Lipoprotein lipase: The regulation of tissue specific expression and its role in lipid and energy metabolism

Current Opinion in Lipidology

Volumn 13, Issue 5, 2002, Pages 471-481

  Preiss Landl, Karina ^a   Zimmermann, Robert ^a   Hämmerle, Günter ^a   Zechner, Rudolf ^a  

^a UNIVERSITY OF GRAZ   (Austria)

Author keywords

Atherosclerosis; Lipoprotein lipase; Obesity; Tissue specific regulation

Indexed keywords

FATTY ACID; GLUCOSE; INSULIN; LIPOPROTEIN LIPASE; TRIACYLGLYCEROL;

ADIPOSE TISSUE; CORRELATION ANALYSIS; DISEASE PREDISPOSITION; ENERGY METABOLISM; ENZYME ACTIVITY; ENZYME REGULATION; GENETIC TRANSCRIPTION; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPID METABOLISM; MACROPHAGE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; TISSUE SPECIFICITY; ANIMAL; ANTIBODY SPECIFICITY; ARTERIOSCLEROSIS; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM;

ANIMALIA;

ANIMALS; ARTERIOSCLEROSIS; ENERGY METABOLISM; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; LIPID METABOLISM; LIPOPROTEIN LIPASE; OBESITY; ORGAN SPECIFICITY;

EID: 0036775676     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-200210000-00002     Document Type: Review

References (121)

