A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease

Neuroscience

Volumn 147, Issue 4, 2007, Pages 1047-1058

  Melrose, H L ^a   Kent, C B ^a   Taylor, J P ^a   Dachsel, J C ^a   Hinkle, K M ^a   Lincoln, S J ^a   Mok, S S ^b,c   Culvenor, J G ^b,c   Masters, C L ^b,c   Tyndall, G M ^a   Bass, D I ^a   Ahmed, Z ^a   Andorfer, C A ^a   Ross, O A ^a   Wszolek, Z K ^a   Delldonne, A ^a   Dickson, D W ^a   Farrer, M J ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c FLOREY INSTITUTE OF NEUROSCIENCE AND MENTAL HEALTH   (Australia)

Author keywords

immunohistochemistry; Lewy body; Lrrk2; neurogenesis; Parkinson's disease; subventricular zone

Indexed keywords

LEUCINE RICH REPEAT KINASE 2;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIFFUSE LEWY BODY DISEASE; DOPAMINERGIC NERVE CELL; MOUSE; NERVE DEGENERATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

ANIMALS; AUTORADIOGRAPHY; BRAIN; CELL LINE, TRANSFORMED; CHROMOSOMES, ARTIFICIAL, BACTERIAL; GENE EXPRESSION; GREEN FLUORESCENT PROTEINS; HUMANS; LEWY BODY DISEASE; MICE; MICE, TRANSGENIC; NEURAL CELL ADHESION MOLECULE L1; PROTEIN-SERINE-THREONINE KINASES; SIALIC ACIDS; TRANSFECTION; TYROSINE 3-MONOOXYGENASE;

EID: 34547107314     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2007.05.027     Document Type: Article

References (41)

