BETA3, a novel helix-loop-helix protein, can act as a negative regulator of BETA2 and MyoD-responsive genes

Molecular and Cellular Biology

Volumn 16, Issue 2, 1996, Pages 626-633

  Peyton, Michael ^a,b   Stellrecht, Christine M M ^a   Naya, Francisco J ^a   Huang, Hsiang Po ^a   Samora, Patrick J ^a   Tsai, Ming Jer ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; HELIX LOOP HELIX PROTEIN; INSULIN; TRANSCRIPTION FACTOR;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONSENSUS SEQUENCE; CONTROLLED STUDY; GENETIC REGULATION; HAMSTER; MUSCLE DEVELOPMENT; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

ANIMALIA; CRICETINAE;

EID: 0030048769     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.2.626     Document Type: Article

References (71)

1. Akazawa, C., M. Ishibashi, C. Shimizu, S. Nakanishi, and R. Kageyama. 1995. A mammalian helix-loop-helix factor structurally related to the product of Drosophila proneural gene atonal is a positive transcriptional regulator expressed in the developing nervous system. J. Biol Them. 270:8730-8738
2. Aplan, P. D., K. Nakahara, S. H. Orkin, and I. R. Kirsch. 1992 The SCL gene product d positive regulator of erythroid differentiation. EMBO J 11:4047-4081.
3. Aronheim, A., H. Ohlsson, C. W. Park, T. Edlund, and M. D. Walker. 1991. Distribution and characterization of helix-loop-helix enhancer binding proteins from pancreatic β cells and lymphocytes. Nucleic Acids Res 19:3893-3899.
4. Begley, C. G., P. D. Aplan, S. M. Denning, B. F. Haynes, T. A. Waldmann, and I. R. Kirsch. 1989 The gene SCL is expressed during early hematopoiesis and encodes a differentiation-related DNA-binding motil. Proc. Natl. Acad. Sci. USA 86:10128-10132.
5. Begley, C. G., S. Lipkowitz, V. Göbel, K. A. Mahon, V. Bertness, A. R. Green, N. M. Gough, and I. R. Kirsch. 1992 Molecular characterization of NSCL. a gene encoding a helix-loop-helix protein expressed in the developing nervous system. Proc. Natl Acad. Sci USA 89:38-42.
6. Benezra, R., R. L. Davis, D. Lockshon, D. L. Turner, and H. Weintraub. 1990 The protein Id: a negative regulator of helix-loop-helix DNA bindings proteins. Cell 61:49-59.
7. Boam, D. S. W., A. R. Clark, and K. Docherty. 1990. Positive and negative regulation of the human insulin gene by multiple trans-acting factors. J. Biol Chem 265:8285-8296.
8. I 14:1245-1255.
9. Catron, K. M., H. Zhang, S. C. Marshall, J. A. Inostroza, J. M. Wilson, and C. Abate. 1995 Transcriptional repression by Msx-1 does not require homeodomain DNA-binding sites. Mol. Cell Biol 15:861-871.
10. Chaney, W. G., D. R. Howard, J. W. Pollard, S. Sallustio, and P. Stanley. 1986. High-frequency transfection of CHO cells using polybrene. Somatic Cell Mol. Genet. 12:237-244.
11. Cordle, S. R., E. Henderson, H. Masucha, P. A. Weil, and R. Stein. 1991 Pancreatic β-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins. Mol Cell. Biol. 11:1734-1738
12. Crowe, D. T., and M.-J. Tsai. 1989 Mutagenesis of the rat insulin II 5′-flanking region defines sequences important for expression in HIT cells. Mol Cell. Biol. 9:1784-1789.
13. Davis, R. L., H. Weintraub, and A. B. Lassar. 1987. Expression of a single transfected cDNA converts fibroblasts to myoblasts. Cell 51:987-1000
14. Davis, R. L., P.-F. Cheng, A. B. Lassar, and H. Weintraub. 1990. The MyoD DNA binding domain contains a recognition code for muscle-specific gene activation. Cell 60:733-746.
