Current status of gene expression profiling in the diagnosis and management of acute leukaemia

British Journal of Haematology

Volumn 145, Issue 5, 2009, Pages 555-568

  Bacher, Ulrike ^a   Kohlmann, Alexander ^b   Haferlach, Torsten ^b  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b MLL MUNICH LEUKEMIA LABORATORY   (Germany)

Author keywords

Acute lymphoblastic leukaemia; Acute myeloid leukaemia; Gene expression profiling; Microarrays; MILE study

Indexed keywords

ASPARAGINASE; CD135 ANTIGEN; DAUNORUBICIN; IMATINIB; MICRORNA; NUCLEOPHOSMIN; PROTEIN KINASE ZAP 70; STEROID; TIPIFARNIB; VINCRISTINE;

ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; GENE EXPRESSION PROFILING; GENETIC VARIABILITY; HUMAN; INTERNET; LYMPHOMA; MICROARRAY ANALYSIS; MICROSATELLITE INSTABILITY; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; RESPONSE VARIABLE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; UNIPARENTAL DISOMY;

GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE REARRANGEMENT; HUMANS; LEUKEMIA; LEUKEMIA, MYELOID, ACUTE; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA;

EID: 66149109199     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2009.07656.x     Document Type: Review

References (118)

1. Alcalay, M., Tiacci, E., Bergomas, R., Bigerna, B., Venturini, E., Minardi, S.P., Meani, N., Diverio, D., Bernard, L., Tizzoni, L., Volorio, S., Luzi, L., Colombo, E., Lo, C.F., Mecucci, C., Falini, B. Pelicci, P.G. (2005) Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance. Blood, 106, 899 902. (Pubitemid 41076430)
2. Armstrong, S.A., Staunton, J.E., Silverman, L.B., Pieters, R., den Boer, M.L., Minden, M.D., Sallan, S.E., Lander, E.S., Golub, T.R. Korsmeyer, S.J. (2002) MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nature Genetics, 30, 41 47.
3. Armstrong, S.A., Kung, A.L., Mabon, M.E., Silverman, L.B., Stam, R.W., den Boer, M.L., Pieters, R., Kersey, J.H., Sallan, S.E., Fletcher, J.A., Golub, T.R., Griffin, J.D. Korsmeyer, S.J. (2003) Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell, 3, 173 183. (Pubitemid 37443389)
4. Armstrong, S.A., Mabon, M.E., Silverman, L.B., Li, A., Gribben, J.G., Fox, E.A., Sallan, S.E. Korsmeyer, S.J. (2004) FLT3 mutations in childhood acute lymphoblastic leukemia. Blood, 103, 3544 3546. (Pubitemid 38525690)
5. Baldus, C.D. Bullinger, L. (2008) Gene expression with prognostic implications in cytogenetically normal acute myeloid leukemia. Seminars in Oncology, 35, 356 364.
6. Barrett, T., Troup, D.B., Wilhite, S.E., Ledoux, P., Rudnev, D., Evangelista, C., Kim, I.F., Soboleva, A., Tomashevsky, M. Edgar, R. (2007) NCBI GEO: mining tens of millions of expression profiles - database and tools update. Nucleic Acids Research, 35, D760 D765.
7. Bhojwani, D., Kang, H., Menezes, R.X., Yang, W., Sather, H., Moskowitz, N.P., Min, D.J., Potter, J.W., Harvey, R., Hunger, S.P., Seibel, N., Raetz, E.A., Pieters, R., Horstmann, M.A., Relling, M.V., den Boer, M.L., Willman, C.L. Carroll, W.L. (2008) Gene expression signatures predictive of early response and outcome in high-risk childhood acute lymphoblastic leukemia: A Children's Oncology Group Study. Journal of Clinical Oncology, 26, 4376 4384.
8. den Boer, M.L., van, S.M., De Menezes, R.X., Cheok, M.H., Buijs-Gladdines, J.G., Peters, S.T., Van Zutven, L.J., Beverloo, H.B., van der Spek, P.J., Escherich, G., Horstmann, M.A., Janka-Schaub, G.E., Kamps, W.A., Evans, W.E. Pieters, R. (2009) A subtype of childhood acute lymphoblastic leukaemia with poor treatment outcome: a genome-wide classification study. Lancet Oncology, 10, 125 134.
9. Brazma, A., Hingamp, P., Quackenbush, J., Sherlock, G., Spellman, P., Stoeckert, C., Aach, J., Ansorge, W., Ball, C.A., Causton, H.C., Gaasterland, T., Glenisson, P., Holstege, F.C., Kim, I.F., Markowitz, V., Matese, J.C., Parkinson, H., Robinson, A., Sarkans, U., Schulze-Kremer, S., Stewart, J., Taylor, R., Vilo, J. Vingron, M. (2001) Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nature Genetics, 29, 365 371. (Pubitemid 34326681)
10. Bueno, M.J., Perez de Castro, I., Gomez de, C.M., Santos, J., Calin, G.A., Cigudosa, J.C., Croce, C.M., Fernandez-Piqueras, J. Malumbres, M. (2008) Genetic and epigenetic silencing of microRNA-203 enhances ABL1 and BCR-ABL1 oncogene expression. Cancer Cell, 13, 496 506.
11. Bullinger, L., Dohner, K., Bair, E., Frohling, S., Schlenk, R.F., Tibshirani, R., Dohner, H. Pollack, J.R. (2004) Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. New England Journal of Medicine, 350, 1605 1616. (Pubitemid 38501163)
12. Bullinger, L., Rucker, F.G., Kurz, S., Du, J., Scholl, C., Sander, S., Corbacioglu, A., Lottaz, C., Krauter, J., Frohling, S., Ganser, A., Schlenk, R.F., Dohner, K., Pollack, J.R. Dohner, H. (2007) Gene-expression profiling identifies distinct subclasses of core binding factor acute myeloid leukemia. Blood, 110, 1291 1300. (Pubitemid 47281428)
13. Bullinger, L., Dohner, K., Kranz, R., Stirner, C., Frohling, S., Scholl, C., Kim, Y.H., Schlenk, R.F., Tibshirani, R., Dohner, H. Pollack, J.R. (2008) An FLT3 gene-expression signature predicts clinical outcome in normal karyotype AML. Blood, 111, 4490 4495.
