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Volumn 87, Issue 6, 2009, Pages 1283-1295

Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

Author keywords

Leucine rich repeat kinase 2 (LRRK2); Neurodegeneration; Parkinson's disease; Signal transduction

Indexed keywords

ALPHA SYNUCLEIN; AMINO ACID; DJ 1 PROTEIN; GLYCINE; GUANOSINE TRIPHOSPHATASE; LEUCINE RICH REPEAT KINASE 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; PARKIN; PROTEIN KINASE; SERINE; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE;

EID: 65549124540     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21949     Document Type: Review
Times cited : (102)

References (135)
  • 3
    • 42549123597 scopus 로고    scopus 로고
    • LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease
    • Alegre-Abarrategui J, Ansorge O, Esiri M, Wade-Martins R. 2008. LRRK2 is a component of granular alpha-synuclein pathology in the brainstem of Parkinson's disease. Neuropathol Appl Neurobiol 34:272-283.
    • (2008) Neuropathol Appl Neurobiol , vol.34 , pp. 272-283
    • Alegre-Abarrategui, J.1    Ansorge, O.2    Esiri, M.3    Wade-Martins, R.4
  • 7
    • 33748876153 scopus 로고    scopus 로고
    • Parkinson's disease: The LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics
    • Bonifati V. 2006. Parkinson's disease: the LRRK2-G2019S mutation: opening a novel era in Parkinson's disease genetics. Eur J Hum Genet 14:1061-1062.
    • (2006) Eur J Hum Genet , vol.14 , pp. 1061-1062
    • Bonifati, V.1
  • 9
    • 0345118282 scopus 로고    scopus 로고
    • Roc, a Ras/GTPase domain in complex proteins
    • Bosgraaf L. 2003. Roc, a Ras/GTPase domain in complex proteins. Biochim Biophys Acta 1643:5-10.
    • (2003) Biochim Biophys Acta , vol.1643 , pp. 5-10
    • Bosgraaf, L.1
  • 11
  • 12
    • 0032421354 scopus 로고    scopus 로고
    • Functions of lipid rafts in biological membranes
    • Brown DA, London E. 1998. Functions of lipid rafts in biological membranes. Annu Rev Cell Dev Biol 14:111-136.
    • (1998) Annu Rev Cell Dev Biol , vol.14 , pp. 111-136
    • Brown, D.A.1    London, E.2
  • 15
    • 0034776095 scopus 로고    scopus 로고
    • Parkin ubiquitinates the alpha-synuclein- interacting protein, synphilin-1: Implications for Lewy-body formation in Parkinson disease
    • Chung KK, Zhang Y, Lim KL, Tanaka Y, Huang H, Gao J, Ross CA, Dawson VL, Dawson TM. 2001. Parkin ubiquitinates the alpha-synuclein- interacting protein, synphilin-1: implications for Lewy-body formation in Parkinson disease. Nat Med 7:1144-1150.
    • (2001) Nat Med , vol.7 , pp. 1144-1150
    • Chung, K.K.1    Zhang, Y.2    Lim, K.L.3    Tanaka, Y.4    Huang, H.5    Gao, J.6    Ross, C.A.7    Dawson, V.L.8    Dawson, T.M.9
  • 18
    • 22244442489 scopus 로고    scopus 로고
    • The biochemistry of Parkinson's disease
    • Cookson MR. 2005. The biochemistry of Parkinson's disease. Annu Rev Biochem 74:29-52.
    • (2005) Annu Rev Biochem , vol.74 , pp. 29-52
    • Cookson, M.R.1
  • 21
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W, Przedborski S. 2003. Parkinson's disease: mechanisms and models. Neuron 39:889-909.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 22
    • 40349101849 scopus 로고    scopus 로고
    • Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
    • Deng J, Lewis PA, Greggio E, Sluch E, Beilina A, Cookson MR. 2008. Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase. Proc Natl Acad Sci U S A 105:1499-1504.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1499-1504
    • Deng, J.1    Lewis, P.A.2    Greggio, E.3    Sluch, E.4    Beilina, A.5    Cookson, M.R.6
  • 23
    • 33645139675 scopus 로고    scopus 로고
    • Di Fonzo A, De Mari M, Chien HF, Ferreira J, Rohe CF, Riboldazzi G, Antonini A, Albani G, Mauro A, Marconi R, Abbruzzese G, Lopiano L, Fincati E, Guidi M, Marini P, Stocchi F, Onofrj M, Toni V, Tinazzi M, Fabbrini G, Lamberti P, Vanacore N, Meco G, Leitner P, Uitti RJ, Wszolek ZK, Gasser T, Simons EJ, Breedveld GJ, Goldwurm S, Pezzoli G, Sampaio C, Barbosa E, Martignoni E, Oostra BA, Bonifati V;Italian Parkinson's Genetics Network. 2006a. Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur J Hum Genet 14:322-331.