1. Goldberg IJ. Lipoprotein lipase and lipolysis: central roles in lipoprotein metabolism and atherogenesis. J Lipid Res 1996; 37:693-707.
2. Semenkovich CF, Chen SH, Wims M, et al. Lipoprotein lipase and hepatic lipase mRNA tissue specific expression, developmental regulation, and evolution. J Lipid Res 1989; 30:423-431.
3. Yacoub LK, Vanni TM, Goldberg IJ. Lipoprotein lipase mRNA in neonatal and adult mouse tissues: comparison of normal and combined lipase deficiency (cld) mice assessed by in situ hybridization. J Lipid Res 1990; 31:1845-1852.
4. Merkel M, Weinstock PH, Chajek-Shaul T, et al. Lipoprotein lipase expression exclusively in liver. A mouse model for metabolism in the neonatal period and during cachexia. J Clin Invest 1998; 102:893-901.
5. Merkel M, Kako Y, Radner H, et al. Catalytically inactive lipoprotein lipase expression in muscle of transgenic mice increases very low density lipoprotein uptake: direct evidence that lipoprotein lipase bridging occurs in vivo. Proc Natl Acad Sci USA 1998; 95:13841-13846.
6. Merkel M, Heeren J, Dudeck W, et al. Inactive lipoprotein lipase (LPL) alone increases selective cholesterol ester uptake in vivo, whereas in the presence of active LPL it also increases triglyceride hydrolysis and whole particle lipoprotein uptake. J Biol Chem 2002; 277:7405-7411.
7. Medh JD, Bowen SL, Fry GL, et al. Lipoprotein lipase binds to low density lipoprotein receptors and induces receptor-mediated catabolism of very low density lipoproteins in vitro. J Biol Chem 1996; 271:17073-17080.
8. Takahashi S, Suzuki J, Kohno M, et al. Enhancement of the binding of triglyceride-rich lipoproteins to the very low density lipoprotein receptor by apolipoprotein E and lipoprotein lipase. J Biol Chem 1995; 270:15747-157454.
9. Kounnas MZ, Chappell DA, Strickland DK, et al. Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro. J Biol Chem 1993; 268:14176-141781.
10. Beisiegel U, Weber W, Bengtsson-Olivecrona G. Lipoprotein lipase enhances the binding of chylomicrons to low density lipoprotein receptor related protein. Proc Natl Acad Sci USA 1991; 88:8342-8346.
11. Seo T, Al-Haideri M, Treskova E, et al. Lipoprotein lipase-mediated selective uptake from low density lipoprotein requires cell surface proteoglycans and is independent of scavenger receptor class B type 1. J Biol Chem 2000; 275:30355-30362.
12. Sattler W, Levak-Frank S, Radner H, et al. Muscle-specific overexpression of lipoprotein lipase in transgenic mice results in increased alpha-tocopherol levels in skeletal muscle. Biochem J 1996; 318:15-19.
13. van Bennekum AM, Kako Y, Weinstock PH, et al. Lipoprotein lipase expression level influences tissue clearance of chylomicron retinyl ester. J Lipid Res 1999; 40:565-574.
14. Greenwood MR. The relationship of enzyme activity to feeding behavior in rats: lipoprotein lipase as the metabolic gatekeeper. Int J Obes 1985; 9(Suppl 1):67-70.
15. Pentikainen MO, Oksjoki R, Oorni K, et al. Lipoprotein lipase in the arterial wall: linking LDL to the arterial extracellular matrix and much more. Arterioscler Thromb Vasc Biol 2002; 22:211-217.
16. Cruz WS, Kwon G, Marshall CA, et al. Glucose and insulin stimulate heparin-releasable lipoprotein lipase activity in mouse islets and INS-1 cells. A potential link between insulin resistance and beta-cell dysfunction. J Biol Chem 2001; 276:12162-12168.
17. Kim JK, Fillmore JJ, Chen Y, et al. Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance. Proc Natl Acad Sci USA 2001; 98:7522-7527.
18. Bey L, Etienne J, Tse C, et al. Cloning, sequencing and structural analysis of 976 base pairs of the promoter sequence for the rat lipoprotein lipase gene. Comparison with the mouse and human sequences. Gene 1998; 209:31-38.
19. Linhart HG, Ishimura-Oka K, DeMayo F, et al. C/EBPalpha is required for differentiation of white, but not brown, adipose tissue. Proc Natl Acad Sci USA 2001; 98:12532-12537.
20. Gimble JM, Hua X, Wanker F, et al. In vitro and in vivo analysis of murine lipoprotein lipase gene promoter: tissue-specific expression. Am J Physiol 1995; 268:E213-E218.
21. Nakshatri H, Nakshatri P. Currie RA. Interaction of Oct-1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter. J Biol Chem 1995; 270:19613-19623.
22. Currie RA, Eckel RH. Characterization of a high affinity octamer transcription factor binding site in the human lipoprotein lipase promoter. Arch Biochem Biophys 1992; 298:630-639.
23. Yang WS, Nevin DN, Iwasaki L, et al. Regulatory mutations in the human lipoprotein lipase gene in patients with familial combined hyperlipidemia and coronary artery disease. J Lipid Res 1996; 37:2627-2637.
