The current status of islet transplantation and its perspectives

Review of Diabetic Studies

Volumn 5, Issue 3, 2008, Pages 136-143

  Kobayashi, Naoya ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Beta cell regeneration; Diabetes; Islet transplantation; Stem cell

Indexed keywords

FIBROBLAST GROWTH FACTOR 2; GLUCAGON LIKE PEPTIDE 1; IMMUNOSUPPRESSIVE AGENT; INSULIN; SCATTER FACTOR; SOMATOMEDIN B;

CADAVER DONOR; CELL REGENERATION; DIABETES MELLITUS; GRAFT REJECTION; GRAFT SURVIVAL; HOMEOSTASIS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN TREATMENT; ISOLATION PROCEDURE; METABOLIC REGULATION; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET CELL FUNCTION; PANCREAS ISLET TRANSPLANTATION; PANCREAS TRANSPLANTATION; QUALITY CONTROL; REGENERATIVE ABILITY; REVIEW; RISK ASSESSMENT; STEM CELL TRANSPLANTATION; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT; XENOGRAFT;

EID: 65349156626     PISSN: 16136071     EISSN: 16140575     Source Type: Journal    
DOI: 10.1900/RDS.2008.5.136     Document Type: Review

References (47)

1. Halban PA. Cellular sources of new pancreatic beta cells and therapeutic implications for regenerative medicine. Nat Cell Biol 2004. 6(11):1021-1025. (Pubitemid 39468001)
2. Kaestner KH. Beta cell transplantation and immunosuppression: can't live with it, can't live without it. J Clin Invest 2007. 117(9):2380-2382. (Pubitemid 47494336)
3. Trucco M. Regeneration of the pancreatic beta cell. J Clin Invest 2005. 115(1):5-12.
4. Shapiro AM, Lakey JR, Ryan EA, Korbutt GS, Toth E, Warnock GL, Kneteman NM, Rajotte RV. Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000. 343(4):230-238. (Pubitemid 30490390)
5. Holz GG, Kuhtreiber WM, Habener JF. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7-37). Nature 1993. 361(6410):362-365. (Pubitemid 23041630)
6. Ido Y, Vindigni A, Chang K, Stramm L, Chance R, Heath WF, DiMarchi RD, Di Cera E, Williamson JR. Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 1997. 277(5325):563-566. (Pubitemid 27369004)
7. Ricordi C, Inverardi L, Kenyon NS, Goss J, Bertuzzi F, Alejandro R. Requirements for success in clinical islet transplantation. Transplantation 2005. 79(10):1298-1300. (Pubitemid 40734788)
8. Shapiro AM, Gallant HL, Hao EG, Lakey JR, McCready T, Rajotte RV, Yatscoff RW, Kneteman NM. The portal immunosuppressive storm: relevance to islet transplantation? Ther Drug Monit 2005. 27(1):35-37. (Pubitemid 40189971)
9. Okitsu T, Matsumoto S, Iwanaga Y, Noguchi H, Nagataa H, Yonekawa Y, Maekawa T, Tanaka K. Kyoto islet isolation method: The optimized one for non-heart-beating donors with highly efficient islet retrieval. Transplant Proc 2005 37(8):3391-3392. (Pubitemid 41659895)
10. Matsumoto S, Okitsu T, Iwanaga Y, Noguchi H, Nagata H, Yonekawa Y, Yamada Y, Fukuda K, Tsukiyama K, Suzuki H, et al. Insulin independence after living-donor distal pancreatectomy and islet allotransplantation. Lancet 2005 365(9471):1642-1644. (Pubitemid 40693414)
11. Stagner JI, Rilo HL, White KK. The pancreas as an islet transplantation site. Confirmation in a syngeneic rodent and canine autotransplant model. J Pancreas 2007. 8(5):628-636. (Pubitemid 47484622)
12. Konstantinova I, Lammert E. Microvascular development: learning from pancreatic islets. Bioessays 2004. 26(10):1069-1075. (Pubitemid 39424810)
13. Bouwens L, Rooman I. Regulation of pancreatic beta-cell mass. Physiol Rev 2005. 85(4):1255-1270. (Pubitemid 41362270)