    • Di Fonzo A, De Mari M, Chien HF, Ferreira J, Rohe CF, Riboldazzi G, Antonini A, Albani G, Mauro A, Marconi R, Abbruzzese G, Lopiano L, Fincati E, Guidi M, Marini P, Stocchi F, Onofrj M, Toni V, Tinazzi M, Fabbrini G, Lamberti P, Vanacore N, Meco G, Leitner P, Uitti RJ, Wszolek ZK, Gasser T, Simons EJ, Breedveld GJ, Goldwurm S, Pezzoli G, Sampaio C, Barbosa E, Martignoni E, Oostra BA, Bonifati V;Italian Parkinson's Genetics Network. 2006a. Comprehensive analysis of the LRRK2 gene in sixty families with Parkinson's disease. Eur J Hum Genet 14:322-331.
  • 28
    • 33745862378 scopus 로고    scopus 로고
    • Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease
    • Fung HC, Chen CM, Hardy J, Hernandez D, Singleton A, Wu YR. 2006a. Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease. Mov Disord 21:880-881.
    • (2006) Mov Disord , vol.21 , pp. 880-881
    • Fung, H.C.1    Chen, C.M.2    Hardy, J.3    Hernandez, D.4    Singleton, A.5    Wu, Y.R.6
  • 29
    • 33846587090 scopus 로고    scopus 로고
    • A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan
    • Fung HC, Chen CM, Hardy J, Singleton AB, Wu YR. 2006b. A common genetic factor for Parkinson disease in ethnic Chinese population in Taiwan. BMC Neurol 6:47.
    • (2006) BMC Neurol , vol.6 , pp. 47
    • Fung, H.C.1    Chen, C.M.2    Hardy, J.3    Singleton, A.B.4    Wu, Y.R.5
  • 30
    • 0028950213 scopus 로고
    • Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins
    • Futey LM, Medley QG, Cote GP, Egelhoff TT. 1995. Structural analysis of myosin heavy chain kinase A from Dictyostelium. Evidence for a highly divergent protein kinase domain, an amino-terminal coiled-coil domain, and a domain homologous to the beta-subunit of heterotrimeric G proteins. J Biol Chem 270:523-529.
    • (1995) J Biol Chem , vol.270 , pp. 523-529
    • Futey, L.M.1    Medley, Q.G.2    Cote, G.P.3    Egelhoff, T.T.4
  • 31
    • 33644929033 scopus 로고    scopus 로고
    • LRRK2 mutations in Spanish patients with Parkinson disease: Frequency, clinical features, and incomplete penetrance
    • Gaig C, Ezquerra M, Marti MJ, Munoz E, Valldeoriola F, Tolosa E. 2006. LRRK2 mutations in Spanish patients with Parkinson disease: frequency, clinical features, and incomplete penetrance. Arch Neurol 63:377-382.
    • (2006) Arch Neurol , vol.63 , pp. 377-382
    • Gaig, C.1    Ezquerra, M.2    Marti, M.J.3    Munoz, E.4    Valldeoriola, F.5    Tolosa, E.6
  • 33
    • 34548489211 scopus 로고    scopus 로고
    • DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents
    • Galter D, Westerlund M, Belin AC, Olson L. 2007. DJ-1 and UCH-L1 gene activity patterns in the brains of controls, Parkinson and schizophrenia patients and in rodents. Physiol Behav 92:46-53.
    • (2007) Physiol Behav , vol.92 , pp. 46-53
    • Galter, D.1    Westerlund, M.2    Belin, A.C.3    Olson, L.4
  • 34
    • 45549085874 scopus 로고    scopus 로고
    • The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules
    • Gandhi PN, Wang X, Zhu X, Chen SG, Wilson-Delfosse AL. 2008. The Roc domain of leucine-rich repeat kinase 2 is sufficient for interaction with microtubules. J Neurosci Res 86:1711-1720.