15. de Pablo, F., and E. J. de la Rosa. 1995. The developing CNS: a scenario for the action of proinsulin, insulin, and insulin-like growth factors. Trends Neurosci 18:143-150
16. Edmondson, D. G., and E. N. Olson. 1989. A single gene with homology to the myc similarity region of MyoD1 is expressed during myogenesis and is sufficient to activate the muscle differentiation program. Genes Dev. 3:628-640
17. Ellenberger, T., D. Fass, M. Arnaud, and S. C. Harrison. 1994. Crystal structure of transcription factor E47: E-box recognition by a basic region helix-loop-helix dimer. Genes Dev. 8:970-980.
18. Fairman, R., R. K. Beran-Steed, S. J. Anthony-Cahill, J. D. Lear, W. F. Stafford III, W. F. DeGrado, P. A. Benfield, and S. L. Brenner. 1993. Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides. Proc Natl. Acad. Sci. USA 90:10429-10433.
19. German, M., S. Ashcroft, K. Docherty, H. Edlund, T. Edlund, S. Goodison, G. Kennedy, O. Madsen, D. Melloul, L. Moss, K. Olson, A. Permutt, J. Phillippe, R. P. Robertson, W. J. Rutter, P. Serup, R. Stein, D. Steiner, M.-J. Tsai, and M. D. Walker. 1995. The insulin gene promoter. a simplified nomenclature. Diabetes 44:1002-1004.
20. German, M. S., M. A. Blanar, C. Nelson, L. G. Moss, and W. J. Rutter. 1991 Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. Mol. Endocrinol. 5:292-299.
21. Gilman, M. 1987 Ribonuclease protection assay, p 4.7.1-4.7.8. In F M Ausubel, R. Brent, R E. Kingston, D D. Moore, J. G. Seidman, J. A Smith, and K. Struhl (ed). Current protocols in molecular biology John Wiley & Sons, New York.
22. Gobel, V., S. Lipkowitz, C. A. Kozak, and I. R. Kirsch. 1992 NSCL-2 a basic domain helix-loop-helix gene expressed in early neurogenesis Cell Growth Differ 3:143-148
23. Han, K., and J. L. Manley. 1993 Functional domains of the Drosophila Engrailed protein. EMBO J. 12:2723-2733.
24. Han, K., and J. L. Manley. 1993. Transcription repression by the Drosophila Even-skipped protein: definition of a minimal repression domain. Genes Dev. 7:491-503.
25. Henthorn, P., M. Kiledjian, and T. Kadesch. 1990. Two distinct transcription factors that bind the immunoglobulin enhancer mE5/kE2 motif Science 247:467-470.
26. Hollenberg, S. M., R. Sternglanz, P. F. Cheng, and H. Weintraub. 1995. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol. Cell. Biol 15:3813-3822
27. Hopwood, N. D., A. Pluck, and J. B. Gurdon. 1989 A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crest. Cell 59:893-903.
28. Hsu, H.-L., J.-T. Cheng, Q. Chen, and R. Baer. 1991. Enhancer-binding activity of the tal-1 oncoprotein in association with the E47/E12 helix-loop-helix proteins Mol. Cell. Biol 11:3037-3042.
29. Hsu, H.-L., L. Huang, J. T. Tsan, W. Funk, W. E. Wright, J.-S. Hu, R. E. Kingston, and R. Baer. 1994. Preferred sequences for DNA recognition by the TAL1 helix-loop-helix proteins Mol. Cell Biol 14:256-1265.
30. Hu, J.-S., E. N. Olson, and R. E. Kingston. 1992. HEB, a helix-loop-helix protein related to E2A and ITF2 that can modulate the DNA-binding ability of myogenic regulatory factors Mol Cell. Biol. 12:1031-1042
31. Hwung, Y.-P., D. T. Crowe, L.-H. Wang, S. Y. Tsai, and M.-J. Tsai. 1988 The COUP transcription factor binds to an upstream promoter clement of the rat insulin II gene Mol. Cell. Biol 8:2070-2077.
32. Hwung, Y.-P., Y.-Z. Gu, and M.-J. Tsai. 1990. Cooperatively of sequence elements mediates tissue specificity of the rat insulin 11 gene. Mol Cell. Biol 10:1784-1788.
33. Jarman, A. P., Y. Grau, L. Y. Jan, and Y. N. Jan. 1993. atonal is a proneural gene that directs organ formation in the Drosophila peripheral nervous system Cell 73:1307-1321
