The Hedgehog receptor Patched controls lymphoid lineage commitment

Blood

Volumn 110, Issue 6, 2007, Pages 1814-1823

  Uhmann, Anja ^a   Dittmann, Kai ^a   Nitzki, Frauke ^a   Dressel, Ralf ^a   Koleva, Milena ^a   Frommhold, Anke ^a   Zibat, Arne ^a   Binder, Claudia ^a   Adham, Ibrahim ^a   Nitsche, Mirko ^a   Heller, Tanja ^a   Armstrong, Victor ^a   Schulz Schaeffer, Walter ^a   Wienands, Jürgen ^a   Hahn, Heidi ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GENOMIC DNA; RECOMBINASE; SONIC HEDGEHOG PROTEIN; TAMOXIFEN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; B LYMPHOBLAST; BONE MARROW; BONE MARROW CELL; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE; GENE EXPRESSION; GENE FREQUENCY; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; LYMPHOID CELL; LYMPHOPOIESIS; MOUSE; MULTIPOTENT STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PTCH GENE; T LYMPHOCYTE;

EID: 34548834154     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-02-075648     Document Type: Article

References (40)

1. Kondo M, Weissman IL, Akashi K. Identification of clonogenic common lymphoid progenitors in mouse bone marrow. Cell. 1997;91:661-672.
2. Akashi K, Traver D, Miyamoto T, Weissman IL. A clonogenic common myeloid progenitor that gives rise to all myeloid lineages. Nature. 2000;404:193-197.
3. Laiosa CV, Stadtfeld M, Graf T. Determinants of lymphoid-myeloid lineage diversification. Annu Rev Immunol. 2006;24:705-738.
4. Busslinger M. Transcriptional control of early B cell development. Annu Rev Immunol. 2004;22:55-79.
5. Bhardwaj G, Murdoch B, Wu D, et al. Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation. Nat Immunol. 2001;2:172-180.
6. Trowbridge JJ, Scott MP, Bhatia M. Hedgehog modulates cell cycle regulators in stem cells to control hematopoietic regeneration. Proc Natl Acad Sci U S A. 2006;103:14134-14139.
7. Andaloussi AE, Graves S, Meng F, Mandal M, Mashayekhi M, Aifantis I. Hedgehog signaling controls thymocyte progenitor homeostasis and differentiation in the thymus. Nat Immunol. 2006;7:418-426.
8. Sacedon R, Diez B, Nunez V, et al. Sonic hedgehog is produced by follicular dendritic cells and protects germinal center B cells from apoptosis. J Immunol. 2005;174:1456-1461.
9. Shah DK, Hager-Theodorides AL, Outram SV, Ross SE, Varas A, Crompton T. Reduced thymocyte development in sonic hedgehog knockout embryos. J Immunol. 2004;172:2296-2306.
10. Outram SV, Varas A, Pepicelli CV, Crompton T. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity. 2000;13:187-197.
11. Rowbotham NJ, Hager-Theodorides AL, Cebecauer M, et al. Activation of the Hedgehog signaling pathway in T lineage cells inhibits TCR repertoire selection in the thymus and peripheral T cell activation. Blood. 2007;109:3757-3766.
12. Ruiz i Altaba A, Sanchez P, Dahmane N. Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat Rev Cancer. 2002;2:361-372.
13. Toftgard R. Hedgehog signalling in cancer. Cell Mol Life Sci. 2000;57:1720-1731.
14. Chiang C, Litingtung Y, Lee E, et al. Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996;383:407-413.
15. Goodrich LV, Milenkovic L, Higgins KM, Scott MP. Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997;277:1109-1113.
16. Hahn H, Wojnowski L, Zimmer AM, Hall J, Miller G, Zimmer A. Rhabdomyosarcomas and radiation hypersensitivity in a mouse model of Gorlin syndrome. Nat Med. 1998;4:619-622.
17. Conrad M, Brielmeier M, Wurst W, Bornkamm GW. Optimized vector for conditional gene targeting in mouse embryonic stem cells. Biotechniques. 2003;34:1136-1138, 1140.
