Lack of G2019S LRRK2 mutation in a cohort of Taiwanese with sporadic Parkinson's disease

Movement Disorders

Volumn 21, Issue 6, 2006, Pages 880-881

  Fung, Hon Chung ^a,b,c   Chen, Chiung Mei ^c   Hardy, John ^a,b   Hernandez, Dena ^a   Singleton, Andrew ^a   Wu, Yih Ru ^c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

LRRK2; Mutation; Parkinson's disease; Taiwan

Indexed keywords

GLYCINE; LEUCINE RICH REPEAT KINASE 2; PROTEIN KINASE; SERINE; UNCLASSIFIED DRUG;

ADULT; AGED; AMINO ACID SUBSTITUTION; ARTICLE; CODON; COHORT ANALYSIS; CONTROLLED STUDY; EUROPE; FEMALE; FOUNDER EFFECT; GENE MUTATION; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MUTATION RATE; PARKINSON DISEASE; PRIORITY JOURNAL; TAIWAN;

ADULT; AGED; AGED, 80 AND OVER; AMINO ACID SUBSTITUTION; FEMALE; FOUNDER EFFECT; GENE FREQUENCY; HUMANS; MALE; MIDDLE AGED; MUTATION; PARKINSON DISEASE; PROTEIN-SERINE-THREONINE KINASES; TAIWAN;

EID: 33745862378     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.20814     Document Type: Article

References (7)

1. Chen RC, Chang SF, SU CL, et al. Prevalence, incidence, and mortality of PD: a door-to-door survey in Ilan County, Taiwan. Neurology 2001;57:1679-1686.
2. Zhang ZX, Roman GC. Worldwide occurrence of Parkinson's disease: an updated review. Neuroepidemiology 1993;12:195-208.
3. Paisan-Ruiz C, Jain S, Evans EW, et al. Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease. Neuron 2004;44:595-600.
4. Zimprich A, Biskup S, Leitner P, et al. Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology. Neuron 2004;44:601-607.
5. Kachergus J, Mata IF, Hulihan M, et al. Identification of a novel LRRK2 mutation linked to autosomal dominant parkinsonism: evidence of a common founder across European populations. Am J Hum Genet 2005;76:672-680.
6. Calne DB, Snow BJ, Lee C. Criteria for diagnosing Parkinson's disease. Ann Neurol 1992;32:S125-SS127.
7. Gilks WP, Abou-Sleiman PM, Gandhi S, et al. A common LRRK2 mutation in idiopathic Parkinson's disease. Lancet 2005;365:415-416.