Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in Zebrafish

Toxicological Sciences

Volumn 109, Issue 2, 2009, Pages 217-227

  Timme Laragy, Alicia R ^a,c   Van Tiem, Lindsey A ^a   Linney, Elwood A ^a,b   Di Giulio, Richard T ^a  

^a DUKE UNIVERSITY   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c WOODS HOLE OCEANOGRAPHIC INSTITUTION   (United States)

Author keywords

Embryonic development; Glutathione; NRF2; PAH; Redox; ROS

Indexed keywords

ACETYLCYSTEINE; ALPHA NAPHTHOFLAVONE; ANTIOXIDANT; BETA NAPHTHOFLAVONE; BUTHIONINE SULFOXIMINE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE 1; GLUTATHIONE TRANSFERASE P1; MANGANESE SUPEROXIDE DISMUTASE; MORPHOLINE DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON; TERT BUTYL HYDROPEROXIDE; TRANSCRIPTION FACTOR NRF2;

ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO DEVELOPMENT; GENE EXPRESSION; GENE FUNCTION; GLUTATHIONE BLOOD LEVEL; GLUTATHIONE METABOLISM; MORTALITY; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; UPREGULATION; ZEBRA FISH;

ANIMALS; ANTIOXIDANTS; BENZOFLAVONES; BETA-NAPHTHOFLAVONE; BUTHIONINE SULFOXIMINE; DRUG SYNERGISM; EMBRYO, NONMAMMALIAN; EMBRYONIC DEVELOPMENT; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GLUTATHIONE; NF-E2-RELATED FACTOR 2; OXIDATION-REDUCTION; OXIDATIVE STRESS; PERICARDIAL EFFUSION; POLYCYCLIC HYDROCARBONS, AROMATIC; TERT-BUTYLHYDROPEROXIDE; UP-REGULATION; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO; PISCES;

EID: 66149090319     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp038     Document Type: Article

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