18. Rodriguez CI, Buchholz F, Galloway J, et al. High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet. 2000;25:139-140.
19. Nagy A, Rossant J, Nagy R, Abramow-Newerly W, Roder JC. Derivation of completely cell culture-derived mice from early-passage embryonic stem cells. Proc Natl Acad Sci U S A. 1993;90:8424-8428.
20. Mansour SL, Thomas KR, Capecchi MR. Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature. 1988;336:348-352.
21. Imai T, Jiang M, Chambon P, Metzger D. Impaired adipogenesis and lipolysis in the mouse upon selective ablation of the retinoid X receptor alpha mediated by a tamoxifen-inducible chimeric Cre recombinase (Cre-ERT2) in adipocytes. Proc Natl Acad Sci U S A. 2001;98:224-228.
22. DeKoter RP, Lee HJ, Singh H. PU. 1 regulates expression of the interleukin-7 receptor in lymphoid progenitors. Immunity. 2002;16:297-309.
23. Bhattacharya D, Rossi DJ, Bryder D, Weissman IL. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med. 2006;203:73-85.
24. Nagao K, Togawa N, Fujii K, et al. Detecting tissue-specific alternative splicing and disease-associated aberrant splicing of the PTCH gene with exon junction microarrays. Hum Mol Genet. 2005;14:3379-3388.
25. Kuhn R, Schwenk F, Aguet M, Rajewsky K. Inducible gene targeting in mice. Science. 1995;269:1427-1429.
26. Bhandoola A, Sambandam A. From stem cell to T cell: one route or many? Nature Rev Immunol. 2006;6:117-126.
27. Loder F, Mutschler B, Ray RJ, et al. B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. J Exp Med. 1999;190:75-89.
28. Nagasawa T. Microenvironmental niches in the bone marrow required from B-cell development. Nat Rev Immunol. 2006;6:107-116.
29. Porse BT, Bryder D, Theilgaard-Monch K, et al. Loss of C/EBP alpha cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage. J Exp Med. 2005;202:85-96.
30. Metcalf D. Stem cells, pre-progenitor cells and lineage-committed cells: are our dogmas correct? Ann N Y Acad Sci. 1999;872:289-303; discussion: 303-284.
31. Okada S, Nakauchi H, Nagayoshi K, Nishikawa S, Miura Y, Suda T. In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells. Blood. 1992;80:3044-3050.
32. Katayama N, Shih JP, Nishikawa S, Kina T, Clark SC, Ogawa M. Stage-specific expression of c-kit protein by murine hematopoietic progenitors. Blood. 1993;82:2353-2360.
33. Iwasaki H, Somoza C, Shigematsu H, et al. Distinctive and indispensable roles of PU. 1 in maintenance of hematopoietic stem cells and their differentiation. Blood. 2005;106:1590-1600.
34. Smale ST, Dorshkind K. Hematopoiesis flies high with Ikaros. Nat Immunol. 2006;7:367-369.
35. Wetmore C. Sonic hedgehog in normal and neoplastic proliferation: insight gained from human tumors and animal models. Curr Opin Genet Dev. 2003;13:34-42.
36. Mazurier F, Fontanellas A, Salesse S, et al. A novel immunodeficient mouse model - RAG2 x common cytokine receptor gamma chain double mutants - requiring exogenous cytokine administration for human hematopoietic stem cell engraftment. J Interferon Cytokine Res. 1999;19:533-541.
37. Orlic D, Girard LJ, Lee D, Anderson SM, Puck JM, Bodine DM. Interleukin-7R alpha mRNA expression increases as stem cells differentiate into T and B lymphocyte progenitors. Exp Hematol. 1997;25:217-222.
38. Passegue E, Wagers AJ, Giuriato S, Anderson WC, Weissman IL. Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates. J Exp Med. 2005;202:1599-1611.
39. Palmer E. Negative selection: clearing out the bad apples from the T-cell repertoire. Nat Rev Immunol. 2003;3:383-391.
40. Germain RN. T-cell development and the CD4-CD8 lineage decision. Nat Rev Immunol. 2002;2:309-322.