    • (2008) J Neurosci Res , vol.86 , pp. 1711-1720
    • Gandhi, P.N.1    Wang, X.2    Zhu, X.3    Chen, S.G.4    Wilson-Delfosse, A.L.5
  • 36
    • 31144443248 scopus 로고    scopus 로고
    • Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M. 2006. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet 15:223-232 [E-pub December 2005].
    • Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M. 2006. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet 15:223-232 [E-pub December 2005].
  • 37
    • 33645160640 scopus 로고    scopus 로고
    • Goldwurm S, Di Fonzo A, Simons EJ, Rohe CF, Zini M, Canesi M, Tesei S, Zecchinelli A, Antonini A, Mariani C, Meucci N, Sacilotto G, Sironi F, Salani G, Ferreira J, Chien HF, Fabrizio E, Vanacore N, Dalla Libera A, Stocchi F, Diroma C, Lamberti P, Sampaio C, Meco G, Barbosa E, Bertoli-Avella AM, Breedveld GJ, Oostra BA, Pezzoli G, Bonifati V. 2005. The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. J Med Genet 42:e65.
    • Goldwurm S, Di Fonzo A, Simons EJ, Rohe CF, Zini M, Canesi M, Tesei S, Zecchinelli A, Antonini A, Mariani C, Meucci N, Sacilotto G, Sironi F, Salani G, Ferreira J, Chien HF, Fabrizio E, Vanacore N, Dalla Libera A, Stocchi F, Diroma C, Lamberti P, Sampaio C, Meco G, Barbosa E, Bertoli-Avella AM, Breedveld GJ, Oostra BA, Pezzoli G, Bonifati V. 2005. The G6055A (G2019S) mutation in LRRK2 is frequent in both early and late onset Parkinson's disease and originates from a common ancestor. J Med Genet 42:e65.
  • 40
    • 51049117271 scopus 로고    scopus 로고
    • Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase
    • Gotthardt K, Weyand M, Kortholt A, Van Haastert PJ, Wittinghofer A. 2008. Structure of the Roc-COR domain tandem of C. tepidum, a prokaryotic homologue of the human LRRK2 Parkinson kinase. EMBO J 27:2352.
    • (2008) EMBO J , vol.27 , pp. 2352
    • Gotthardt, K.1    Weyand, M.2    Kortholt, A.3    Van Haastert, P.J.4    Wittinghofer, A.5
  • 44
    • 33646538477 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2: Relevance to Parkinson's disease
    • Guo L, Wang W, Chen SG. 2006. Leucine-rich repeat kinase 2: relevance to Parkinson's disease. Int J Biochem Cell Biol 38:1469-1475.
    • (2006) Int J Biochem Cell Biol , vol.38 , pp. 1469-1475
    • Guo, L.1    Wang, W.2    Chen, S.G.3
  • 45
    • 34548604567 scopus 로고    scopus 로고
    • The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity
    • Guo L, Gandhi PN, Wang W, Petersen RB, Wilson-Delfosse AL, Chen SG. 2007. The Parkinson's disease-associated protein, leucine-rich repeat kinase 2 (LRRK2), is an authentic GTPase that stimulates kinase activity. Exp Cell Res 313:3658-3670.
    • (2007) Exp Cell Res , vol.313 , pp. 3658-3670
    • Guo, L.1    Gandhi, P.N.2    Wang, W.3    Petersen, R.B.4    Wilson-Delfosse, A.L.5    Chen, S.G.6
  • 46
    • 42149172511 scopus 로고    scopus 로고
    • RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player
    • Habig K, Walter M, Poths S, Riess O, Bonin M. 2008. RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player. Neurogenetics 9:83-94.
    • (2008) Neurogenetics , vol.9 , pp. 83-94
    • Habig, K.1    Walter, M.2    Poths, S.3    Riess, O.4    Bonin, M.5
  • 53
    • 0033617289 scopus 로고    scopus 로고
    • Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change
    • Huang L, Wong TY, Lin RC, Furthmayr H. 1999. Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change. J Biol Chem 274:12803-12810.
