Stem cell aging

Journals of Gerontology - Series A Biological Sciences and Medical Sciences

Volumn 64, Issue 2, 2009, Pages 202-204

  Sharpless, Norman E ^a   Schatten, Gerald ^b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; PROTEIN P53;

BONE MARROW; BRAIN; CALORIC RESTRICTION; CELL AGING; CELL DIFFERENTIATION; CELL FUNCTION; CELL NUCLEUS TRANSPLANTATION; CELL PROLIFERATION; CELL REGENERATION; CHROMATIN STRUCTURE; CONFERENCE PAPER; DNA DAMAGE; EMBRYONIC STEM CELL; ENVIRONMENTAL FACTOR; GENE EXPRESSION; GENE MUTATION; GERM CELL; HOMEOSTASIS; HUMAN; INTESTINE; MEMORY T LYMPHOCYTE; MUSCLE; NONHUMAN; OOCYTE; ORGANOGENESIS; OVARY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN MODIFICATION; SEX DIFFERENCE; SOMATIC CELL; STEM CELL; TELOMERE; TISSUE ENGINEERING; AGING; ANIMAL; ANIMAL MODEL; CELL SURVIVAL; DNA REPAIR; FEMALE; GENETICS; HEMATOPOIETIC STEM CELL; MALE; PHYSIOLOGY; REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY;

AGING; ANIMALS; CELL AGING; CELL SURVIVAL; DNA DAMAGE; DNA REPAIR; FEMALE; HEMATOPOIETIC STEM CELLS; HUMANS; MALE; MODELS, ANIMAL; RISK FACTORS; SENSITIVITY AND SPECIFICITY; SEX FACTORS; STEM CELLS;

EID: 64949133483     PISSN: 10795006     EISSN: None     Source Type: Journal    
DOI: 10.1093/gerona/gln070     Document Type: Conference Paper

References (20)

1. Chen J, Astle CM, Harrison DE. Genetic regulation of primitive hematopoietic stem cell senescence. Exp Hematol. 2000;28:442-450. (Pubitemid 30214156)
2. Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, Weissman IL. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature. 2007;447:725-729. (Pubitemid 46889729)
3. Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature. 2005;433:760-764.
4. Tyner SD, Venkatachalam S, Choi J, et al. p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002;415:45-53. (Pubitemid 34062443)
5. INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature. 2006;443:448-452.
6. Janzen V, Forkert R, Fleming HE, et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature. 2006;443:421-426. (Pubitemid 44477274)
7. Bracken AP, Kleine-Kohlbrecher D, Dietrich N, et al. The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells. Genes Dev. 2007;21:525-530. (Pubitemid 46409467)
8. Kahn A, Fraga M, Epigenetics and aging: Status, challenges, and needs for the future. J Gerontol A Biol Sci Med Sci. 2009; doi:10.1093/gerona/gln064.
9. Ju Z, Jiang H, Jaworski M, et al. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat Med. 2007;13:742-747. (Pubitemid 46889751)
10. Austad SN, Comparative biology of aging. J Gerontol A Biol Sci Med Sci. 2009; doi:10.1093/gerona/gln060.
11. Ohlstein B, Spradling A. The adult Drosophila posterior midgut is maintained by pluripotent stem cells. Nature. 2006;439:470-474. (Pubitemid 43152837)
12. Micchelli CA, Perrimon N. Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature. 2006;439:475-479. (Pubitemid 43152838)
13. Gurdon JB. From nuclear transfer to nuclear reprogramming: the reversal of cell differentiation. Annu Rev Cell Dev Biol. 2006;22:1-22. (Pubitemid 44777987)
14. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006;126:663-676. (Pubitemid 44233629)
15. Yu J, Vodyanik MA, Kim S-O, et al. Induced pluripotent stem cell lines derived from human somatic cells. Science. 2007;318:1917-1920.
16. Meissner A, Wernig M, Jaenisch R. Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Nature Biotechnol. 2007;25:1177-1181. (Pubitemid 47538112)
17. Park IH, Zhao R, West JA, et al. Reprogramming of human somatic cells to pluripotency with defined factors. Nature. 2008;451:141-146.
18. Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature. 2008;455:627-632.
19. Ryu BY, Orwig KE, Oatley JM, Avarbock MR, Brinster RL. Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal. Stem Cells. 2006;24:1505-1511. (Pubitemid 44464667)
20. Conrad S, Renninger M, Hennenlotter J, et al. Generation of pluripotent stem cells from adult human testis. Nature. Published online October 8, 2008.