14. Cairoli, R., Beghini, A., Grillo, G., Nadali, G., Elice, F., Ripamonti, C.B., Colapietro, P., Nichelatti, M., Pezzetti, L., Lunghi, M., Cuneo, A., Viola, A., Ferrara, F., Lazzarino, M., Rodeghiero, F., Pizzolo, G., Larizza, L. Morra, E. (2006) Prognostic impact of c-KIT mutations in core binding factor leukemias: an Italian retrospective study. Blood, 107, 3463 3468.
15. Calvano, S.E., Xiao, W., Richards, D.R., Felciano, R.M., Baker, H.V., Cho, R.J., Chen, R.O., Brownstein, B.H., Cobb, J.P., Tschoeke, S.K., Miller-Graziano, C., Moldawer, L.L., Mindrinos, M.N., Davis, R.W., Tompkins, R.G. Lowry, S.F. (2005) A network-based analysis of systemic inflammation in humans. Nature, 437, 1032 1037. (Pubitemid 41486985)
16. Campo Dell'Orto, M., Zangrando, A., Trentin, L., Li, R., Liu, W.M., te, K.G., Basso, G. Kohlmann, A. (2007) New data on robustness of gene expression signatures in leukemia: comparison of three distinct total RNA preparation procedures. BMC Genomics, 8, 188.
17. Chen, J.S., Coustan-Smith, E., Suzuki, T., Neale, G.A., Mihara, K., Pui, C.H. Campana, D. (2001) Identification of novel markers for monitoring minimal residual disease in acute lymphoblastic leukemia. Blood, 97, 2115 2120. (Pubitemid 32239094)
18. Cheok, M.H., Yang, W., Pui, C.H., Downing, J.R., Cheng, C., Naeve, C.W., Relling, M.V. Evans, W.E. (2003) Treatment-specific changes in gene expression discriminate in vivo drug response in human leukemia cells. Nature Genetics, 34, 85 90. (Pubitemid 36548796)
19. Chiaretti, S., Li, X., Gentleman, R., Vitale, A., Vignetti, M., Mandelli, F., Ritz, J. Foa, R. (2004) Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival. Blood, 103, 2771 2778. (Pubitemid 38393036)
20. Chiaretti, S., Li, X., Gentleman, R., Vitale, A., Wang, K.S., Mandelli, F., Foa, R. Ritz, J. (2005) Gene expression profiles of B-lineage adult acute lymphocytic leukemia reveal genetic patterns that identify lineage derivation and distinct mechanisms of transformation. Clinical Cancer Research, 11, 7209 7219. (Pubitemid 41507677)
21. Chiaretti, S., Guarini, A., De Propris, M.S., Tavolaro, S., Intoppa, S., Vitale, A., Iacobelli, S., Elia, L., Ariola, C., Ritz, J. Foa, R. (2006) ZAP70 expression in acute lymphoblastic leukemia: association with the E2A/PBX1 rearrangement and the pre-B stage of differentiation and prognostic implications. Blood, 107, 197 204. (Pubitemid 43053544)
22. Choi, S., Henderson, M.J., Kwan, E., Beesley, A.H., Sutton, R., Bahar, A.Y., Giles, J., Venn, N.C., Pozza, L.D., Baker, D.L., Marshall, G.M., Kees, U.R., Haber, M. Norris, M.D. (2007) Relapse in children with acute lymphoblastic leukemia involving selection of a preexisting drug-resistant subclone. Blood, 110, 632 639.
23. Cordero, F., Botta, M. Calogero, R.A. (2007) Microarray data analysis and mining approaches. Briefings in Functional Genomics & Proteomics, 6, 265 281.
24. Debernardi, S., Lillington, D.M., Chaplin, T., Tomlinson, S., Amess, J., Rohatiner, A., Lister, T.A. Young, B.D. (2003) Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events. Genes, Chromosomes & Cancer, 37, 149 158. (Pubitemid 36529782)
25. Eisen, M.B., Spellman, P.T., Brown, P.O. Botstein, D. (1998) Cluster analysis and display of genome-wide expression patterns. Proceedings of the National Academy of Sciences of the United States of America, 95, 14863 14868. (Pubitemid 29003722)
26. Faber, J., Gregory, R.I. Armstrong, S.A. (2008) Linking miRNA regulation to BCR-ABL expression: the next dimension. Cancer Cell, 13, 467 469.
