Identification of the amino acid residues in the extracellular domain of rat P2X 7 receptor involved in functional inhibition by acidic pH

British Journal of Pharmacology

Volumn 156, Issue 1, 2009, Pages 135-142

  Liu, X ^a   Ma, W ^b   Surprenant, A ^b   Jiang, L H ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Acidification; At P2X 7 receptor; Heterologous expression; Mutagenesis

Indexed keywords

2',3' O (4 BENZOYLBENZOYL)ADENOSINE 5' TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; PURINERGIC P2X7 RECEPTOR; UNCLASSIFIED DRUG; AMINO ACID; PURINERGIC P2 RECEPTOR;

ACIDIFICATION; AMINO ACID SUBSTITUTION; ARTICLE; CELL PH; CELL STRAIN HEK293; CONTROLLED STUDY; DATA ANALYSIS; HUMAN; HUMAN CELL; IC 50; PATCH CLAMP; POINT MUTATION; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR SENSITIVITY; SITE DIRECTED MUTAGENESIS; WILD TYPE; ANIMAL; CELL LINE; DRUG ANTAGONISM; EXTRACELLULAR SPACE; GENETICS; METABOLISM; MOUSE; PH; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT;

AMINO ACIDS; ANIMALS; CELL LINE; EXTRACELLULAR SPACE; HUMANS; HYDROGEN-ION CONCENTRATION; MICE; MUTAGENESIS, SITE-DIRECTED; PATCH-CLAMP TECHNIQUES; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, PURINERGIC P2;

EID: 65549148944     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2008.00002.x     Document Type: Article

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