The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation

PLoS ONE

Volumn 4, Issue 4, 2009, Pages

  Silva, Raquel M ^a,c   Duarte, Iven C N ^a   Paredes, João A ^a   Lima Costa, Tatiana ^a   Perrot, Michel ^b   Boucherie, Hélian ^b   Goodfellow, Brian J ^a   Gomes, Ana C ^a   Mateus, Denisa D ^a   Moura, Gabriela R ^a   Santos, Manuel A S ^a  

^a UNIVERSITY OF AVEIRO   (Portugal)

^b CNRS   (France)

^c UNIVERSITY OF PORTO   (Portugal)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID DERIVATIVE; BIOLOGICAL MARKER; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MESSENGER RNA; NICOTINAMIDASE; PEPTIDE; PNC 1 PROTEIN; TRANSFER RNA; UNCLASSIFIED DRUG; PNC1 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN;

ARTICLE; CELL DEATH; CELL DEGENERATION; CELL FUNCTION; CELL GROWTH; CODON; CONTROLLED STUDY; DEGENERATIVE DISEASE; DENDRITIC CELL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENVIRONMENTAL FACTOR; ESCHERICHIA COLI; GENE CONTROL; GENE MUTATION; GENETIC CODE; GENETIC ENGINEERING; IN VIVO STUDY; LONGEVITY; NEOPLASM; NONHUMAN; PROTEIN FOLDING; PROTEIN SYNTHESIS; RNA TRANSLATION; SACCHAROMYCES CEREVISIAE; STRESS; UPREGULATION; YEAST; FUNGAL GENE; GENETICS; NUCLEAR MAGNETIC RESONANCE;

ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE;

GENES, FUNGAL; LONGEVITY; NICOTINAMIDASE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BIOSYNTHESIS; RNA, MESSENGER; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; UP-REGULATION;

EID: 65449173889     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0005212     Document Type: Article

References (50)

