Selective synergy in anti-inflammatory cytokine production upon cooperated signaling via TLR4 and TLR2 in murine conventional dendritic cells

Molecular Immunology

Volumn 45, Issue 10, 2008, Pages 2734-2742

  Hirata, Noriyuki ^a   Yanagawa, Yoshiki ^a   Ebihara, Takashi ^b   Seya, Tsukasa ^b   Uematsu, Satoshi ^c   Akira, Shizuo ^c   Hayashi, Fumie ^a   Iwabuchi, Kazuya ^a   Onoé, Kazunori ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b HOKKAIDO UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Cytokines; Dendritic cells; Signal transduction; Toll like receptor

Indexed keywords

CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 12; LIGAND; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN P40; STRESS ACTIVATED PROTEIN KINASE 1; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MARROW CELL; CELL SURFACE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOLOGICAL MARKERS; CELL MEMBRANE; CELLS, CULTURED; DENDRITIC CELLS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; INTERLEUKIN-10; INTERLEUKIN-12; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIGANDS; LIPOPOLYSACCHARIDES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASE INHIBITORS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4;

MURINAE;

EID: 41849101964     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.02.010     Document Type: Article

References (48)

1. Akira S., Takeda K., and Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2 (2001) 675-680
2. Bagchi A., Herrup E.A., Warren H.S., Trigilio J., Shin H.S., Valentine C., and Hellman J. MyD88-dependent and MyD88-independent pathways in synergy, priming, and tolerance between TLR agonists. J. Immunol. 178 (2007) 1164-1171
3. Banchereau J., and Steinman R.M. Dendritic cells and the control of immunity. Nature 392 (1998) 245-251
4. Belkaid Y. Regulatory T cells and infection: a dangerous necessity. Nat. Rev. Immunol. 7 (2007) 875-888
5. Brightbill H.D., Libraty D.H., Krutzik S.R., Yang R.B., Belisle J.T., Bleharski J.R., Maitland M., Norgard M.V., Plevy S.E., Smale S.T., Brennan P.J., Bloom B.R., Godowski P.J., and Modlin R.L. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors. Science 285 (1999) 732-736
6. Covert M.W., Leung T.H., Gaston J.E., and Baltimore D. Achiving stability of lipopolysaccharide-induced NF-κB activation. Science 309 (2005) 1854-1857
7. David M.D., Cochrane C.L., Duncan S.K., and Schrader J.W. Pure lipopolysaccharide or synthetic lipid A induces activation of p21 Ras in primary macrophages through a pathway dependent on Src family kinases and PI3K. J. Immunol. 175 (2005) 8236-8241
8. Fitzgerald K.A., Palsson-McDermott E.M., Bowie A.G., Jefferies C.A., Mansell A.S., Brady G., Brint E., Dunne A., Gray P., Harte M.T., McMurray D., Smith D.E., Sims J.E., Bird T.A., and O'Neill L.A. Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. Nature 413 (2001) 78-83
9. Fujihara M., Muroi M., Tanamoto K., Suzuki T., Azuma H., and Ikeda H. Molecular mechanisms of macrophage activation and deactivation by lipopolysaccharide: roles of the receptor complex. Pharmacol. Ther. 100 (2003) 171-194
10. Häcker H., Redecke V., Blagoev B., Kratchmarova I., Hsu L.C., Wang G.G., Kamps M.P., Raz E., Wagner H., Häcker G., Mann M., and Karin M. Specificity in Toll-like receptor signalling through distinct effector functions of TRAF3 and TRAF6. Nature 439 (2006) 204-207
11. Hart D.N.J. Dendritic cells: unique leukocyte populations which control the primary immune response. Blood 90 (1997) 3245-3287
12. Hellman J., Tehan M.M., and Warren H.S. Murein lipoprotein, peptidoglycan-associated lipoprotein, and outer membrane protein A are present in purified rough and smooth lipopolysaccharides. J. Infect. Dis. 188 (2003) 286-289
13. Hirschfeld M., Ma Y., Weis J.H., Vogel S.N., and Weis J.J. Cutting edge: repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2. J. Immunol. 165 (2000) 618-622
14. Hoebe K., and Beutler B. TRAF3: a new component of the TLR-signaling apparatus. Trends Mol. Med. 12 (2006) 187-189
15. Horng T., Barton G.M., and Medzhitov R. Tirap: an adapter molecule in the Toll signaling pathway. Nat. Immunol. 2 (2001) 835-841
16. Imler J.L., and Hoffmann J.A. Toll signaling: the TIReless quest for specificity. Nat. Immunol. 4 (2003) 105-106
17. Inaba K., Inaba M., Romani N., Aya H., Deguchi M., Ikehara S., Muramatsu S., and Steinman R.M. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor. J. Exp. Med. 176 (1992) 1693-1702
18. Kawai T., and Akira S. Pathogen recognition with Toll-like receptors. Curr. Opin. Immunol. 17 (2005) 338-344
19. Kawai T., and Akira S. Signaling to NF-κB by Toll-like receptors. Trends Mol. Med. 13 (2007) 460-469
20. Liu Y.W., Chen C.C., Tseng H.P., and Chang W.C. Lipopolysaccharide-induced transcriptional activation of interleukin-10 is mediated by MAPK- and NF-κB-induced CCAAT/enhancer-binding protein δ in mouse macrophages. Cell. Signal. 18 (2006) 1492-1500
