Genome-wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation-mediated fusion events

Genes Chromosomes and Cancer

Volumn 37, Issue 2, 2003, Pages 149-158

  Debernardi, Silvana ^a   Lillington, Debra M ^a   Chaplin, Tracy ^a   Tomlinson, Simon ^b   Amess, John ^c   Rohatiner, Ama ^a   Lister, T Andrew ^a   Young, Bryan D ^a  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; CYTOGENETICS; DNA MICROARRAY; GENE EXPRESSION; GENE IDENTIFICATION; GENOME ANALYSIS; HOMEOBOX; HUMAN; HUMAN CELL; KARYOTYPE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UPREGULATION;

ADULT; AGED; BONE MARROW; CHILD; CLUSTER ANALYSIS; CYTOGENETIC ANALYSIS; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, HOMEOBOX; GENES, NEOPLASM; GENOME, HUMAN; HUMANS; KARYOTYPING; LEUKEMIA, MYELOCYTIC, ACUTE; LEUKEMIA, MYELOID; LEUKEMIA, MYELOMONOCYTIC, ACUTE; LEUKEMIA, PROMYELOCYTIC, ACUTE; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS, FUSION; RNA, NEOPLASM; TRANSLOCATION, GENETIC;

EID: 0037732933     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.10198     Document Type: Article

References (29)