34. Jen, Y., H. Weintraub, and R. Benezra. 1992. Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins. Genes Dev. 6:1465-1479
35. Johnson, J. E., S. J. Birren, and D. J. Anderson. 1990. Two rat homologues of Drosophila achaete-scute specifically expressed in neuronal precursors. Nature (London) 346:858-861.
36. Karlsson, L., T. Edlund, J. B. Moss, W. J. Rutter, and M. D. Walker. 1987. A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer Proc. Natl Acad. Sci USA 84:8819-8823.
37. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs Nucleic Acids Res. 15:8125-8132.
38. Lassar, A. B., R. L. Davis, W. E. Wright, T. Kadesch, C. Murre, A. Voronova, D. Baltimore, and H. Weintraub. 1991. Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo Cell 66:305-315.
39. Lee, J. E., S. M. Hollenberg, L. Snider, D. L. Turner, N. Lipnick, and H. Weintraub. 1995. Conversion of Xenopus ectoderm into neurons by neuroD, a basic helix-loop-helix protein. Science 268:836-844.
40. Licht, J. D., M. J. Grossel, J. Figge, and U. M. Hansen. 1990 Drosophila Kruppel protein is a transcriptional repressor Nature (London) 346:76-79.
41. Madden, S. L., D. M. Cook, and F. J. Tauscher III. 1993 A structure-function analysis of transcriptional repression mediated by the WT1. Wilms tumor suppressor protein. Oncogene 8:1713-1720.
42. Maniatis, T., E. F. Fritsch, and J. Sambrook. 1982 Molecular cloning. a laboratory manual Cold Spring Harbor Laboratory, Cold Spring Harbor, N.Y
43. Mellentin, J. D., S. D. Smith, and M. L. Cleary. 1989. lyl-1. a novel gene altered by chromosomal translocation in T cell leukemia, codes for a protein with a helix-loop-helix DNA binding motif Cell 58:77-83.
44. Murre, C., P. S. McCaw, and D. Baltimore. 1989. A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD and myc proteins. Cell 56:777-783
45. Murre, C., P. S. McCaw, H. Vaessin, M. Caudy, L. Y. Jan, Y. N. Jan, C. V. Cabrera, J. N. Buskin, S. D. Hauschka, A. B. Lassar, H. Weintraub, and D. Baltimore. 1989 Interactions between heterologous helix-loop-helix proteins generate complexes that bind specifically to a common DNA sequence. Cell 58:537-544
46. Murre, C., A. Voronova, and D. Baltimore. 1991. B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits. Mol. Cell. Biol 11: 1156-1160.
47. Naya, F. J., C. M. M. Stellrecht, and M.-J. Tsai. 1995. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. Genes Dev 8:1009-1019
48. Nelson, C., L.-P. Shen, A. Meister, E. Fodor, and W. J. Rutter. 1990 Pan: a transcriptional regulator that binds chymotrypsin, insulin, and AP-4 enhancei motifs. Genes Dev. 4:1035-1043.
49. Ohsako, S., J. Hyer, G. Panganiban, I. Oliver, and M. Caudy. 1994. hairy functions as a DNA-binding helix-loop-helix repressor of Diosophila sensory organ formation. Genes Dev. 8:2743-2755.
50. Peyton, M., L. Moss, and M.-J. Tsai. 1994 Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E-box. J. Biol. Chem. 269:25936.
51. Rashbass, J., M. V. Taylor, and J. B. Gurdon. 1992. The DNA-binding protein E12 co-operates with XMyoD in the activation of muscle-specific gene expression in Xenopus embryos. EMBO J. 11:2981-2990.
52. Saiki, R. K., D. H. Gelfand, S. Stoffel, S. J. Scharf, R. Higuchi, G. T. Horn, K. B. Mullins, and H. A. Erlich. 1988. Primer-directed enzymatic amplification of DNA with thermostable DNA polymerase. Science 239:487-491.
