Muscarinic receptor subtypes in the alimentary tract

Journal of Physiology and Pharmacology

Volumn 60, Issue 1, 2009, Pages 3-21

  Tobin, Gunnar ^a,b   Giglio, D ^a   Lundgren, O ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b Department of Pharmacology ^*  (Sweden)

Author keywords

Contraction; Gastrointestinal tract; Muscarinic receptor; Salivary glands; Secretion; Vasodilatation

Indexed keywords

BICARBONATE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; PEPSINOGEN;

BLOOD FLOW; CELL GROWTH; CELL PROLIFERATION; DIGESTIVE SYSTEM; ENZYME RELEASE; FLUID TRANSPORT; HUMAN; INFLAMMATION; INNERVATION; INTESTINE FLUID; INTESTINE MUSCLE; MUCUS SECRETION; NONHUMAN; PANETH CELL; PERIPHERAL NERVOUS SYSTEM; PHYSIOLOGICAL PROCESS; PRESYNAPTIC NERVE; PROTEIN EXPRESSION; REVIEW; SALIVARY GLAND; SALIVATION; SIGNAL TRANSDUCTION; STEM CELL; STOMACH ACID SECRETION; STOMACH MUSCLE;

ACETYLCHOLINE; ANIMALS; GASTROINTESTINAL TRACT; GENE EXPRESSION REGULATION; HUMANS; RECEPTORS, MUSCARINIC; SALIVARY GLANDS; SIGNAL TRANSDUCTION;

EID: 65949103174     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (265)

1. Uchiyama T, Chess-Williams R. Muscarinic receptor subtypes of the bladder and gastrointestinal tract. J Smooth Muscle Res 2004; 40(6): 237-247. (Pubitemid 40364079)
2. Lecci A, Santicioli P, Maggi CA. Pharmacology of transmission to gastrointestinal muscle. Curr Opin Pharmacol 2002; 2(6): 630-641. (Pubitemid 35476913)
3. Tobin G. Salivary secretion control. In: Encyclopedia of Neuroscience, MD Binder, N Hirokawa, U Windhorst, MC Hirsch (eds). Springer; 2008.
4. Caulfield MP, Birdsall NJ. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 1998; 50(2): 279-290. (Pubitemid 28304029)
5. Eglen RM. Muscarinic receptor subtypes in neuronal and non-neuronal cholinergic function. Auton Autacoid Pharmacol 2006; 26(3): 219-233. (Pubitemid 43898622)
6. Kubo T, Fukuda K, Mikami Aet al. Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor. Nature 1986; 323(6087): 411-416. (Pubitemid 16026268)
7. Hulme EC. Muscarinic acetylcholine receptors: typical G-coupled receptors. Symp Soc Exp Biol 1990; 44: 39-54.
8. Hulme EC, Birdsall NJ, Buckley NJ. Muscarinic receptor subtypes. Annu Rev Pharmacol Toxicol 1990; 30: 633-673. (Pubitemid 20139559)
9. Caulfield MP. Muscarinic receptors - characterization, coupling and function. Pharmacol Ther 1993; 58(3): 319-379. (Pubitemid 23273186)
10. Goyal RK. Identification, localization and classification of muscarinic receptor subtypes in the gut. Life Sci 1988; 43(26): 2209-2220.
11. Unno T, Matsuyama H, Izumi Y, Yamada M, Wess J, Komori S. Roles of M2 and M3 muscarinic receptors in cholinergic nerve-induced contractions in mouse ileum studied with receptor knockout mice. Br J Pharmacol 2006; 149(8): 1022-1030.
12. Somogyi GT, de Groat WC. Function, signal transduction mechanisms and plasticity of presynaptic muscarinic receptors in the urinary bladder. Life Sci 1999; 64(6-7): 411-418.
13. Casanova MF, Trippe J, 2nd. Regulatory mechanisms of cortical laminar development. Brain Res Rev 2006; 51(1): 72-84. (Pubitemid 43782533)
14. Ventura S, Pennefather J, Mitchelson F. Cholinergic innervation and function in the prostate gland. Pharmacol Ther 2002; 94(1-2): 93-112. (Pubitemid 34615960)
15. Ukegawa JI, Takeuchi Y, Kusayanagi S, Mitamura K. Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells. J Cancer Res Clin Oncol 2003; 129(5): 272-278. (Pubitemid 36791682)
16. Profita M, Giorgi RD, Sala A et al. Muscarinic receptors, leukotriene B4 production and neutrophilic inflammation in COPD patients. Allergy 2005; 60(11): 1361-1369. (Pubitemid 41476178)
17. Racke K, Juergens UR, Matthiesen S. Control by cholinergic mechanisms. Eur J Pharmacol 2006; 533(1-3): 57-68. (Pubitemid 43340004)
18. Kawashima K, Fujii T. Expression of non-neuronal acetylcholine in lymphocytes and its contribution to the regulation of immune function. Front Biosci 2004; 9: 2063-2085.
19. Lanzafame AA, Christopoulos A, Mitchelson F. Cellular signaling mechanisms for muscarinic acetylcholine receptors. Receptors Channels 2003; 9(4): 241-260. (Pubitemid 37069446)
20. Gudermann T, Kalkbrenner F, Schultz G. Diversity and selectivity of receptor-G protein interaction. Annu Rev Pharmacol Toxicol 1996; 36: 429-459. (Pubitemid 26168705)
21. Wu G, Bogatkevich GS, Mukhin YV, Benovic JL, Hildebrandt JD, Lanier SM. Identification of Gbetagamma binding sites in the third intracellular loop of the M(3)- muscarinic receptor and their role in receptor regulation. J Biol Chem 2000; 275(12): 9026-9034. (Pubitemid 30180262)
22. Zholos AV, Zholos AA, Bolton TB. G-protein-gated TRP-like cationic channel activated by muscarinic receptors: effect of potential on single-channel gating. J Gen Physiol 2004; 123(5): 581-598. (Pubitemid 38590860)
23. van Koppen CJ, Kaiser B. Regulation of muscarinic acetylcholine receptor signaling. Pharmacol Ther 2003; 98(2): 197-220. (Pubitemid 36513775)
24. Lucas JL, Wang D, Sadee W. Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors. Pharm Res 2006; 23(4): 647-653.
25. Eglen RM, Nahorski SR. The muscarinic M(5) receptor: a silent or emerging subtype? Br J Pharmacol 2000; 130(1): 13-21. (Pubitemid 30248420)
26. Schmidt M, Voss M, Weernink PA, Wetzel J, Amano M, Kaibuchi K et al. A role for rho-kinase in rho-controlled phospholipase D stimulation by the m3 muscarinic acetylcholine receptor. J Biol Chem 1999; 274(21): 14648-14654. (Pubitemid 129518789)
27. Hall A. G proteins and small GTPases: distant relatives keep in touch. Science 1998; 280(5372): 2074-2075. (Pubitemid 28366192)
28. Sakai H, Hirano T, Takeyama H, Chiba Y, Misawa M. Acetylcholine-induced phosphorylation of CPI-17 in rat bronchial smooth muscle: the roles of Rho-kinase and protein kinase C. Can J Physiol Pharmacol 2005; 83(4): 375-381. (Pubitemid 40961267)
29. Chiba Y, Misawa M. The role of RhoA-mediated Ca2+ sensitization of bronchial smooth muscle contraction in airway hyperresponsiveness. J Smooth Muscle Res 2004; 40(4-5): 155-167. (Pubitemid 40204723)
30. Kimura K, Ito M, Amano M, Chihara K, Fukata Y, Nakafuku M et al. Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase). Science 1996; 273(5272): 245-248. (Pubitemid 26285892)
31. Matthiesen S, Bahulayan A, Holz O, Racke K. MAPK pathway mediates muscarinic receptor-induced human lung fibroblast proliferation. Life Sci 2007; 80(24-25): 2259-2262. (Pubitemid 46818284)
32. Rossignol TM, Jones SV. Regulation of a family of inwardly rectifying potassium channels (Kir2) by the m1 muscarinic receptor and the small GTPase Rho. Pflugers Arch 2006; 452(2): 164-174. (Pubitemid 44029841)
33. Roberson ED, English JD, Adams JP, Selcher JC, Kondratick C, Sweatt JD. The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. J Neurosci 1999; 19(11): 4337-4348. (Pubitemid 29241087)
34. Lin K, Wang D, Sadee W. Serum response factor activation by muscarinic receptors via RhoA. Novel pathway specific to M1 subtype involving calmodulin, calcineurin, and Pyk2. J Biol Chem 2002; 277(43): 40789-40798. (Pubitemid 35215664)
35. van Koppen CJ, Meyer zu Heringdorf D, Alemany R, Jakobs KH. Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors. Life Sci 2001; 68(22-23): 2535-2540.