24. Morin CL, Schlaepfer IR, Eckel RH. Tumor necrosis factor-alpha eliminates binding of NF-Y and an octamer-binding protein to the lipoprotein lipase promoter in 3T3-L1 adipocytes. J Clin Invest 1995; 95:1684-1689.
25. Currie RA. NF-Y is associated with the histone acetyltransferases GCN5 and P/CAF. J Biol Chem 1998; 273:1430-1434.
26. Zlatanova J, Caiafa P, Van Holde K. Linker histone binding and displacement: versatile mechanism for transcriptional regulation. FASEB J 2000; 14:1697-1704.
27. Philipsen S, Suske G. A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res 1999; 27:2991-3000.
28. Yang WS, Deeb SS. Sp1 and Sp3 transactivate the human lipoprotein lipase gene promoter through binding to a CT element: synergy with the sterol regulatory element binding protein and reduced transactivation of a naturally occurring promoter variant. J Lipid Res 1998; 39:2054-2064.
29. Schoonjans K, Gelman L, Haby C, et al. Induction of LPL gene expression by sterols is mediated by a sterol regulatory element and is independent of the presence of multiple E boxes. J Mol Biol 2000; 304:323-334.
30. Hughes TR, Tengku-Muhammad TS, Irvine SA, et al. A novel role of Sp1 and Sp3 in the interferon-gamma-mediated suppression of macrophage lipoprotein lipase gene transcription. J Biol Chem 2002; 277:11097-11106.
31. Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, et al. PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 1996; 15:5336-5348.
32. Braissant O, Foufelle F, Scotto C, et al. Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 1996; 137:354-366.
33. Barbier O, Torra IP, Duguay Y, et al. Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol 2002; 22:717-726.
34. Vidal-Puig AJ, Considine RV, Jimenez-Linan M, et al. Peroxisome proliferator-activated receptor gene expression in human tissues. Effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 1997; 99:2416-2422.
35. Torra IP, Chinetti G, Duval C, et al. Peroxisome proliferator-activated receptors: from transcriptional control to clinical practice. Curr Opin Lipidol 2001; 12:245-254.
36. Hauser S, Adelmant G, Sarraf P, et al. Degradation of the peroxisome proliferator-activated receptor gamma is linked to ligand-dependent activation. J Biol Chem 2000; 275:18527-18533.
37. Hirotani M, Tsukamoto T, Bourdeaux J, et al. Stabilization of peroxisome proliferator-activated receptor alpha by the ligand. Biochem Biophys Res Commun 2001; 288:106-110.
38. Blanquart C, Barbier O, Fruchart JC, et al. Peroxisome proliferator-activated receptor alpha (PPARalpha) turnover by the ubiquitin-proteasome system controls the ligand-induced expression level of its target genes. J Biol Chem (in press).
39. Tanuma Y, Nakabayashi H, Esumi M, et al. A silencer element for the lipoprotein lipase gene promoter and cognate double- and single-stranded DNA-binding proteins. Mol Cell Biol 1995; 15:517-523.
40. Robinson CE, Wu X, Nawaz Z, et al. A corepressor and chicken ovalbumin upstream promoter transcriptional factor proteins modulate peroxisome proliferator-activated receptor-gamma2/retinoid X receptor alpha-activated transcription from the murine lipoprotein lipase promoter. Endocrinology 1999; 140:1586-1593.
41. Zhang Y, Repa JJ, Gauthier K, et al. Regulation of lipoprotein lipase by the oxysterol receptors, LXRalpha and LXRbeta. J Biol Chem 2001; 276:43018-43024.
42. Schoonjans K, Staels B, Devos P, et al. Developmental extinction of liver lipoprotein lipase mRNA expression might be regulated by an NF-1-like site. FEBS Lett 1993; 329:89-95.
43. Sartippour MR, Lambert A, Laframboise M, et al. Stimulatory effect of glucose on macrophage lipoprotein lipase expression and production. Diabetes 1998; 47:431-438.
44. Homma H, Kurachi H, Nishio Y, et al. Estrogen suppresses transcription of lipoprotein lipase gene. Existence of a unique estrogen response element on the lipoprotein lipase promoter. J Biol Chem 2000; 275:11404-11411.
45. Zhang W, Bensadoun A. Identification of a silencing element in the chicken lipoprotein lipase gene promoter: characterization of the silencer-binding protein and delineation of its target nucleotide sequence. Biochim Biophys Acta 1999; 1436:390-404.
46. Levak-Frank S, Hofmann W, Weinstock PH, et al. Induced mutant mouse lines that express lipoprotein lipase in cardiac muscle, but not in skeletal muscle and adipose tissue, have normal plasma triglyceride and high-density lipoprotein-cholesterol levels. Proc Natl Acad Sci USA 1999; 96:3165-3170.
47. Michaud SE, Renier G. Direct regulatory effect of fatty acids on macrophage lipoprotein lipase: potential role of PPARs. Diabetes 2001; 50:660-666.
