-
1
-
-
0034252183
-
Histone acetylation modifiers in the pathogenesis of malignant disease
-
Mahlknecht U and Hoelzer D: Histone acetylation modifiers in the pathogenesis of malignant disease. Mol Med 6: 623-644, 2000.
-
(2000)
Mol Med
, vol.6
, pp. 623-644
-
-
Mahlknecht, U.1
Hoelzer, D.2
-
2
-
-
0033600176
-
Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity
-
Frye RA: Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity. Biochem Biophys Res Commun 260: 273-279, 1999.
-
(1999)
Biochem Biophys Res Commun
, vol.260
, pp. 273-279
-
-
Frye, R.A.1
-
3
-
-
0033887456
-
Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins
-
Frye RA: Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem Biophys Res Commun 273: 793-798, 2000.
-
(2000)
Biochem Biophys Res Commun
, vol.273
, pp. 793-798
-
-
Frye, R.A.1
-
4
-
-
0034705129
-
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases
-
Landry J, Sutton A, Tafrov ST, et al: The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci USA 97: 5807-5811, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 5807-5811
-
-
Landry, J.1
Sutton, A.2
Tafrov, S.T.3
-
5
-
-
0034687694
-
Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose
-
Tanner KG, Landry J, Sternglanz R and Denu JM: Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proc Natl Acad Sci USA 97: 14178-14182, 2000.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 14178-14182
-
-
Tanner, K.G.1
Landry, J.2
Sternglanz, R.3
Denu, J.M.4
-
6
-
-
0028841317
-
The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability
-
Brachmann CB, Sherman JM, Devine SE, Cameron EE, Pillus L and Boeke JD: The SIR2 gene family, conserved from bacteria to humans, functions in silencing, cell cycle progression, and chromosome stability. Genes Dev 9: 2888-2902, 1995.
-
(1995)
Genes Dev
, vol.9
, pp. 2888-2902
-
-
Brachmann, C.B.1
Sherman, J.M.2
Devine, S.E.3
Cameron, E.E.4
Pillus, L.5
Boeke, J.D.6
-
7
-
-
34547098165
-
Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation
-
North BJ and Verdin E: Mitotic regulation of SIRT2 by cyclin-dependent kinase 1-dependent phosphorylation. J Biol Chem 282: 19546-19555, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 19546-19555
-
-
North, B.J.1
Verdin, E.2
-
8
-
-
0037135972
-
The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase
-
Schwer B, North BJ, Frye RA, Ott M and Verdin E: The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase. J Cell Biol 158: 647-657, 2002.
-
(2002)
J Cell Biol
, vol.158
, pp. 647-657
-
-
Schwer, B.1
North, B.J.2
Frye, R.A.3
Ott, M.4
Verdin, E.5
-
9
-
-
4944245398
-
Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin
-
Vaquero A, Scher M, Lee D, Erdjument-Bromage H, Tempst P and Reinberg D: Human SirT1 interacts with histone H1 and promotes formation of facultative heterochromatin. Mol Cell 16: 93-105, 2004.
-
(2004)
Mol Cell
, vol.16
, pp. 93-105
-
-
Vaquero, A.1
Scher, M.2
Lee, D.3
Erdjument-Bromage, H.4
Tempst, P.5
Reinberg, D.6
-
10
-
-
0141618441
-
Structure and autoregulation of the yeast Hst2 homolog of Sir2
-
Zhao K, Chai X, Clements A and Marmorstein R: Structure and autoregulation of the yeast Hst2 homolog of Sir2. Nat Struct Biol 10: 864-871, 2003.
-
(2003)
Nat Struct Biol
, vol.10
, pp. 864-871
-
-
Zhao, K.1
Chai, X.2
Clements, A.3
Marmorstein, R.4
-
11
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M and Guarente L: Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403: 795-800, 2000.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
12
-
-
3943054839
-
The Sir2 family of protein deacetylases
-
Blander G and Guarente L: The Sir2 family of protein deacetylases. Annu Rev Biochem 73: 417-435, 2004.
-
(2004)
Annu Rev Biochem
, vol.73
, pp. 417-435
-
-
Blander, G.1
Guarente, L.2
-
14
-
-
0030831573
-
Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA
-
Fritze CE, Verschueren K, Strich R and Easton Esposito R: Direct evidence for SIR2 modulation of chromatin structure in yeast rDNA. EMBO J 16: 6495-6509, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 6495-6509
-
-
Fritze, C.E.1
Verschueren, K.2
Strich, R.3
Easton Esposito, R.4
-
15
-
-
0033617290
-
Pch2 links chromatin silencing to meiotic checkpoint control
-
San-Segundo PA and Roeder GS: Pch2 links chromatin silencing to meiotic checkpoint control. Cell 97: 313-324, 1999.
-
(1999)
Cell
, vol.97
, pp. 313-324
-
-
San-Segundo, P.A.1
Roeder, G.S.2
-
16
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M and Guarente L: The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 13: 2570-2580, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
17
-
-
34249083199
-
Sirtuins in mammals: Insights into their biological function
-
Michan S and Sinclair D: Sirtuins in mammals: insights into their biological function. Biochem J 404: 1-13, 2007.