36. Meyer zu Heringdorf D, Lass H, Alemany R, Laser KT, Neumann E, Zhang C et al. Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. Embo J 1998; 17(10): 2830-2837.
37. Itagaki K, Hauser CJ. Sphingosine 1-phosphate, a diffusible calcium influx factor mediating store-operated calcium entry. J Biol Chem 2003; 278(30): 27540-27547. (Pubitemid 36899938)
38. Pfaff M, Powaga N, Akinci S, Schutz W, Banno Y, Wiegand S et al. Activation of the SPHK/S1P signalling pathway is coupled to muscarinic receptor-dependent regulation of peripheral airways. Respir Res 2005; 6: 48. (Pubitemid 41363575)
39. Re L. Modulation of acetylcholine release by presynaptic muscarinic autoreceptors. Acta Physiol Pharmacol Ther Latinoam 1999; 49(4): 215-223.
40. Grimm U, Moser U, Mutschler E, Lambrecht G. Muscarinic receptors: focus on presynaptic mechanisms and recently developed novel agonists and antagonists. Pharmazie 1994; 49(10): 711-726. (Pubitemid 24320044)
41. Khanin R, Parnas I, Parnas H. On the feedback between theory and experiment in elucidating the molecular mechanisms underlying neurotransmitter release. Bull Math Biol 2006; 68(5): 997-1009. (Pubitemid 44195535)
42. Langer SZ. 25 years since the discovery of presynaptic receptors: present knowledge and future perspectives. Trends Pharmacol Sci 1997; 18(3): 95-99. (Pubitemid 27145735)
43. Kilbinger H, Dietrich C, von Bardeleben RS. Functional relevance of presynaptic muscarinic autoreceptors. J Physiol Paris 1993; 87(2): 77-81. (Pubitemid 23263493)
44. Slutsky I, Wess J, Gomeza J, Dudel J, Parnas I, Parnas H. Use of knockout mice reveals involvement of M2-muscarinic receptors in control of the kinetics of acetylcholine release. J Neurophysiol 2003; 89(4): 1954-1967. (Pubitemid 36444251)
45. Alberts P. Classification of the presynaptic muscarinic receptor subtype that regulates 3H-acetylcholine secretion in the guinea pig urinary bladder in vitro. J Pharmacol Exp Ther 1995; 274(1): 458-468.
46. Zhou H, Meyer A, Starke K, Gomeza J, Wess J, Trendelenburg AU. Heterogeneity of release-inhibiting muscarinic autoreceptors in heart atria and urinary bladder: a study with M(2)- and M(4)-receptor-deficient mice. Naunyn Schmiedebergs Arch Pharmacol 2002; 365(2): 112-122. (Pubitemid 34253104)
47. D'Agostino G, Barbieri A, Chiossa E, Tonini M. M4 muscarinic autoreceptor-mediated inhibition of -3H-acetylcholine release in the rat isolated urinary bladder. J Pharmacol Exp Ther 1997; 283(2): 750-756. (Pubitemid 27514636)
48. D'Agostino G, Bolognesi ML, Lucchelli A, Vicini D, Balestra B, Spelta V et al. Prejunctional muscarinic inhibitory control of acetylcholine release in the human isolated detrusor: involvement of the M4 receptor subtype. Br J Pharmacol 2000; 129(3): 493-500. (Pubitemid 30083870)
49. Tobin G, Ryberg AT, Gentle S, Edwards AV. Distribution and function of muscarinic receptor subtypes in the ovine submandibular gland. J Appl Physiol 2006; 100(4): 1215-1223. (Pubitemid 43671479)
50. Tobin G, Sjogren C. In vivo and in vitro effects of muscarinic receptor antagonists on contractions and release of [3H]acetylcholine in the rabbit urinary bladder. Eur J Pharmacol 1995; 281(1): 1-8.
51. Tobin G, Sjogren C. Prejunctional facilitatory and inhibitory modulation of parasympathetic nerve transmission in the rabbit urinary bladder. J Auton Nerv Syst 1998; 68(3): 153-156. (Pubitemid 28218209)
52. Somogyi GT, Tanowitz M, de Groat WC. M1 muscarinic receptor-mediated facilitation of acetylcholine release in the rat urinary bladder. J Physiol 1994; 480: 81-89. (Pubitemid 24310001)
53. Kortezova N, Shikova L, Papasova M. Participation of M1 receptors in NO pathway in cat ileum. Acta Physiol Pharmacol Bulg 1998; 23(1): 1-4.
54. Tobin G. Presynaptic muscarinic M1 and M2 receptor modulation of auriculotemporal nerve transmission in the rat. J Auton Nerv Syst 1998; 72(1): 61-71. (Pubitemid 28414403)
55. Slutsky I, Parnas H, Parnas I. Presynaptic effects of muscarine on ACh release at the frog neuromuscular junction. J Physiol 1999; 514: 769-782. (Pubitemid 29060323)
56. Slutsky I, Rashkovan G, Parnas H, Parnas I. Ca2+-independent feedback inhibition of acetylcholine release in frog neuromuscular junction. J Neurosci 2002; 22(9): 3426-3433. (Pubitemid 37465748)
57. Kimura F, Baughman RW. Distinct muscarinic receptor subtypes suppress excitatory and inhibitory synaptic responses in cortical neurons. J Neurophysiol 1997; 77(2): 709-716. (Pubitemid 27087773)
58. Nikbakht MR, Stone TW. Occlusive responses to adenosine A1 receptor and muscarinic M2 receptor activation on hippocampal presynaptic terminals. Brain Res 1999; 829(1-2): 193196.
59. Fernandez-Fernandez JM, Abogadie FC, Milligan G, Delmas P, Brown DA. Multiple pertussis toxin-sensitive G-proteins can couple receptors to GIRK channels in rat sympathetic neurons when expressed heterologously, but only native G(i)-proteins do so in situ. Eur J Neurosci 2001; 14(2): 283-292. (Pubitemid 32777634)
60. Eltze M, Galvan M. Involvement of muscarinic M2 and M3, but not of M1 and M4 receptors in vagally stimulated contractions of rabbit bronchus/trachea. Pulm Pharmacol 1994; 7(2): 109-120.
61. Scholz KP, Miller RJ. Inhibition of quantal transmitter release in the absence of calcium influx by a G protein-linked adenosine receptor at hippocampal synapses. Neuron 1992; 8(6): 1139-1150.
62. Grillner P, Bonci A, Svensson TH, Bernardi G, Mercuri NB. Presynaptic muscarinic (M3) receptors reduce excitatory transmission in dopamine neurons of the rat mesencephalon. Neuroscience 1999; 91(2): 557-565. (Pubitemid 29193265)
63. Oliveira L, Correia-de-Sa P. Protein kinase A and Ca(v)1 (L-type) channels are common targets to facilitatory adenosine A2A and muscarinic M1 receptors on rat motoneurons. Neurosignals 2005; 14(5): 262-272. (Pubitemid 41661360)
64. Santafe MM, Lanuza MA, Garcia N, Tomas J. Muscarinic autoreceptors modulate transmitter release through protein kinase C and protein kinase A in the rat motor nerve terminal. Eur J Neurosci 2006; 23(8): 2048-2056.
