Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC

Bioscience Reports

Volumn 29, Issue 2, 2009, Pages 77-87

  Heinrich, Annette ^a   B̈Oer, Ulrike ^a   Tzvetkov, Mladen ^a   Oetjen, Elke ^a   Knepel, Willhart ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

CAMP response element binding protein (CREB); Glutathione transferase (GST) pull down assay; Lithium; Mammalian two hybrid assay; Protein protein interaction; Transducer of regulated CREB (TORC)

Indexed keywords

CRTC1 PROTEIN, HUMAN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; LITHIUM; TRANSCRIPTION FACTOR;

ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL CULTURE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; HAMSTER; IMMUNOHISTOCHEMISTRY; INSULINOMA; ISOLATION AND PURIFICATION; METABOLISM; PATHOLOGY; PROMOTER REGION; TRANSCRIPTION INITIATION; TWO HYBRID SYSTEM;

ANIMALS; CELL NUCLEUS; CELLS, CULTURED; CHROMATIN IMMUNOPRECIPITATION; CRICETINAE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GLUTATHIONE TRANSFERASE; IMMUNOHISTOCHEMISTRY; INSULINOMA; LITHIUM; MODELS, BIOLOGICAL; PROMOTER REGIONS, GENETIC; RECOMBINANT FUSION PROTEINS; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION; TRANSFECTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 66349115164     PISSN: 01448463     EISSN: 15734935     Source Type: Journal    
DOI: 10.1042/BSR20080116     Document Type: Article

References (50)