27. Falini, B., Mecucci, C., Tiacci, E., Alcalay, M., Rosati, R., Pasqualucci, L., La, S.R., Diverio, D., Colombo, E., Santucci, A., Bigerna, B., Pacini, R., Pucciarini, A., Liso, A., Vignetti, M., Fazi, P., Meani, N., Pettirossi, V., Saglio, G., Mandelli, F., Lo-Coco, F., Pelicci, P.G. Martelli, M.F. (2005) Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. New England Journal of Medicine, 352, 254 266. (Pubitemid 40110814)
28. Falini, B., Nicoletti, I., Martelli, M.F. Mecucci, C. (2007) Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. Blood, 109, 874 885. (Pubitemid 46220630)
29. Fenaux, P., Lai, J.L., Morel, P., Nelken, B., Taboureau, O., Deminatti, M. Bauters, F. (1989) Cytogenetics and their prognostic value in childhood and adult acute lymphoblastic leukemia (ALL) excluding L3. Hematological Oncology, 7, 307 317. (Pubitemid 19171454)
30. Ferrando, A.A. Look, A.T. (2003) Gene expression profiling in T-cell acute lymphoblastic leukemia. Seminars in Hematology, 40, 274 280. (Pubitemid 37296777)
31. Ferrando, A.A., Neuberg, D.S., Staunton, J., Loh, M.L., Huard, C., Raimondi, S.C., Behm, F.G., Pui, C.H., Downing, J.R., Gilliland, D.G., Lander, E.S., Golub, T.R. Look, A.T. (2002) Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia. Cancer Cell, 1, 75 87. (Pubitemid 41039178)
32. Flotho, C., Coustan-Smith, E., Pei, D., Iwamoto, S., Song, G., Cheng, C., Pui, C.H., Downing, J.R. Campana, D. (2006) Genes contributing to minimal residual disease in childhood acute lymphoblastic leukemia: prognostic significance of CASP8AP2. Blood, 108, 1050 1057. (Pubitemid 44154644)
33. Garzon, R., Volinia, S., Liu, C.G., Fernandez-Cymering, C., Palumbo, T., Pichiorri, F., Fabbri, M., Coombes, K., Alder, H., Nakamura, T., Flomenberg, N., Marcucci, G., Calin, G.A., Kornblau, S.M., Kantarjian, H., Bloomfield, C.D., Andreeff, M. Croce, C.M. (2008) MicroRNA signatures associated with cytogenetics and prognosis in acute myeloid leukemia. Blood, 111, 3183 3189.
34. Gentleman, R.C., Carey, V.J., Bates, D.M., Bolstad, B., Dettling, M., Dudoit, S., Ellis, B., Gautier, L., Ge, Y., Gentry, J., Hornik, K., Hothorn, T., Huber, W., Iacus, S., Irizarry, R., Leisch, F., Li, C., Maechler, M., Rossini, A.J., Sawitzki, G., Smith, C., Smyth, G., Tierney, L., Yang, J.Y. Zhang, J. (2004) Bioconductor: open software development for computational biology and bioinformatics. Genome Biology, 5, R80.
35. Golub, T.R., Slonim, D.K., Tamayo, P., Huard, C., Gaasenbeek, M., Mesirov, J.P., Coller, H., Loh, M.L., Downing, J.R., Caligiuri, M.A., Bloomfield, C.D. Lander, E.S. (1999) Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science, 286, 531 537.
36. Gondek, L.P., Tiu, R., O'Keefe, C.L., Sekeres, M.A., Theil, K.S. Maciejewski, J.P. (2008) Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML. Blood, 111, 1534 1542.
37. Gupta, M., Raghavan, M., Gale, R.E., Chelala, C., Allen, C., Molloy, G., Chaplin, T., Linch, D.C., Cazier, J.B. Young, B.D. (2008) Novel regions of acquired uniparental disomy discovered in acute myeloid leukemia. Genes, Chromosomes & Cancer, 47, 729 739.
38. Haferlach, T. (2008) Molecular genetic pathways as therapeutic targets in acute myeloid leukemia. Hematology/American Society Hematology. Education Program, 2008, 400 411.
39. Haferlach, T., Kohlmann, A., Schnittger, S., Dugas, M., Hiddemann, W., Kern, W. Schoch, C. (2005a) Global approach to the diagnosis of leukemia using gene expression profiling. Blood, 106, 1189 1198. (Pubitemid 41130867)
40. Haferlach, T., Kohlmann, A., Schnittger, S., Dugas, M., Hiddemann, W., Kern, W. Schoch, C. (2005b) AML M3 and AML M3 variant each have a distinct gene expression signature but also share patterns different from other genetically defined AML subtypes. Genes, Chromosomes & Cancer, 43, 113 127. (Pubitemid 40575744)
41. Haferlach, T., Kohlmann, A., Basso, G., Bene, M.C., Chiaretti, S., Downing, J.R., Hernandez, J.M., Hofmann, W.K., Kipps, T.J., Koay, E.S., Te Kronnie, G., Liu, W., McIntyre, E., Mills, K.I., Papenhausen, P., Preudhomme, C., Rassenti, L.Z., Shurtleff, S.A., De Vos, J., Yeoh, A.E., Williams, P.M., Wieczorek, L. Foa, R. (2008) The clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: final report on 3252 cases from the International MILE Study Group. Blood (ASH Annual Meeting Abstracts), 112, Abstract 753.
42. Haferlach, T., Kohlmann, A., Klein, H.U., Ruckert, C., Dugas, M., Williams, P.M., Kern, W., Schnittger, S., Bacher, U., Loffler, H. Haferlach, C. (2009) AML with translocation t(8;16)(p11;p13) demonstrates unique cytomorphological, cytogenetic, molecular and prognostic features. Leukemia, doi
43. Heerema, N.A., Sather, H.N., Sensel, M.G., Kraft, P., Nachman, J.B., Steinherz, P.G., Lange, B.J., Hutchinson, R.S., Reaman, G.H., Trigg, M.E., Arthur, D.C., Gaynon, P.S. Uckun, F.M. (1998) Frequency and clinical significance of cytogenetic abnormalities in pediatric T-lineage acute lymphoblastic leukemia: a report from the Children's Cancer Group. Journal of Clinical Oncology, 16, 1270 1278. (Pubitemid 28175739)
44. Henderson, M.J., Choi, S., Beesley, A.H., Sutton, R., Venn, N.C., Marshall, G.M., Kees, U.R., Haber, M. Norris, M.D. (2008) Mechanism of relapse in pediatric acute lymphoblastic leukemia. Cell Cycle, 7, 1315 1320.
45. Heuser, M., Wingen, L.U., Steinemann, D., Cario, G., von, N.N., Tauscher, M., Bullinger, L., Krauter, J., Heil, G., Dohner, H., Schlegelberger, B. Ganser, A. (2005) Gene-expression profiles and their association with drug resistance in adult acute myeloid leukemia. Haematologica, 90, 1484 1492. (Pubitemid 41658761)
46. Hoffmann, K., Firth, M.J., Beesley, A.H., Freitas, J.R., Ford, J., Senanayake, S., de Klerk, N.H., Baker, D.L. Kees, U.R. (2008) Prediction of relapse in paediatric pre-B acute lymphoblastic leukaemia using a three-gene risk index. British Journal of Haematology, 140, 656 664.
