Intracerebroventricular injection of neuronal and inducible nitric oxide synthase inhibitors attenuates fever due to LPS in rats

Journal of Physiology and Pharmacology

Volumn 58, Issue 3, 2007, Pages 551-561

  Soszynski, D ^a   Chelminiak, M ^a  

^a NICOLAUS COPERNICUS UNIVERSITY   (Poland)

Author keywords

Aminoguanidine; Biotelemetry; Body temperature; Endotoxin; Fever mechanism; Inducible nitric oxide synthase; Neuronal nitric oxide synthase; Rat; vL NIO

Indexed keywords

AMINOGUANIDINE; INDUCIBLE NITRIC OXIDE SYNTHASE; LIPOPOLYSACCHARIDE; N5 (1 IMINO 3 BUTENYL) ORNITHINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY TEMPERATURE; CONTROLLED STUDY; FEVER; INJECTION; MALE; NONHUMAN; RAT; TELEMETRY; WISTAR RAT;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; FEVER; GUANIDINES; INJECTIONS, INTRAVENTRICULAR; LIPOPOLYSACCHARIDES; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; NITRIC OXIDE SYNTHASE TYPE II; ORNITHINE; RATS; RATS, WISTAR; TIME FACTORS;

EID: 34948860655     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (32)

1. Kluger MJ, Kozak W, Conn CA, Leon LR, Soszynski D. Role of fever in disease. Ann NY Acad Sci 1998; 856: 224-233.
2. Kluger MJ, Kozak W, Leon LR, Soszynski D, Conn CA. Cytokines and fever. Neuroimmunomodulation 1995; 2: 216-223.
3. Blatteis CM, Sehic E. Prostaglandin E2: a putative fever mediator. In: Mackowiak PA, ed. Fever: Basic Mechanism and Management. New York, Raven-Lippincott, 1997: p 117-148.
4. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991; 43: 109-142.
5. Steiner AA, Branco LGS. Nitric oxide in the regulation of body temperature and fever. J Therm Biol 2001; 26: 325-330.
6. Mathai M, Hjelmquist H, Keil R, Gerstberger R. Nitric oxide increases cutaneous and respiratory heat dissipation in concious rabbits. Prog Brain Res 1998; 115: 129-139.
7. Taylor WF, Bishop VS. A role of nitric oxide in active thermoregulatory vasodilation. Am J Physiol 1993; 26: 1355-1359.
8. Monda S, Amaro S, Sullo A, DeLuca B. Nitric oxide reduces body temperature and sympathetic input to brown adipose tissue during PGE1-hyperthermia. Brain Res Bull 1995; 38: 489-493.
9. DeLuca B, Monda S, Sullo A. Changes in eating behavior and thermogenic activity following inhibition of nitric oxide formation. Am J Physiol 1995; 268: 1533-1539.
10. Gourine AV. Pharmacological evidence that nitric oxide can act as an endogenous antipyretic factor in endotoxin-induced fever in rabbits. Gen Pharmacol 1995; 26: 835-841.
11. Steiner AA, Antunes-Rodrigues J, McCann SM, Branco LGS. Antipyretic role of the NO-cGMP pathway in the anteroventral preoptic region of the rat brain. Am J Physiol 2002; 282: 584-593.
12. Thiemermann C. Nitric oxide in septic shock. Gen Pharmacol 1997; 29: 159-166.
13. Soszynski D, Krajewska M. Time-course of changes in plasma nitric oxide following lipopolysaccharide and turpentine injection in rats. J Therm Biol 2002; 27: 387-391.
14. Braulio VB, Ten Have GAM, Vissers YLJ, Deutz NEP. Time course of nitric oxide production after endotoxin challenge in mice. Am J Physiol 2004; 287: 912-918.
15. Roth J, Storr B, Voigt K, Zeisberger E. Inhibition of nitric oxide synthase attenuates lipopolysaccharide-induced fever without reduction of circulating cytokines in guinea-pigs. Pfluger Arch - Eur J Physiol 1998; 436: 858-862.