    • (1999) J Biol Chem , vol.274 , pp. 12803-12810
    • Huang, L.1    Wong, T.Y.2    Lin, R.C.3    Furthmayr, H.4
  • 56
    • 33846818834 scopus 로고    scopus 로고
    • GTP Binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease
    • Ito G, Okai T, Fujino G, Takeda K, Ichijo H, Katada T, Iwatsubo T. 2007. GTP Binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease. Biochemistry 46:1380-1388.
    • (2007) Biochemistry , vol.46 , pp. 1380-1388
    • Ito, G.1    Okai, T.2    Fujino, G.3    Takeda, K.4    Ichijo, H.5    Katada, T.6    Iwatsubo, T.7
  • 57
    • 34447118788 scopus 로고    scopus 로고
    • LRRK2 phosphorylates moesin at threonine-558: Characterization of how Parkinson's disease mutants affect kinase activity
    • Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR. 2007. LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity. Biochem J 405:307-317.
    • (2007) Biochem J , vol.405 , pp. 307-317
    • Jaleel, M.1    Nichols, R.J.2    Deak, M.3    Campbell, D.G.4    Gillardon, F.5    Knebel, A.6    Alessi, D.R.7
  • 58
    • 0030002810 scopus 로고    scopus 로고
    • A deduced Thermomonospora curvata protein containing serine/threonine protein kinase and WD-repeat domains
    • Janda L, Tichy P, Spizek J, Petricek M. 1996. A deduced Thermomonospora curvata protein containing serine/threonine protein kinase and WD-repeat domains. J Bacteriol 178:1487-1489.
    • (1996) J Bacteriol , vol.178 , pp. 1487-1489
    • Janda, L.1    Tichy, P.2    Spizek, J.3    Petricek, M.4
  • 59
    • 0142058806 scopus 로고    scopus 로고
    • Numb and Numblike control cell number during vertebrate neurogenesis
    • Johnson JE. 2003. Numb and Numblike control cell number during vertebrate neurogenesis. Trends Neurosci 26:395-396.
    • (2003) Trends Neurosci , vol.26 , pp. 395-396
    • Johnson, J.E.1
  • 62
    • 34648836415 scopus 로고    scopus 로고
    • The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease
    • Kalinderi K, Fidani L, Bostantjopoulou S, Katsarou Z, Kotsis A. 2007. The G2019S LRRK2 mutation is uncommon amongst Greek patients with sporadic Parkinson's disease. Eur J Neurol 14:1088-1090.
    • (2007) Eur J Neurol , vol.14 , pp. 1088-1090
    • Kalinderi, K.1    Fidani, L.2    Bostantjopoulou, S.3    Katsarou, Z.4    Kotsis, A.5
  • 67
    • 2342641505 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase signaling
    • Kyosseva SV. 2004. Mitogen-activated protein kinase signaling. Int Rev Neurobiol 59:201-220.
    • (2004) Int Rev Neurobiol , vol.59 , pp. 201-220
    • Kyosseva, S.V.1
  • 68
    • 34248574535 scopus 로고    scopus 로고
    • Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
    • Lee SB, Kim W, Lee S, Chung J. 2007. Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila. Biochem Biophys Res Commun 358:534-539.
    • (2007) Biochem Biophys Res Commun , vol.358 , pp. 534-539
    • Lee, S.B.1    Kim, W.2    Lee, S.3    Chung, J.4
  • 70
    • 22544465257 scopus 로고    scopus 로고
    • LRRK2 haplotype analyses in European and North African families with Parkinson disease: A common founder for the G2019S mutation dating from the 13th century
    • Lesage S, Leutenegger AL, Ibanez P, Janin S, Lohmann E, Durr A, Brice A. 2005. LRRK2 haplotype analyses in European and North African families with Parkinson disease: a common founder for the G2019S mutation dating from the 13th century. Am J Hum Genet 77:330-332.
    • (2005) Am J Hum Genet , vol.77 , pp. 330-332
    • Lesage, S.1    Leutenegger, A.L.2    Ibanez, P.3    Janin, S.4    Lohmann, E.5    Durr, A.6    Brice, A.7
  • 73
    • 34548621385 scopus 로고    scopus 로고
    • Leucine- rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants
    • Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z. 2007. Leucine- rich repeat kinase 2 (LRRK2)/PARK8 possesses GTPase activity that is altered in familial Parkinson's disease R1441C/G mutants. J Neurochem 103:238-247.