47. Hofmann, W.K., de, V.S., Elashoff, D., Gschaidmeier, H., Hoelzer, D., Koeffler, H.P. Ottmann, O.G. (2002) Relation between resistance of Philadelphia-chromosome-positive acute lymphoblastic leukaemia to the tyrosine kinase inhibitor STI571 and gene-expression profiles: a gene-expression study. Lancet, 359, 481 486. (Pubitemid 34164295)
48. Holleman, A., Cheok, M.H., den Boer, M.L., Yang, W., Veerman, A.J., Kazemier, K.M., Pei, D., Cheng, C., Pui, C.H., Relling, M.V., Janka-Schaub, G.E., Pieters, R. Evans, W.E. (2004) Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. New England Journal of Medicine, 351, 533 542.
49. Illmer, T. Ehninger, G. (2007) FLT3 kinase inhibitors in the management of acute myeloid leukemia. Clinical Lymphoma & Myeloma, 8 (Suppl 1 S24 S34.
50. Ioannidis, J.P. (2007) Is molecular profiling ready for use in clinical decision making? Oncologist, 12, 301 311. (Pubitemid 46556796)
51. Jongen-Lavrencic, M., Sun, S.M., Dijkstra, M.K., Valk, P.J. Lowenberg, B. (2008) MicroRNA expression profiling in relation to the genetic heterogeneity of acute myeloid leukemia. Blood, 111, 5078 5085.
52. Kearney, L. Horsley, S.W. (2005) Molecular cytogenetics in haematological malignancy: current technology and future prospects. Chromosoma, 114, 286 294. (Pubitemid 41644376)
53. Kern, W., Kohlmann, A., Wuchter, C., Schnittger, S., Schoch, C., Mergenthaler, S., Ratei, R., Ludwig, W.D., Hiddemann, W. Haferlach, T. (2003) Correlation of protein expression and gene expression in acute leukemia. Cytometry. Part B, Clinical Cytometry, 55, 29 36. (Pubitemid 38295406)
54. Kohlmann, A., Schoch, C., Schnittger, S., Dugas, M., Hiddemann, W., Kern, W. Haferlach, T. (2003) Molecular characterization of acute leukemias by use of microarray technology. Genes, Chromosomes & Cancer, 37, 396 405. (Pubitemid 36775782)
55. Kohlmann, A., Schoch, C., Dugas, M., Rauhut, S., Weninger, F., Schnittger, S., Kern, W. Haferlach, T. (2005a) Pattern robustness of diagnostic gene expression signatures in leukemia. Genes, Chromosomes & Cancer, 42, 299 307. (Pubitemid 40173992)
56. Kohlmann, A., Schoch, C., Dugas, M., Schnittger, S., Hiddemann, W., Kern, W. Haferlach, T. (2005b) New insights into MLL gene rearranged acute leukemias using gene expression profiling: shared pathways, lineage commitment, and partner genes. Leukemia, 19, 953 964. (Pubitemid 40862005)
57. Kohlmann, A., Kipps, T.J., Rassenti, L.Z., Downing, J.R., Shurtleff, S.A., Mills, K.I., Gilkes, A.F., Hofmann, W.K., Basso, G., Dell'orto, M.C., Foa, R., Chiaretti, S., De, V.J., Rauhut, S., Papenhausen, P.R., Hernandez, J.M., Lumbreras, E., Yeoh, A.E., Koay, E.S., Li, R., Liu, W.M., Williams, P.M., Wieczorek, L. Haferlach, T. (2008a) An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase. British Journal of Haematology, 142, 802 807.
58. Kohlmann, A., Haschke-Becher, E., Wimmer, B., Huber-Wechselberger, A., Meyer-Monard, S., Huxol, H., Siegler, U., Rossier, M., Matthes, T., Rebsamen, M., Chiappe, A., Diemand, A., Rauhut, S., Johnson, A., Liu, W.M., Williams, P.M., Wieczorek, L. Haferlach, T. (2008b) Intraplatform reproducibility and technical precision of gene expression profiling in 4 laboratories investigating 160 leukemia samples: the DACH study. Clinical Chemistry, 54, 1705 1715.
59. Lacayo, N.J., Meshinchi, S., Kinnunen, P., Yu, R., Wang, Y., Stuber, C.M., Douglas, L., Wahab, R., Becton, D.L., Weinstein, H., Chang, M.N., Willman, C.L., Radich, J.P., Tibshirani, R., Ravindranath, Y., Sikic, B.I. Dahl, G.V. 2004) Gene expression profiles at diagnosis in de novo childhood AML patients identify FLT3 mutations with good clinical outcomes. Blood, 104, 2646 2654. (Pubitemid 39434943)
60. Langer, C., Radmacher, M.D., Ruppert, A.S., Whitman, S.P., Paschka, P., Mrozek, K., Baldus, C.D., Vukosavljevic, T., Liu, C.G., Ross, M.E., Powell, B.L., de la, C.A., Kolitz, J.E., Larson, R.A., Marcucci, G. Bloomfield, C.D. (2008) High BAALC expression associates with other molecular prognostic markers, poor outcome, and a distinct gene-expression signature in cytogenetically normal patients younger than 60 years with acute myeloid leukemia: a Cancer and Leukemia Group B (CALGB) study. Blood, 111, 5371 5379.
61. Li, Z., Lu, J., Sun, M., Mi, S., Zhang, H., Luo, R.T., Chen, P., Wang, Y., Yan, M., Qian, Z., Neilly, M.B., Jin, J., Zhang, Y., Bohlander, S.K., Zhang, D.E., Larson, R.A., Le Beau, M.M., Thirman, M.J., Golub, T.R., Rowley, J.D. Chen, J. (2008) Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proceedings of the National Academy of Sciences of the United States of America, 105, 15535 15540.