14. Bonner-Weir S. Beta-cell turnover: its assessment and implications. Diabetes 2001. 50(Suppl 1):S20-S24. (Pubitemid 32148210)
15. Zulewski H, Abraham EJ, Gerlach MJ, Daniel PB, Moritz W, Müller B, Vallejo M, Thomas MK, Habener JF. Multi-potential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 2001. 50(3):521-533. (Pubitemid 32195216)
16. Bonner-Weir S, Taneja M, Weir GC, Tatarkiewicz K, Song KH, Sharma A, O'Neil JJ. In vitro cultivation of human islets from expanded ductal tissue. Proc Natl Acad Sci U S A 2000. 97(14):7999-8004. (Pubitemid 30460762)
17. Lechner A, Habener JF. Stem/progenitor cells derived from adult tissues: potential for the treatment of diabetes mellitus. Am J Physiol Endocrinol Metab 2003. 284(2):E259-E266. (Pubitemid 36120097)
18. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004. 429(6987):41-46. (Pubitemid 38620543)
19. Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 2007. 117(9):2553-2561. (Pubitemid 47494356)
20. Bernard C, Berthault MF, Saulnier C, Ktorza A. Neogenesis vs. apoptosis As main components of pancreatic beta cell mass changes in glucose-infused normal and mildly diabetic adult rats. Faseb J 1999. 13(10):1195-1205. (Pubitemid 29300365)
21. Maedler K, Sergeev P, Ris F, Oberholzer J, Joller-Jemelka HI, Spinas GA, Kaiser N, Halban PA, Donath MY. Glucose-induced beta cell production of IL-1beta contributes to glucotoxicity in human pancreatic islets. J Clin Invest 2002. 110(6):851-860. (Pubitemid 35050963)
22. Otani K, Kulkarni RN, Baldwin AC, Krutzfeldt J, Ueki K, Stoffel M, Kahn CR, Polonsky KS. Reduced beta-cell mass and altered glucose sensing impair insulin-secretory function in betaIRKO mice. Am J Physiol Endocrinol Metab 2004. 286(1):E41-E49. (Pubitemid 38036608)
23. Hill DJ, Strutt B, Arany E, Zaina S, Coukell S, Graham CF. Increased and persistent circulating insulin-like growth factor II in neonatal transgenic mice suppresses developmental apoptosis in the pancreatic islets. Endocrinology 2000. 141(3):1151-1157. (Pubitemid 32260458)
24. Ilieva A, Yuan S, Wang RN, Agapitos D, Hill DJ, Rosenberg L. Pancreatic islet cell survival following islet isolation: the role of cellular interactions in the pancreas. J Endocrinol 1999. 161(3):357-364. (Pubitemid 29278791)
25. Elghazi L, Cras-Meneur C, Czernichow P, Scharfmann R. Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation. Proc Natl Acad Sci U S A 2002. 99(6):3884-3889. (Pubitemid 34252200)
26. Hart AW, Baeza N, Apelqvist A, Edlund H. Attenuation of FGF signalling in mouse beta-cells leads to diabetes. Nature 2000. 408(6814):864-868. (Pubitemid 32016097)
27. Rivas-Carrillo JD, Navarro-Alvarez N, Soto-Gutierrez A, Okitsu T, Chen Y, Tabata Y, Misawa H, Noguchi H, Matsumoto S, Tanaka N, Kobayashi N. Amelioration of diabetes in mice after single-donor islet transplantation using the controlled release of gelatinized FGF-2. Cell Transplant 2006. 15(10):939-944. (Pubitemid 46174544)
28. Garcia-Ocana A, Takane KK, Syed MA, Philbrick WM, Vasavada RC, Stewart AF. Hepatocyte growth factor overexpression in the islet of transgenic mice increases beta cell proliferation, enhances islet mass, and induces mild hypoglycemia. J Biol Chem 2000. 275(2):1226-1232. (Pubitemid 30051175)
29. Nakano M, Yasunami Y, Maki T, Kodama S, Ikehara Y, Nakamura T, Tanaka M, Ikeda S. Hepatocyte growth factor is essential for amelioration of hyperglycemia in streptozotocin-induced diabetic mice receiving a marginal mass of intrahepatic islet grafts. Transplantation 2000. 69(2):214-221. (Pubitemid 30075277)