65. Abrams P, Andersson KE, Buccafusco JJ, Chapple C, de Groat WC, Fryer AD et al. Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. Br J Pharmacol 2006; 148(5): 565-578. (Pubitemid 43993048)
66. Eglen RM. Muscarinic receptors and gastrointestinal tract smooth muscle function. Life Sci 2001; 68: 2573-2578. (Pubitemid 32455696)
67. Eglen RM. Muscarinic receptor subtype pharmacology and physiology. Prog Med Chem 2005; 43: 105-136. (Pubitemid 40605496)
68. Eglen RM, Hegde SS, Watson N. Muscarinic receptor subtypes and smooth muscle function. Pharmacol Rev 1996; 48(4): 531-565. (Pubitemid 27023820)
69. Ehlert FJ. Contractile role of M2 and M3 muscarinic receptors in gastrointestinal, airway and urinary bladder smooth muscle. Life Sci 2003; 74: 355-366. (Pubitemid 37357066)
70. Kume H, Mikawa K, Takagi K, Kotlikoff MI. Role of G proteins and KCa channels in the muscarinic and beta-adrenergic regulation of airway smooth muscle. Am J Physiol 1995; 268: L221-L229.
71. Kotlikoff MI, Wang YX. Calcium release and calcium-activated chloride channels in airway smooth muscle cells. Am J Respir Crit Care Med 1998; 158: S109-S114. (Pubitemid 28536578)
72. Zholos AV. Regulation of TRP-like muscarinic cation current in gastrointestinal smooth muscle with special reference to PLC/InsP3/Ca2+ system. Acta Pharmacol Sin 2006; 27(7): 833-842. (Pubitemid 44366016)
73. vom Dorp F, Sari AY, Sanders H, Keiper M, Oude Weernink PA, Jakobs KH et al. Inhibition of phospholipase C-epsilon by Gi-coupled receptors. Cell Signal 2004; 16(8): 921-928.
74. Sakamoto T, Unno T, Matsuyama H, Uchiyama M, Hattori M, Nishimura M et al. Characterization of muscarinic receptor-mediated cationic currents in longitudinal smooth muscle cells of mouse small intestine. J Pharmacol Sci 2006; 100(3): 215-226.
75. Sakamoto T, Unno T, Kitazawa T, Taneike T, Yamada M, Wess J et al. Three distinct muscarinic signalling pathways for cationic channel activation in mouse gut smooth muscle cells. J Physiol 2007; 582: 41-61. (Pubitemid 46993560)
76. Kotlikoff MI, Dhulipala P, Wang YX. M2 signaling in smooth muscle cells. Life Sci 1999; 64: 437-442.
77. Culp DJ, Luo W, Richardson LA, Watson GE, Latchney LR. Both M1 and M3 receptors regulate exocrine secretion by mucous acini. Am J Physiol 1996; 271: C1963-C1972.
78. Berkeley JL, Gomeza J, Wess J, Hamilton SE, Nathanson NM, Levey AI. M1 muscarinic acetylcholine receptors activate extracellular signal-regulated kinase in CA1 pyramidal neurons in mouse hippocampal slices. Mol Cell Neurosci 2001; 18(5): 512-524. (Pubitemid 34008391)
79. Hamilton SE, Nathanson NM. The M1 receptor is required for muscarinic activation of mitogen-activated protein (MAP) kinase in murine cerebral cortical neurons. J Biol Chem 2001; 276(19): 15850-15853. (Pubitemid 37406616)
80. Bandyopadhyay BC, Swaim WD, Liu X, Redman RS, Patterson RL, Ambudkar IS. Apical localization of a functional TRPC3/TRPC6-Ca2+-signaling complex in polarized epithelial cells. Role in apical Ca2+ influx. J Biol Chem 2005; 280(13): 12908-12916. (Pubitemid 40491113)
81. Beech DJ. TRPC1: store-operated channel and more. Pflugers Arch 2005; 451(1): 53-60. (Pubitemid 41424907)
82. Kim JY, Saffen D. Activation of M1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on TRPC6 channels. J Biol Chem 2005; 280(36): 32035-32047. (Pubitemid 41291955)
83. Pemberton KE, Hill-Eubanks LJ, Jones SV. Modulation of low-threshold T-type calcium channels by the five muscarinic receptor subtypes in NIH 3T3 cells. Pflugers Arch 2000; 440(3): 452-461. (Pubitemid 30445719)
84. Durand S, Tartas M, Bouye P, Koitka A, Saumet JL, Abraham P. Prostaglandins participate in the late phase of the vascular response to acetylcholine iontophoresis in humans. J Physiol 2004; 561: 811-819. (Pubitemid 40074936)
85. Furchgott RF. Endothelium-derived relaxing factor: discovery, early studies, and identification as nitric oxide. Biosci Rep 1999; 19(4): 235-251.
86. Stojic D, Radenkovic M, Krsljak E, Popovic J, Pesic S, Grbovic L. Influence of the endothelium on the vasorelaxant response to acetylcholine and vasoactive intestinal polypeptide in the isolated rabbit facial artery. Eur J Oral Sci 2003; 111(2): 137-143. (Pubitemid 37467779)
87. Anderson LC, Garrett JR. Neural regulation of blood flow in the rat submandibular gland. Eur J Morphol 1998; 36 Suppl: 213-218. (Pubitemid 28555611)
88. de Groat WC. Integrative control of the lower urinary tract: preclinical perspective. Br J Pharmacol 2006; 147 Suppl 2: S25-S40. (Pubitemid 43237573)
89. Andersson KE, Persson K. Nitric oxide synthase and nitric oxide-mediated effects in lower urinary tract smooth muscles. World J Urol 1994; 12(5): 274-280.
90. Schachter M, Matthews B, Bhoola KD. Evidence that nitric oxide or a related substance is a neurovasodilator in the submandibular gland of the cat. Agents Actions Suppl 1992; 38 (Pt 2): 366-370.
91. Feddersen CO, Mathias MM, McMurtry IF, Voelkel NF. Acetylcholine induces vasodilation and prostacyclin synthesis in rat lungs. Prostaglandins 1986; 31(5): 973-987. (Pubitemid 16082206)
92. Berra A, Ganzinelli S, Saravia M, Borda E, Sterin-Borda L. Inducible nitric oxide synthase subserves cholinergic vasodilation in retina. Vis Neurosci 2005; 22(3): 371-377. (Pubitemid 41329352)
93. Borda E, Berra A, Saravia M, Ganzinelli S, Sterin-Borda L. Correlations between neuronal nitric oxide synthase and muscarinic M3/M1 receptors in the rat retina. Exp Eye Res 2005; 80(3): 391-399. (Pubitemid 40249895)
94. Elhusseiny A, Hamel E. Muscarinic - but not nicotinic - acetylcholine receptors mediate a nitric oxide-dependent dilation in brain cortical arterioles: a possible role for the M5 receptor subtype. J Cereb Blood Flow Metab 2000; 20(2): 298-305. (Pubitemid 30108448)
95. Sterin-Borda L, Ganzinelli S, Berra A, Borda E. Novel insight into the mechanisms involved in the regulation of the m1 muscarinic receptor, iNOS and nNOS mRNA levels. Neuropharmacology 2003; 45(2): 260-269. (Pubitemid 36782539)
96. Giglio D, Ryberg AT, To K, Delbro DS, Tobin G. Altered muscarinic receptor subtype expression and functional responses in cyclophosphamide induced cystitis in rats. Auton Neurosci 2005; 122: 9-20. (Pubitemid 41476370)
97. Wang SZ, Lee SY, Zhu SZ, Wotta DR, Parsons AM, el- Fakahany EE. Activation of neuronal nitric oxide synthase by M2 muscarinic receptors associated with a small increase in intracellular calcium. Pharmacology 1997; 55(1): 10-17. (Pubitemid 27354662)
98. Alm P, Ekstrom J, Larsson B, Tobin G, Andersson KE. Nitric oxide synthase immunoreactive nerves in rat and ferret salivary glands, and effects of denervation. Histochem J 1997; 29(9): 669-676. (Pubitemid 27489869)
99. Soinila J, Nuorva K, Soinila S. Nitric oxide synthase in human salivary glands. Histochem Cell Biol 2006; 125(6): 717-723. (Pubitemid 43780178)
100. Proctor GB, Carpenter GH. Regulation of salivary gland function by autonomic nerves. Auton Neurosci 2007; 133(1): 3-18. (Pubitemid 46483257)
101. Shimomura H, Tanaka S, Komine N, Shimooka S, Imai A, Nashida T. Soluble guanylyl cyclase is localised in the acinar cells and participates in amylase secretion in rat parotid gland. Arch Oral Biol 2004; 49(9): 691-696. (Pubitemid 38991614)
102. Tobin G, Giglio D, Gotrick B. Studies of muscarinic receptor subtypes in salivary gland function in anaesthetized rats. Auton Neurosci 2002; 100: 1-9.