62. Lindvall, C., Furge, K., Bjorkholm, M., Guo, X., Haab, B., Blennow, E., Nordenskjold, M. Teh, B.T. (2004) Combined genetic and transcriptional profiling of acute myeloid leukemia with normal and complex karyotypes. Haematologica, 89, 1072 1081. (Pubitemid 39295478)
63. Lipshutz, R.J., Fodor, S.P., Gingeras, T.R. Lockhart, D.J. (1999) High density synthetic oligonucleotide arrays. Nature Genetics, 21, 20 24. (Pubitemid 29031487)
64. Lo-Coco, F., Cuneo, A., Pane, F., Cilloni, D., Diverio, D., Mancini, M., Testoni, N., Bardi, A., Izzo, B., Bolli, N., La, S.R., Fazi, P., Iacobelli, S., Piciocchi, A., Vignetti, M., Amadori, S., Mandelli, F., Pelicci, P.G., Mecucci, C., Falini, B. Saglio, G. (2008) Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia. Haematologica, 93, 1017 1024.
65. Marasca, R., Maffei, R., Zucchini, P., Castelli, I., Saviola, A., Martinelli, S., Ferrari, A., Fontana, M., Ravanetti, S. Torelli, G. (2006) Gene expression profiling of acute promyelocytic leukaemia identifies two subtypes mainly associated with flt3 mutational status. Leukemia, 20, 103 114.
66. Marcucci, G., Mrozek, K. Bloomfield, C.D. (2005a) Molecular heterogeneity and prognostic biomarkers in adults with acute myeloid leukemia and normal cytogenetics. Current Opinion in Hematology, 12, 68 75. (Pubitemid 40192577)
67. Marcucci, G., Baldus, C.D., Ruppert, A.S., Radmacher, M.D., Mrozek, K., Whitman, S.P., Kolitz, J.E., Edwards, C.G., Vardiman, J.W., Powell, B.L., Baer, M.R., Moore, J.O., Perrotti, D., Caligiuri, M.A., Carroll, A.J., Larson, R.A., de la, C.A. Bloomfield, C.D. (2005b) Overexpression of the ETS-related gene, ERG, predicts a worse outcome in acute myeloid leukemia with normal karyotype: a Cancer and Leukemia Group B study. Journal of Clinical Oncology, 23, 9234 9242. (Pubitemid 46260179)
68. Marcucci, G., Radmacher, M.D., Maharry, K., Mrozek, K., Ruppert, A.S., Paschka, P., Vukosavljevic, T., Whitman, S.P., Baldus, C.D., Langer, C., Liu, C.G., Carroll, A.J., Powell, B.L., Garzon, R., Croce, C.M., Kolitz, J.E., Caligiuri, M.A., Larson, R.A. Bloomfield, C.D. (2008) MicroRNA expression in cytogenetically normal acute myeloid leukemia. New England Journal of Medicine, 358, 1919 1928.
69. Mardia, K., Kent, J. Bibby, J 1979) Multivariate analysis, Academic Press, London.
70. Meijer, E. Cornelissen, J.J. (2008) Allogeneic stem cell transplantation in acute myeloid leukemia in first or subsequent remission: weighing prognostic markers predicting relapse and risk factors for non-relapse mortality. Seminars in Oncology, 35, 449 457.
71. Metzeler, K.H., Hummel, M., Bloomfield, C.D., Spiekermann, K., Braess, J., Sauerland, M.C., Heinecke, A., Radmacher, M., Marcucci, G., Whitman, S.P., Maharry, K., Paschka, P., Larson, R.A., Berdel, W.E., Buchner, T., Wormann, B., Mansmann, U., Hiddemann, W., Bohlander, S.K. Buske, C. (2008) An 86 probe set gene expression signature predicts survival in cytogenetically normal acute myeloid leukemia. Blood, 112, 4193 4201.
72. Mi, S., Lu, J., Sun, M., Li, Z., Zhang, H., Neilly, M.B., Wang, Y., Qian, Z., Jin, J., Zhang, Y., Bohlander, S.K., Le Beau, M.M., Larson, R.A., Golub, T.R., Rowley, J.D. Chen, J. (2007) MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proceedings of the National Academy of Sciences of the United States of America, 104, 19971 19976.
73. Mitchell, S.A., Brown, K.M., Henry, M.M., Mintz, M., Catchpoole, D., LaFleur, B. Stephan, D.A. (2004) Inter-platform comparability of microarrays in acute lymphoblastic leukemia. BMC Genomics, 5, 71.
74. Moos, P.J., Raetz, E.A., Carlson, M.A., Szabo, A., Smith, F.E., Willman, C., Wei, Q., Hunger, S.P. Carroll, W.L. (2002) Identification of gene expression profiles that segregate patients with childhood leukemia. Clinical Cancer Research, 8, 3118 3130. (Pubitemid 35155021)
75. Mullighan, C.G., Goorha, S., Radtke, I., Miller, C.B., Coustan-Smith, E., Dalton, J.D., Girtman, K., Mathew, S., Ma, J., Pounds, S.B., Su, X., Pui, C.H., Relling, M.V., Evans, W.E., Shurtleff, S.A. Downing, J.R. (2007a) Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature, 446, 758 764. (Pubitemid 46582031)
76. Mullighan, C.G., Kennedy, A., Zhou, X., Radtke, I., Phillips, L.A., Shurtleff, S.A. Downing, J.R. (2007b) Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias. Leukemia, 21, 2000 2009. (Pubitemid 47299976)
77. Mullighan, C.G., Su, X., Zhang, J., Radtke, I., Phillips, L.A., Miller, C.B., Ma, J., Liu, W., Cheng, C., Schulman, B.A., Harvey, R.C., Chen, I.M., Clifford, R.J., Carroll, W.L., Reaman, G., Bowman, W.P., Devidas, M., Gerhard, D.S., Yang, W., Relling, M.V., Shurtleff, S.A., Campana, D., Borowitz, M.J., Pui, C.H., Smith, M., Hunger, S.P., Willman, C.L. Downing, J.R. (2009) Deletion of IKZF1 and Prognosis in Acute Lymphoblastic Leukemia. New England Journal of Medicine, 360, 470 480.
