Effect of alpha-lipoic acid on LPS-induced oxidative stress in the heart

Journal of Physiology and Pharmacology

Volumn 60, Issue 1, 2009, Pages 61-68

  Goraca, Anna ^a,b   Piechota, A ^a   Huk Kolega, H ^a  

^a MEDICAL UNIVERSITY OF LODZ   (Poland)

^b Department of Cardiovascular Physiology ^*  (Poland)

Author keywords

Endotoxic shock; Lipoic acid; Lipopolysaccharide

Indexed keywords

GLUTATHIONE; HYDROGEN PEROXIDE; LIPOPOLYSACCHARIDE; PROTEIN; THIOBARBITURIC ACID REACTIVE SUBSTANCE; THIOCTIC ACID; THIOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HEART INJURY; HOMOGENATE; ISOLATED HEART; LIPID PEROXIDATION; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; RAT; SEPTIC SHOCK;

ANIMALS; ANTIOXIDANTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESCHERICHIA COLI; FREE RADICAL SCAVENGERS; GLUTATHIONE; HEART; HYDROGEN PEROXIDE; LIPID PEROXIDATION; LIPOPOLYSACCHARIDES; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; RATS; RATS, WISTAR; SULFHYDRYL COMPOUNDS; THIOBARBITURIC ACID REACTIVE SUBSTANCES; THIOCTIC ACID;

