Effects of proton pump inhibitors on thyroid hormone metabolism in rats. A comparison of UDP-glucuronyltransferase induction

Biochemical Pharmacology

Volumn 54, Issue 11, 1997, Pages 1225-1231

  Masubuchi, Noriko ^a   Hakusui, Hideo ^a   Okazaki, Osamu ^a  

^a DAIICHI SANKYO CO   (Japan)

Author keywords

Lansoprazole; Omeprazole; Pantoprazole; Proton pump inhibitors; Thyroxine; UDP glucuronyltransferase

Indexed keywords

GLUCURONOSYLTRANSFERASE; IODINE 125; LANSOPRAZOLE; LIOTHYRONINE; OMEPRAZOLE; PANTOPRAZOLE; PROTON PUMP INHIBITOR; THYROXINE;

ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; CONTROLLED STUDY; DOSE RESPONSE; DRUG BILE LEVEL; DRUG BLOOD LEVEL; ENZYME ACTIVITY; FEMALE; GLUCURONIDATION; ISOTOPE LABELING; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; THYROID HORMONE METABOLISM;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; ANIMALS; BENZIMIDAZOLES; BILE; ENZYME INHIBITORS; FEMALE; GLUCURONOSYLTRANSFERASE; OMEPRAZOLE; PROTON PUMPS; RATS; RATS, SPRAGUE-DAWLEY; SULFOXIDES; THYROID HORMONES;

EID: 0030681084     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(97)00327-4     Document Type: Article

References (37)