    • (2007) J Neurochem , vol.103 , pp. 238-247
    • Li, X.1    Tan, Y.C.2    Poulose, S.3    Olanow, C.W.4    Huang, X.Y.5    Yue, Z.6
  • 76
    • 34548432121 scopus 로고    scopus 로고
    • Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation
    • Luzon-Toro B, de la Torre ER, Delgado A, Perez-Tur J, Hilfiker S. 2007. Mechanistic insight into the dominant mode of the Parkinson's disease-associated G2019S LRRK2 mutation. Hum Mol Genet 16:2031-2039.
    • (2007) Hum Mol Genet , vol.16 , pp. 2031-2039
    • Luzon-Toro, B.1    de la Torre, E.R.2    Delgado, A.3    Perez-Tur, J.4    Hilfiker, S.5
  • 77
    • 33751256567 scopus 로고    scopus 로고
    • The familial Parkinsonism gene LRRK2 regulates neurite process morphology
    • MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A. 2006. The familial Parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52:587-593.
    • (2006) Neuron , vol.52 , pp. 587-593
    • MacLeod, D.1    Dowman, J.2    Hammond, R.3    Leete, T.4    Inoue, K.5    Abeliovich, A.6
  • 78
    • 0037032835 scopus 로고    scopus 로고
    • The protein kinase complement of the human genome
    • Manning G, Martinez R, Hunter T, Sudarsanam S. 2002. The protein kinase complement of the human genome. Science 298:1912-1934.
    • (2002) Science , vol.298 , pp. 1912-1934
    • Manning, G.1    Martinez, R.2    Hunter, T.3    Sudarsanam, S.4
  • 79
    • 33750931271 scopus 로고    scopus 로고
    • The Parkinson disease gene LRRK2: Evolutionary and structural insights
    • Marin I. 2006. The Parkinson disease gene LRRK2: evolutionary and structural insights. Mol Biol Evol 23:2423-2433.
    • (2006) Mol Biol Evol , vol.23 , pp. 2423-2433
    • Marin, I.1
  • 80
    • 28344457936 scopus 로고    scopus 로고
    • Mata IF, Taylor JP, Lincoln S, Aasly J, Lynch T, Hulihan MM, Cobb SA, Wu RM, Lu CS, Lahoz C, Wszolek ZK, Farrer MJ. 2005. Lrrk2 pathogenic substitutions in Parkinson's disease. Neurogenetics 6:171-177 [E-pub September 2005].
    • Mata IF, Taylor JP, Lincoln S, Aasly J, Lynch T, Hulihan MM, Cobb SA, Wu RM, Lu CS, Lahoz C, Wszolek ZK, Farrer MJ. 2005. Lrrk2 pathogenic substitutions in Parkinson's disease. Neurogenetics 6:171-177 [E-pub September 2005].
  • 83
    • 33646146878 scopus 로고    scopus 로고
    • Anatomical localization of leucine-rich repeat kinase 2 in mouse brain
    • Melrose H, Lincoln S, Tyndall G, Dickson D, Farrer M. 2006. Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience 139:791-794.
    • (2006) Neuroscience , vol.139 , pp. 791-794
    • Melrose, H.1    Lincoln, S.2    Tyndall, G.3    Dickson, D.4    Farrer, M.5
  • 85
    • 14744299357 scopus 로고    scopus 로고
    • The RIP kinases: Crucial integrators of cellular stress
    • Meylan J. 2005. The RIP kinases: crucial integrators of cellular stress. Trends Biochem Sci 30:151-159.
    • (2005) Trends Biochem Sci , vol.30 , pp. 151-159
    • Meylan, J.1
  • 88
    • 0032547839 scopus 로고    scopus 로고
    • Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons
    • Paglini G, Kunda P, Quiroga S, Kosik K, Caceres A. 1998. Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons. J Cell Biol 143:443-455.
    • (1998) J Cell Biol , vol.143 , pp. 443-455
    • Paglini, G.1    Kunda, P.2    Quiroga, S.3    Kosik, K.4    Caceres, A.5
  • 92
    • 42049122637 scopus 로고    scopus 로고
    • Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls
    • Paisan-Ruiz C, Nath P, Washecka N, Gibbs JR, Singleton AB. 2008. Comprehensive analysis of LRRK2 in publicly available Parkinson's disease cases and neurologically normal controls. Hum Mutat 29:485-490.