1. Mota de Freitas, D., Castro, M. M. and Geraldes, C. F. (2006) Is competition between Li+ and Mg2+ the underlying theme in the proposed mechanisms for the pharmacological action of lithium salts in bipolar disorder? Acc. Chem. Res. 39, 283-291
2. Quiroz, J. A., Gould, T. D. and Manji, H. K. (2004) Molecular effects of lithium. Mol. Interv. 4, 259-272
3. Manji, H. K., Quiroz, J. A., Sporn, J., Payne, J. L., Denicoff, K., Gray, N. A., Zarate, Jr., C. A. and Charney, D. S. (2003) Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for difficult-to-treat depression. Biol. Psychiatry 53, 707-742
4. Zarate, Jr., C. A., Du, J., Quiroz, J., Gray, N. A., Denicoff, K. D., Singh, J., Charney, D. S. and Manji, H. K. (2003) Regulation of cellular plasticity cascades in the pathophysiology and treatment of mood disorders: role of the glutamatergic system. Ann. N.Y. Acad. Sci. 1003, 273-291
5. McClung, C. A. and Nestler, E. J. (2008) Neuroplasticity mediated by altered gene expression. Neuropsychopharmacology 33, 3-17
6. Chuang, D. M., Chen, R. W., Chalecka-Franaszek, E., Ren, M., Hashimoto, R., Senatorov, V., Kanai, H., Hough, C., Hiroi, T. and Leeds, P. (2002) Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar Disord. 4, 129-136
7. Manji, H. K., Moore, G. J. and Chen, G. (2000) Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness. J. Clin. Psychiatry 61 (Suppl 9), 82-96
8. Boer, U., Eglins, J., Krause, D., Schnell, S., Schofl, C. and Knepel, W. (2007) Enhancement by lithium of cAMP-induced CRE/CREB-directed gene transcription conferred by TORC on the CREB basic leucine zipper domain. Biochem. J. 408, 69-77
9. Mayr, B. and Montminy, M. (2001) Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat. Rev. Mol. Cell Biol. 2, 599-609
10. Bittinger, M. A., McWhinnie, E., Meltzer, J., Iourgenko, V., Latario, B., Liu, X., Chen, C. H., Song, C., Garza, D. and Labow, M. (2004) Activation of cAMP response element-mediated gene expression by regulated nuclear transport of TORC proteins. Curr. Biol. 14, 2156-2161
11. Conkright, M. D., Canettieri, G., Screaton, R., Guzman, E., Miraglia, L., Hogenesch, J. B. and Montminy, M. (2003) TORCs: transducers of regulated CREB activity. Mol. Cell 12, 413-423
12. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L., Meltzer, J., Garza, D. et al. (2003) Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Natl. Acad. Sci. U.S.A. 100, 12147-12152
13. Ravnskjaer, K., Kester, H., Liu, Y., Zhang, X., Lee, D., Yates, III, J. R. and Montminy, M. (2007) Cooperative interactions between CBP and TORC2 confer selectivity to CREB target gene expression. EMBO J. 26, 2880-2889
14. Screaton, R. A., Conkright, M. D., Katoh, Y., Best, J. L., Canettieri, G., Jeffries, S., Guzman, E., Niessen, S., Yates, III, J. R., Takemori, H. et al. (2004) The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell 119, 61-74
15. Katoh, Y., Takemori, H., Lin, X. Z., Tamura, M., Muraoka, M., Satoh, T., Tsuchiya, Y., Min, L., Doi, J., Miyauchi, A. et al. (2006) Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade. FEBS J. 273, 2730-2748
16. Koo, S. H., Flechner, L., Qi, L., Zhang, X., Screaton, R. A., Jeffries, S., Hedrick, S., Xu, W., Boussouar, F., Brindle, P. et al. (2005) The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism. Nature 437, 1109-1111
17. Shaw, R. J., Lamia, K. A., Vasquez, D., Koo, S. H., Bardeesy, N., Depinho, R. A., Montminy, M. and Cantley, L. C. (2005) The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642-1646
18. Oetjen, E., Diedrich, T., Eggers, A., Eckert, B. and Knepel, W. (1994) Distinct properties of the cAMP-responsive element of the rat insulin I gene. J. Biol. Chem. 269, 27036-27044
19. Kruger, M., Schwaninger, M., Blume, R., Oetjen, E. and Knepel, W. (1997) Inhibition of CREB- and cAMP response element-mediated gene transcription by the immunosuppressive drugs cyclosporin A and FK506 in T cells. Naunyn Schmiedebergs Arch. Pharmacol. 356, 433-440
20. Sadowski, I. and Ptashne, M. (1989) A vector for expressing GAL4(1-147) fusions in mammalian cells. Nucleic Acids Res. 17, 7539
21. Oetjen, E., Thoms, K. M., Laufer, Y., Pape, D., Blume, R., Li, P. and Knepel, W. (2005) The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level. Br. J. Pharmacol. 144, 982-993
22. Plaumann, S., Blume, R., Borchers, S., Steinfelder, H. J., Knepel, W. and Oetjen, E. (2008) Activation of the dual-leucinezipper- bearing kinase and induction of β-cell apoptosis by the immunosuppressive drug cyclosporin A. Mol. Pharmacol. 73, 652-659
23. Kratzner, R., Frohlich, F., Lepler, K., Schroder, M., Roher, K., Dickel, C., Tzvetkov, M. V., Quentin, T., Oetjen, E. and Knepel, W. (2008) A peroxisome proliferator-activated receptor γ-retinoid X receptor heterodimer physically interacts with the transcriptional activator PAX6 to inhibit glucagon gene transcription. Mol. Pharmacol. 73, 509-517
24. Canettieri, G., Morantte, I., Guzman, E., Asahara, H., Herzig, S., Anderson, S. D., Yates, III, J. R. and Montminy, M. (2003) Attenuation of a phosphorylation-dependent activator by an HDAC-PP1 complex. Nat. Struct. Biol. 10, 175-181
