Has gene expression profiling improved diagnosis, classification, and outcome prediction in AML?

Best Practice and Research: Clinical Haematology

Volumn 21, Issue 1, 2008, Pages 21-28

  Willman, Cheryl L ^a  

^a UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

acute myelogenous leukemia; AML; gene expression profiling; molecular classifiers

Indexed keywords

CD135 ANTIGEN; NUCLEOPHOSMIN; RAS PROTEIN;

ACUTE GRANULOCYTIC LEUKEMIA; AGE DISTRIBUTION; CANCER CLASSIFICATION; CANCER RISK; CANCER SURVIVAL; CYTOGENETICS; DRUG TARGETING; GENE CLUSTER; GENE DELETION; GENE EXPRESSION PROFILING; GENETIC HETEROGENEITY; GENOMICS; HUMAN; KARYOTYPE; LEUKOCYTE COUNT; MICROARRAY ANALYSIS; OVERALL SURVIVAL; POINT MUTATION; PRIORITY JOURNAL; PROGNOSIS; PROTEOMICS; REVIEW; SEX DIFFERENCE;

AGED; COHORT STUDIES; CYTOGENETIC ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; MUTATION; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; REGISTRIES; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 40749118403     PISSN: 15216926     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.beha.2007.11.008     Document Type: Review

References (9)

1. Ross M.E., Mahfouz R., Onciu M., et al. Gene expression profiling of pediatric acute myelogenous leukemia. Blood 104 (2004) 3679-3687
2. Valk P.J., Verhaak R.G., Beijen M.A., et al. Prognostically useful gene-expression profiles in acute myeloid leukemia. The New England Journal of Medicine 350 (2004) 1617-1628
3. Bullinger L., Dohner K., Bair E., et al. Use of gene-expression profiling to identify prognostic subclasses in adult acute myeloid leukemia. The New England Journal of Medicine 350 (2004) 1605-1616
4. Falini B., Mecucci C., Tiacci E., et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. The New England Journal of Medicine 352 (2005) 254-266
5. Verhaak R.G., Goudswaard C.S., van P.W., et al. Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance. Blood 106 (2005) 3747-3754
6. Wilson C.S., Davidson G.S., Martin S.B., et al. Gene expression profiling of adult acute myeloid leukemia identifies novel biologic clusters for risk classification and outcome prediction. Blood 108 (2006) 685-696
7. Davidson G.S., Hendrickson B., Johnson D.K., et al. Knowledge mining with VxInsight: Discovery through interaction. Journal of Intelligent Information Systems 11 (1998) 259-285
8. Simon R. Roadmap for developing and validating therapeutically relevant genomic classifiers. Journal of Clinical Oncology 23 (2005) 7332-7341
9. Radmacher M.D., Marcucci G., Ruppert A.S., et al. Independent confirmation of a prognostic gene-expression signature in adult acute myeloid leukemia with a normal karyotype: a Cancer and Leukemia Group B study. Blood 108 (2006) 1677-1683