103. Looms D, Tritsaris K, Pedersen AM, Nauntofte B, Dissing S. Nitric oxide signalling in salivary glands. J Oral Pathol Med 2002; 31(10): 569-584. (Pubitemid 35301937)
104. Rosignoli F, Perez Leiros C. Activation of nitric oxide synthase through muscarinic receptors in rat parotid gland. Eur J Pharmacol 2002; 439: 27-33. (Pubitemid 34286603)
105. Lomniczi A, Suburo AM, Elverdin JC, Mastronardi CA, Diaz S, Rettori V et al. Role of nitric oxide in salivary secretion. Neuroimmunomodulation 1998; 5(5): 226-233. (Pubitemid 28423702)
106. Soinila S, Vanhatalo S, Lumme A, Back N, Soinila J. Nitric oxide synthase in the autonomic and sensory ganglia innervating the submandibular salivary gland. Microsc Res Tech 1996; 35(1): 32-43. (Pubitemid 26282075)
107. Ohama T, Hori M, Ozaki H. Mechanism of abnormal intestinal motility in inflammatory bowel disease: how smooth muscle contraction is reduced? J Smooth Muscle Res 2007; 43(2): 43-54.
108. Pavlov VA, Tracey KJ. Controlling inflammation: the cholinergic anti-inflammatory pathway. Biochem Soc Trans 2006; 34: 1037-1040. (Pubitemid 46768984)
109. Brunn G, Wessler I, Racke K. Mucosa-dependent muscarinic liberation of prostaglandins from rat isolated trachea. Br J Pharmacol 1995; 116(3): 1991-1998.
110. Koyama S, Rennard SI, Robbins RA. Acetylcholine stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. Am J Physiol 1992; 262: L466-L471.
111. Mita Y, Dobashi K, Suzuki K, Mori M, Nakazawa T. Induction of muscarinic receptor subtypes in monocytic/macrophagic cells differentiated from EoL-1 cells. Eur J Pharmacol 1996; 297: 121-127. (Pubitemid 26062150)
112. Gosens R, Bos IS, Zaagsma J, Meurs H. Protective effects of tiotropium bromide in the progression of airway smooth muscle remodeling. Am J Respir Crit Care Med 2005; 171(10): 1096-1102. (Pubitemid 40663720)
113. Frucht H, Jensen RT, Dexter D, Yang WL, Xiao Y. Human colon cancer cell proliferation mediated by the M3 muscarinic cholinergic receptor. Clin Cancer Res 1999; 5(9): 2532-2539. (Pubitemid 29437339)
114. Yang WL, Frucht H. Cholinergic receptor up-regulates COX-2 expression and prostaglandin E(2) production in colon cancer cells. Carcinogenesis 2000; 21(10): 1789-1793.
115. Metzen J, Bittinger F, Kirkpatrick CJ, Kilbinger H, Wessler I. Proliferative effect of acetylcholine on rat trachea epithelial cells is mediated by nicotinic receptors and muscarinic receptors of the M1-subtype. Life Sci 2003; 72: 2075-2080. (Pubitemid 36298950)
116. Wessler I, Kirkpatrick CJ, Racke K. Non-neuronal acetylcholine, a locally acting molecule, widely distributed in biological systems: expression and function in humans. Pharmacol Ther 1998; 77(1): 59-79. (Pubitemid 28059940)
117. Wessler IK, Kirkpatrick CJ. The Non-neuronal cholinergic system: an emerging drug target in the airways. Pulm Pharmacol Ther 2001; 14(6): 423-434. (Pubitemid 34081694)
118. Reinheimer T, Baumgartner D, Hohle KD, Racke K, Wessler I. Acetylcholine via muscarinic receptors inhibits histamine release from human isolated bronchi. Am J Respir Crit Care Med 1997; 156: 389-395. (Pubitemid 27351969)
119. Klapproth H, Reinheimer T, Metzen J, Munch M, Bittinger F, Kirkpatrick CJ et al. Non-neuronal acetylcholine, a signalling molecule synthezised by surface cells of rat and man. Naunyn Schmiedebergs Arch Pharmacol 1997; 355(4): 515-523. (Pubitemid 27140478)
120. Reinheimer T, Mohlig T, Zimmermann S, Hohle KD, Wessler I. Muscarinic control of histamine release from airways. Inhibitory M1-receptors in human bronchi but absence in rat trachea. Am J Respir Crit Care Med 2000; 162: 534-538. (Pubitemid 30647196)
121. Zia S, Ndoye A, Nguyen VT, Grando SA. Nicotine enhances expression of the alpha 3, alpha 4, alpha 5, and alpha 7 nicotinic receptors modulating calcium metabolism and regulating adhesion and motility of respiratory epithelial cells. Res Commun Mol Pathol Pharmacol 1997; 97(3): 243-262. (Pubitemid 27495085)
122. Budd DC, McDonald J, Emsley N, Cain K, Tobin AB. The C-terminal tail of the M3-muscarinic receptor possesses anti-apoptotic properties. J Biol Chem 2003; 278(21): 19565-19573. (Pubitemid 36799355)
123. Laszlo GS, Rosoff ML, Amieux PS, Nathanson NM. Multiple promoter elements required for leukemia inhibitory factor-stimulated M2 muscarinic acetylcholine receptor promoter activity. J Neurochem 2006; 98(4): 1302-1315. (Pubitemid 44127803)
124. Krymskaya VP, Orsini MJ, Eszterhas AJ, Brodbeck KC, Benovic JL, Panettieri RA, Jr. et al. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. Am J Respir Cell Mol Biol 2000; 23(4): 546-554.
125. Gosens R, Nelemans SA, Grootte Bromhaar MM, McKay S, Zaagsma J, Meurs H. Muscarinic M3-receptors mediate cholinergic synergism of mitogenesis in airway smooth muscle. Am J Respir Cell Mol Biol 2003; 28(2): 257-262. (Pubitemid 36169656)
126. Prenzel N, Zwick E, Daub H, Leserer M, Abraham R, Wallasch C et al. EGF receptor transactivation by G-protein- coupled receptors requires metalloproteinase cleavage of proHB-EGF. Nature 1999; 402: 884-888. (Pubitemid 30017171)
127. Tsai W, Morielli AD, Peralta EG. The m1 muscarinic acetylcholine receptor transactivates the EGF receptor to modulate ion channel activity. Embo J 1997; 16(15): 4597-4605. (Pubitemid 27326597)
128. Stirnweiss J, Valkova C, Ziesche E, Drube S, Liebmann C. Muscarinic M2 receptors mediate transactivation of EGF receptor through Fyn kinase and without matrix metalloproteases. Cell Signal 2006; 18(8): 1338-1349. (Pubitemid 43674036)
129. Cheng K, Zimniak P, Raufman JP. Transactivation of the epidermal growth factor receptor mediates cholinergic agonist-induced proliferation of H508 human colon cancer cells. Cancer Res 2003; 63(20): 6744-16450 (Pubitemid 37322954)
130. Garrett JR, Kidd A. The innervation of salivary glands as revealed by morphological methods. Microsc Res Tech 1993; 26(1): 75-91. (Pubitemid 23250464)
131. Ekstrom J. Autonomic control of salivary secretion. Proc Finn Dent Soc 1989; 85(4-5): 323-331; discussion 361-363.
132. Garrett JR. The proper role of nerves in salivary secretion: a review. J Dent Res 1987; 66(2): 387-397.
133. Ekstrom J. Role of nonadrenergic, noncholinergic autonomic transmitters in salivary glandular activities. In: Frontiers of Oral Biology, RWA Linden, (ed.), Basel, Karger; 1999, pp 94-130.