1. +-ATPase-inhibitor pantoprazole (BY1023/SK&F96022) in healthy volunteers. Z Gastroenterol 28: 443-447, 1990.
2. Petersen KU, Omeprazole and the cytochrome P450 system. Aliment Pharmacol Ther 9: 1-9, 1995.
3. Moules IK, Lansoprazole, pharmacokinetics and pharmacodynamics. Br J Clin Pract Suppl 75: 41-47, 1994.
4. Judmaier G, Koelz HR and Pantoprazole-Duodenal Ulcer Study Group, Comparison of pantoprazole and ranitidine in the treatment of acute duodenal ulcer. Aliment Pharmacol Ther 8: 81-86, 1994.
5. Hotz J, Plein K, Schönekäs H and Rose K, Pantoprazole is superior to ranitidine in the treatment of acute gastric ulcer. Scand J Gastroenterol 30: 111-115, 1995.
6. Curi-Pedrosa R, Daujat M, Pichard L, Ourlin JC, Clair P, Gervot L, Lesca P, Domergue J, Joyeux H, Fourtanier G and Maurel P, Omeprazole and lansoprazole are mixed inducers of CYP1A and CYP3A in human hepatocytes in primary culture. J Pharmacol Exp Ther 269: 384-392, 1993.
7. Diaz D, Fabre I, Daujat M, Aubert BS, Bories P, Michel H and Maurel P, Omeprazole is an aryl hydrocarbon-like inducer of human hepatic cytochrome P450. Gastroenterology 99: 737-747, 1990.
8. Nousbaum JB, Berthou F, Carlhant D, Riche C, Robaszkiewicz M and Gouerou H, Four-week treatment with omeprazole increases the metabolism of caffeine. Am J Gastroenterol 89: 371-375, 1994.
9. Roux A, Naline E, Molinier P, Dellatolas F, Lemaire M and Flouvat B, Effect of lansoprazole and omeprazole on the metabolism of theophylline and antipyrine in man. Eur J Drug Metab Pharmacokinet 18: 125, 1993.
10. Granneman GR, Karol MD, Locke CS and Cavanaugh JH, Pharmacokinetic interaction between lansoprazole and theophylline. Ther Drug Monit 17: 460-464, 1995.
11. Steinijans VW, Huber R, Hartmann M, Zech K, Bliesath H, Wurst W and Radtke HW, Lack of pantoprazole drug interaction in man: An updated review. Int J Clin Pharmacol Ther Toxicol 29: 369-375, 1991.
12. Tucker GT, The interaction of proton pump inhibitors with cytochrome P450. Aliment Pharmacol Ther 8: 33-38, 1994.
13. Atkinson JE, Daly IW, Bolte HF, Morishima H and Sasaki S, One-year oral gavage toxicity study of lansoprazole (AG-1749) in rats. Jpn Pharmacol Ther (Suppl) 18: 59-91, 1990.
14. Hill RN, Erdreich LS, Paynter OE, Roberts PA, Rosenthal SL and Wilkinson CF, Thyroid follicular cell carcinogenesis. Fundam Appl Toxicol 12: 629-697, 1989.
15. Capen CC, Delellos RA and Yarrington JT, Thyroid follicular cells. In: Handbook of Toxicologic Pathology (Eds. Haschek, WM and Rousseaux CG), pp. 675-751. Academic Press, San Diego, CA, 1991.
16. McClain RM, Posch RC, Bosakowski T and Armstrong JM, Studies on the mode of action for thyroid gland tumor promotion in rats by phenobarbital. Toxicol Appl Pharmacol 94: 254-265, 1988.
17. McClain RM, Levin AA, Posch R and Downing JC, The effect of phenobarbital on the metabolism and excretion of thyroxine in rats. Toxicol Appl Pharmacol 99: 216-228, 1989.
18. Raaij JAGM, Kaptein E, Visser TJ and Berg KJ, Increased glucuronidation of thyroid hormone in hexachlorobenzene-treated rats. Biochem Pharmacol 45: 627-631, 1993.
19. Barter RA and Klaassen CD, UDP-glucuronosyltransferase inducers reduce thyroid hormone levels in rats by an extrathyroidal mechanism. Toxicol Appl Pharmacol 113: 36-42, 1992.
20. Dammann HG, Müllen A, Balks HJ, Damaschke A, Steinhoff J, Hennig U, Schwarz JA and Fuchs W, The effects of lansoprazole, 30 or 60 mg daily, on intragastric pH and on endocrine function in healthy volunteers. Aliment Pharmacol Ther 7: 191-196, 1993.
21. Dammann HG, Bethke T, Burkhardt F, Wolf N, Khalil H and Luehmann R, Effects of pantoprazole on endocrine function in healthy male volunteers. Aliment Pharmacol Ther 8: 549-554, 1994.
22. McGilchrist AJ, Howden CW, Kenyon CJ, Beastall GH and Reid JL, The effects of omeprazole on endocrine function in man. Eur J Clin Pharmacol 32: 423-425, 1987.
23. Howden CW, Beastall GH and Reid JL, An investigation into the effects of omeprazole on renal tubular function and endocrine function in man. Scand J Gastroenterol 21(Suppl 118): 169-170, 1986.
24. Lowry OH, Rosebrough NJ, Farr AL and Randall RJ, Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275, 1951.
25. Goldstein JA and Taurog A, Enhanced biliary excretion of thyroxine glucuronide in rats pretreated with benzpyrene. Biochem Pharmacol 17: 1049-1065, 1968.
26. Matsui M and Hakozaki M, Discontinuous variation in hepatic uridine diphosphate glucuronyltransferase toward androsterone in Wistar rats. A regulatory factor for in vivo metabolism of androsterone. Biochem Pharmacol 28: 411-415, 1979.
27. 4 sulfate. Endocrinology 125: 2175-2186, 1989.
28. Burchell B, Nebert DW, Nelson DR, Bock KW, Iyanagi T, Jansen PLM, Lancet D, Mulder GJ, Chowdhury JR, Siest G, Tephly TR and Mackenzie PI, The UDP-glucuronosyltransferase gene superfamily: Suggested nomenclature based on evolutionary divergene. DNA Cell Biol 10: 487-494, 1991.
29. Beetstra JB, Engelen JGM, Karels P, Hoek HJ, Jong M, Docter R, Krenning EP, Hennemann G, Brouwer A and Visser TJ, Thyroxine and 3,3′,5-triiodothyronine are glucuronidated in rat liver by different uridine diphosphate-glucuronyltransferases. Endocrinology 128: 741-746, 1991.
30. Visser TJ, Kaptein E and Harpur ES, Differential expression and ciprofibrate induction of hepatic UDP-glucuronyltransferases for thyroxine and triiodothyronine in Fischer rats. Biochem Pharmacol 42: 444-446, 1991.
31. Bastomsky CH and Papapetrou PD, The effect of methylcholanthrene on biliary thyroxine excretion in normal and Gunn rats. J Endocrinol 56: 267-273, 1973.
32. Saito K, Kaneko H, Sato K, Yoshitake A and Yamada H, Hepatic UDP-glucuronyltransferase(s) activity toward thyroid hormones in rats: Induction and effects on serum thyroid hormone levels following treatment with various enzyme inducers. Toxicol Appl Pharmacol 111: 99-106, 1991.
33. Visser TJ, Kaptein E, Toor H, Raaij JAGM, Berg KJ, Joe CTT, Engelen JGM and Brouwer A, Glucuronidation of thyroid hormone in rat liver: Effects of in vivo treatment with microsomal enzyme inducers and in vitro assay conditions. Endocrinology 133: 2177-2186, 1993.
34. Masubuchi N, Hakusui H and Okazaki O, Effects of pantoprazole on xenobiotic metabolizing enzymes in rat liver microsomes: A comparison with other proton pump inhibitors. Drug Metab Dispos 25: 584-589, 1997.
35. Sandro V, Catinot R, Kriszt W, Cordier A and Richert L, Male rat hepatic UDP-glucuronosyltransferase activity toward thyroxine. Activation and induction properties - Relation with thyroxine plasma disappearance rate. Biochem Pharmacol 43: 1563-1569, 1992.
36. Johnson S, McKillop D, Miller J and Smith IK, The effects on rat thyroid function of a hepatic microsomal enzyme inducer. Hum Exp Toxicol 12: 153-158, 1993.
37. Köhrle J, Brabant G and Hesch RD, Metabolism of the thyroid hormones. Horm Res 26: 58-78, 1987.