30. King A, Lock J, Xu G, Bonner-Weir S, Weir GC. Islet transplantation outcomes in mice are better with fresh islets and exendin-4 treatment. Diabetologia 2005. 48(10):2074-2079. (Pubitemid 41416919)
31. Xu G, Stoffers DA, Habener JF, Bonner-Weir S. Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 1999. 48(12):2270-2276. (Pubitemid 30395416)
32. Bertuzzi F, Ricordi C. Prediction of clinical outcome in islet allotransplantation. Diabetes Care 2007. 30(2):410-417. (Pubitemid 46201652)
33. Girman P, Berkova Z, Dobolilova E, Saudek F. How to use image analysis for islet counting. Rev Diabet Stud 2008. 5(1):38-46.
34. Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Chen Y, Yuasa T, Tanaka K, Narushima M, Miki A, et al. Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice. Diabetes 2007. 56(5):1259-1267. (Pubitemid 46715606)
35. Ichii H, Inverardi L, Pileggi A, Molano RD, Cabrera O, Caicedo A, Messinger S, Kuroda Y, Berggren PO, Ricordi C. A novel method for the assessment of cellular composition and beta-cell viability in human islet preparations. Am J Transplant 2005. 5(7):1635-1645. (Pubitemid 40910445)
36. Halme DG, Kessler DA. FDA regulation of stem-cell-based therapies. N Engl J Med 2006. 355(16):1730-1735. (Pubitemid 44583964)
37. Efrat S. Ex-vivo Expansion of Adult Human Pancreatic Beta-Cells. Rev Diabet Stud 2008. 5(2):116-122.
38. Koblas T, Harman SM, Saudek F. The application of umbilical cord blood cells in the treatment of diabetes mellitus. Rev Diabet Stud 2005. 2(4):228-234.
39. D'Amour KA, Bang AG, Eliazer S, Kelly OG, Agulnick AD, Smart NG, Moorman MA, Kroon E, Carpenter MK, Baetge EE. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006. 24(11):1392-1401. (Pubitemid 44722103)
40. Lechner A, Yang YG, Blacken RA, Wang L, Nolan AL, Habener JF. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 2004. 53(3):616-623. (Pubitemid 38270630)
41. Rajagopal J, Anderson WJ, Kume S, Martinez OI, Melton DA. Insulin staining of ES cell progeny from insulin uptake. Science 2003. 299(5605):363. (Pubitemid 36120032)
42. Fujikawa T, Oh SH, Pi L, Hatch HM, Shupe T, Petersen BE. Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells. Am J Pathol 2005. 166(6):1781-1791. (Pubitemid 40734401)
43. Hussain MA, Theise ND. Stem-cell therapy for diabetes mellitus. Lancet 2004. 364(9429):203-205. (Pubitemid 38891693)
44. Suri A, Calderon B, Esparza TJ, Frederick K, Bittner P, Unanue ER. Immunological reversal of autoimmune diabetes without hematopoietic replacement of beta cells. Science 2006. 311(5768):1778-1780.
45. Hering BJ, Wijkstrom M, Graham ML, Hardstedt M, Aasheim TC, Jie T, Ansite JD, Nakano M, Cheng J, Li W, et al. Prolonged diabetes reversal after intraportal xenotransplantation of wild-type porcine islets in immunosuppressed nonhuman primates. Nat Med 2006. 12(3):301-303. (Pubitemid 43355076)
46. Paradis K, Langford G, Long Z, Heneine W, Sandstrom P, Switzer WM, Chapman LE, Lockey C, Onions D, Otto E. Search for cross-species transmission of porcine endogenous retrovirus in patients treated with living pig tissue. The XEN 111 Study Group. Science 1999. 285(5431):1236-1241. (Pubitemid 29398604)
47. Kandaswamy R, Sutherland D. Pancreas versus islet transplantation in diabetes mellitus: how to allocate deceased donor pancreata? Transplant Proc 2006. 38(2):365-367.