78. Murati, A., Gervais, C., Carbuccia, N., Finetti, P., Cervera, N., Adelaide, J., Struski, S., Lippert, E., Mugneret, F., Tigaud, I., Penther, D., Bastard, C., Poppe, B., Speleman, F., Baranger, L., Luquet, I., Cornillet-Lefebvre, P., Nadal, N., Nguyen-Khac, F., Perot, C., Olschwang, S., Bertucci, F., Chaffanet, M., Lessard, M., Mozziconacci, M.J. Birnbaum, D. (2009) Genome profiling of acute myelomonocytic leukemia: alteration of the MYB locus in MYST3-linked cases. Leukemia, 23, 85 94.
79. Neben, K., Schnittger, S., Brors, B., Tews, B., Kokocinski, F., Haferlach, T., Muller, J., Hahn, M., Hiddemann, W., Eils, R., Lichter, P. Schoch, C. (2005) Distinct gene expression patterns associated with FLT3- and NRAS-activating mutations in acute myeloid leukemia with normal karyotype. Oncogene, 24, 1580 1588. (Pubitemid 40403060)
80. Parkinson, H., Kapushesky, M., Shojatalab, M., Abeygunawardena, N., Coulson, R., Farne, A., Holloway, E., Kolesnykov, N., Lilja, P., Lukk, M., Mani, R., Rayner, T., Sharma, A., William, E., Sarkans, U. Brazma, A. (2007) ArrayExpress - a public database of microarray experiments and gene expression profiles. Nucleic Acids Research, 35, 747 750.
81. Pui, C.H. (1996) Acute leukemia in children. Current Opinion in Hematology, 3, 249 258.
82. Pui, C.H. Evans, W.E. (1998) Acute lymphoblastic leukemia. New England Journal of Medicine, 339, 605 615. (Pubitemid 28385659)
83. Radmacher, M.D., Marcucci, G., Ruppert, A.S., Mrozek, K., Whitman, S.P., Vardiman, J.W., Paschka, P., Vukosavljevic, T., Baldus, C.D., Kolitz, J.E., Caligiuri, M.A., Larson, R.A. Bloomfield, C.D. (2006) Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood, 108, 1677 1683. (Pubitemid 44316137)
84. Raetz, E.A., Perkins, S.L., Bhojwani, D., Smock, K., Philip, M., Carroll, W.L. Min, D.J. (2006) Gene expression profiling reveals intrinsic differences between T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma. Pediatric Blood & Cancer, 47, 130 140. (Pubitemid 44025244)
85. Raghavan, M., Smith, L.L., Lillington, D.M., Chaplin, T., Kakkas, I., Molloy, G., Chelala, C., Cazier, J.B., Cavenagh, J.D., Fitzgibbon, J., Lister, T.A. Young, B.D. (2008) Segmental uniparental disomy is a commonly acquired genetic event in relapsed acute myeloid leukemia. Blood, 112, 814 821.
86. Raimondi, S.C., Behm, F.G., Roberson, P.K., Pui, C.H., Rivera, G.K., Murphy, S.B. Williams, D.L. (1988) Cytogenetics of childhood T-cell leukemia. Blood, 72, 1560 1566.
87. Raponi, M., Lancet, J.E., Fan, H., Dossey, L., Lee, G., Gojo, I., Feldman, E.J., Gotlib, J., Morris, L.E., Greenberg, P.L., Wright, J.J., Harousseau, J.L., Lowenberg, B., Stone, R.M., De, P.P., Wang, Y. Karp, J.E. (2008) A 2-gene classifier for predicting response to the farnesyltransferase inhibitor tipifarnib in acute myeloid leukemia. Blood, 111, 2589 2596.
88. Ross, M.E., Mahfouz, R., Onciu, M., Liu, H.C., Zhou, X., Song, G., Shurtleff, S.A., Pounds, S., Cheng, C., Ma, J., Ribeiro, R.C., Rubnitz, J.E., Girtman, K., Williams, W.K., Raimondi, S.C., Liang, D.C., Shih, L.Y., Pui, C.H. Downing, J.R. (2004) Gene expression profiling of pediatric acute myelogenous leukemia. Blood, 104, 3679 3687. (Pubitemid 39564445)
89. Rucker, F.G., Bullinger, L., Schwaenen, C., Lipka, D.B., Wessendorf, S., Frohling, S., Bentz, M., Miller, S., Scholl, C., Schlenk, R.F., Radlwimmer, B., Kestler, H.A., Pollack, J.R., Lichter, P., Dohner, K. Dohner, H. (2006) Disclosure of candidate genes in acute myeloid leukemia with complex karyotypes using microarray-based molecular characterization. Journal of Clinical Oncology, 24, 3887 3894. (Pubitemid 46630736)
90. Schlenk, R.F., Dohner, K., Krauter, J., Frohling, S., Corbacioglu, A., Bullinger, L., Habdank, M., Spath, D., Morgan, M., Benner, A., Schlegelberger, B., Heil, G., Ganser, A. Dohner, H. (2008) Mutations and treatment outcome in cytogenetically normal acute myeloid leukemia. New England Journal of Medicine, 358, 1909 1918.
91. Schneider, N.R., Carroll, A.J., Shuster, J.J., Pullen, D.J., Link, M.P., Borowitz, M.J., Camitta, B.M., Katz, J.A. Amylon, M.D. (2000) New recurring cytogenetic abnormalities and association of blast cell karyotypes with prognosis in childhood T-cell acute lymphoblastic leukemia: a pediatric oncology group report of 343 cases. Blood, 96, 2543 2549.
