Hepatic UDP-glucuronosyltransferases responsible for glucuronidation of thyroxine in humans

Drug Metabolism and Disposition

Volumn 36, Issue 1, 2008, Pages 51-55

  Kato, Yoshihisa ^a   Ikushiro, Shin Ichi ^b   Emi, Yoshikazu ^c   Tamaki, Sekihiro ^b   Suzuki, Hiroshi ^d   Sakaki, Toshiyuki ^d   Yamada, Shizuo ^d   Degawa, Masakuni ^d  

^a TOKUSHIMA BUNRI UNIVERSITY   (Japan)

^b TOYAMA PREFECTURAL UNIVERSITY   (Japan)

^c UNIVERSITY OF HYOGO   (Japan)

^d UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE; GLUCURONOSYLTRANSFERASE 1A1; GLUCURONOSYLTRANSFERASE 1A10; GLUCURONOSYLTRANSFERASE 1A3; GLUCURONOSYLTRANSFERASE 1A9; GLUCURONOSYLTRANSFERASE 2B7; THYROXINE; URIDINE DIPHOSPHATE;

ARTICLE; CORRELATION COEFFICIENT; GLUCURONIDATION; HORMONE ACTION; HORMONE INHIBITION; HORMONE METABOLISM; HUMAN; HUMAN TISSUE; LIVER MICROSOME; PRIORITY JOURNAL;

ANIMALS; BACULOVIRIDAE; CALCITRIOL; ENZYME INHIBITORS; GENETIC VECTORS; GLUCURONOSYLTRANSFERASE; HUMANS; IMMUNOBLOTTING; INSECTS; ISOENZYMES; KINETICS; LIVER; RECOMBINANT PROTEINS; THYROXINE; TRANSFECTION;

EID: 37549046024     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.107.018184     Document Type: Article

References (24)

1. Barter RA and Klaassen CD (1992) Rat liver microsomal UDP-glucuronosyltransferase activity toward thyroxine: characterization, induction, and form specificity. Toxicol Appl Pharmacol 115:261-267.
2. Burchell B, Brierley CH, and Rance D (1995) Specificity of human UDP-glucuronosyltransferases and xenobiotic glucuronidation. Life Sci 57:1819-1831.
3. Cheng Z, Radominska-Pandya A, and Tephly TR (1998) Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8. Arch Biochem Biophys 356:301-305.
4. Court MH (2005) Isoform-selective probe substrates for in vitro studies of human UDPglucuronosyltransferases. Methods Enzymol 400:104-116.
5. Dehal SS, Gange PV, Crespi CL, and Patten CJ (2001) Characterization of a probe substrate and an inhibitor of UDP-glucuronosyltransferase 1A4 activity in human liver microsomes (HLM) and cDNA-expressed UGT-enzymes. Drug Metab Rev 33 (Suppl. 1):162.
6. Findlay KAB, Kaptein E, Visser TJ, and Burchell B (2000) Characterization of the uridine diphosphate-glucuronosyltransferase-catalyzing thyroid hormone glucuronidation in man. J Clin Endocrinol Metab 85:2879-2883.
7. Green MD, Oturu EM, and Tephly TR (1994) Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug Metab Dispos 22:799-805.
8. Gregory PA, Lewinsky RH, Gardner-Stephen DA, and Mackenzie PI (2004) Regulation of UDP glucuronosyltransferases in the gastrointestinal tract. Toxicol Appl Pharmacol 199:354-363.
9. Guéraud F and Paris A (1998) Glucuronidation: a dual control. Gen Pharmacol 31:683-688.
10. Ikushiro S, Emi Y, and Iyanagi T (1995) Identification and analysis of drug-responsive expression of UDP-glucuronosyltransferase family 1 (UGT1) isoform in rat hepatic microsomes using anti-peptide antibodies. Arch Biochem Biophys 324:267-272.
11. Ikushiro S, Emi Y, Kato Y, Yamada S, and Sakaki T (2006) Monospecific antipeptide antibodies against human hepatic UDP-glucuronosyltransferase 1A subfamily (UGT1A) isoforms. Drug Metab Pharmacokinet 21:70-74.
12. Iyanagi T (2007) Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification. Int Rev Cytol 260:35-112.
13. 3 by human UDP-glucuronosyltransferase 1A3. Drug Metab Dispos 33:102-107.
14. King CD, Green MD, Rios GR, Coffman BL, Owens IS, Bishop WP, and Tephly TR (1996) The glucuronidation of exogenous and endogenous compounds by stably expressed rat and human UDP-glucuronosyltransferase1.1. Arch Biochem Biophys 332:92-100.
15. Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, and Nebert DW (2005) Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily. Pharmacogenet Genomics 10:677-685.
16. Nakajima M, Tanaka E, Kobayashi T, Ohashi N, Kume T, and Yokoi T (2002) Imipramine N-glucuronidation in human liver microsomes: biphasic kinetics and characterization of UDP-glucuronosyltransferase isoforms. Drug Metab Dispos 30:636-642.
17. Radominska-Pandya A, Czernik PJ, Little JM, Battaglia E, and Mackenzie PI (1999) Structural and functional studies of UDP-glucuronosyltransferases. Drug Metab Rev 31:817-899.
18. Senafi SB, Clarke DJ, and Burchell B (1994) Investigation of the substrate specificity of a cloned expressed human bilirubin UDP- glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation. Biochem J 303:233-240.
19. Trottier J, Verreault M, Grepper S, Monté D, Bélanger J, Kaeding J, Caron P, Inaba T, and Barbier O (2006) Human UDP- glucuronosyltransferase (UGT) 1A3 enzyme conjugates chenodeoxycholic acid in the liver. Hepatology 44:1158-1170.
20. Tukey RH and Strassburg CP (2000) Human UDP-glucuronosyltransferases: metabolism, expression, and disease. Annu Rev Pharmacol Toxicol 40:581-616.
21. Visser TJ (1996) Pathways of thyroid hormone metabolism. Acta Med Austriaca 1/2:10-16.
22. Visser TJ, Kaptein E, Gijzel AL, de Herder WW, Ebner T, and Burchell B (1993) Glucuronidation of thyroid hormone by human bilirubin and phenol UDP-glucuronyltransferase isoenzymes. FEBS Lett 324:358-360.
23. Wu SY, Green WL, Huang WS, Hays MT, and Chopra IJ (2005) Alternate pathways of thyroid hormone metabolism. Thyroid 15:943-958.
24. Yamanaka H, Nakajima M, Katoh M, and Yokoi T (2007) Glucuronidation of thyroxine in human liver, jejunum, and kidney microsomes. Drug Metab Dispos 35:1642-1648.