48. Ranganathan G, Vu D, Kern PA. Translational regulation of lipoprotein lipase by epinephrine involves a trans-acting binding protein interacting with the 3′ untranslated region. J Biol Chem 1997; 272:2515-2519.
49. Ranganathan G, Li C, Kern PA. The translational regulation of lipoprotein lipase in diabetic rats involves the 3′-untranslated region of the lipoprotein lipase mRNA. J Biol Chem 2000; 275:40986-40991.
50. Ranganathan G, Kaakaji R, Kern PA. Role of protein kinase C in the translational regulation of lipoprotein lipase in adipocytes. J Biol Chem 1999; 274:9122-9127.
51. Ben-Zeev O, Doolittle MH, Davis RC, et al. Maturation of lipoprotein lipase. Expression of full catalytic activity requires glucose trimming but not translocation to the cis-Golgi compartment. J Biol Chem 1992; 267:6219-6227.
52. Masuno H, Blanchette-Mackie EJ, Schultz CJ, et al. Retention of glucose by N-linked oligosaccharide chains impedes expression of lipoprotein lipase activity: effect of castanospermine. J Lipid Res 1992; 33:1343-1349.
53. Park JW, Blanchette-Mackie EJ, Scow RO. Brefeldin A enables synthesis of active lipoprotein lipase in cld/cld and castanospermine-treated mouse brown adipocytes via translocation of Golgi components to endoplasmic reticulum. Biochem J 1996; 317:125-134.
54. Vannier C, Ailhaud G. Biosynthesis of lipoprotein lipase in cultured mouse adipocytes. II. Processing, subunit assembly, and intracellular transport. J Biol Chem 1989; 264:13206-13216.
55. Ben-Zeev O, Mao HZ, Doolittle MH. Maturation of lipoprotein lipase in the endoplasmic reticulum. Concurrent formation of functional dimers and inactive aggregates. J Biol Chem 2002; 277:10727-10738.
56. Bergo M, Olivecrona G, Olivecrona T. Forms of lipoprotein lipase in rat tissues: in adipose tissue the proportion of inactive lipase increases on fasting. Biochem J 1996; 313:893-898.
57. Gbaguidi FG, Chinetti G, Milosavljevic D, et al. Peroxisome proliferator-activated receptor (PPAR) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages. FEBS Lett 2002; 512:85-90.
58. Davies PJ, Berry SA, Shipley GL, et al. Metabolic effects of rexinoids: tissue-specific regulation of lipoprotein lipase activity. Mol Pharmacol 2001; 59:170-176.
59. Ewart HS, Severson DL. Insulin and dexamethasone stimulation of cardiac lipoprotein lipase activity involves the actin-based cytoskeleton. Biochem J 1999; 340:485-490.
60. Bergo M, Wu G, Ruge T, et al. Down-regulation of adipose tissue lipoprotein lipase during fasting requires that a gene, separate from the lipase gene, is switched on. J Biol Chem 2002; 277:11927-11932.
61. Austin MA, Hokanson JE, Edwards KL. Hypertriglyceridemia as a cardiovascular risk factor. Am J Cardiol 1998; 81:7B-12B.
62. Wilson DE, Emi M, Iverius PH, et al. Phenotypic expression of heterozygous lipoprotein lipase deficiency in the extended pedigree of a proband homozygous for a missense mutation. J Clin Invest 1990; 86:735-750.
63. Bijvoet S, Gagne SE, Moorjani S, et al. Alterations in plasma lipoproteins and apolipoproteins before the age of 40 in heterozygotes for lipoprotein lipase deficiency. J Lipid Res 1996; 37:640-650.
64. Nordestgaard BG, Abildgaard S, Wittrup HH, et al. Heterozygous lipoprotein lipase deficiency: frequency in the general population, effect on plasma lipid levels, and risk of ischemic heart disease. Circulation 1997; 96:1737-1744.
65. Gehrisch S. Common mutations of the lipoprotein lipase gene and their clinical significance. Curr Atheroscler Rep 1999; 1:70-78.
66. Kern PA, Ranganathan S, Li C, et al. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am J Physiol Endocrinol Metab 2001; 280:E745-E751.
67. Levak-Frank S, Weinstock PH, Hayek T, et al. Induced mutant mice expressing lipoprotein lipase exclusively in muscle have subnormal triglycerides yet reduced high density lipoprotein cholesterol levels in plasma. J Biol Chem 1997; 272:17182-17190.
68. Brunzell JD. Familial lipoprotein lipase deficiency and other causes of the chylomicronemia syndrom. The Metabolic and Molecular Bases of Inherited Disease 1995; 11:1913-1932.
69. Strauss JG, Frank S, Kratky D, et al. Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice. J Biol Chem 2001; 276:36083-36090.
70. Bodzioch M, Orso E, Klucken J, et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet 1999; 22:347-351.
71. Rust S, Rosier M, Funke H, et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet 1999; 22:352-355.
72. Brooks-Wilson A, Marcil M, Clee SM, et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet 1999; 22:336-345.