92. Schoch, C., Kohlmann, A., Schnittger, S., Brors, B., Dugas, M., Mergenthaler, S., Kern, W., Hiddemann, W., Eils, R. Haferlach, T. (2002a) Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proceedings of the National Academy of Sciences of the United States of America, 99, 10008 10015.
93. Schoch, C., Haferlach, T., Bursch, S., Gerstner, D., Schnittger, S., Dugas, M., Kern, W., Loffler, H. Hiddemann, W. (2002b) Loss of genetic material is more common than gain in acute myeloid leukemia with complex aberrant karyotype: a detailed analysis of 125 cases using conventional chromosome analysis and fluorescence in situ hybridization including 24-color FISH. Genes, Chromosomes & Cancer, 35, 20 29.
94. Schoch, C., Kern, W., Kohlmann, A., Hiddemann, W., Schnittger, S. Haferlach, T. (2005) Acute myeloid leukemia with a complex aberrant karyotype is a distinct biological entity characterized by genomic imbalances and a specific gene expression profile. Genes, Chromosomes & Cancer, 43, 227 238. (Pubitemid 40726868)
95. Schotte, D., Chau, J.C., Sylvester, G., Liu, G., Chen, C., van, d.V., VBroekhuis, M.J., Peters, T.C., Pieters, R. Boer, M.L. (2009) Identification of new microRNA genes and aberrant microRNA profiles in childhood acute lymphoblastic leukemia. Leukemia, 23, 313 322.
96. Shi, L., Reid, L.H., Jones, W.D., Shippy, R., Warrington, J.A., Baker, S.C., Collins, P.J., de, L.F., Kawasaki, E.S., Lee, K.Y., Luo, Y., Sun, Y.A., Willey, J.C., Setterquist, R.A., Fischer, G.M., Tong, W., Dragan, Y.P., Dix, D.J., Frueh, F.W., Goodsaid, F.M., Herman, D., Jensen, R.V., Johnson, C.D., Lobenhofer, E.K., Puri, R.K., Schrf, U., Thierry-Mieg, J., Wang, C., Wilson, M., Wolber, P.K., Zhang, L., Amur, S., Bao, W., Barbacioru, C.C., Lucas, A.B., Bertholet, V., Boysen, C., Bromley, B., Brown, D., Brunner, A., Canales, R., Cao, X.M., Cebula, T.A., Chen, J.J., Cheng, J., Chu, T.M., Chudin, E., Corson, J., Corton, J.C., Croner, L.J., Davies, C., Davison, T.S., Delenstarr, G., Deng, X., Dorris, D., Eklund, A.C., Fan, X.H., Fang, H., Fulmer-Smentek, S., Fuscoe, J.C., Gallagher, K., Ge, W., Guo, L., Guo, X., Hager, J., Haje, P.K., Han, J., Han, T., Harbottle, H.C., Harris, S.C., Hatchwell, E., Hauser, C.A., Hester, S., Hong, H., Hurban, P., Jackson, S.A., Ji, H., Knight, C.R., Kuo, W.P., LeClerc, J.E., Levy, S., Li, Q.Z., Liu, C., Liu, Y., Lombardi, M.J., Ma, Y., Magnuson, S.R., Maqsodi, B., McDaniel, T., Mei, N., Myklebost, O., Ning, B., Novoradovskaya, N., Orr, M.S., Osborn, T.W., Papallo, A., Patterson, T.A., Perkins, R.G., Peters, E.H., Peterson, R., Philips, K.L., Pine, P.S., Pusztai, L., Qian, F., Ren, H., Rosen, M., Rosenzweig, B.A., Samaha, R.R., Schena, M., Schroth, G.P., Shchegrova, S., Smith, D.D., Staedtler, F., Su, Z., Sun, H., Szallasi, Z., Tezak, Z., Thierry-Mieg, D., Thompson, K.L., Tikhonova, I., Turpaz, Y., Vallanat, B., Van, C., Walker, S.J., Wang, S.J., Wang, Y., Wolfinger, R., Wong, A., Wu, J., Xiao, C., Xie, Q., Xu, J., Yang, W., Zhang, L., Zhong, S., Zong, Y. Slikker, W., Jr. (2006) The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements. Nature Biotechnology, 24, 1151 1161. (Pubitemid 44359727)
97. Simon, R. (2005) Roadmap for developing and validating therapeutically relevant genomic classifiers. Journal of Clinical Oncology, 23, 7332 7341. (Pubitemid 46202346)
98. Southern, E., Mir, K. Shchepinov, M. (1999) Molecular interactions on microarrays. Nature Genetics, 21, 5 9. (Pubitemid 29031484)
99. Staal, F.J., Cario, G., Cazzaniga, G., Haferlach, T., Heuser, M., Hofmann, W.K., Mills, K., Schrappe, M., Stanulla, M., Wingen, L.U., van Dongen, J.J. Schlegelberger, B. (2006) Consensus guidelines for microarray gene expression analyses in leukemia from three European leukemia networks. Leukemia, 20, 1385 1392. (Pubitemid 44084051)
100. Stapnes, C., Ryningen, A., Hatfield, K., Oyan, A.M., Eide, G.E., Corbascio, M., Kalland, K.H., Gjertsen, B.T. Bruserud, O. (2007) Functional characteristics and gene expression profiles of primary acute myeloid leukaemia cells identify patient subgroups that differ in susceptibility to histone deacetylase inhibitors. International Journal of Oncology, 31, 1529 1538.
101. Steinbach, D., Schramm, A., Eggert, A., Onda, M., Dawczynski, K., Rump, A., Pastan, I., Wittig, S., Pfaffendorf, N., Voigt, A., Zintl, F. Gruhn, B. (2006) Identification of a set of seven genes for the monitoring of minimal residual disease in pediatric acute myeloid leukemia. Clinical Cancer Research, 12, 2434 2441.