    • (2008) Hum Mutat , vol.29 , pp. 485-490
    • Paisan-Ruiz, C.1    Nath, P.2    Washecka, N.3    Gibbs, J.R.4    Singleton, A.B.5
  • 94
    • 40449088676 scopus 로고    scopus 로고
    • Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies
    • Perry G, Zhu X, Babar AK, Siedlak SL, Yang Q, Ito G, Iwatsubo T, Smith MA, Chen SG. 2008. Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies. Neurodegener Dis 5:222-224.
    • (2008) Neurodegener Dis , vol.5 , pp. 222-224
    • Perry, G.1    Zhu, X.2    Babar, A.K.3    Siedlak, S.L.4    Yang, Q.5    Ito, G.6    Iwatsubo, T.7    Smith, M.A.8    Chen, S.G.9
  • 95
    • 39549117093 scopus 로고    scopus 로고
    • Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SHSY5Y cells
    • Plowey ED, Cherra SJ 3rd, Liu YJ, Chu CT. 2008. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SHSY5Y cells. J Neurochem 105:1048-1056.
    • (2008) J Neurochem , vol.105 , pp. 1048-1056
    • Plowey, E.D.1    Cherra 3rd, S.J.2    Liu, Y.J.3    Chu, C.T.4
  • 99
    • 33947663512 scopus 로고    scopus 로고
    • LRK-1, a C. elegans PARK8-related kinase, regulates axonaldendritic polarity of SV proteins
    • Sakaguchi-Nakashima A, Meir JY, Jin Y, Matsumoto K, Hisamoto N. 2007. LRK-1, a C. elegans PARK8-related kinase, regulates axonaldendritic polarity of SV proteins. Curr Biol 17:592-598.
    • (2007) Curr Biol , vol.17 , pp. 592-598
    • Sakaguchi-Nakashima, A.1    Meir, J.Y.2    Jin, Y.3    Matsumoto, K.4    Hisamoto, N.5
  • 101
    • 5444270967 scopus 로고    scopus 로고
    • Neuronal pathology in Parkinson's disease
    • Schulz JB, Falkenburger BH. 2004. Neuronal pathology in Parkinson's disease. Cell Tissue Res 318:135-147.
    • (2004) Cell Tissue Res , vol.318 , pp. 135-147
    • Schulz, J.B.1    Falkenburger, B.H.2
  • 103
    • 22844445441 scopus 로고    scopus 로고
    • Mixed lineage kinasec- jun N-terminal kinase signaling pathway: A new therapeutic target in Parkinson's disease
    • Silva RM, Kuan CY, Rakic P, Burke RE. 2005. Mixed lineage kinasec- jun N-terminal kinase signaling pathway: a new therapeutic target in Parkinson's disease. Mov Disord 20:653-664.
    • (2005) Mov Disord , vol.20 , pp. 653-664
    • Silva, R.M.1    Kuan, C.Y.2    Rakic, P.3    Burke, R.E.4
  • 105
    • 28744453588 scopus 로고    scopus 로고
    • Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease
    • Skipper L, Li Y, Bonnard C, Pavanni R, Yih Y, Chua E, Sung WK, Tan L, Wong MC, Tan EK, Liu J. 2005. Comprehensive evaluation of common genetic variation within LRRK2 reveals evidence for association with sporadic Parkinson's disease. Hum Mol Genet 14:3549-3556.
    • (2005) Hum Mol Genet , vol.14 , pp. 3549-3556
    • Skipper, L.1    Li, Y.2    Bonnard, C.3    Pavanni, R.4    Yih, Y.5    Chua, E.6    Sung, W.K.7    Tan, L.8    Wong, M.C.9    Tan, E.K.10    Liu, J.11
  • 107
    • 29444437871 scopus 로고    scopus 로고
    • Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA. 2005. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A 102:18676-18681 [E-pub December 2005].
    • Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA. 2005. Leucine-rich repeat kinase 2 (LRRK2) interacts with parkin, and mutant LRRK2 induces neuronal degeneration. Proc Natl Acad Sci U S A 102:18676-18681 [E-pub December 2005].
