
    • (2001) Ann Intern Med , vol.134 , pp. 573-586
    • Santini, V.1    Kantarjian, H.M.2    Issa, J.P.3
  • 24
    • 0036861629 scopus 로고    scopus 로고
    • DNA methyltransferase inhibitors-state of the art
    • Goffin J, Eisenhauer E: DNA methyltransferase inhibitors-state of the art. Ann Oncol 2002;13:1699-1716.
    • (2002) Ann Oncol , vol.13 , pp. 1699-1716
    • Goffin, J.1    Eisenhauer, E.2
  • 25
    • 0034326784 scopus 로고    scopus 로고
    • Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter
    • Plumb JA, Strathdee G, Sludden J, Kaye SB, Brown R: Reversal of drug resistance in human tumor xenografts by 2′-deoxy-5-azacytidine-induced demethylation of the hMLH1 gene promoter. Cancer Res 2000;60:6039-6044.
    • (2000) Cancer Res , vol.60 , pp. 6039-6044
    • Plumb, J.A.1    Strathdee, G.2    Sludden, J.3    Kaye, S.B.4    Brown, R.5
  • 27
    • 0037869289 scopus 로고    scopus 로고
    • Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines
    • Arnold CN, Goel A, Boland CR: Role of hMLH1 promoter hypermethylation in drug resistance to 5-fluorouracil in colorectal cancer cell lines. Int J Cancer 2003;106:66-73.
    • (2003) Int J Cancer , vol.106 , pp. 66-73
    • Arnold, C.N.1    Goel, A.2    Boland, C.R.3
  • 29
    • 0037372967 scopus 로고    scopus 로고
    • P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53
    • Shen L, Kondo Y, Hamilton SR, Rashid A, Issa JP: P14 methylation in human colon cancer is associated with microsatellite instability and wild-type p53. Gastroenterology 2003;124:626-633.
    • (2003) Gastroenterology , vol.124 , pp. 626-633
    • Shen, L.1    Kondo, Y.2    Hamilton, S.R.3    Rashid, A.4    Issa, J.P.5
  • 30
    • 0034660892 scopus 로고    scopus 로고
    • The Pezcoller lecture: Cancer cell cycles revisited
    • Sherr CJ: The Pezcoller lecture: cancer cell cycles revisited. Cancer Res 2000;60:3689-3695.
    • (2000) Cancer Res , vol.60 , pp. 3689-3695
    • Sherr, C.J.1
  • 31
    • 0035141040 scopus 로고    scopus 로고
    • DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation
    • Raveh T, Droguett G, Horwitz MS, DePinho RA, Kimchi A: DAP kinase activates a p19ARF/p53-mediated apoptotic checkpoint to suppress oncogenic transformation. Nat Cell Biol 2001;3:1-7.
    • (2001) Nat Cell Biol , vol.3 , pp. 1-7
    • Raveh, T.1    Droguett, G.2    Horwitz, M.S.3    DePinho, R.A.4    Kimchi, A.5
  • 32
    • 0035057219 scopus 로고    scopus 로고
    • Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2′-deoxycytidine
    • Karpf AR, Moore BC, Ririe TO, Jones DA: Activation of the p53 DNA damage response pathway after inhibition of DNA methyltransferase by 5-aza-2′-deoxycytidine. Mol Pharmacol 2001;59:751-757.
    • (2001) Mol Pharmacol , vol.59 , pp. 751-757
    • Karpf, A.R.1    Moore, B.C.2    Ririe, T.O.3    Jones, D.A.4
  • 33
    • 0344284564 scopus 로고    scopus 로고
    • Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin
    • Shimodaira H, Yoshioka-Yamashita A, Kolodner RD, Wang JY: Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci USA 2003;100:2420-2425.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2420-2425
    • Shimodaira, H.1    Yoshioka-Yamashita, A.2    Kolodner, R.D.3    Wang, J.Y.4
  • 34
    • 0033676843 scopus 로고    scopus 로고
    • TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers
    • Conway KE, McConnell BB, Bowring CE, Donald CD, Warren ST, Vertino PM: TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers. Cancer Res 2000;60:6236-6242.
    • (2000) Cancer Res , vol.60 , pp. 6236-6242
    • Conway, K.E.1    McConnell, B.B.2    Bowring, C.E.3    Donald, C.D.4    Warren, S.T.5    Vertino, P.M.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.