Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors

Journal of Alzheimer's Disease

Volumn 16, Issue 3, 2009, Pages 551-564

  Miyoshi, Katsue ^a   Ohyagi, Yasumasa ^a,d   Sakae, Nobutaka ^a   Motomura, Kyoko ^a   Ma, Linqing ^a   Taniwaki, Takayuki ^a   Furuya, Hirokazu ^b   Tabira, Takeshi ^c   Kira, Jun Ichi ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b Omuta National Hospital   (Japan)

^c NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^d NONE   (Japan)

Author keywords

Alzheimer's disease; Apoptosis; Caspase; Presenilin; secretase; secretase

Indexed keywords

BETA SECRETASE INHIBITOR; CASPASE 3; CASPASE 4; CASPASE 7; CASPASE 8; CASPASE 9; GAMMA SECRETASE INHIBITOR; HYDROGEN PEROXIDE; PRESENILIN 1; THAPSIGARGIN; CASP4 PROTEIN, HUMAN; CASPASE; ENZYME INHIBITOR; INITIATOR CASPASE; OXIDIZING AGENT; PSEN1 PROTEIN, HUMAN; SECRETASE;

APOPTOSIS; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE MUTATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; UPREGULATION; ALZHEIMER DISEASE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; GENETIC TRANSFECTION; GENETICS; METABOLISM; MUTATION; NERVE CELL; NEUROBLASTOMA; PHYSIOLOGY; TUMOR CELL LINE;

ALZHEIMER DISEASE; AMYLOID PRECURSOR PROTEIN SECRETASES; APOPTOSIS; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CASPASES; CASPASES, INITIATOR; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; HYDROGEN PEROXIDE; MUTATION; NEUROBLASTOMA; NEURONS; OXIDANTS; PRESENILIN-1; THAPSIGARGIN; TRANSFECTION;

EID: 65549124117     PISSN: 13872877     EISSN: None     Source Type: Journal    
DOI: 10.3233/JAD-2009-0989     Document Type: Article

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