The immunosuppressive drugs cyclosporin A and tacrolimus inhibit membrane depolarization-induced CREB transcriptional activity at the coactivator level

British Journal of Pharmacology

Volumn 144, Issue 7, 2005, Pages 982-993

  Oetjen, Elke ^a   Thoms, Kai Martin ^a   Laufer, Yvonne ^a   Pape, Daniela ^a   Blume, Roland ^a   Li, Pingfeng ^a   Knepel, Willhart ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Molecular Pharmacology   (Germany)

Author keywords

Calcineurin; cAMP response element binding protein (CREB); CREB binding protein (CBP); Cyclosporin A; Pancreatic cell

Indexed keywords

CALCINEURIN; CALCINEURIN PHOSPHATASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; CYCLOSPORIN A; FORSKOLIN; IMMUNOSUPPRESSIVE AGENT; PHOSPHATASE; SERINE; TACROLIMUS; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR GAL4; TRANSCRIPTION FACTOR NFAT; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPHOSPHORYLATION; DRUG MECHANISM; DRUG SENSITIVITY; ENZYME INHIBITION; GENE DELETION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IC 50; MEMBRANE DEPOLARIZATION; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; TWO HYBRID SYSTEM;

ANIMALS; CREB-BINDING PROTEIN; CRICETINAE; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLOSPORINE; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS; MEMBRANE POTENTIALS; NUCLEAR PROTEINS; TACROLIMUS; TRANS-ACTIVATORS; TRANSCRIPTION, GENETIC;

EID: 17844366894     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706127     Document Type: Article

References (41)

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