21. McGuirk P., and Mills K.H. Pathogen-specific regulatory T cells provoke a shift in the Th1/Th2 paradigm in immunity to infectious diseases. Trends Immunol. 23 (2002) 450-455
22. Means T.K., Lien E., Yoshimura A., Wang S., Golenbock D.T., and Fenton M.J. The CD14 ligands lipoarabinomannan and lipopolysaccharide differ in their requirement for Toll-like receptors. J. Immunol. 163 (1999) 6748-6755
23. Means T.K., Golenbock D.T., and Fenton M.J. The biology of Toll-like receptors. Cytokine Growth Factor Rev. 11 (2000) 219-232
24. Medzhitov R., Preston-Hurlburt P., Kopp E., Stadlen A., Chen C., Ghosh S., and Janeway Jr. C.A. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2 (1998) 253-258
25. Miller S.I., Ernst R.K., and Bader M.W. LPS, TLR4 and infectious disease diversity. Nat. Rev. Microbiol. 3 (2005) 36-46
26. Nakahara T., Moroi Y., Uchi H., and Furue M. Differential role of MAPK signaling in human dendritic cell maturation and Th1/Th2 engagement. J. Dermatol. Sci. 42 (2006) 1-11
27. Napolitani G., Rinaldi A., Bertoni F., Sallusto F., and Lanzavecchia A. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nat. Immunol. 6 (2005) 769-776
28. Norkina O., Dolganiuc A., Shapiro T., Kodys K., Mandrekar P., and Szabo G. Acute alcohol activates STAT3, AP-1, and Sp-1 transcription factors via the family of Src kinases to promote IL-10 production in human monocytes. J. Leukoc. Biol. 82 (2007) 752-762
29. O'Garra A., and Vieira P. Th1 cells control themselves by producing interleukin-10. Nat. Rev. Immunol. 7 (2007) 425-428
30. O'Neill L.A. Targeting signal transduction as a strategy to treat inflammatory diseases. Nat. Rev. Drug Discov. 5 (2006) 549-563
31. O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7 (2007) 353-364
32. Pengal R.A., Ganesan L.P., Wei G., Fang H., Ostrowski M.C., and Tridandapani S. Lipopolysaccharide-induced production of interleukin-10 is promoted by the serine/threonine kinase Akt. Mol. Immunol. 43 (2006) 1557-1564
33. Poltorak A., He X., Smirnova I., Liu M.Y., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
34. Polumuri S.K., Toshchakov V.Y., and Vogel S.N. Role of phosphatidylinositol-3 kinase in transcriptional regulation of TLR-induced IL-12 and IL-10 by Fcγ receptor ligation in murine macrophages. J. Immunol. 179 (2007) 236-246
35. Qian C., Jiang X., An H., Yu Y., Guo Z., Liu S., Xu H., and Cao X. TLR agonists promote ERK-mediated preferential IL-10 production of regulatory dendritic cells (diffDCs), leading to NK-cell activation. Blood 108 (2006) 2307-2315
36. Qureshi S.T., Lariviere L., Leveque G., Clermont S., Moore K.J., Gros P., and Malo D. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189 (1999) 615-625
37. Rutella S., Danese S., and Leone G. Tolerogenic dendritic cells: cytokine modulation comes of age. Blood 108 (2006) 1435-1440
38. Saegusa K., Yotsumoto S., Kato S., and Aramaki Y. Phosphatidylinositol 3-kinase-mediated regulation of IL-10 and IL-12 production in macrophages stimulated with CpG oligodeoxynucleotide. Mol. Immunol. 44 (2007) 1323-1330
39. Sato S., Nomura F., Kawai T., Takeuchi O., Mühlradt P.F., Takeda K., and Akira S. Synergy and cross-tolerance between toll-like receptor (TLR) 2- and TLR4-mediated signaling pathways. J. Immunol. 165 (2000) 7096-7101
40. Steinman R.M. The dendritic cell system and its role in immunogenicity. Annu. Rev. Immunol. 9 (1991) 271-296
41. Takeda K., Kaisho T., and Akira S. Toll-like receptors. Annu. Rev. Immunol. 21 (2003) 335-376
42. Takeuchi O., Hoshino K., Kawai T., Sanjo H., Takada H., Ogawa T., Takeda K., and Akira S. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 11 (1999) 443-451
43. Tapping R.I., Akashi S., Miyake K., Godowski P.J., and Tobias P.S. Toll-like receptor 4, but not Toll-like receptor 2, is a signaling receptor for Escherichia and Salmonella lipopolysaccharides. J. Immunol. 165 (2000) 5780-5787
44. Theiner G., Rössner S., Dalpke A., Bode K., Berger T., Gessner A., and Lutz M.B. TLR9 cooperates with TLR4 to increase IL-12 release by murine dendritic cells. Mol. Immunol. 45 (2008) 244-252
45. Trinchieri G., and Sher A. Cooperation of Toll-like receptor signals in innate immune defence. Nat. Rev. Immunol. 7 (2007) 179-190
46. Underhill D.M., Ozinsky A., Hajjar A.M., Stevens A., Wilson C.B., Bassetti M., and Aderem A. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 401 (1999) 811-815
47. Yanagawa Y., Iijima N., Iwabuchi K., and Onoé K. Activation of extracellular signal-related kinase by TNF-α controls the maturation and function of murine dendritic cells. J. Leukoc. Biol. 71 (2002) 125-132
48. Yanagawa Y., and Onoé K. Enhanced IL-10 production by TLR4- and TLR2-primed dendritic cells upon TLR restimulation. J. Immunol. 178 (2007) 6173-6180