Down-regulation of a morphogen (sonic hedgehog) gradient in the gastric epithelium of Helicobacter pylori-infected Mongolian gerbils

Journal of Pathology

Volumn 206, Issue 2, 2005, Pages 186-197

  Suzuki, Hidekazu ^a   Minegishi, Yuriko ^a   Nomoto, Yohei ^a   Ota, Takayuki ^a   Masaoka, Tatsuhiro ^a   van den Brink, Gijs R ^b   Hibi, Toshifumi ^a  

^a KEIO UNIVERSITY   (Japan)

^b ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

Atrophy; Gastritis; Helicobacter pylori; Mongolian gerbils; Parietal cell; Sonic hedgehog; Zymogenic cell

Indexed keywords

MESSENGER RNA; MORPHOGEN; SONIC HEDGEHOG PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; CELL PROLIFERATION; CONTROLLED STUDY; DATA ANALYSIS; DOWN REGULATION; EXPERIMENTAL MODEL; GASTRITIS; GENE EXPRESSION; GERBIL; HELICOBACTER INFECTION; HELICOBACTER PYLORI; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; INOCULATION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH ANTRUM; STOMACH EPITHELIUM; STOMACH FUNDUS; STOMACH GLAND; STOMACH PARIETAL CELL; TISSUE DIFFERENTIATION;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; DOWN-REGULATION; GASTRIC MUCOSA; GASTRITIS, ATROPHIC; GERBILLINAE; HEDGEHOG PROTEINS; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; MALE; MOLECULAR SEQUENCE DATA; RNA, MESSENGER; TRANS-ACTIVATORS;

EID: 19944381545     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1763     Document Type: Article

References (29)

1. Hermiston ML, Wong MH, Gordon JI. Forced expression of E-cadherin in the mouse intestinal epithelium slows cell migration and provides evidence for nonautonomous regulation of cell fate in a self-renewing system. Genes Dev 1996; 10: 985-996.
2. Brittan M, Wright NA. Stem cell in gastrointestinal structure and neoplastic development. Gut 2004; 53: 899-910.
3. Tabata T, Takei Y. Morphogens, their identification and regulation. Development 2004; 131: 703-712.
4. Ramalho-Santos M, Melton DA, McMahon AP. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 2000; 127: 2763-2772.
5. van den Brink GR, Hardwick JC, Tytgat GN, et al. Sonic hedgehog regulates gastric gland morphogenesis in man and mouse. Gastroenterology 2001; 121: 317-328.
6. van den Brink GR, Hardwick JC, Nielsen C, et al. Sonic hedgehog expression correlates with fundic gland differentiation in the adult gastrointestinal tract. Gut 2002; 51: 628-633.
7. Lee ER, Trasler J, Dwivedi S, Leblond CP. Division of the mouse gastric mucosa into zymogenic and mucous regions on the basis of gland features. Am J Anat 1982; 164: 187-207.
8. Karam SM, Leblond CP. Dynamics of epithelial cells in the corpus of the mouse stomach. II. Outward migration of pit cells. Anat Rec 1993; 236: 280-296.
9. Karam SM, Leblond CP. Dynamics of epithelial cells in the corpus of the mouse stomach. III. Inward migration of neck cells followed by progressive transformation into zymogenic cells. Anat Rec 1993; 236: 297-313.
10. Karam SM. Dynamics of epithelial cells in the corpus of the mouse stomach. IV. Bidirectional migration of parietal cells ending in their gradual degeneration and loss. Anat Record 1993; 236: 314-332.
11. Karam SM, Leblond CP. Dynamics of epithelial cells in the corpus of the mouse stomach. V. Behavior of entero-endocrine and caveolated cells: general conclusions on cell kinetics in the oxyntic epithelium. Anat Rec 1993; 236: 333-340.
12. Warren JR, Marshall BJ. Unidentified curved bacilli on gastric epithelium in active chronic gastritis. Lancet 1983; i: 1273-1275.
13. Marshall BJ. Helicobacter pylori in peptic ulcer: have Koch's postulates been fulfilled? Ann Med 1995; 27: 565-568.
14. Kuipers EJ, Lee A, Klinkenberg-Knol EC, Meuwissen SG. Review article: the development of atrophic gastritis - Helicobacter pylori and the effects of acid suppressive therapy. Aliment Pharmacol Ther 1995; 9: 331-340.
15. Uemura N, Okamoto S, Yamamoto S, et al. Helicobacter pylori infection and the development of gastric cancer. N Engl J Med 2001; 345: 784-789.
16. Hirayama F, Takagi S, Kusuhara H, Iwao E, Yokoyama Y, Ikeda Y. Induction of gastric ulcer and intestinal metaplasia in Mongolian gerbils infected with Helicobacter pylori. J Gastroenterol 1996; 31: 755-757.
17. Watanabe T, Tada M, Nagai H, Sasaki S, Nakao M. Helicobacter pylori infection induces gastric cancer in Mongolian gerbils. Gastroenterology 1998; 115: 642-648.
18. Masaoka T, Suzuki H, Hosoda H, et al. Enhanced plasma ghrelin levels in rats with streptozotocin-induced diabetes. FEBS Lett 2003; 541: 64-68.
19. Suzuki H, Mori M, Seto K, et al. H. pylori-associated gastric pro- and anti-oxidant formation in Mongolian gerbils. Free Radic Biol Med 1999; 26: 679-684.
20. Suzuki H, Masaoka T, Hosoda H, et al. Helicobacter pylori infection modifies gastric and plasma ghrelin dynamics in Mongolian gerbils. Gut 2004; 53: 187-194.
21. Yoshida S, Ohbo K, Takakura A, et al. Sgn1, a basic helix-loop-helix transcription factor delineates the salivary gland duct cell lineage in mice. Dev Biol 2001; 240: 517-530.
22. Hoshino M, Sone M, Fukata M, et al. Identification of the stef gene that encodes a novel guanine nucleotide exchange factor specific for Rac1. J Biol Chem 1999; 274: 17 837-17 844.
23. Ishihara K, Kurihara M, Goso Y, et al. Peripheral alpha-linked N - acetylglucosamine on the carbohydrate moiety of mucin derived from mammalian gastric gland mucous cells: epitope recognized by a newly characterized monoclonal antibody. Biochem J 1996; 318: 409-416.
24. Suerbaum S, Michetti P. Helicobacter pylori infection. N Engl J Med 2002; 347: 1175-1186.
25. Honda S, Fujioka T, Tokieda M, Gotoh T, Nishizono A, Nasu M. Gastric ulcer, atrophic gastritis, and intestinal metaplasia caused by Helicobacter pylori infection in Mongolian gerbils. Scand J Gastroenterol 1998; 33: 454-460.
26. Honda S, Fujioka T, Tokieda M, Satoh R, Nishizono A, Nasu M. Development of Helicobacter pylori-induced gastric carcinoma in Mongolian gerbils. Cancer Res 1998; 58: 4255-4259.
27. Sugiyama A, Maruta F, Ikeno T, et al. Helicobacter pylori infection enhances N-methyl-N-nitrosourea-induced stomach carcinogenesis in the Mongolian gerbil. Cancer Res 1998; 58: 2067-2069.
28. Ho SB, Roberton AM, Shekels LL, Lyftogt CT, Niehans GA, Toribara NW. Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression. Gastroenterology 1995; 109: 735-747.
29. Kakei N, Ichinose M, Tatematsu M, et al. Effects of long-term omeprazole treatment on adult rat gastric mucosa - enhancement of the epithelial cell proliferation and suppression of its differentiation. Biochem Biophys Res Commun 1995; 214: 861-868.