Cdc42 and mDia3 regulate microtubule attachment to kinetochores

Nature

Volumn 428, Issue 6984, 2004, Pages 767-771

  Yasuda, Shingo ^a   Oceguera Yanez, Fabian ^a   Kato, Takayuki ^a,d   Okamoto, Muneo ^a   Yonemura, Shigenobu ^b   Terada, Yasuhiko ^c   Ishizaki, Toshimasa ^a   Narumiya, Shuh ^a  

^a KYOTO UNIVERSITY FACULTY OF MEDICINE   (Japan)

^b RIKEN Center for Biosystems Dynamics Research   (Japan)

^c UNIVERSITY OF MINNESOTA   (United States)

^d OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CADMIUM; PROTEINS; SIGNALING; STABILITY;

CHROMATIDS; CYTOSKELETON; KINETOCHORES; MICROTUBULES (MTS); MITOSIS;

CELLS;

ACTIN; CELL PROTEIN; GUANOSINE TRIPHOSPHATASE; MDIA3 PROTEIN; PROTEIN CDC42; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; UNCLASSIFIED DRUG;

CHROMOSOME;

ANAPHASE; ANIMAL CELL; ARTICLE; CELL STRUCTURE; CENTROMERE; CHROMOSOME SEGREGATION; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; HUMAN; HUMAN CELL; METAPHASE; MICROTUBULE; MITOSIS SPINDLE; MOLECULAR INTERACTION; MOLECULAR STABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SISTER CHROMATID;

ANIMALS; CARRIER PROTEINS; CDC42 GTP-BINDING PROTEIN; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); GUANOSINE DIPHOSPHATE; HELA CELLS; HUMANS; KINETOCHORES; MICE; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; NIH 3T3 CELLS; RHO GTP-BINDING PROTEINS; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 1942455757     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02452     Document Type: Article

References (30)

1. Scholey, J. M., Brust-Masher, I. & Mogilner, A. Cell division. Nature 422, 746-752 (2003).
2. Cleveland, D. W., Mao, Y. & Sullivan, K. F. Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling. Cell 112, 407-421 (2003).
3. Etienne-Manneville, S. & Hall, A. Rho GTPases in cell biology. Nature 420, 629-635 (2002).
4. Mabuchi, I. et al. A rho-like protein is involved in the organisation of the contractile ring in dividing sand dollar eggs. Zygotes 1, 325-331 (1993).
5. Just, I. et al. Glucosylation of Rho proteins by Clostridium difficle toxin B. Nature 375, 500-503 (1995).
6. Eda, M. et al. Rho-dependent transfer of Citron-kinase to the cleavage furrow of dividing cells. J. Cell Sci. 114, 3273-3284 (2001).
7. Wasserman, S. FH proteins as cytoskeletal organizers. Trends Cell Biol. 8, 111-115 (1998).
8. Watanabe, N. et al. p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J. 16, 3044-3056 (1997).
9. Ishizaki, T., Morishima, Y., Furuyashiki, T., Kato, T. & Narumiya, S. Coordination of microtubules and actin cytoskeleton by a Rho effector, mDia1. Nature Cell Biol. 3, 8-14 (2001).
10. Gundersen, G. G. Evolutionary conservation of microtubule-capture mechanisms. Nature Rev. Mol. Cell. Biol. 3, 296-304 (2002).
11. Alberts, A. S., Bouquin, N., Johnston, L. H. & Treisman, R. Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein β subunits and the yeast response regulator protein Skn7. J. Biol. Chem. 273, 8616-8622 (1998).
12. Bione, S. et al. A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility. Am. J. Hum. Genet. 62, 533-541 (1998).
13. Watanabe, N. et al. Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nature Cell Biol. 1, 136-143 (1999).
14. Kato, T. et al. Localization of a mammalian homolog of Diaphanous, mDia1, to the mitotic spindle in HeLa cells. J. Cell Sci. 114, 775-784 (2001).
15. Goshima, G., Kiyomitsu, T., Yoda, K. & Yanagida, M. Human centromere chromatin protein hMis12, essential for equal segregation, is independent of CENP-A loading pathway. J. Cell Biol. 160, 25-39 (2003).
16. Kellum, R. HP1 complexes and heterochromatin assembly. Curr. Top. Microbiol. Immunol. 274, 53-77 (2003).
17. Ando, S. et al. CENP-A, -B, and -C chromatin complex that contains the I-type α-satellite array constitutes the prekinetochore in HeLa cells. Mol. Cell. Biol. 22, 2229-2241 (2002).
18. Adams, R. R., Carmena, M. & Earnshaw, W. C. Chromosomal passengers and the (aurora) ABCs of mitosis. Trends Cell. Biol. 11, 49-54 (2001).
19. Arakawa, Y. et al. Control of axon elongation via an SDF-1α /Rho/mDia pathway in cultured cerebellar granule neurons. J. Cell Biol. 161, 381-391 (2003).
20. Tirnauer, J. S., Canman, J. C., Salmon, E. D. & Mitchison, T. J. EB1 targets to kinetochores with attached, polymerizing microtubules. Mol. Biol. Cell 13, 4308-4316 (2002).
21. Anand, S., Penrhyn-Lowe, S. & Venkitaraman, A. R. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 3, 51-62 (2003).
22. Tatsumoto, T., Xie, X., Blumenthal, R., Okamoto, I. & Miki, T. Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis. J. Cell Biol. 147, 921-928 (1999).
23. Hirose, K. et al. MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody. J. Biol. Chem. 276, 5821-5828 (2001).
24. Van de Putte, T. et al. Mice with a homozygous gene trap vector insertion in mgcRac GAP die during pre-implantation development. Mech. Dev. 102, 33-44 (2001).
25. Rodriguez, O. C. et al. Conserved microtubule-actin interactions in cell movement and morphogenesis. Nature Cell Biol. 5, 599-609 (2003).
26. Etienne-Manneville, S. & Hall, A. Cdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity. Nature 421, 753-756 (2003).
27. Pellman, D. Cancer. A CINtillating new job for the APC tumor suppressor. Science 291, 2555-2556 (2001).
28. Yao, X. et al. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint. Nature Cell Biol. 2, 484-491 (2000).
29. Andreassen, P. R., Palmer, D. K., Wener, M. H. & Marholis, R. L. Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis. J. Cell Sci. 99, 523-534 (1991).
30. Maiato, H. et al. Human CLASP1 is an outer kinetochore component that regulates spindle microtubule dynamics. Cell 113, 891-904 (2003).