1. Baker S.A., Baker K.A., and Hagg T. Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. Eur J Neurosci 20 (2004) 575-579
2. Benarroch E. Basic neurosciences with clinical applications (2006), Butterworth, Heinemann, Elsevier, Philadelphia
3. Biskup S., Moore D.J., Celsi F., Higashi S., West A.B., Andrabi S.A., Kurkinen K., Yu S.W., Savitt J.M., Waldvogel H.J., Faull R.L., Emson P.C., Torp R., Ottersen O.P., Dawson T.M., and Dawson V.L. Localization of LRRK2 to membranous and vesicular structures in mammalian brain. Ann Neurol 60 (2006) 557-569
4. Charrier E., Reibel S., Rogemond V., Aguera M., Thomasset N., and Honnorat J. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol Neurobiol 28 (2003) 51-64
5. Covy J., Van Deerlin V., and Giasson B. Lack of evidence for Lrrk2 in alpha-synuclein pathological inclusions. Ann Neurol 60 (2006) 618-619
6. Dachsel J.C., Ross O.A., Mata I.F., Kachergus J., Toft M., Cannon A., Baker M., Adamson J., Hutton M., Dickson D.W., and Farrer M.J. Lrrk2 G2019S substitution in frontotemporal lobar degeneration with ubiquitin-immunoreactive neuronal inclusions. Acta Neuropathol 113 (2007) 601-606 Berl
7. Dachsel J.C., Taylor J., Mok S.S., Ross O.A., Hinkle K.M., Bailey R., Hines J., Szutu J., Madden B., Petrucelli L., and Farrer M.J. Identification of potential protein interactors of Lrrk2. Parkinsonism Relat Disord (2007) [Epub ahead of print]
8. In: deGroot J. (Ed). Correlative neuroanatomy (1991), Appleton and Lange, Norwalk, CT/San Mateo, CA
9. Dickson D.W., Liu W., Hardy J., Farrer M., Mehta N., Uitti R., Mark M., Zimmerman T., Golbe L., Sage J., Sima A., D'Amato C., Albin R., Gilman S., and Yen S.H. Widespread alterations of alpha-synuclein in multiple system atrophy. Am J Pathol 155 (1999) 1241-1251
10. Doetsch F., Garcia-Verdugo J.M., and Alvarez-Buylla A. Cellular composition and three-dimensional organization of the subventricular germinal zone in the adult mammalian brain. J Neurosci 17 (1997) 5046-5061
11. Farrer M.J. Genetics of Parkinson disease: paradigm shifts and future prospects. Nat Rev Genet 7 (2006) 306-318
12. Galter D., Westerlund M., Carmine A., Lindqvist E., Sydow O., and Olson L. LRRK2 expression linked to dopamine-innervated areas. Ann Neurol 59 (2006) 714-719
13. Gheusi G., Cremer H., McLean H., Chazal G., Vincent J.D., and Lledo P.M. Importance of newly generated neurons in the adult olfactory bulb for odor discrimination. Proc Natl Acad Sci U S A 97 (2000) 1823-1828
14. Giasson B.I., Covy J.P., Bonini N.M., Hurtig H.I., Farrer M.J., Trojanowski J.Q., and Van Deerlin V.M. Biochemical and pathological characterization of Lrrk2. Ann Neurol 59 (2006) 315-322
15. Gloeckner C.J., Kinkl N., Schumacher A., Braun R.J., O'Neill E., Meitinger T., Kolch W., Prokisch H., and Ueffing M. The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity. Hum Mol Genet 15 (2006) 223-232
16. Greggio E., Jain S., Kingsbury A., Bandopadhyay R., Lewis P., Kaganovich A., van der Brug M.P., Beilina A., Blackinton J., Thomas K.J., Ahmad R., Miller D.W., Kesavapany S., Singleton A., Lees A., Harvey R.J., Harvey K., and Cookson M.R. Kinase activity is required for the toxic effects of mutant LRRK2/dardarin. Neurobiol Dis 23 (2006) 329-341
17. Gu Y., Hamajima N., and Ihara Y. Neurofibrillary tangle-associated collapsin response mediator protein-2 (CRMP-2) is highly phosphorylated on Thr-509, Ser-518, and Ser-522. Biochemistry 39 (2000) 4267-4275
18. Higashi S., Moore D.J., Colebrooke R.E., Biskup S., Dawson V.L., Arai H., Dawson T.M., and Emson P.C. Expression and localization of Parkinson's disease-associated leucine-rich repeat kinase 2 in the mouse brain. J Neurochem 100 (2007) 368-381
19. Jaleel M., Nichols R.J., Deak M., Campbell D.G., Gillardon F., Knebel A., and Alessi D.R. LRRK2 phosphorylates moesin at Thr558: characterisation of how Parkinson's disease mutants affect kinase activity. Biochem J 405 (2007) 307-317
20. Johnson J.E. Numb and Numblike control cell number during vertebrate neurogenesis. Trends Neurosci 26 (2003) 395-396
21. Korten J.J., and Meulstee J. Olfactory disturbances in Parkinsonism. Clin Neurol Neurosurg 82 (1980) 113-118