1. Edelmann P, Gallant J (1977) Mistranslation in E. coli. Cell 10: 131-137.
2. Farabaugh PJ, Bjork GR (1999) How translational accuracy influences reading frame maintenance. EMBO J 18: 1427-1434.
3. Kramer EB, Farabaugh PJ (2007) The frequency of translational misreading errors in E. coli is largely determined by tRNA competition. RNA 13: 87-96.
4. Ortego BC, Whittenton JJ, Li H, Tu SC, Willson RC (2007) In vivo translational inaccuracy in Escherichia coli: missense reporting using extremely low activity mutants of Vibrio harveyi luciferase. Biochemistry 46: 13864-13873.
5. Murgola EJ, Pagel FT, Hijazi KA (1984) Codon context effects in missense suppression. J Mol Biol 175: 19-27.
6. Parker J, Precup J (1986) Mistranslation during phenylalanine starvation. Mol Gen Genet 204: 70-74.
7. Stansfield I, Jones KM, Herbert P, Lewendon A, Shaw WV, et al. (1998) Missense translation errors in Saccharomyces cerevisiae. J Mol Biol 282: 13-24.
8. Yewdell JW, Anton LC, Bennink JR (1996) Defective ribosomal products (DRiPs): a major source of antigenic peptides for MHC class I molecules? J Immunol 157: 1823-1826.
9. Yewdell JW, Schubert U, Bennink JR (2001) At the crossroads of cell biology and immunology: DRiPs and other sources of peptide ligands for MHC class I molecules. J Cell Sci 114: 845-851.
10. Santos MA, Moura G, Massey SE, Tuite MF (2004) Driving change: the evolution of alternative genetic codes. Trends Genet 20: 95-102.
11. Silva RM, Miranda I, Moura G, Santos MA (2004) Yeast as a model organism for studying the evolution of non-standard genetic codes. Brief Funct Genomic Proteomic 3: 35-46.
12. Schultz DW, Yarus M (1994) Transfer RNA mutation and the malleability of the genetic code. J Mol Biol 235: 1377-1380.
13. Knight RD, Landweber LF, Yarus M (2001) How mitochondria redefine the code. J Mol Evol 53: 299-313.
14. Miranda I, Silva R, Santos MA (2006) Evolution of the genetic code in yeasts. Yeast 23: 203-213.
15. Gomes AC, Miranda I, Silva RM, Moura GR, Thomas B, et al. (2007) A genetic code alteration generates a proteome of high diversity in the human pathogen Candida albicans. Genome Biol 8: R206.
16. Miranda I, Rocha R, Santos MC, Mateus DD, Moura GR, et al. (2007) A genetic code alteration is a phenotype diversity generator in the human pathogen Candida albicans. PLoS ONE 2: e996.
17. Ling J, Roy H, Qin D, Rubio MA, Alfonzo JD, et al. (2007) Pathogenic mechanism of a human mitochondrial tRNAPhe mutation associated with myoclonic epilepsy with ragged red fibers syndrome. Proc Natl Acad Sci U S A 104: 15299-15304.
18. Rabilloud T, Strub JM, Carte N, Luche S, Van Dorsselaer A, et al. (2002) Comparative proteomics as a new tool for exploring human mitochondrial tRNA disorders. Biochemistry 41: 144-150.
19. Yasukawa T, Suzuki T, Ueda T, Ohta S, Watanabe K (2000) Modification defect at anticodon wobble nucleotide of mitochondrial tRNAs(Leu)(UUR) with pathogenic mutations of mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes. J Biol Chem 275: 4251-4257.
20. Wilson FH, Hariri A, Farhi A, Zhao H, Petersen KF, et al. (2004) A cluster of metabolic defects caused by mutation in a mitochondrial tRNA. Science 306: 1190-1194.
21. Nangle LA, Motta CM, Schimmel P (2006) Global effects of mistranslation from an editing defect in mammalian cells. Chem Biol 13: 1091-1100.
22. Lee JW, Beebe K, Nangle LA, Jang J, Longo-Guess CM, et al. (2006) Editing-defective tRNA synthetase causes protein misfolding and neurodegeneration. Nature 443: 50-55.
23. Kimata Y, Yanagida M (2004) Suppression of a mitotic mutant by tRNA-Ala anticodon mutations that produce a dominant defect in late mitosis. J Cell Sci 117: 2283-2293.
24. Silva RM, Paredes JA, Moura GR, Manadas B, Lima-Costa T, et al. (2007) Critical roles for a genetic code alteration in the evolution of the genus Candida. EMBO J 26: 4555-4565.
25. Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA (2003) Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185.
26. Ghislain M, Talla E, Francois JM (2002) Identification and functional analysis of the Saccharomyces cerevisiae nicotinamidase gene, PNC1. Yeast 19: 215-224.
27. Gallo CM, Smith DL Jr, Smith JS (2004) Nicotinamide clearance by Pnc1 directly regulates Sir2-mediated silencing and longevity. Mol Cell Biol 24: 1301-1312.
28. Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, et al. (2003) Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 302: 2124-2126.
29. Lin SJ, Defossez PA, Guarente L (2000) Requirement of NAD and SIR2 for lifespan extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126-2128.
30. Lin SJ, Guarente L (2003) Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol 15: 241-246.
31. Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, et al. (2005) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310: 1193-1196.
32. Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580.
33. Sinclair DA, Guarente L (1997) Extrachromosomal rDNA circles - a cause of aging in yeast. Cell 91: 1033-1042.
34. Lamming DW, Latorre-Esteves M, Medvedik O, Wong SN, Tsang FA, et al. (2005) HST2 mediates SIR2-independent life-span extension by calorie restriction. Science 309: 1861-1864.
35. Fabrizio P, Gattazzo C, Battistella L, Wei M, Cheng C, et al. (2005) Sir2 blocks extreme life-span extension. Cell 123: 655-667.
36. Trotter EW, Kao CM, Berenfeld L, Botstein D, Petsko GA, et al. (2002) Misfolded proteins are competent to mediate a subset of the responses to heat shock in Saccharomyces cerevisiae. J Biol Chem 277: 44817-44825.
37. Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, et al. (1998) Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics 150: 613-632.
38. Torres EM, Sokolsky T, Tucker CM, Chan LY, Boselli M, et al. (2007) Effects of aneuploidy on cellular physiology and cell division in haploid yeast. Science 317: 916-924.
39. Oberdoerffer P, Sinclair DA (2007) The role of nuclear architecture in genomic instability and ageing. Nat Rev Mol Cell Biol 8: 692-702.
40. Smith JS, Brachmann CB, Pillus L, Boeke JD (1998) Distribution of a limited Sir2 protein pool regulates the strength of yeast rDNA silencing and is modulated by Sir4p. Genetics 149: 1205-1219.
41. Yang H, Lavu S, Sinclair DA (2006) Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity? Exp Gerontol 41: 718-726.
42. Yang H, Yang T, Baur JA, Perez E, Matsui T, et al. (2007) Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival. Cell 130: 1095-1107.
43. Reverter-Branchat G, Cabiscol E, Tamarit J, Ros J (2004) Oxidative damage to specific proteins in replicative and chronological-aged Saccharomyces cerevisiae: common targets and prevention by calorie restriction. J Biol Chem 279: 31983-31989.
44. Sinclair DA (2003) Cell biology. An age of instability. Science 301: 1859-1860.
45. Santos MA, Perreau VM, Tuite MF (1996) Transfer RNA structural change is a key element in the reassignment of the CUG codon in Candida albicans. EMBO J 15: 5060-5068.
46. Boucherie H, Dujardin G, Kermorgant M, Monribot C, Slonimski P, et al. (1995) Two-dimensional protein map of Saccharomyces cerevisiae: construction of a gene-protein index. Yeast 11: 601-613.
47. Boucherie H, Sagliocco F, Joubert R, Maillet I, Labarre J, et al. (1996) Two-dimensional gel protein database of Saccharomyces cerevisiae. Electrophoresis 17: 1683-1699.
48. Boucherie H, Monribot C (2005) Two-Dimensional Gel Electrophoresis of Total Yeast Proteins. In: Xiao W, ed. Yeast Protocols: Second Edition. Totowa, NJ: Humana Press. pp 47-64.
49. Gietz RD, Woods RA (1994) High efficiency transformation with lithium acetate. In: Johnston JR, ed. Molecular Genetics of Yeast: A Practical Approach. Oxford: IRL Press. pp 121-134.
50. Lahue E, Heckathorn J, Meyer Z, Smith J, Wolfe C (2005) The Saccharomyces cerevisiae Sub2 protein suppresses heterochromatic silencing at telomeres and subtelomeric genes. Yeast 22: 537-551.