16. Scammell TE, Elmquist JK, Saper CB. Inhibition of nitric oxide synthase produces hypothermia and depresses lipopolysaccharide fever. Am J Physiol 1996; 271: 333-338.
17. Kamerman P, Fuller A. Effects of nitric oxide synthase inhibitors on the febrile response to lipopolysaccharide and muramyl dipeptide in guinea pigs. Life Sci 2000; 67: 2639-2645.
18. Soszynski D. The inhibition of nitric oxide synthase suppresses LPS- and psychological-stress-induced fever in rats. Physiol Behav 2001; 72: 65-72.
19. Kozak W, Kozak A. Differential role of nitric oxide synthase isoforms in fever of different etiologiest: studies using NOS gene-deficient mice. J Appl Physiol 2003; 94: 2534-2544.
20. G-nitroarginine in brain in vitro and in vivo. Biochem Biophys Res Commun 1991; 176: 1136-1141.
21. Pellegrino LJ, Pellegrino AS, Cushman AJ. A stereotaxic atlas of the rat brain. New York, Plenum Press, 1979.
22. Soszynski D. Inhibition of nitric oxide synthase delays the development of tolerance to LPS in rats. Physiol Behav 2002; 76: 159-169.
23. Chabrier PE, Demerle-Pallardy C, Auguet M. Nitric oxide synthases: targets for therapeutic strategies in neurological diseases. Cell Mol. Life Sci 1999; 55: 1029-1035.
24. Bredt DS, Snyder SH. Nitric oxide: a physiologic messenger molecule. Ann Rev Biochem 1994; 63: 175-195.
25. Harada S, Imaki T, Chicaga N, Narusz M, Lemura H. Distinct distribution and time-course changes in neuronal nitric oxide synthase and inducible NOS in the paraventricular nucleus following lipopolysaccharide injection. Brain Res 1999; 821: 322-332.
26. Schmidt HHHW, Gagne GD, Nakane M, Pollock JS, Miller MF, Murad F. Mapping of nitric oxide synthase in the rat suggest frequent co-localization with NAPH diaphorase but not with soluble guanyl cyclase, and novel paraneural functions for nitrergic signal transduction. J Histochem Cytochem 1992; 40:, 1439-1456.
27. Wakita T, Shintani F, Yagi G, Asai M, Nozawa S. Combination of inflammatory cytokines increases nitrite and nitrate levels in the paraventricular nucleus of conscious rats. Brain Res 2001; 905: 12-20.
28. Kakizaki Y, Watanobe A, Kohsaka A, Suda T. Temporal profiles of interleukin-1b, interleukin-6, and tumor necrosis factor-a in the plasma and hypothalamic paraventricular nucleus after intravenous or intraperitoneal administration of lipopolysaccharide in the rat: estimation by push-pull perfusion. Endocr J 1999; 46: 487-496.
29. Scammell TE, Elmquist JK, Saper CB. Microinjection of cyclooxygenase inhibitor into the anteroventral preoptic region attenuates LPS fever. Am J Physiol 1998; 274: 333-338.
30. Minghetii L, Walsh DT, Levi G, Perry VH. In vivo expression of cyclooxygenase-2 in rat brain following intraparenchymal injection of bacterial endotoxin and inflammatory cytokines. J Neurophatol Exp Neurol 1999; 11: 1184-1191.
31. Perkins DJ, Kniss DA. Blockade of nitric oxide formation down-regulates cyclooxygenase-2 and decreases PGE2 biosynthesis in macrophages. J Leukocyte Biol 1999; 54: 792-799.
32. Tetsuka T, Daphna-Iken D, Miller BW, Guan Z, Baier LD, Morrison AR. Nitric oxide amplifies interleukin-1 induced cyclooxygenase-2 expression in rat mesangial cells. J Clin Invest 1996; 97: 2051-2056.