134. Edwards AV. Autonomic control of salivary blood flow. In: Frontiers of Oral Biology, RWA Linden, (ed.), Basel, Karger; 1999, pp 101-117.
135. Bloom SR, Edwards AV. Vasoactive intestinal peptide in relation to atropine resistant vasodilatation in the submaxillary gland of the cat. J Physiol 1980; 300: 41-53. (Pubitemid 10109667)
136. Lundberg JM, Anggard A, Fahrenkrug J, Hokfelt T, Mutt V. Vasoactive intestinal polypeptide in cholinergic neurons of exocrine glands: functional significance of coexisting transmitters for vasodilation and secretion. Proc Natl Acad Sci U S A 1980; 77(3): 1651-1655. (Pubitemid 10073819)
137. Lundberg JM, Anggard A, Fahrenkrug J. Complementary role of vasoactive intestinal polypeptide (VIP) and acetylcholine for cat submandibular gland blood flow and secretion. Acta Physiol Scand 1982; 114(3): 329-337.
138. Edwards AV, Garrett JR. Nitric oxide-related vasodilator responses to parasympathetic stimulation of the submandibular gland in the cat. J Physiol 1993; 464: 379-392. (Pubitemid 23169321)
139. Anderson LC, Garrett JR. Neural regulation of submandibular gland blood flow in the streptozotocindiabetic rat: evidence for impaired endothelium-dependent vasodilatation. Arch Oral Biol 2004; 49(3): 183-191. (Pubitemid 38157583)
140. Edwards AV, Tobin G, Ekstrom J, Bloom SR. Nitric oxide and release of the peptide VIP from parasympathetic terminals in the submandibular gland of the anaesthetized cat. Exp Physiol 1996; 81(3): 349-359. (Pubitemid 26163071)
141. Lung MA. Variations in blood flow on mandibular glandular secretion to autonomic nervous stimulations in anaesthetized dogs. J Physiol 1990; 431: 479-493.
142. Smaje LH, Gamble J. Transcapillary transport during secretion by the rabbit submandibular salivary gland. J Dent Res 1987; 66(2): 564-568.
143. Lung MA. Autonomic nervous control of venous pressure and secretion in submandibular gland of anesthetized dogs. Am J Physiol 1998; 275: G331-G341. (Pubitemid 128734902)
144. Thakor AS, Brown CN, Edwards AV. Effects of prolonged reduction in blood flow on submandibular secretory function in anesthetized sheep. J Appl Physiol 2003; 95(2): 751-757. (Pubitemid 36944301)
145. Baum BJ, Wellner RB. Receptors in salivary glands. In: Neuronal Mechanisms of Salivary Secretion. JR Garrett, J Ekstrom, LC Anderson (eds). Basel, Karger; 1999, pp 44-58.
146. Dai YS, Ambudkar IS, Horn VJ, Yeh CK, Kousvelari EE, Wall SJ et al. Evidence that M3 muscarinic receptors in rat parotid gland couple to two second messenger systems. Am J Physiol 1991; 261: C1063-C1073.
147. Bockman CS, Bradley ME, Dang HK, Zeng W, Scofield MA, Dowd FJ. Molecular and pharmacological characterization of muscarinic receptor subtypes in a rat parotid gland cell line: comparison with native parotid gland. J Pharmacol Exp Ther 2001; 297(2): 718-726. (Pubitemid 32378005)
148. Buckley NJ, Burnstock G. Autoradiographic localization of peripheral M1 muscarinic receptors using [3H]pirenzepine. Brain Res 1986; 375(1): 83-91. (Pubitemid 16062984)
149. Hammer R, Berrie CP, Birdsall NJ, Burgen AS, Hulme EC. Pirenzepine distinguishes between different subclasses of muscarinic receptors. Nature 1980; 283: 90-92. (Pubitemid 10170891)
150. Martos F, Monferini E, Giraldo E, De Paoli AM, Hammer R. Characterization of muscarinic receptors in salivary and lacrimal glands of the rat. Eur J Pharmacol 1987; 143(2): 189-194. (Pubitemid 17159933)
151. Vilaro MT, Palacios JM, Mengod G. Localization of m5 muscarinic receptor mRNA in rat brain examined by in situ hybridization histochemistry. Neurosci Lett 1990; 114(2): 154-159. (Pubitemid 20188950)
152. Flynn DD, Reever CM, Ferrari-DiLeo G. Pharmacological strategies to selectively label and localize muscarinic receptor subtypes. Drug Dev Res 1997; 40: 104-116. (Pubitemid 27281619)
153. Khosravani N, Ekman R, Ekstrom J. Acetylcholine synthesis, muscarinic receptor subtypes, neuropeptides and secretion of ferret salivary glands with special reference to the zygomatic gland. Arch Oral Biol 2007; 52(5): 417-426. (Pubitemid 46420315)
154. Mei L, Roeske WR, Izutsu KT, Yamamura HI. Characterization of muscarinic acetylcholine receptors in human labial salivary glands. Eur J Pharmacol 1990; 176(3): 367-370. (Pubitemid 20076291)
155. Ryberg AT, Warfvinge G, Axelsson L, Soukup O, Gotrick B, Tobin G. Expression of muscarinic receptor subtypes in salivary glands of rats, sheep and man. Arch Oral Biol 2008; 53(1): 66-74. (Pubitemid 350216088)
156. Tobin G. Muscarinic receptor subtypes in the submandibular gland and the urinary bladder of the rabbit: in vivo and in vitro functional comparisons of receptor antagonists. J Auton Pharmacol 1995; 15(6): 451-463. (Pubitemid 26106369)
157. Meloy TD, Daniels DV, Hegde SS, Eglen RM, Ford AP. Functional characterization of rat submaxillary gland muscarinic receptors using microphysiometry. Br J Pharmacol 2001; 132(7): 1606-1614. (Pubitemid 32281051)
158. Gautam D, Heard TS, Cui Y, Miller G, Bloodworth L, Wess J. Cholinergic stimulation of salivary secretion studied with M1 and M3 muscarinic receptor single- and doubleknockout mice. Mol Pharmacol 2004; 66(2): 260-267. (Pubitemid 38989482)
159. Nakamura T, Matsui M, Uchida K, Futatsugi A, Kusakawa S, Matsumoto N et al. M(3) muscarinic acetylcholine receptor plays a critical role in parasympathetic control of salivation in mice. J Physiol 2004; 558: 561-575. (Pubitemid 39117602)
160. Bymaster FP, McKinzie DL, Felder CC, Wess J. Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem Res 2003; 28: 437-442. (Pubitemid 36314830)
161. Takeuchi J, Fulton J, Jia ZP, Abramov-Newerly W, Jamot L, Sud M et al. Increased drinking in mutant mice with truncated M5 muscarinic receptor genes. Pharmacol Biochem Behav 2002; 72: 117-123. (Pubitemid 34251317)
162. Tobin G. Presynaptic muscarinic receptor mechanisms and submandibular responses to stimulation of the parasympathetic innervation in bursts in rats. Auton Neurosci 2002; 99(2): 111-118.