22. Lee A.W., Emsley J.G., Brown R.E., and Hagg T. Marked differences in olfactory sensitivity and apparent speed of forebrain neuroblast migration in three inbred strains of mice. Neuroscience 118 (2003) 263-270
23. Macleod D., Dowman J., Hammond R., Leete T., Inoue K., and Abeliovich A. The familial parkinsonism gene LRRK2 regulates neurite process morphology. Neuron 52 (2006) 587-593
24. Mandairon N., Sacquet J., Jourdan F., and Didier A. Long-term fate and distribution of newborn cells in the adult mouse olfactory bulb: Influences of olfactory deprivation. Neuroscience 141 (2006) 443-451
25. Melrose H., Lincoln S., Tyndall G., Dickson D., and Farrer M. Anatomical localization of leucine-rich repeat kinase 2 in mouse brain. Neuroscience 139 (2006) 791-794
26. Miklossy J., Arai T., Guo J.P., Klegeris A., Yu S., McGeer E.G., and McGeer P.L. LRRK2 expression in normal and pathologic human brain and in human cell lines. J Neuropathol Exp Neurol 65 (2006) 953-963
27. Paisan-Ruiz C., Jain S., Evans E.W., Gilks W.P., Simon J., van der Brug M., de Munain A.L., Aparicio S., Gil A.M., Khan N., Johnson J., Martinez J.R., Nicholl D., Carrera I.M., Pena A.S., de Silva R., Lees A., Marti-Masso J.F., Perez-Tur J., Wood N.W., and Singleton A.B. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 44 (2004) 595-600
28. In: Paxinos G. (Ed). The rat nervous system (1995), Academic Press, Inc, Sydney, Australia
29. Petreanu L., and Alvarez-Buylla A. Maturation and death of adult-born olfactory bulb granule neurons: role of olfaction. J Neurosci 22 (2002) 6106-6113
30. Rajput A., Dickson D.W., Robinson C.A., Ross O.A., Dachsel J.C., Lincoln S.J., Cobb S.A., Rajput M.L., and Farrer M.J. Parkinsonism, Lrrk2 G2019S, and tau neuropathology. Neurology 67 (2006) 1506-1508
31. Ross O.A., Toft M., Whittle A.J., Johnson J.L., Papapetropoulos S., Mash D.C., Litvan I., Gordon M.F., Wszolek Z.K., Farrer M.J., and Dickson D.W. Lrrk2 and Lewy body disease. Ann Neurol 59 (2006) 388-393
32. Saino-Saito S., Sasaki H., Volpe B.T., Kobayashi K., Berlin R., and Baker H. Differentiation of the dopaminergic phenotype in the olfactory system of neonatal and adult mice. J Comp Neurol 479 (2004) 389-398
33. Simon-Sanchez J., Herranz-Perez V., Olucha-Bordonau F., and Perez-Tur J. LRRK2 is expressed in areas affected by Parkinson's disease in the adult mouse brain. Eur J Neurosci 23 (2006) 659-666
34. Stenmark P., Ogg D., Flodin S., Flores A., Kotenyova T., Nyman T., Nordlund P., and Kursula P. The structure of human collapsin response mediator protein 2, a regulator of axonal growth. J Neurochem 101 (2007) 906-917
35. Taymans J.M., Van den Haute C., and Baekelandt V. Distribution of PINK1 and LRRK2 in rat and mouse brain. J Neurochem 98 (2006) 951-961
36. Veyrac A., Giannetti N., Charrier E., Reymond-Marron I., Aguera M., Rogemond V., Honnorat J., and Jourdan F. Expression of collapsin response mediator proteins 1, 2 and 5 is differentially regulated in newly generated and mature neurons of the adult olfactory system. Eur J Neurosci 21 (2005) 2635-2648
37. Wszolek Z.K., Pfeiffer R.F., Tsuboi Y., Uitti R.J., McComb R.D., Stoessl A.J., Strongosky A.J., Zimprich A., Muller-Myhsok B., Farrer M.J., Gasser T., Calne D.B., and Dickson D.W. Autosomal dominant parkinsonism associated with variable synuclein and tau pathology. Neurology 62 (2004) 1619-1622
38. Yoshida H., Watanabe A., and Ihara Y. Collapsin response mediator protein-2 is associated with neurofibrillary tangles in Alzheimer's disease. J Biol Chem 273 (1998) 9761-9768
39. Zhu X., Babar A., Siedlak S.L., Yang Q., Ito G., Iwatsubo T., Smith M.A., Perry G., and Chen S.G. LRRK2 in Parkinson's disease and dementia with Lewy bodies. Mol Neurodegener 1 (2006) 17
40. Zhu X., Siedlak S.L., Smith M.A., Perry G., and Chen S.G. LRRK2 protein is a component of Lewy bodies. Ann Neurol 60 (2006) 617-618
41. Zimprich A., Biskup S., Leitner P., Lichtner P., Farrer M., Lincoln S., Kachergus J., Hulihan M., Uitti R.J., Calne D.B., Stoessl A.J., Pfeiffer R.F., Patenge N., Carbajal I.C., Vieregge P., Asmus F., Muller-Myhsok B., Dickson D.W., Meitinger T., Strom T.M., Wszolek Z.K., and Gasser T. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 44 (2004) 601-607