Increased carnitine palmitoyl transferase 1 expression and decreased sterol regulatory element-binding protein 1c expression are associated with reduced intramuscular triglyceride accumulation after insulin therapy in high-fat-diet and streptozotocin-induced diabetic rats

Metabolism: Clinical and Experimental

Volumn 58, Issue 6, 2009, Pages 779-786

  Bi, Yan ^a   Cai, Mengyin ^a   Liang, Hua ^a   Sun, Weiping ^a   Li, Xiubin ^a   Wang, Chunxia ^a   Zhu, Yanhua ^a   Chen, Xiang ^a   Li, Ming ^a   Weng, Jianping ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CARNITINE PALMITOYLTRANSFERASE I; CD36 ANTIGEN; FATTY ACID BINDING PROTEIN; FATTY ACID TRANSPORTER; GLICLAZIDE; ISOPHANE INSULIN; LIPOPROTEIN LIPASE; STAT3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; INSULIN TREATMENT; LIPID DIET; LIPID METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SKELETAL MUSCLE; STREPTOZOCIN DIABETES; UPREGULATION;

ANIMALS; CARNITINE O-PALMITOYLTRANSFERASE; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; GENE EXPRESSION REGULATION; INSULIN; LIPID METABOLISM; LIPOPROTEIN LIPASE; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STREPTOZOCIN; TRIGLYCERIDES;

EID: 65549167291     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.01.011     Document Type: Article

References (36)