1. Alcalay M, Orleth A, Sebastiani C, Meani N, Chiaradonna F, Casciar C, Sciurpi MT, Gelmetti V, Riganelli D, Minucci S, Fagioli M, Pelicei PG. 2001. Common themes in the pathogenesis of acute myeloid leukemia. Oncogene 20:5680-5694.
2. Armstrong SA, Staunton JE, Silverman LB, Pieters R, den Boer ML, Minden MD, Sallan SE, Lander ES, Golub TR, Korsmeyer SJ. 2002. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet 30:41-47.
3. Borrow J, Shearman AM, Scanton VP Jr, Becher R, Collins T, Williams AJ, Dube I, Kacz F, Kwong YL, Morris C, Ohvashiki K, Toyama K, Rowle J, Housman DE. 1996. The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9. Nat Genet 12:159-167.
4. Brown J, Jawad M, Twigg SR, Saracoglu K, Sauerbrey A, Thomas AE, Eils R, Harboct J, Kearney L. 2002. A cryptic c(5;11)(q35;p15.5) in 2 children with acute myeloid leukemia with apparently normal karyotypes, identified by a multiplex fluorescence in situ hybridization telomere assay. Blood 99:2526-2531.
5. Brunning RD, Matutes E, Harris NL, Flandrin G, Vardiman J, Bennett JM, Head D. 2001. Acute myeloid leukaemias. In: Jaffe ES, Harris NL, Stein H, Vardiman JW, editors. Tumours of haemopoietic and lymphoid tissues. Lyon: IARC Press. p 76-107.
6. Corral J, Lavenir I, Impey H, Warren AJ, Forster A, Larson TA, Bell S, McKenzie AN, King G, Rabbitts TH. 1996. An Mll-AF9 fusion gene made by homologous recombination causes acute leukemia in chimeric mice: a method to create fusion oncogenes. Cell 85:853-861.
7. Demiroglu A, Steer EJ, Heath C, Taylor K, Bentley M, Allen SL, Koduru P, Brody JP, Hawson G, Rodwell R, Doody ML, Carnicero F, Reiter A, Goldman JM, Melo JV, Cross NC. 2001, The t(8;22) in chronic myeloid leukemia fuses BCR to FGFR1: transforming activity and specific inhibition of FGFR1 fusion proteins. Blood 98:3778-3783.
8. Dimartino JF, Cleary ML. 1999. Mll rearrangements in haematological malignancies: lessons from clinical and biological studies. Br J Haematol 106:614-626.
9. Drabkin HA, Parsy C, Ferguson K, Guilhot F, Lacotte L, Roy L, Zeng C, Baron A, Hunger SP, Varella-Garcia M, Gemmill R, Brizard F, Brizard A, Roche J. 2002. Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia. Leukemia 16:186-195.
10. Gelmetti V, Zhang J, Fanelli M, Minucci S, Pelicci PG, Lazar MA. 1998. Aberrant recruitment of the nuclear receptor corepressorhiscone deacetylase complex by the acute myeloid leukemia fusion partner ETO. Mol Cell Biol 18:7185-7191.
11. Giampaolo A, Sterpetti P, Bulgarini D, Samoggia P, Pelosi E, Valtieri M, Peschle C. 1994. Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation. Blood 84:3637-3647.
12. Golub TR, Slonim DK, Tamayo P, Huard C, Gaasenbeek M, Mesirov JP, Coller H, Loh ML, Downing JR, Caligiuri MA, Bloomfield CD, Lander ES. 1999. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286:531-537.
13. Grimwade D, Walker H, Oliver F, Wheatley K, Harrison C, Harrison G, Rees J, Hann I, Stevens R, Burnett A, Goldstone A. 1998. The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties. Blood 92:2322-2333.
14. Hanson RD, Hess JL, Yu BD, Ernst P, van Lohuizen M, Berns A, van der Lugt N, Shashikant C, Ruddle FH, Seto M, Korsmeyer SJ. 1999. Mammalian trithorax and polycomb-group homologues are antagonistic regulators of homeotic development. Proc Natl Acad Sci USA 96:14372-14377.
15. Heibert SW, Lutterbach B, Durst K, Wang L, Linggi B, Wu S, Wood L, Amann J, King D, Hou Y. 2001. Mechanisms of transcriptional repression by the t(8;21)-, t(12;21)-, and inv(16)-encoded fusion proteins. Cancer Chemother Pharmacol 48:S31-S34.
16. Higuchi M, O'Brien D, Kumaravelu P, Lenny N, Yeoh EJ, Downing JR. 2002. Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia. Cancer Cell 1:63-74.
17. Kawagoe H, Kawagoe R, Sano K. 2001. Targeted down-regulation of MLL-AF9 with ancisense oligodeoxyribonucleotide reduces the expression of the HOXA7 and -A10 genes and induces apoptosis in a human leukemia cell line, THP-1. Leukemia 15:1743-1749.
18. Lawrence HJ, Rozenfeld S, Cruz C, Matsukuma K, Kwong A, Komuves L, Buchberg AM, Largman C. 1999. Frequent co-expression of the HOXA9 and MEIS1 homeobox genes in human myeloid leukemias. Leukemia 13:1993-1999.
19. Leblond-Francillard M, Picon A, Bertagna X, de Keyzer Y. 1997. High expression of the POU factor Brn3a in aggressive neuroendocrine tumors. J Clin Endocrinol Metab 82:89-94.
20. Licht JD. 2001. AML1 and the AML1-ETO fusion protein in the pathogenesis of t(8;21) AML. Oncogene 20:5660-5679.
21. Liu P, Tarle SA, Hajra A, Claxton DF, Marlton P, Freedman M, Siciliano MJ, Collins FS. 1993. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261:1041-1044.
22. Look AT. 1997. Oncogenic transcription factors in the human acute leukemias. Science 278:1059-1064.
23. Mrozek K, Heinonen K, Bloomfield CD. 2000. Prognostic value of cytogenetic findings in adults with acute myeloid leukemia. Int J Hematol 72:261-271.
24. Rocke DM, Lorenzato S. 1995. A two-component model for measurement error in analytical chemistry. Technometrics 37:176-184.
25. Sauvageau G, Lansdorp PM, Eaves CJ, Hogge DE, Dragowska WH, Reid DS, Largman C, Lawrence HJ, Humphries RK. 1994. Differential expression of homeobox genes in functionally distinct CD34+ subpopulations of human bone marrow cells. Proc Natl Acad Sci USA 91:12223-12227.
26. Schoch C, Kohlmann A, Schnittger S, Brors B, Dugas M, Mergenthaler S, Kern W, Hiddemann W, Eils R, Haferlach T. 2002. Acute myeloid leukemias with reciprocal rearrangements can be distinguished by specific gene expression profiles. Proc Natl Acad Sci USA 99:10008-10013.
27. Thorsteinsdottir U, Kroon E, Jerome L, Blasi F, Sauvageau G. 2001. Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia. Mol Cell Biol 21:224-234.
28. van Baren N, Chambost H, Ferrant A, Michaux L, Ikeda H, Millard I, Olive D, Boon T, Coulie PG. 1998. PRAME, a gene encoding an antigen recognized on a human melanoma by cytolytic T cells, is expressed in acute leukaemia cells. Br J Haematol 102:1376-1379.
29. Yeoh EJ, Ross ME, Shurtleff SA, Williams WK, Patel D, Mahfouz R, Behm FG, Raimondi SC, Relling MV, Patel A, Cheng C, Campana D, Wilkins D, Zhou X, Li J, Liu H, Pui CH, Evans WE, Naeve C, Wong L, Downing JR. 2002. Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. Cancer Cell 1:133-143.