163. Andersson PO, Bloom SR, Edwards AV, Jarhult J. Effects of stimulation of the chorda tympani in bursts on submaxillary responses in the cat. J Physiol 1982; 322: 469-483. (Pubitemid 12177766)
164. Bloom SR, Edwards AV. The relationship between release of vasoactive intestinal peptide in the salivary gland of the cat in response to parasympathetic stimulation and the atropine resistant vasodilatation. J Physiol 1979; 295: 35-36. (Pubitemid 10248418)
165. Andersson PO, Bloom SR, Edwards AV. Parotid responses to stimulation of the parasympathetic innervation in bursts in weaned lambs. J Physiol 1982; 330: 163-174.
166. Tobin G, Ekstrom J, Edwards AV. Submandibular responses to stimulation of the parasympathetic innervation in bursts in the anaesthetized ferret. J Physiol (Lond) 1990; 431: 417-425.
167. Pedersen AM, Dissing S, Fahrenkrug J, Hannibal J, Reibel J, Nauntofte B. Innervation pattern and Ca2+ signalling in labial salivary glands of healthy individuals and patients with primary Sjogren's syndrome (pSS). J Oral Pathol Med 2000; 29(3): 97-109. (Pubitemid 30156929)
168. Dawson LJ, Field EA, Harmer AR, Smith PM. Acetylcholine-evoked calcium mobilization and ion channel activation in human labial gland acinar cells from patients with primary Sjogren's syndrome. Clin Exp Immunol 2001; 124(3): 480-485. (Pubitemid 32701712)
169. Cha S, Singson E, Cornelius J, Yagna JP, Knot HJ, Peck AB. Muscarinic acetylcholine type-3 receptor desensitization due to chronic exposure to Sjogren's syndrome-associated autoantibodies. J Rheumatol 2006; 33(2): 296-306. (Pubitemid 43209306)
170. Waterman SA, Gordon TP, Rischmueller M. Inhibitory effects of muscarinic receptor autoantibodies on parasympathetic neurotransmission in Sjogren's syndrome. Arthritis Rheum 2000; 43(7): 1647-1654. (Pubitemid 30452487)
171. Haarala M, Alanen A, Hietarinta M, Kiilholma P. Lower urinary tract symptoms in patients with Sjogren's syndrome and systemic lupus erythematosus. Int Urogynecol J Pelvic Floor Dysfunct 2000; 11(2): 84-86. (Pubitemid 30219291)
172. Beroukas D, Goodfellow R, Hiscock J, Jonsson R, Gordon TP, Waterman SA. Up-regulation of M3-muscarinic receptors in labial salivary gland acini in primary Sjogren's syndrome. Lab Invest 2002; 82(2): 203-210. (Pubitemid 34160457)
173. Wang F, Jackson MW, Maughan V, Cavill D, Smith AJ, Waterman SA et al. Passive transfer of Sjogren's syndrome IgG produces the pathophysiology of overactive bladder. Arthritis Rheum 2004; 50(11): 3637-3645. (Pubitemid 39488691)
174. Mignogna MD, Fedele S, Lo Russo L, Lo Muzio L, Wolff A. Sjogren's syndrome: the diagnostic potential of early oral manifestations preceding hyposalivation/xerostomia. J Oral Pathol Med 2005; 34(1): 1-6. (Pubitemid 40142922)
175. Mignogna MD, Fedele S, Lo Russo L, Lo Muzio L. Sialorrhoea as early oral clinical manifestation of primary Sjogren's syndrome? Rheumatology (Oxford) 2003; 42(9): 1113-1114. (Pubitemid 37221006)
176. Cook DI, Van Lennep EW, Roberts ML, Young JA. Secretion by the major salivary glands. In: Physiology of the Gastrointestinal Tract. LR Johnson (ed). New York, Raven Press, 1994, pp 1061-1117.
177. Edwards CM, Corkery PP, Edwards AV. Submandibular responses to stimulation of the parasympathetic innervation in anesthetized sheep. J Appl Physiol 2003; 95(4):1598-1605. (Pubitemid 37169306)
178. Emmelin N, Garrett JR, Ohlin P. Neural control of salivary myoepithelial cells. J Physiol 1968; 196(2): 381-396.
179. Ryberg AT, Selberg H, Soukup O, Gradin K, Tobin G. Cholinergic submandibular effects and muscarinic receptor expression in blood vessels of the rat. Arch Oral Biol 2008; 53(7): 605-616.
180. Ding X, Murray PA. Regulation of pulmonary venous tone in response to muscarinic receptor activation. Am J Physiol Lung Cell Mol Physiol 2005; 288(1): L131-L140. (Pubitemid 40023895)
181. Wang M, Lung MA. Acetylcholine induces contractile and relaxant effects in canine nasal venous systems. Eur Respir J 2006; 28(4): 839-846. (Pubitemid 46332006)
182. Berggreen E, Wiig H. Lowering of interstitial fluid pressure in rat submandibular gland: a novel mechanism in saliva secretion. Am J Physiol Heart Circ Physiol 2006; 290(4): H1460-H1468.
183. Smaje LH. Spontaneous salivation in the rabbit submandibular gland. J Physiol 1973; 231(1): 179-193.
184. Hanna-Mitchell AT, Beckel JM, Barbadora S, Kanai AJ, de Groat WC, Birder LA. Non-neuronal acetylcholine and urinary bladder urothelium. Life Sci 2007; 80(24-25): 2298-2302.
185. Kim DK, Prabhakar NR, Kumar GK. Acetylcholine release from the carotid body by hypoxia: evidence for the involvement of autoinhibitory receptors. J Appl Physiol 2004; 96(1): 376-383. (Pubitemid 38032024)
186. Kummer W, Haberberger R. Extrinsic and intrinsic cholinergic systems of the vascular wall. Eur J Morphol 1999; 37(4-5): 223-226. (Pubitemid 29510038)
187. Kirkpatrick CJ, Bittinger F, Unger RE, Kriegsmann J, Kilbinger H, Wessler I. The non-neuronal cholinergic system in the endothelium: evidence and possible pathobiological significance. Jpn J Pharmacol 2001; 85(1): 24-28. (Pubitemid 32149388)
188. Ekstrom J. Acetylcholine synthesis and its dependence on nervous activity. Experientia 1978; 34(10): 1247-1253. (Pubitemid 9025910)
189. Koop I, Squires PE, Meloche RM, Buchan AM. Effect of cholinergic agonists on gastrin release from primary cultures of human antral G cells. Gastroenterology 1997; 112(2): 357-363. (Pubitemid 27078822)
190. Li YY. Mechanisms for regulation of gastrin and somatostatin release from isolated rat stomach during gastric distention. World J Gastroenterol 2003; 9(1): 129-133. (Pubitemid 36131294)
191. Lawton DE, Simcock DC, Candy EJ, Simpson HV. Gastrin secretion by ovine antral mucosa in vitro. Comp Biochem Physiol A Mol Integr Physiol 2000; 126(2): 233-243. (Pubitemid 30628917)
192. Norlen P, Bernsand M, Konagaya T, Hakanson R. ECL-cell histamine mobilization in conscious rats: effects of locally applied regulatory peptides, candidate neurotransmitters and inflammatory mediators. Br J Pharmacol 2001; 134(8): 1767-1777. (Pubitemid 34038111)
193. Lindstrom E, Hakanson R. Neurohormonal regulation of secretion from isolated rat stomach ECL cells: a critical reappraisal. Regul Pept 2001; 97: 169-180. (Pubitemid 32119519)
194. Sachs G, Zeng N, Prinz C. Physiology of isolated gastric endocrine cells. Annu Rev Physiol 1997; 59: 243-256. (Pubitemid 27142441)
195. Sandor A, Kidd M, Lawton GP, Miu K, Tang LH, Modlin IM. Neurohormonal modulation of rat enterochromaffin-like cell histamine secretion. Gastroenterology 1996; 110(4): 1084-1092. (Pubitemid 26113748)
196. Aihara T, Nakamura Y, Taketo MM, Matsui M, Okabe S. Cholinergically stimulated gastric acid secretion is mediated by M(3) and M(5) but not M(1) muscarinic acetylcholine receptors in mice. Am J Physiol Gastrointest Liver Physiol 2005; 288(6): G1199-G1207. (Pubitemid 40741073)
197. Kajimura M, Reuben MA, Sachs G. The muscarinic receptor gene expressed in rabbit parietal cells is the M3 subtype. Gastroenterology 1992; 103(3): 870-875.