-
(2007)
Biochem J
, vol.404
, pp. 1-13
-
-
Michan, S.1
Sinclair, D.2
-
18
-
-
34547875773
-
Sirtuins: Critical regulators at the crossroads between cancer and aging
-
Saunders LR and Verdin E: Sirtuins: critical regulators at the crossroads between cancer and aging. Oncogene 26: 5489-5504, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 5489-5504
-
-
Saunders, L.R.1
Verdin, E.2
-
19
-
-
28544444366
-
Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
-
Ford J, Jiang M and Milner J: Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival. Cancer Res 65: 10457-10463, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 10457-10463
-
-
Ford, J.1
Jiang, M.2
Milner, J.3
-
20
-
-
0037130175
-
Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
-
Lin SJ, Kaeberlein M, Andalis AA, et al: Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration. Nature 418: 344-348, 2002.
-
(2002)
Nature
, vol.418
, pp. 344-348
-
-
Lin, S.J.1
Kaeberlein, M.2
Andalis, A.A.3
-
21
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma
-
Picard F, Kurtev M, Chung N, et al: Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma. Nature 429: 771-776, 2004.
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
-
22
-
-
3242719545
-
Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
-
Yeung F, Hoberg JE, Ramsey CS, et al: Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 23: 2369-2380, 2004.
-
(2004)
EMBO J
, vol.23
, pp. 2369-2380
-
-
Yeung, F.1
Hoberg, J.E.2
Ramsey, C.S.3
-
23
-
-
8644224064
-
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
-
Rogina B and Helfand SL: Sir2 mediates longevity in the fly through a pathway related to calorie restriction. Proc Natl Acad Sci USA 101: 15998-16003, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 15998-16003
-
-
Rogina, B.1
Helfand, S.L.2
-
24
-
-
0035826271
-
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
-
Tissenbaum HA and Guarente L: Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans. Nature 410: 227-230, 2001.
-
(2001)
Nature
, vol.410
, pp. 227-230
-
-
Tissenbaum, H.A.1
Guarente, L.2
-
25
-
-
3943071801
-
Sirtuin activators mimic caloric restriction and delay ageing in metazoans
-
Wood JG, Rogina B, Lavu S, et al: Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430: 686-689, 2004.
-
(2004)
Nature
, vol.430
, pp. 686-689
-
-
Wood, J.G.1
Rogina, B.2
Lavu, S.3
-
26
-
-
0035913911
-
Negative control of p53 by Sir2alpha promotes cell survival under stress
-
Luo J, Nikolaev AY, Imai S, et al: Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137-148, 2001.
-
(2001)
Cell
, vol.107
, pp. 137-148
-
-
Luo, J.1
Nikolaev, A.Y.2
Imai, S.3
-
27
-
-
0035913903
-
hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase
-
Vaziri H, Dessain SK, Ng Eaton E, et al: hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 107: 149-159, 2001.
-
(2001)
Cell
, vol.107
, pp. 149-159
-
-
Vaziri, H.1
Dessain, S.K.2
Ng Eaton, E.3
-
28
-
-
1342264308
-
Mammalian SIRT1 represses forkhead transcription factors
-
Motta MC, Divecha N, Lemieux M, et al: Mammalian SIRT1 represses forkhead transcription factors. Cell 116: 551-563, 2004.
-
(2004)
Cell
, vol.116
, pp. 551-563
-
-
Motta, M.C.1
Divecha, N.2
Lemieux, M.3
-
29
-
-
10844236451
-
Nutrient availability regulates SIRT1 through a forkhead-dependent pathway
-
Nemoto S, Fergusson MM and Finkel T: Nutrient availability regulates SIRT1 through a forkhead-dependent pathway. Science 306: 2105-2108, 2004.
-
(2004)
Science
, vol.306
, pp. 2105-2108
-
-
Nemoto, S.1
Fergusson, M.M.2
Finkel, T.3
-
30
-
-
12144290563
-
Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase
-
Brunet A, Sweeney LB, Sturgill JF, et al: Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science 303: 2011-2015, 2004.
-
(2004)
Science
, vol.303
, pp. 2011-2015
-
-
Brunet, A.1
Sweeney, L.B.2
Sturgill, J.F.3
-
31
-
-
12144286529
-
Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis
-
Cohen HY, Lavu S, Bitterman KJ, et al: Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis. Mol Cell 13: 627-638, 2004.
-
(2004)
Mol Cell
, vol.13
, pp. 627-638
-
-
Cohen, H.Y.1
Lavu, S.2
Bitterman, K.J.3
-
32
-
-
0141719702
-
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
-
Howitz KT, Bitterman KJ, Cohen HY, et al: Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425: 191-196, 2003.
-
(2003)
Nature
, vol.425
, pp. 191-196
-
-
Howitz, K.T.1
Bitterman, K.J.2
Cohen, H.Y.3
-
33
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson RM, Bitterman KJ, Wood JG, Medvedik O and Sinclair DA: Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 423: 181-185, 2003.