  • 109
    • 0033961490 scopus 로고    scopus 로고
    • Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: Genes associated with familial Parkinson's disease
    • Solano SM, Miller DW, Augood SJ, Young AB, Penney JB Jr. 2000. Expression of alpha-synuclein, parkin, and ubiquitin carboxy-terminal hydrolase L1 mRNA in human brain: genes associated with familial Parkinson's disease. Ann Neurol 47:201-210.
    • (2000) Ann Neurol , vol.47 , pp. 201-210
    • Solano, S.M.1    Miller, D.W.2    Augood, S.J.3    Young, A.B.4    Penney Jr., J.B.5
  • 110
    • 33750331692 scopus 로고    scopus 로고
    • LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP
    • Spanaki C, Latsoudis H, Plaitakis A. 2006. LRRK2 mutations on Crete: R1441H associated with PD evolving to PSP. Neurology 67:1518-1519.
    • (2006) Neurology , vol.67 , pp. 1518-1519
    • Spanaki, C.1    Latsoudis, H.2    Plaitakis, A.3
  • 112
    • 0030846295 scopus 로고    scopus 로고
    • Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
    • Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y. 1997. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem 272:23371-23375.
    • (1997) J Biol Chem , vol.272 , pp. 23371-23375
    • Takahashi, K.1    Sasaki, T.2    Mammoto, A.3    Takaishi, K.4    Kameyama, T.5    Tsukita, S.6    Takai, Y.7
  • 114
    • 39149133528 scopus 로고    scopus 로고
    • Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease
    • in press
    • Tan EK, Lee J, Chen CP, Wong MC, Zhao Y. 2007a. Case control analysis of LRRK2 Gly2385Arg in Alzheimer's disease. Neurobiol Aging (in press).
    • (2007) Neurobiol Aging
    • Tan, E.K.1    Lee, J.2    Chen, C.P.3    Wong, M.C.4    Zhao, Y.5
  • 117
    • 32044458576 scopus 로고    scopus 로고
    • LRRK2: A common pathway for parkinsonism, pathogenesis and prevention?
    • Taylor JP, Farrer MJ. 2006. LRRK2: a common pathway for parkinsonism, pathogenesis and prevention? Trends Mol Med 12:76-82.
    • (2006) Trends Mol Med , vol.12 , pp. 76-82
    • Taylor, J.P.1    Farrer, M.J.2
  • 118
    • 33745917404 scopus 로고    scopus 로고
    • Distribution of PINK1 and LRRK2 in rat and mouse brain
    • Taymans JM, Van den Haute C, Baekelandt V. 2006. Distribution of PINK1 and LRRK2 in rat and mouse brain. J Neurochem 98:951-961.
    • (2006) J Neurochem , vol.98 , pp. 951-961
    • Taymans, J.M.1    Van den Haute, C.2    Baekelandt, V.3
  • 122
    • 41549124987 scopus 로고    scopus 로고
    • Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons
    • Wang D, Tang B, Zhao G, Pan Q, Xia K, Bodmer R, Zhang Z. 2008. Dispensable role of Drosophila ortholog of LRRK2 kinase activity in survival of dopaminergic neurons. Mol Neurodegener 3:3.
    • (2008) Mol Neurodegener , vol.3 , pp. 3
    • Wang, D.1    Tang, B.2    Zhao, G.3    Pan, Q.4    Xia, K.5    Bodmer, R.6    Zhang, Z.7
  • 124
    • 28044460070 scopus 로고    scopus 로고
    • West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM. 2005. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 102:16842-16847 [E-pub November 2005].
    • West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM. 2005. Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity. Proc Natl Acad Sci U S A 102:16842-16847 [E-pub November 2005].
  • 128
    • 40449120980 scopus 로고    scopus 로고
    • Investigating convergent actions of genes linked to familial Parkinson's disease
    • Wolozin B, Saha S, Guillily M, Ferree A, Riley M. 2008. Investigating convergent actions of genes linked to familial Parkinson's disease. Neurodegen Dis 5:182-185.
    • (2008) Neurodegen Dis , vol.5 , pp. 182-185
    • Wolozin, B.1    Saha, S.2    Guillily, M.3    Ferree, A.4    Riley, M.5


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