198. Schubert ML. Gastric secretion. Curr Opin Gastroenterol 2000; 16(6): 463-468. (Pubitemid 32511230)
199. Aihara T, Fujishita T, Kanatani K, Furutani K, Nakamura E, Taketo MM et al. Impaired gastric secretion and lack of trophic responses to hypergastrinemia in M3 muscarinic receptor knockout mice. Gastroenterology 2003; 125(6): 1774-1784. (Pubitemid 37500442)
200. Wada K, Sakamoto C, Matozaki T, Nishisaki H, Konda Y, Nakano O et al. M3 muscarinic receptors mediate pepsinogen secretion via polyphosphoinositide hydrolysis in guinea pig gastric chief cells. Gastroenterol Jpn 1992; 27(4): 473-481.
201. Xie G, Drachenberg C, Yamada M, Wess J, Raufman JP. Cholinergic agonist-induced pepsinogen secretion from murine gastric chief cells is mediated by M1 and M3 muscarinic receptors. Am J Physiol Gastrointest Liver Physiol 2005; 289(3): G521-G529. (Pubitemid 41216390)
202. Blandizzi C, Colucci R, Carignani D, Lazzeri G, Del Tacca M. Positive modulation of pepsinogen secretion by gastric acidity after vagal cholinergic stimulation. J Pharmacol Exp Ther 1997; 283(3): 1043-1050. (Pubitemid 28016475)
203. Rumessen JJ, Vanderwinden JM. Interstitial cells in the musculature of the gastrointestinal tract: Cajal and beyond. Int Rev Cytol 2003; 229: 115-208. (Pubitemid 41782964)
204. Ward SM, McLaren GJ, Sanders KM. Interstitial cells of Cajal in the deep muscular plexus mediate enteric motor neurotransmission in the mouse small intestine. J Physiol 2006; 573: 147-159. (Pubitemid 43670864)
205. Wang XY, Sanders KM, Ward SM. Relationship between interstitial cells of Cajal and enteric motor neurons in the murine proximal colon. Cell Tissue Res 2000; 302(3): 331-342.
206. Ward SM, Beckett EA, Wang X, Baker F, Khoyi M, Sanders KM. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. J Neurosci 2000; 20(4): 1393-1403. (Pubitemid 30220419)
207. Furness JB. Novel gut afferents: Intrinsic afferent neurons and intestinofugal neurons. Auton Neurosci 2006; 125(1-2): 81-85.
208. Burns AJ, Lomax AE, Torihashi S, Sanders KM, Ward SM. Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc Natl Acad Sci U S A 1996; 93(21): 12008-12013. (Pubitemid 26347239)
209. Suzuki T, Won KJ, Horiguchi K, Kinoshita K, Hori M, Torihashi S et al. Muscularis inflammation and the loss of interstitial cells of Cajal in the endothelin ETB receptor null rat. Am J Physiol Gastrointest Liver Physiol 2004; 287(3): G638-G646. (Pubitemid 39096631)
210. Torihashi S, Ward SM, Nishikawa S, Nishi K, Kobayashi S, Sanders KM. c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract. Cell Tissue Res 1995; 280(1): 97-111.
211. Stengel PW, Cohen ML. M1 receptor-mediated nitric oxide-dependent relaxation unmasked in stomach fundus from M3 receptor knockout mice. J Pharmacol Exp Ther 2003; 304(2): 675-682. (Pubitemid 36152344)
212. Moro E, Crema F, Dandolo C, De Ponti F, Frigo G. Effect of muscarinic receptor blockade on canine gastric tone and compliance in vivo. Pharmacol Res 2005; 51(4): 289-296. (Pubitemid 40430801)
213. Hammer R. Muscarinic receptors in the stomach. Scand J Gastroenterol Suppl 1980; 66: 5-11.
214. Lambrecht G, Gross J, Mutschler E. Neuronal somadendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci 1999; 64: 403-410. (Pubitemid 29066686)
215. Krokhina EM. Sympathetic innervation of the gastrointestinal tract of mammals. Arch Anat Microsc Morphol Exp 1973; 62(3): 307-321.
216. Takeuchi K, Niida H, Minami M, Okabe S. Determination of bicarbonate output using pH deflection in the rat duodenum: influences of prostaglandins and cholinergic agents. Jpn J Pharmacol 1990; 52(2): 225-232. (Pubitemid 20070265)
217. Hogan DL, Yao B, Steinbach JH, Isenberg JI. The enteric nervous system modulates mammalian duodenal mucosal bicarbonate secretion. Gastroenterology 1993; 105(2): 410-417. (Pubitemid 23213525)
218. Safsten B, Jedstedt G, Flemstrom G. Cholinergic influence on duodenal mucosal bicarbonate secretion in the anesthetized rat. Am J Physiol 1994; 267: G10-G17. (Pubitemid 2128235)
219. Takeuchi K, Niida H, Okabe S. Characterization of alkaline response induced by cholinergic agents in the rat duodenum: involvement of M2 receptors and the calciumdependent process. J Pharmacol Exp Ther 1990; 254(2): 465-470. (Pubitemid 20262082)
220. Ballesteros MA, Wolosin JD, Hogan DL, Koss MA, Isenberg JI. Cholinergic regulation of human proximal duodenal mucosal bicarbonate secretion. Am J Physiol 1991; 261: G327-G331.
221. Jonson C, Nylander O, Flemstrom G, Fandriks L. Vagal stimulation of duodenal HCO3(-)-secretion in anaesthetized rats. Acta Physiol Scand 1986; 128(1): 65-70.
222. Glad H, Svendsen P, Olsen O, Schaffalitzky de Muckadell OB. Importance of vagus nerves in duodenal acid neutralization in anesthetized pigs. Am J Physiol 1997; 272: G154-G160. (Pubitemid 127750002)
223. Forssell H, Stenquist B, Olbe L. Vagal stimulation of human gastric bicarbonate secretion. Gastroenterology 1985; 89(3): 581-586. (Pubitemid 15239162)
224. 2 as stimulants of human gastric bicarbonate secretion. Acta Physiol Scand 1988; 134(1): 75-78.
225. Konturek SJ, Thor P, Bilski J, Tasler J, Cieszkowski M. Cephalic phase of gastroduodenal alkaline secretion. Am J Physiol 1987; 252: G742-G747.
226. Larsen R, Hansen MB, Bindslev N, Mertz-Nielsen A. Functional characterization of muscarinic receptor subtypes in human duodenal secretion. Acta Physiol Scand 2004; 182(1): 63-68. (Pubitemid 39223067)
227. Jodal M, Hallback DA, Lundgren O. Tissue osmolality in intestinal villi during luminal perfusion with isotonic electrolyte solutions. Acta Physiol Scand 1978; 102(1): 94-107. (Pubitemid 8255580)
228. Jodal M, Lundgren O. Countercurrent mechanisms in the mammalian gastrointestinal tract. Gastroenterology 1986; 91(1): 225-241. (Pubitemid 16086679)
229. Karlstrom L, Jodal M, Lundgren O. Blood flow distribution, lymph flow, villus tissue osmolality and fluid and electrolyte transport after exposing the cat small intestine to sodium deoxycholate. Acta Physiol Scand 1986; 128(1): 83-96. (Pubitemid 16023711)
230. Furness JB. The organisation of the autonomic nervous system: peripheral connections. Auton Neurosci 2006; 130: 1-5.