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
34
-
-
0018800089
-
A rapid alkaline extraction procedure for screening recombinant plasmid DNA
-
Birnboim HC and Doly J: A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 7: 1513-1523, 1979.
-
(1979)
Nucleic Acids Res
, vol.7
, pp. 1513-1523
-
-
Birnboim, H.C.1
Doly, J.2
-
36
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul SF, Madden TL, Schaffer AA, et al: Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25: 3389-3402, 1997.
-
(1997)
Nucleic Acids Res
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
-
37
-
-
0020714456
-
Rapid similarity searches of nucleic acid and protein data banks
-
Wilbur WJ and Lipman DJ: Rapid similarity searches of nucleic acid and protein data banks. Proc Natl Acad Sci USA 80: 726-730, 1983.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 726-730
-
-
Wilbur, W.J.1
Lipman, D.J.2
-
38
-
-
0037093346
-
Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence
-
Langley E, Pearson M, Faretta M, et al: Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. Embo J 21: 2383-2396, 2002.
-
(2002)
Embo J
, vol.21
, pp. 2383-2396
-
-
Langley, E.1
Pearson, M.2
Faretta, M.3
-
39
-
-
0035868764
-
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription
-
Muth V, Nadaud S, Grummt I and Voit R: Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J 20: 1353-1362, 2001.
-
(2001)
EMBO J
, vol.20
, pp. 1353-1362
-
-
Muth, V.1
Nadaud, S.2
Grummt, I.3
Voit, R.4
-
40
-
-
0037474507
-
Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression
-
Takata T and Ishikawa F: Human Sir2-related protein SIRT1 associates with the bHLH repressors HES1 and HEY2 and is involved in HES1- and HEY2-mediated transcriptional repression. Biochem Biophys Res Commun 301: 250-257, 2003.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 250-257
-
-
Takata, T.1
Ishikawa, F.2
-
41
-
-
0242322010
-
Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression
-
Senawong T, Peterson VJ, Avram D, et al: Involvement of the histone deacetylase SIRT1 in chicken ovalbumin upstream promoter transcription factor (COUP-TF)-interacting protein 2-mediated transcriptional repression. J Biol Chem 278: 43041-43050, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 43041-43050
-
-
Senawong, T.1
Peterson, V.J.2
Avram, D.3
-
42
-
-
33751113602
-
Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction
-
Haigis MC and Guarente LP: Mammalian sirtuins - emerging roles in physiology, aging, and calorie restriction. Genes Dev 20: 2913-2921, 2006.
-
(2006)
Genes Dev
, vol.20
, pp. 2913-2921
-
-
Haigis, M.C.1
Guarente, L.P.2
-
43
-
-
0037207475
-
The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis
-
McBurney MW, Yang X, Jardine K, et al: The mammalian SIR2alpha protein has a role in embryogenesis and gametogenesis. Mol Cell Biol 23: 38-54, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 38-54
-
-
McBurney, M.W.1
Yang, X.2
Jardine, K.3
-
44
-
-
0141814680
-
Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice
-
Cheng HL, Mostoslavsky R, Saito S, et al: Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proc Natl Acad Sci USA 100: 10794-10799, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 10794-10799
-
-
Cheng, H.L.1
Mostoslavsky, R.2
Saito, S.3
-
45
-
-
0043244921
-
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state
-
Fulco M, Schiltz RL, Iezzi S, et al: Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell 12: 51-62, 2003.
-
(2003)
Mol Cell
, vol.12
, pp. 51-62
-
-
Fulco, M.1
Schiltz, R.L.2
Iezzi, S.3
-
46
-
-
0021112516
-
Homology between the KpnI primate and BamH1 (M1F-1) rodent families of long interspersed repeated sequences
-
Singer MF, Thayer RE, Grimaldi G, Lerman MI and Fanning TG: Homology between the KpnI primate and BamH1 (M1F-1) rodent families of long interspersed repeated sequences. Nucleic Acids Res 11: 5739-5745, 1983.
-
(1983)
Nucleic Acids Res
, vol.11
, pp. 5739-5745
-
-
Singer, M.F.1
Thayer, R.E.2
Grimaldi, G.3
Lerman, M.I.4
Fanning, T.G.5
-
47
-
-
38949212965
-
Aging and anti-aging: Unexpected side effects of everyday medication through sirtuin 1 modulation
-
Engel N and Mahlknecht U: Aging and anti-aging: unexpected side effects of everyday medication through sirtuin 1 modulation. Int J Mol Med 21: 223-232, 2008.
-
(2008)
Int J Mol Med
, vol.21
, pp. 223-232
-
-
Engel, N.1
Mahlknecht, U.2
-
48
-
-
0036898253
-
Acetylation inactivates the transcriptional repressor BCL6
-
Bereshchenko OR, Gu W and Dalla-Favera R: Acetylation inactivates the transcriptional repressor BCL6. Nat Genet 32: 606-613, 2002.
-
(2002)
Nat Genet
, vol.32
, pp. 606-613
-
-
Bereshchenko, O.R.1
Gu, W.2
Dalla-Favera, R.3
|