53. Santerre, R. F., R. A. Cook, R. M. D. Crisel, J. D. Sharp, R. J. Schmidt, D. C. Williams, and C. P. Wilson. 1981 insulin synthesis in a clonal cell line of simian virus 40-transformed hamster pancreatic beta cells Proc. Natl. Acad. Sci. USA 78:4339-4343.
54. Seed, B., and J.-Y. Sheen. 1988. A simple phase-extraction assay for chloramphenicol acyltransferase activity Gene 67:271-277.
55. Shieh, S.-Y., and M.-J. Tsai. 1991. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. J. Biol. Chem. 266:16707-16714.
56. Steiner, D. F., S. J. Chan, J. M. Welsh, and S. C. M. Kwok. 1985 Structure and evolution of the insulin gene Annu Rev. Genet. 19:463-484.
57. Stellrecht, C. M. M., F. J. Naya, H.-P. Huang, M. Peyton, and M.-T. Tsaj. Unpublished data.
58. Sternberg, E. A., G. Spizz, W. M. Perry, D. Vizard, T. Weil, and E. N. Olson. 1988 Identification of upstream and intragenic regulatory elements that confer cell-type-restricted and differentiation-specific expression on the muscle creatine kinase gene. Mol. Cell. Biol. 8:2896-2909.
59. Sun, X.-H., and D. Baltimore. 1991. An inhibitory domain of E12 transcription factor prevents DNA binding in E12 homodimers but not in E12 heterodimers Cell 64:459-470.
60. Thisse, B., C. Stoetzel, C. Gorostiza-Thisse, and F. Perrin-Schmitt. 1988 Sequence of the twist gene and nuclear localization of its protein in endomesodermal cells of early Drosophila embryos. EMBO J 7:2175-2183
61. Van Doren, M., H. Ellis, and J. W. Posakony. 1991 The Drosophila extramacrochaetae protein antagonizes sequence-specific DNA binding by daughteiles/achaete-scute protein complexes. Development 113:245-255.
62. Van Doren, M., A. M. Bailey, J. Esnayra, K. Ede, and J. W. Puma. 1994. Negative regulation of proneural gene activity. hairy is a direct transcriptional repressor of achaete. Genes Dev. 8:2729-2742
63. Villares, R., and C. V. Cabrera. 1987. The achaete-scute gene complex of D melanogaster: conserved domains in a subset of genes required for neurogenesis and their homology to mvc. Cell 50:415-424.
64. Voronova, A., and D. Baltimore. 1990. Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains. Proc. Natl. Acad. Sci. USA 87:4722-4726.
65. Walker, M. D., C. W. Park, A. Rosen, and A. Aronheim. 1990. A cDNA from a mouse pancreatic β cell encoding a putative transcription factor of the insulin gene. Nucleic Acids Res 18:1159-1166.
66. Wang, Y., B. W. O'Malley, Jr., S. Y. Tsai, and B. W. O'Malley. 1994. A regulatory system for use in gene transfer. Proc Natl. Acad Sci. USA 91:8180-8184.
67. Whelan, J., D. Poon, P. A. Weil, and R. Stein. 1989. Pancreatic β-cell-type-specific expression of the rat insulin II gene is controlled by positive and negative cellular transcriptional elements. Mol. Cell Biol. 9:3253-3259
68. Wolf, C., C. Thisse, C. Stoetzel, B. Thisse, P. Gerlinger, and F. Perrin-Schmitt. 1991. The m-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus .α-twist and the Drosophila twist genes Dev. Biol. 143:363-373
69. Wright, W. E., D. A. Sassoon, and V. K. Lin. 1989. Myogenin, a factor regulating myogenesis, has a domain homologous to MyoD. Cell 56:607-617.
70. Xia, Y., L. Brown, C. Y.-C. Yang, J. T. Tsan, M. J. Siciliano, R. Espinosa III, M. M. LeBeau, and R. J. Baer. 1991. TAL2, a helix-loop-helix gene activated by the (7,9)(q34:q32) translocation in human T-cell leukemia. Proc. Natl Acad. Sci. USA 88:11416-11420
71. Zhang, Y., J. Babin, A. L. Feldhaus, H. Singh, P. A. Sharp, and M. Bina. 1991. HTF4: a new human helix-loop-helix protein. Nucleic Acids Res. 19:4555.