EID: 65949106570     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Grandel U, Fink L, Blum A et al. Endotoxin-induced myocardial tumor necrosis factor-alpha synthesis depresses contractility of isolated rat hearts. Evidence for a role of sphingosine and cyclooxygenase-2-derived thromboxane production. Circulation 2000; 102: 2758-2771.
2. Krishnagopalan S, Kumar A, Parrillo JE, Kumar A. Myocardial dysfunction in the patient with sepsis. Curr Opin Crit Care 2002; 8: 376-388.
3. Ramana KV, Willis MS, White MD et al. Endotoxin-induced cardiomyopathy and systemic inflammation in mice is prevented by aldose reductase inhibition. Circulation 2006; 114: 1838-1846. (Pubitemid 44673359)
4. Tanguy S, de Leiris J, Besse S, Boucher F. Ageing exacerbates th cardiotoxicity of hydrogen peroxide through the Fenton reaction in rats. Mech Ageing Dev 2003; 124: 229-235. (Pubitemid 36293932)
5. Packer L. Neuroprotection by the metabolic antioxidant alpha-lipoic acid. Free Radic Biol Med 1997: 22: 359-378.
6. Han D, Handelman G, Marcocci L et al. Lipoic acid increases de novo synthesis of cellular glutathione by improving cysteine utilization. Biofactors 1997; 6: 321-338. (Pubitemid 27487808)
7. Goraca A, Jozefowicz-Okonkwo G. Protective effects of early treatment with lipoic acid in LPS-induced lung injury in rats. J Physiol Pharmacol 2007; 58: 541-549. (Pubitemid 47523096)
8. Coombes JS, Powers SK, Hamilton KL et al. Improved cardiac performance after ischemia in aged rats supplemented with vitamin E and α-lipoic acid. Am J Physiol 2000; 279: R2149-R2155.
9. Soszyński D, Chelminiak M. Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors attenuates fever due to LPS in rats. J Physiol Pharmacol 2007; 58: 551-561. (Pubitemid 47523097)
10. Skibska B, Jozefowicz-Okonkwo G, Goraca A. Protective effects of early administration of alfa-lipoic acid against lipopolysaccharide-induced plasma lipid peroxidation. Pharmocol Rep 2006: 399-404. (Pubitemid 44111075)
11. Ellman GL. SH groups determination in biological fluids. Anal Biochem 1970; 46: 237.
12. Lowry OH, Rosebrough AL, Farr AL, Randall R. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193: 265-275.
13. Ritter C, Andrades M, Frota Junior ML et al. Oxidative parameters and mortility in sepsis induced by cecal ligation and perforation. Intensive Care Med 2003; 29: 1782-1789. (Pubitemid 37373825)
14. De Azevedo LC, Park M, Noritomi DT, Maciej AT, Brunialti MK, Salomao R. Characterization of an animal model of severe sepsis associated with respiratory dysfunction. Clinics 2007; 62: 491-498.
15. Zhao L, Chen YH, Wang HJ et al. Reactive oxygen species contribute to lipopolysaccharide-induced tetragenesis in mice. Toxicol Sci 2008; 103: 149-157.
16. Jaworek J, Konturek SJ, Macko M et al. Endotoxemia in newborn rats attenuates acute pancreatitis at adult age. J Physiol Pharmacol 2007; 58: 131-147. (Pubitemid 350021143)
17. Luqman S and Rizvi SJ. Protection of lipid peroxidation and carbonyl formation in proteins by capsaicin in human erythrocytes subjected to oxidative stress. Phytother Res 2006; 20: 303-306.
18. Rozenberg S, Besse S, Brisson H et al. Endotoxin-induced myocardial dysfunction in senescent rats. Critical Care 2006; 10: R124-132. (Pubitemid 47086877)
19. Pigeolet E, Corbisier P, Houbion A et al. Glutathione peroxidase, superoxide dismutase, and catalase inactivation by peroxides and oxygen derived free radicals. Mech Ageing Dev 1990; 51: 283-297. (Pubitemid 20041562)
20. Viola HM, Arthur PG, Hool LC. Transient exposure to hydrogen peroxide causes an increase in mitochondria-derived superoxide as a result of sustained alteration in L-type Ca2+ channel function in the absence of apoptosis in ventricular myocytes. Circ Res 2007; 100: 1036-1044. (Pubitemid 46598928)
21. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite oxidation of sulfhydryls: The cytotoxic potential of superoxide and nitric oxide. J Biol Chem 1991; 266: 4244-4250. (Pubitemid 21909347)
22. Savitha S, Tamilselvan J, Anusuyadevi M, Panneerselvam C. Oxidative stress on mitochondrial antioxidant defense system in the aging process. Role of DL-α-lipoic acid and L-carnitine. Clin Chim Acta 2005; 355: 173-180. (Pubitemid 40501145)
23. Malmezat T, Breuille D, Capitan P, Mirand PP, Obled Ch. Glutathione tunover is increased during the acute phase of sepsis in rats. J Nutr 2000; 130: 1239-1246. (Pubitemid 30233274)
24. Nordberg J, Arner ES. Reactive oxygen species, antioxidants and the mammalian thioredoxin system. Free Rad Biol 2001; 31: 1287-1312. (Pubitemid 33145299)
25. Tsiotou AG, Sakorafas GH, Anagnostopoulos G, Bramis J. Septic shock; current pathogenetic concept from a clinical perspective. Med Sci Monit 2005; 11: RA76-RA85. (Pubitemid 40445995)
26. Biewenga GP, Haenen GR, Bast A. The pharmacology of the antioxidant lipoic acid. Gen Pharmacol 1997; 29: 315-331. (Pubitemid 27412452)
27. Lu SC. Regulation of glutathione synthesis. Molecular Aspects Medicine 2008; doi: 10.1016/j. mam. 2008.05.005.
28. Trujillo M, Folkes L, Bartesaghi S, Kalyanaraman B, Wardman P, Radi R. Peroxynitrite-derived carbonate and nitrogen dioxide radicals readily react with lipoic acid and dihydrolipoic acid. Free Rad Biol Med 2005; 39: 279-288. (Pubitemid 40814553)
29. Novotny L, Rauko P, Cojocel C. alpha-Lipoic acid- the potential for use in cancer therapy. Neoplasma 2008; 55: 81-86.
30. Zhang W, Wei H, Hagen T, Fre B. α-Lipoic acid attenuates LPS-induced inflammatory responses by activating the phosphoinositide 3-kinase/Akt signaling pathway. Proc Natl Acad Sci USA 2007; 104: 4077-4082. (Pubitemid 47181581)
31. Li X, Liu Z, Luo C et al. Lipoamide protects retinal pigment epithelial cells from oxidative stress and mitochondrial dysfunction. Free Radic Biol Med 2008; 144: 1465-1474.
32. Riedel W, Lang U, Oetjen U, Schlapp U, Shibata M. Inhibition of oxygen radical formation by methylene blue, aspiryn, or alpha-lipoic acid, prevents bacterial-lipopolysaccharide- induced fever. Mol Cell Biochem 2003; 247: 83-94. (Pubitemid 36798512)