1. Savage D.B., Petersen K.F., and Shulman G.I. Mechanisms of insulin resistance in humans and possible links with inflammation. Hypertension 45 (2005) 828-833
2. Krebs M., and Roden M. Molecular mechanisms of lipid-induced insulin resistance in muscle, liver and vasculature. Diabetes Obes Metab 7 (2005) 621-632
3. McGarry J.D. Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51 (2002) 7-18
4. Preiss-Landl K., Zimmermann R., Hammerle G., et al. Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism. Curr Opin Lipidol 13 (2002) 471-481
5. Voshol P.J., Jong M.C., Dahlmans V.E., et al. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes 50 (2001) 2585-2590
6. Kim J.K., Fillmore J.J., Chen Y., et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci U S A 98 (2001) 7522-7527
7. Blaak E.E. Fatty acid metabolism in obesity and type 2 diabetes mellitus. Proc Nutr Soc 62 (2003) 753-760
8. Henry R.R., Ciaraldi T.P., Abrams-Carter L., et al. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. J Clin Invest 98 (1996) 1231-1236
9. Kelley D.E., and Mandarino L.J. Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49 (2000) 677-683
10. Petersen K.F., Dufour S., Befroy D., et al. Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes. N Engl J Med 350 (2004) 664-671
11. Petersen K.F., Befroy D., Dufour S., et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science 300 (2003) 1140-1142
12. Simoneau J.A., Veerkamp J.H., Turcotte L.P., et al. Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J 13 (1999) 2051-2060
13. Kim J.Y., Hickner R.C., Cortright R.L., et al. Lipid oxidation is reduced in obese human skeletal muscle. Am J Physiol Endocrinol Metab 279 (2000) E1039-E1044
14. Rasmussen B.B., Holmback U.C., Volpi E., et al. Malonyl coenzyme A and the regulation of functional carnitine palmitoyltransferase-1 activity and fat oxidation in human skeletal muscle. J Clin Invest 110 (2002) 1687-1693
15. Tsintzas K., Jewell K., Kamran M., et al. Differential regulation of metabolic genes in skeletal muscle during starvation and refeeding in humans. J Physiol l575 (2006) 291-303
16. Gosmain Y., Dif N., Berbe V., et al. Regulation of SREBP-1 expression and transcriptional action on HKII and FAS genes during fasting and refeeding in rat tissues. J Lipid Res 46 (2005) 697-705
17. Guillet-Deniau I., Pichard A.L., Kone A., et al. Glucose induces de novo lipogenesis in rat muscle satellite cells through a sterol-regulatory-element-binding-protein-1c-dependent pathway. J Cell Sci 117 (2004) 1937-1944
18. Guillet-Deniau I., Mieulet V., Le Lay S., et al. Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression. Diabetes 51 (2002) 1722-1728
19. Commerford S.R., Peng L., Dube J.J., et al. In vivo regulation of SREBP-1c in skeletal muscle: effects of nutritional status, glucose, insulin, and leptin. Am J Physiol Regul Integr Comp Physiol l287 (2004) R218-R227
20. Slawik M., and Vidal-Puig A.J. Lipotoxicity, overnutrition and energy metabolism in aging. Ageing Res Rev 5 (2006) 144-164
21. Li Y., Xu W., Liao Z., et al. Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients is associated with improvement of beta-cell function. Diabetes Care 27 (2004) 2597-2602
22. Weng J., Li Y., Xu W., et al. Effect of intensive insulin therapy on beta-cell function and glycaemic control in patients with newly diagnosed type 2 diabetes: a multicentre randomised parallel-group trial. Lancet 371 (2008) 1753-1760
23. Bi Y., Sun W.P., Chen X., et al. Effect of early insulin therapy on nuclear factor kappaB and cytokine gene expressions in the liver and skeletal muscle of high-fat diet, streptozotocin-treated diabetic rats. Acta Diabetol 45 (2008) 167-178
24. Reed M.J., Meszaros K., Entes L.J., et al. A new rat model of type 2 diabetes: the fat-fed, streptozotocin-treated rat. Metabolism 49 (2000) 1390-1394
25. Goodpaster B.H., He J., Watkins S., et al. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86 (2001) 5755-5761
26. Prentki M., Joly E., El-Assaad W., et al. Malonyl-CoA signaling, lipid partitioning, and glucolipotoxicity: role in beta-cell adaptation and failure in the etiology of diabetes. Diabetes 51 (2002) S405-S413
27. Kim J.A., Wei Y., and Sowers J.R. Role of mitochondrial dysfunction in insulin resistance. Circ Res 102 (2008) 401-414
28. Liu H.Y., Zheng G., Zhu H., and Woldegiorgis G. Hormonal and nutritional regulation of muscle carnitine palmitoyltransferase I gene expression in vivo. Arch Biochem Biophys 465 (2007) 437-442
29. Schenk S., and Horowitz J.F. Coimmunoprecipitation of FAT/CD36 and CPT I in skeletal muscle increases proportionally with fat oxidation after endurance exercise training. Am J Physiol Endocrinol Metab 291 (2006) E254-E260
30. Campbell S.E., Tandon N.N., Woldegiorgis G., et al. A novel function for fatty acid translocase (FAT)/CD36: involvement in long chain fatty acid transfer into the mitochondria. J Biol Chem 279 (2004) 36235-36241
31. Raghow R., Yellaturu C., Deng X., et al. SREBPs: the crossroads of physiological and pathological lipid homeostasis. Trends Endocrinol Meta 19 (2008) 65-73
32. Ducluzeau P.H., Perretti N., Laville M., et al. Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 50 (2001) 1134-1142
33. Nadeau K.J., Leitner J.W., Gurerich I., et al. Insulin regulation of sterol regulatory element-binding protein-1 expression in L-6 muscle cells and 3T3 L1 adipocytes. J Biol Chem 279 (2004) 34380-34387
34. Sewter C., Berger D., Considine R.V., et al. Human obesity and type 2 diabetes are associated with alterations in SREBP1 isoform expression that are reproduced ex vivo by tumor necrosis factor-alpha. Diabetes 51 (2002) 1035-1041
35. Lawler Jr. J.F., Yin M., Diehl A.M., et al. Tumor necrosis factor-alpha stimulates the maturation of sterol regulatory element binding protein-1 in human hepatocytes through the action of neutral sphingomyelinase. J Biol Chem 273 (1998) 5053-5059
36. Schoonjans K., Gelman L., Haby C., et al. Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes. J Mol Biol l304 (2000) 323-334