102. Subramanian, A., Tamayo, P., Mootha, V.K., Mukherjee, S., Ebert, B.L., Gillette, M.A., Paulovich, A., Pomeroy, S.L., Golub, T.R., Lander, E.S. Mesirov, J.P. (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proceedings of the National Academy of Sciences of the United States of America, 102, 15545 15550. (Pubitemid 41528093)
103. Sulong, S., Moorman, A.V., Irving, J.A., Strefford, J.C., Konn, Z.J.,
104. Swerdlow, S., Campo, E., Lee Harris, N., Jaffe, E., Pileri, S., Stein, H., Thiele, J. Vardiman, J. (2008) WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, 4 edn, WHO Press, Lyon.
105. Taketani, T., Taki, T., Sugita, K., Furuichi, Y., Ishii, E., Hanada, R., Tsuchida, M., Sugita, K., Ida, K. Hayashi, Y. (2004) FLT3 mutations in the activation loop of tyrosine kinase domain are frequently found in infant ALL with MLL rearrangements and pediatric ALL with hyperdiploidy. Blood, 103, 1085 1088. (Pubitemid 38129575)
106. Tallman, M.S. (2006) New agents for the treatment of acute myeloid leukemia. Best practice & research. Clinical Haematology, 19, 311 320. (Pubitemid 43315459)
107. Valk, P.J., Verhaak, R.G., Beijen, M.A., Erpelinck, C.A., Barjesteh van Waalwijk van Doorn-Khosrovani, S, Boer, J.M., Beverloo, H.B., Moorhouse, M.J., van der Spek, P.J., Lowenberg, B. Delwel, R. (2004) Prognostically useful gene-expression profiles in acute myeloid leukemia. New England Journal of Medicine, 350, 1617 1628. (Pubitemid 38528701)
108. Verhaak, R.G., Goudswaard, C.S., van, P.W., Bijl, M.A., Sanders, M.A., Hugens, W., Uitterlinden, A.G., Erpelinck, C.A., Delwel, R., Lowenberg, B. Valk, P.J. (2005) Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood, 106, 3747 3754. (Pubitemid 41739008)
109. Verhaak, R.G., Wouters, B.J., Erpelinck, C.A., Abbas, S., Beverloo, H.B., Lugthart, S., Lowenberg, B., Delwel, R. Valk, P.J. (2009) Prediction of molecular subtypes in acute myeloid leukemia based on gene expression profiling. Haematologica, 94, 131 134.
110. Whitman, S.P., Ruppert, A.S., Radmacher, M.D., Mrozek, K., Paschka, P., Langer, C., Baldus, C.D., Wen, J., Racke, F., Powell, B.L., Kolitz, J.E., Larson, R.A., Caligiuri, M.A., Marcucci, G. Bloomfield, C.D. (2008) FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications. Blood, 111, 1552 1559.
111. Willenbrock, H., Juncker, A.S., Schmiegelow, K., Knudsen, S. Ryder, L.P. (2004) Prediction of immunophenotype, treatment response, and relapse in childhood acute lymphoblastic leukemia using DNA microarrays. Leukemia, 18, 1270 1277. (Pubitemid 39023138)
112. Willman, C.L. (2008) Has gene expression profiling improved diagnosis, classification, and outcome prediction in AML? Best practice & research. Clinical Haematology, 21, 21 28.
113. Wilson, C.S., Davidson, G.S., Martin, S.B., Andries, E., Potter, J., Harvey, R., Ar, K., Xu, Y., Kopecky, K.J., Ankerst, D.P., Gundacker, H., Slovak, M.L., Mosquera-Caro, M., Chen, I.M., Stirewalt, D.L., Murphy, M., Schultz, F.A., Kang, H., Wang, X., Radich, J.P., Appelbaum, F.R., Atlas, S.R., Godwin, J. Willman, C.L. (2006) Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood, 108, 685 696. (Pubitemid 44061371)
114. Wouters, B.J., Jorda, M.A., Keeshan, K., Louwers, I., Erpelinck-Verschueren, C.A., Tielemans, D., Langerak, A.W., He, Y., Yashiro-Ohtani, Y., Zhang, P., Hetherington, C.J., Verhaak, R.G., Valk, P.J., Lowenberg, B., Tenen, D.G., Pear, W.S. Delwel, R. (2007) Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood, 110, 3706 3714. (Pubitemid 350159640)
115. Wouters, B.J., Lowenberg, B. Delwel, R. (2009) A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects. Blood, 113, 291 298.
116. Yang, J.J., Bhojwani, D., Yang, W., Cai, X., Stocco, G., Crews, K., Wang, J., Morrison, D., Devidas, M., Hunger, S.P., Willman, C.L., Raetz, E.A., Pui, C.H., Evans, W.E., Relling, M.V. Carroll, W.L. (2008) Genome-wide copy number profiling reveals molecular evolution from diagnosis to relapse in childhood acute lymphoblastic leukemia. Blood, 112, 4178 4183.
117. Yeoh, E.J., Ross, M.E., Shurtleff, S.A., Williams, W.K., Patel, D., Mahfouz, R., Behm, F.G., Raimondi, S.C., Relling, M.V., Patel, A., Cheng, C., Campana, D., Wilkins, D., Zhou, X., Li, J., Liu, H., Pui, C.H., Evans, W.E., Naeve, C., Wong, L. Downing, J.R. (2002) Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell, 1, 133 143. (Pubitemid 41039160)
118. Zembutsu, H., Yanada, M., Hishida, A., Katagiri, T., Tsuruo, T., Sugiura, I., Takeuchi, J., Usui, N., Naoe, T., Nakamura, Y. Ohno, R. (2007) Prediction of risk of disease recurrence by genome-wide cDNA microarray analysis in patients with Philadelphia chromosome-positive acute lymphoblastic leukemia treated with imatinib-combined chemotherapy. International Journal of Oncology, 31, 313 322.