25. Zhang, Y., Zhang, D., Li, W., Chen, J., Peng, Y. and Cao, W. (2003) A novel real-time quantitative PCR method using attached universal template probe. Nucleic Acids Res. 31, e123
26. Wu, H., Zhou, Y. and Xiong, Z. Q. (2007) Transducer of regulated CREB and late phase long-term synaptic potentiation. FEBS J. 274, 3218-3223
27. Zhou, Y., Wu, H., Li, S., Chen, Q., Cheng, X. W., Zheng, J., Takemori, H. and Xiong, Z. Q. (2006) Requirement of TORC1 for late-phase long-term potentiation in the hippocampus. PLoS ONE 1, e16
28. Schwaninger, M., Lux, G., Blume, R., Oetjen, E., Hidaka, H. and Knepel, W. (1993) Membrane depolarization and calcium influx induce glucagon gene transcription in pancreatic islet cells through the cyclic AMP-responsive element. J. Biol. Chem. 268, 5168-5177
29. Hashimoto, M., Hsu, L. J., Rockenstein, E., Takenouchi, T., Mallory, M. and Masliah, E. (2002) α-Synuclein protects against oxidative stress via inactivation of the c-Jun N-terminal kinase stress-signaling pathway in neuronal cells. J. Biol. Chem. 277, 11465-11472
30. Cerf, M. E. (2006) Transcription factors regulating β-cell function. Eur. J. Endocrinol. 155, 671-679
31. D'Elia, A. V., Puppin, C., Pellizzari, L., Pianta, A., Bregant, E., Lonigro, R., Tell, G., Fogolari, F., van Heyningen, V. and Damante, G. (2006) Molecular analysis of a human PAX6 homeobox mutant. Eur. J. Hum. Genet. 14, 744-751
32. Peyton, M., Stellrecht, C. M., Naya, F. J., Huang, H. P., Samora, P. J. and Tsai, M. J. (1996) BETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes. Mol. Cell. Biol. 16, 626-633
33. Schwaninger, M., Blume, R., Kruger, M., Lux, G., Oetjen, E. and Knepel, W. (1995) Involvement of the Ca2+-dependent phosphatase calcineurin in gene transcription that is stimulated by cAMP through cAMP response elements. J. Biol. Chem. 270, 8860-8866
34. Schwaninger, M., Blume, R., Oetjen, E., Lux, G. and Knepel, W. (1993) Inhibition of cAMP-responsive element-mediated gene transcription by cyclosporin A and FK506 after membrane depolarization. J. Biol. Chem. 268, 23111-23115
35. Kovacs, K. A., Steullet, P., Steinmann, M., Do, K. Q., Magistretti, P. J., Halfon, O. and Cardinaux, J. R. (2007) TORC1 is a calciumand cAMP-sensitive coincidence detector involved in hippocampal long-term synaptic plasticity. Proc. Natl. Acad. Sci. U.S.A. 104, 4700-4705
36. Ryves, W. J., Dajani, R., Pearl, L. and Harwood, A. J. (2002) Glycogen synthase kinase-3 inhibition by lithium and beryllium suggests the presence of two magnesium binding sites. Biochem. Biophys. Res. Commun. 290, 967-972
37. Ryves, W. J. and Harwood, A. J. (2001) Lithium inhibits glycogen synthase kinase-3 by competition for magnesium. Biochem. Biophys. Res. Commun. 280, 720-725
38. Shaywitz, A. J. and Greenberg, M. E. (1999) CREB: a stimulusinduced transcription factor activated by a diverse array of extracellular signals. Annu. Rev. Biochem. 68, 821-861
39. Takemori, H. and Okamoto, M. (2008) Regulation of CREB-mediated gene expression by salt inducible kinase. J. Steroid Biochem. Mol. Biol. 108, 287-291
40. Takemori, H., Kajimura, J. and Okamoto, M. (2007) TORC-SIK cascade regulates CREB activity through the basic leucine zipper domain. FEBS J. 274, 3202-3209
41. Amelio, A. L., Miraglia, L. J., Conkright, J. J., Mercer, B. A., Batalov, S., Cavett, V., Orth, A. P., Busby, J., Hogenesch, J. B. and Conkright, M. D. (2007) A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway. Proc. Natl. Acad. Sci. U.S.A. 104, 20314-20319
42. Schumacher, M. A., Goodman, R. H. and Brennan, R. G. (2000) The structure of a CREB bZIP.somatostatin CRE complex reveals the basis for selective dimerization and divalent cation-enhanced DNA binding. J. Biol. Chem. 275, 35242-35247
43. Klein, P. S. and Melton, D. A. (1996) A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. U.S.A. 93, 8455-8459
44. Liang, M. H., Wendland, J. R. and Chuang, D. M. (2008) Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Mol. Cell. Neurosci. 37, 440-453
45. Manji, H. K. and Duman, R. S. (2001) Impairments of neuroplasticity and cellular resilience in severe mood disorders: implications for the development of novel therapeutics. Psychopharmacol. Bull. 35, 5-49
46. Manji, H. K. and Zarate, C. A. (2002) Molecular and cellular mechanisms underlying mood stabilization in bipolar disorder: implications for the development of improved therapeutics. Mol. Psychiatry 7 (Suppl 1), S1-S7
47. Chuang, D. M. (2004) Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases? Crit. Rev. Neurobiol. 16, 83-90
48. Lonze, B. E. and Ginty, D. D. (2002) Function and regulation of CREB family transcription factors in the nervous system. Neuron 35, 605-623
49. Brocard, J. B., Rajdev, S. and Reynolds, I. J. (1993) Glutamate-induced increases in intracellular free Mg2+ in cultured cortical neurons. Neuron 11, 751-757
50. Hartnett, K. A., Stout, A. K., Rajdev, S., Rosenberg, P. A., Reynolds, I. J. and Aizenman, E. (1997) NMDA receptor-mediated neurotoxicity: a paradoxical requirement for extracellular Mg2+ in Na+/Ca2+-free solutions in rat cortical neurons in vitro. J. Neurochem. 68, 1836-1845