Physical stability enhancement of theophylline via cocrystallization

International Journal of Pharmaceutics

Volumn 320, Issue 1-2, 2006, Pages 114-123

  Trask, Andrew V ^a   Motherwell, W D Sam ^b   Jones, William ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b CAMBRIDGE CRYSTALLOGRAPHIC DATA CENTRE   (United Kingdom)

Author keywords

Cocrystal; Crystal engineering; Crystalline molecular complex; Hydrate; Hydrogen bond; Relative humidity; Stability; Theophylline

Indexed keywords

CAFFEINE; DICARBOXYLIC ACID; GLUTARIC ACID; MALEIC ACID; MALONIC ACID; OXALIC ACID; RESPIRATORY TRACT AGENT; THEOPHYLLINE;

ARTICLE; CHEMICAL MODIFICATION; COMPARATIVE STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG DESIGN; DRUG STABILITY; DRUG STORAGE; DRUG SYNTHESIS; HUMIDITY; HYDRATION; HYDROGEN BOND; PHARMACEUTICAL ENGINEERING; PRIORITY JOURNAL; SOLID;

BRONCHODILATOR AGENTS; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DICARBOXYLIC ACIDS; DRUG STABILITY; FEASIBILITY STUDIES; GLUTARATES; HYDROGEN BONDING; MALEATES; MALONATES; MOLECULAR STRUCTURE; OXALIC ACID; THEOPHYLLINE; WATER;

EID: 33746425242     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.04.018     Document Type: Article

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