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A general explanation of the role of the liquid phase in liquid-assisted grinding does not exist and it is very likely that it can vary from case to case. For that reason, we find it appropriate to encompass all possible mechanisms of mechanochemical cocrystal formation that utilize an additional liquid phase under the common name liquid-assisted grinding. In that way, a bias towards a particular mechanism, introduced by the term solvent-drop grinding, is avoided. From that perspective, solvent-drop grinding is more appropriate to describe a strategy of liquid-assisted grinding that utilizes the solubility of reactants in the liquid phase to enhance or enable cocrystal formation
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A general explanation of the role of the liquid phase in liquid-assisted grinding does not exist and it is very likely that it can vary from case to case. For that reason, we find it appropriate to encompass all possible mechanisms of mechanochemical cocrystal formation that utilize an additional liquid phase under the common name "liquid-assisted grinding". In that way, a bias towards a particular mechanism, introduced by the term "solvent-drop grinding", is avoided. From that perspective, solvent-drop grinding is more appropriate to describe a strategy of liquid-assisted grinding that utilizes the solubility of reactants in the liquid phase to enhance or enable cocrystal formation.
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A typical procedure that is applied for rapid screening in our laboratory is as follows: a sample of 200 mg of a solid mixture of cocrystal components in the appropriate stoichiometric composition is placed in a 10 mL stainless steel grinding jar, along with 50μL of a suitable liquid and two stainless steel grinding balls of 7 mm diameter. The samples are then ground in a Retsch MM200 grinding mill for 20 min, typically resulting in quantitative yields of cocrystal.
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A typical procedure that is applied for rapid screening in our laboratory is as follows: a sample of 200 mg of a solid mixture of cocrystal components in the appropriate stoichiometric composition is placed in a 10 mL stainless steel grinding jar, along with 50μL of a suitable liquid and two stainless steel grinding balls of 7 mm diameter. The samples are then ground in a Retsch MM200 grinding mill for 20 min, typically resulting in quantitative yields of cocrystal.
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