73. Shimada M, Ishibashi S, Inaba T, et al. Suppression of diet-induced atherosclerosis in low density lipoprotein receptor knockout mice overexpressing lipoprotein lipase. Proc Natl Acad Sci USA 1996; 93:7242-7246.
74. Yagyu H, Ishibashi S, Chen Z, et al. Overexpressed lipoprotein lipase protects against atherosclerosis in apolipoprotein E knockout mice. J Lipid Res 1999; 40:1677-1685.
75. Fan J, Unoki H, Kojima N, et al. Overexpression of lipoprotein lipase in transgenic rabbits inhibits diet-induced hypercholesterolemia and atherosclerosis. J Biol Chem 2001; 276:40071-40079.
76. Van Eck M, Zimmermann R, Groot PH, et al. Role of macrophage-derived lipoprotein lipase in lipoprotein metabolism and atherosclerosis. Arterioscler Thromb Vasc Biol 2000; 20:E53-E62.
77. Babaev VR, Fazio S, Gleaves LA, et al. Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in vivo. J Clin Invest 1999; 103:1697-1705.
78. Rutledge JC, Woo MM, Rezai AA, et al. Lipoprotein lipase increases lipoprotein binding to the artery wall and increases endothelial layer permeability by formation of lipolysis products. Circ Res 1997; 80:819-828.
79. Hendriks WL, van der Boom H, van Vark LC, et al. Lipoprotein lipase stimulates the binding and uptake of moderately oxidized low-density lipoprotein by J774 macrophages. Biochem J 1996; 314:563-568.
80. Wang X, Greilberger J, Levak-Frank S, et al. Endogenously produced lipoprotein lipase enhances the binding and cell association of native, mildly oxidized and moderately oxidized low-density lipoprotein in mouse peritoneal macrophages. Biochem J 1999; 343:347-353.
81. Wang X, Greilberger J, Jurgens G. Calcium and lipoprotein lipase synergistically enhance the binding and uptake of native and oxidized LDL in mouse peritoneal macrophages. Atherosclerosis 2000; 150:357-363.
82. Zimmermann R, Panzenbock U, Wintersperger A, et al. Lipoprotein lipase mediates the uptake of glycated LDL in fibroblasts, endothelial cells, and macrophages. Diabetes 2001; 50:1643-1653.
83. Auwerx JH, Deeb S, Brunzell JD, et al. Transcriptional activation of the lipoprotein lipase and apolipoprotein E genes accompanies differentiation in some human macrophage-like cell lines. Biochemistry 1988; 27:2651-2655.
84. Hill MR, Kelly K, Wu X, et al. Lipopolysaccharide regulation of lipoprotein lipase expression in murine macrophages. Infect Immun 1995; 63:858-864.
85. Desanctis JB, Varesio L, Radzioch D. Prostaglandins inhibit lipoprotein lipase gene expression in macrophages. Immunology 1994; 81:605-610.
86. Querfeld U, Ong JM, Prehn J, et al. Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages. J Lipid Res 1990; 31:1379-1386.
87. Tengku-Muhammad TS, Hughes TR, Cryer A, et al. Differential regulation of lipoprotein lipase in the macrophage J774.2 cell line by cytokines. Cytokine 1996; 8:525-533.
88. Mori N, Gotoda T, Ishibashi S, et al. Effects of human recombinant macrophage colony-stimulating factor on the secretion of lipoprotein lipase from macrophages. Arterioscler Thromb 1991; 11:1315-1321.
89. Inaba T, Kawamura M, Gotoda T, et al. Effects of platelet-derived growth factor on the synthesis of lipoprotein lipase in human monocyte-derived macrophages. Arterioscler Thromb Vasc Biol 1995; 15:522-528.
90. Beauchamp MC, Renier G. Homocysteine induces protein kinase C activation and stimulates c-Fos and lipoprotein lipase expression in macrophages. Diabetes 2002; 51:1180-1187.
91. Renier G, Desfaits AC, Lambert A, et al. Role of oxidant injury on macrophage lipoprotein lipase (LPL) production and sensitivity to LPL. J Lipid Res 1996; 37:799-809.
92. Beauchamp MC, Letendre E, Renier G. Macrophage lipoprotein lipase expression is increased in patients with heterozygous familial hypercholesterolemia. J Lipid Res 2002; 43:215-222.
93. Sartippour MR, Renier G. Upregulation of macrophage lipoprotein lipase in patients with type 2 diabetes: role of peripheral factors. Diabetes 2000; 49:597-602.
94. Sartippour MR, Renier G. Differential regulation of macrophage peroxisome proliferator-activated receptor expression by glucose: role of peroxisome proliferator-activated receptors in lipoprotein lipase gene expression. Arterioscler Thromb Vasc Biol 2000; 20:104-110.
95. Fitzgerald ML, Moore KJ, Freeman MW. Nuclear hormone receptors and cholesterol trafficking: the orphans find a new home. J Mol Med 2002; 80:271-281.
96. Kern PA. Potential role of TNFalpha and lipoprotein lipase as candidate genes for obesity. J Nutr 1997; 127:1917S-1922S.
97. Borensztajn J. Heart and skeletal muscle lipoprotein lipase. In: Borensztajn J, editor. Lipoprotein lipase. Chicago: Evener; 1987. pp. 133-148.