231. Sjovall H, Redfors S, Hallback DA, Eklund S, Jodal M, Lundgren O. The effect of splanchnic nerve stimulation on blood flow distribution, villous tissue osmolality and fluid and electrolyte transport in the small intestine of the cat. Acta Physiol Scand 1983; 117(3): 359-365.
232. Sjovall H, Brunsson I, Jodal M, Lundgren O. The effect of vagal nerve stimulation on net fluid transport in the small intestine of the cat. Acta Physiol Scand 1983; 117(3): 351-357.
233. Greenwood B, Read NW. Vagal control of fluid transport, transmural potential difference, and motility in the ferret jejunum. Am J Physiol 1985; 249: G651-G654.
234. Greenwood B, Davison JS. Investigation of the vagally induced changes in transmural potential difference in the ferret jejunum in vivo. J Auton Nerv Syst 1987; 19(2): 113-118. (Pubitemid 17068483)
235. Barrett KE, Keely SJ. Chloride secretion by the intestinal epithelium: molecular basis and regulatory aspects. Annu Rev Physiol 2000; 62: 535-572. (Pubitemid 30618274)
236. Hulten L, Jodal M, Lundgren O. The effects of graded electrical stimulation or reflex activation of the sympathetic and the parasympathetic nerve supply on the regional blood flow in cat colon. Bibl Anat 1969; 10: 312-315.
237. Wright RD, Florey HW, Jennings MA. The secretion of the colon of the cat. Q J Exp Physiol Cogn Med Sci 1938; 28(3): 207-229.
238. Zimmerman TW, Dobbins JW, Binder HJ. Mechanism of cholinergic regulation of electrolyte transport in rat colon in vitro. Am J Physiol 1982; 242(2): G116-G123.
239. Zimmerman TW, Binder HJ. Muscarinic receptors on rat isolated colonic epithelial cells. A correlation between inhibition of [3H]quinuclidinyl benzilate binding and alteration in ion transport. Gastroenterology 1982; 83(6): 1244-1251. (Pubitemid 13235924)
240. Rimele TJ, O'Dorisio MS, Gaginella TS. Evidence for muscarinic receptors on rat colonic epithelial cells: binding of [3H]quinuclidinyl benzilate. J Pharmacol Exp Ther 1981; 218(2): 426-434. (Pubitemid 11044119)
241. Isaacs PE, Whitehead JS, Kim YS. Muscarinic acetylcholine receptors of the small intestine and pancreas of the rat: distribution and the effect of vagotomy. Clin Sci (Lond) 1982; 62(2): 203-207. (Pubitemid 12189774)
242. Wahawisan R, Wallace LJ, Gaginella TS. Muscarinic receptors on rat ileal villus and crypt cells. J Pharm Pharmacol 1986; 38(2): 150-153. (Pubitemid 16146075)
243. Cooke HJ. Neurobiology of the intestinal mucosa. Gastroenterology 1986; 90(4): 1057-1081. (Pubitemid 16124789)
244. Mellander A, Abrahamsson H, Sjovall H. The migrating motor complex - the motor component of a cholinergic enteric secretomotor programme? Acta Physiol Scand 1995; 154(3): 329-341.
245. Lundgren O, Jodal M. The enteric nervous system and cholera toxin-induced secretion. Comp Biochem Physiol A Physiol 1997; 118(2): 319-327. (Pubitemid 27439172)
246. Lindqvist SM, Sharp P, Johnson IT, Satoh Y, Williams MR. Acetylcholine-induced calcium signaling along the rat colonic crypt axis. Gastroenterology 1998; 115(5): 1131-1143. (Pubitemid 28485604)
247. Lindqvist S, Hernon J, Sharp P, Johns N, Addison S, Watson M et al. The colon-selective spasmolytic otilonium bromide inhibits muscarinic M(3) receptor-coupled calcium signals in isolated human colonic crypts. Br J Pharmacol 2002; 137(7): 1134-1142. (Pubitemid 35440754)
248. Specian RD, Neutra MR. Regulation of intestinal goblet cell secretion. I. Role of parasympathetic stimulation. Am J Physiol 1982; 242(4): G370-G379.
249. Phillips TE, Phillips TH, Neutra MR. Regulation of intestinal goblet cell secretion. IV. Electrical field stimulation in vitro. Am J Physiol 1984; 247: G682-G687.
250. Mantle M, Thakore E, Mathison R, Davison JS. Intestinal mucin secretion in streptozotocin-diabetic rats: lack of response to cholinergic stimulation and cholera toxin. Dig Dis Sci 1991; 36(11): 1574-1581.
251. Moore BA, Sharkey KA, Mantle M. Neural mediation of cholera toxin-induced mucin secretion in the rat small intestine. Am J Physiol 1993; 265: G1050-G1056. (Pubitemid 2033635)
252. Moore BA, Sharkey KA, Mantle M. Role of 5-HT in cholera toxin-induced mucin secretion in the rat small intestine. Am J Physiol 1996; 270: G1001-G1009. (Pubitemid 126756951)
253. Furuya S, Naruse S, Hayakawa T. Intravenous injection of guanylin induces mucus secretion from goblet cells in rat duodenal crypts. Anat Embryol (Berl) 1998; 197(5): 359-367. (Pubitemid 28220943)
254. Kanno H, Horikawa Y, Hodges RR, Zoukhri D, Shatos MA, Rios JD et al. Cholinergic agonists transactivate EGFR and stimulate MAPK to induce goblet cell secretion. Am J Physiol Cell Physiol 2003; 284(4): C988-C998. (Pubitemid 36336955)
255. Specian RD, Neutra MR. Mechanism of rapid mucus secretion in goblet cells stimulated by acetylcholine. J Cell Biol 1980; 85(3): 626-640. (Pubitemid 10007432)
256. Greenwood B, Mantle M. Mucin and protein release in the rabbit jejunum: effects of bethanechol and vagal nerve stimulation. Gastroenterology 1992; 103(2): 496-505.
257. Rios JD, Forde K, Diebold Y, Lightman J, Zieske JD, Dartt DA. Development of conjunctival goblet cells and their neuroreceptor subtype expression. Invest Ophthalmol Vis Sci 2000; 41(8): 2127-2137. (Pubitemid 30450984)
258. Motterle L, Diebold Y, Enriquez de Salamanca A, Saez V, Garcia-Vazquez C, Stern ME et al. Altered expression of neurotransmitter receptors and neuromediators in vernal keratoconjunctivitis. Arch Ophthalmol 2006; 124(4): 462-468.
259. Bjerknes M, Cheng H. Modulation of specific intestinal epithelial progenitors by enteric neurons. Proc Natl Acad Sci U S A 2001; 98(22): 12497-12502. (Pubitemid 33019974)
260. th ed. Philadelphia, W. B. Saunders; 1957.
261. Sundstrom G, Helander HF. Quantitative electron microscopic studies on rat ileal Paneth cells under various physiological and experimental conditions. Hepatogastroenterology 1980; 27(4): 286-293. (Pubitemid 10056095)
262. Satoh Y. Atropine inhibits the degranulation of Paneth cells in ex-germ-free mice. Cell Tissue Res 1988; 253(2): 397-402. (Pubitemid 18165764)
263. Satoh Y, Ishikawa K, Oomori Y, Takeda S, Ono K. Bethanechol and a G-protein activator, NaF/AlCl3, induce secretory response in Paneth cells of mouse intestine. Cell Tissue Res 1992; 269(2): 213-220.
264. Satoh Y, Ono K, Moutairou K. Paneth cells of African giant rats (Cricetomys gambianus). Acta Anat (Basel) 1994; 151(1): 49-53. (Pubitemid 24359558)
265. Gosling JA, Dixon JS. The structure and innervation of smooth muscle in the wall of the bladder neck and proximal urethra. Br J Urol 1975; 47(5): 549-558.