98. Nikkilä. EA. Role of lipoprotein lipase in metabolic adaption to exercise and training. In: Borensztajn J, editor. Lipoprotein lipase. Chicago: Evener; 1987. pp. 187-199.
99. Greiwe JS, Holloszy JO, Semenkovich CF. Exercise induces lipoprotein lipase and GLUT-4 protein in muscle independent of adrenergic-receptor signalling. J Appl Physiol 2000; 89:176-181.
100. Brun LD, Gagne C, Julien P, et al. Familial lipoprotein lipase-activity deficiency: study of total body fatness and subcutaneous fat tissue distribution. Metabolism 1989; 38:1005-1009.
101. Weinstock PH, Bisgaier CL, Aalto-Setala K, et al. Severe hypertriglyceridemia, reduced high density lipoprotein, and neonatal death in lipoprotein lipase knockout mice. Mild hypertriglyceridemia with impaired very low density lipoprotein clearance in heterozygotes. J Clin Invest 1995; 96:2555-2568.
102. Jensen DR, Schlaepfer IR, Morin CL, et al. Prevention of diet-induced obesity in transgenic mice overexpressing skeletal muscle lipoprotein lipase. Am J Physiol 1997; 273:R683-R689.
103. Levak Frank S, Radner H, Walsh A, et al. Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J Clin Invest 1995; 96:976-986.
104. Weinstock PH, Levak-Frank S, Hudgins LC, et al. Lipoprotein lipase controls fatty acid entry into adipose tissue, but fat mass is preserved by endogenous synthesis in mice deficient in adipose tissue lipoprotein lipase. Proc Natl Acad Sci USA 1997; 94:10261-10266.
105. Ullrich NF, Purnell JQ, Brunzell JD. Adipose tissue fatty acid composition in humans with lipoprotein lipase deficiency. J. Investig Med 2001; 49:273-275.
106. Randle PJ. Regulatory interactions between lipids and carbohydrates: the glucose fatty acid cycle after 35 years. Diabetes Metab Rev 1998; 14:263-283.
107. Levak-Frank S, Radner H, Walsh A, et al. Muscle-specific overexpression of lipoprotein lipase causes a severe myopathy characterized by proliferation of mitochondria and peroxisomes in transgenic mice. J Clin Invest 1995; 96:976-986.
108. Shimada M, Shimano H, Gotoda T. Overexpression of human lipoprotein lipase in transgenic mice. Resistance to diet-induced hypertriglyceridemia and hypercholesterolemia. J Biol Chem 1994; 268:17924-17929.
109. Voshol PJ, Jong MC, Dahlmans VE, et al. In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake. Diabetes 2001; 50:2585-2590.
110. Ferreira LD, Pulawa LK, Jensen DR, et al. Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance. Diabetes 2001; 50:1064-1068.
111. Turcotte LP, Swenberger JR, Zavitz Tucker M, et al. Increased fatty acid uptake and altered fatty acid metabolism in insulin-resistant muscle of obese Zucker rats. Diabetes 2001; 50:1389-1396.
112. Matsumoto M, Ogawa W, Teshigawara K, et al. Role of the insulin receptor substrate 1 and phosphatidylinositol 3-kinase signalling pathway in insulin-induced expression of sterol regulatory element binding protein 1c and glucokinase genes in rat hepatocytes. Diabetes 2002; 51:1672-1680.
113. Guillet-Deniau I, Mieulet V, Le Lay S, et al. Sterol regulatory element binding protein-1c expression and action in rat muscles: insulin-like effects on the control of glycolytic and lipogenic enzymes and UCP3 gene expression. Diabetes 2002; 51:1722-1728.
114. Enerback S, Semb H, Tavernier J, et al. Tissue-specific regulation of guinea pig lipoprotein lipase; effects of nutritional state and of tumor necrosis factor on mRNA levels in adipose tissue, heart and liver. Gene 1988; 64:97-106.
115. Feingold KR, Serio MK, Adi S, et al. Tumor necrosis factor stimulates hepatic lipid synthesis and secretion. Endocrinology 1989; 124:2336-2342.
116. Previs SF, Withers DJ, Ren JM, et al. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo. J Biol Chem 2000; 275:38990-38994.
117. Crespin SR, Greenough WB 3rd, Steinberg D. Stimulation of insulin secretion by long-chain free fatty acids. A direct pancreatic effect. J Clin Invest 1973; 52:1979-1984.
118. Marshall BA, Tordjman K, Host HH, et al. Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion. J Biol Chem 1999; 274:27426-27432.
119. Sako Y, Grill VE. A 48-hour lipid infusion in the rat time-dependently inhibits glucose-induced insulin secretion and B cell oxidation through a process likely coupled to fatty acid oxidation. Endocrinology 1990; 127:1580-1589.
120. Zhou YP, Grill VE. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. J Clin Invest 1994; 93:870-876.
121. Bollheimer LC, Skelly RH, Chester MW, et al. Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation. J Clin Invest 1998; 101:1094-1101.