Bee venom suppresses LPS-mediated NO/iNOS induction through inhibition of PKC-α expression

Journal of Ethnopharmacology

Volumn 123, Issue 1, 2009, Pages 15-21

  Lee, Kwang Gill ^a   Cho, Hyun Ji ^b,c   Bae, Young Seuk ^c   Park, Kwan Kyu ^b   Choe, Jung Yoon ^b   Chung, Il Kyung ^d   Kim, Mihyun ^e   Yeo, Joo Hong ^a   Park, Kyung Ho ^f   Lee, Yun Sik ^g   Kim, Cheorl Ho ^h   Chang, Young Chae ^b  

^a National Institute of Animal Science   (South Korea)

^b The Catholic University of Korea   (South Korea)

^c Kyungpook National University   (South Korea)

^d Catholic University of Daegu   (South Korea)

^e Inje University   (South Korea)

^f Kyung Hee University   (South Korea)

^g Kyung Hee University Hospital   (South Korea)

^h Sungkyunkwan University   (South Korea)

Author keywords

Bee venom; C6 glioma cells; ERK1 2; iNOS; NF B; PKC

Indexed keywords

BEE VENOM; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE; NITRITE; PROTEIN KINASE C ALPHA; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME INHIBITION; GEL MOBILITY SHIFT ASSAY; GLIOMA CELL; IMMUNOBLOTTING; IMMUNOPATHOLOGY; INFLAMMATORY DISEASE; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRADITIONAL MEDICINE;

ANIMALS; BEE VENOMS; CELL LINE, TUMOR; ELECTROPHORETIC MOBILITY SHIFT ASSAY; ENZYME INDUCTION; LIPOPOLYSACCHARIDES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN KINASE C-ALPHA; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

APOIDEA; RATTUS;

EID: 64249115761     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.02.044     Document Type: Article

References (47)

1. Aggarwal B.B. Nuclear factor-kappaB: the enemy within. Cancer Cell 6 (2004) 203-208
2. Aggarwal B.B., Shishodia S., Sandur S.K., Pandey M.K., and Sethi G. Inflammation and cancer: how hot is the link?. Biochemical Pharmacology 72 (2006) 1605-1621
3. Beckman J.S., and Koppenol W.H. Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly. American Journal of Physiology 271 (1996) C1424-C1437
4. Blanco-Rivero J., Balfagon G., and Ferrer M. Male castration increases neuronal nitric oxide synthase activity in the rat mesenteric artery through protein kinase C activation. Journal of Vascular Research 42 (2005) 526-534
5. Blanco-Rivero J., Sagredo A., Balfagon G., and Ferrer M. Protein kinase C activation increases endothelial nitric oxide release in mesenteric arteries from orchidectomized rats. Journal of Endocrinology 192 (2007) 189-197
6. Block M.L., Zecca L., and Hong J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Reviews Neuroscience 8 (2007) 57-69
7. Brown G.C. Mechanisms of inflammatory neurodegeneration: iNOS and NADPH oxidase. Biochemical Society Transactions 35 (2007) 1119-1121
8. Brown G.C., and Bal-Price A. Inflammatory neurodegeneration mediated by nitric oxide, glutamate, and mitochondria. Molecular Neurobiology 27 (2003) 325-355
9. Chakravortty D., Kato Y., Sugiyama T., Koide N., Mu M.M., Yoshida T., and Yokochi T. Inhibition of caspase 3 abrogates lipopolysaccharide-induced nitric oxide production by preventing activation of NF-kappaB and c-Jun NH2-terminal kinase/stress-activated protein kinase in RAW 264.7 murine macrophage cells. Infection and Immunity 69 (2001) 1315-1321
10. Chen B.C., and Lin W.W. PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation. British Journal of Pharmacology 134 (2001) 1055-1065
11. Chen T.H., Chang P.C., Chang M.C., Lin Y.F., and Lee H.M. Chloroquine induces the expression of inducible nitric oxide synthase in C6 glioma cells. Pharmacological Research 51 (2005) 329-336
12. Clerk A., and Sugden P.H. Untangling the Web: specific signaling from PKC isoforms to MAPK cascades. Circulation Research 89 (2001) 847-849
13. Dehvari N., Isacsson O., Winblad B., Cedazo-Minguez A., and Cowburn R.F. Presenilin regulates extracellular regulated kinase (Erk) activity by a protein kinase C alpha dependent mechanism. Neuroscience Letters 436 (2008) 77-80
14. Dhar A., Young M.R., and Colburn N.H. The role of AP-1, NF-kappaB and ROS/NOS in skin carcinogenesis: the JB6 model is predictive. Molecular and Cellular Biochemistry 234-235 (2002) 185-193
15. Diaz-Meco M.T., Dominguez I., Sanz L., Dent P., Lozano J., Municio M.M., Berra E., Hay R.T., Sturgill T.W., and Moscat J. Zeta PKC induces phosphorylation and inactivation of I kappa B-alpha in vitro. EMBO Journal 13 (1994) 2842-2848
16. Esposito G., De Filippis D., Carnuccio R., Izzo A.A., and Iuvone T. The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. Journal of Molecular Medicine 84 (2006) 253-258
17. Fujisawa H., Ogura T., Hokari A., Weisz A., Yamashita J., and Esumi H. Inducible nitric oxide synthase in a human glioblastoma cell line. Journal of Neurochemistry 64 (1995) 85-91
18. Ganster R.W., Taylor B.S., Shao L., and Geller D.A. Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B. Proceeding of The National Academy Sciences of The United States of America 98 (2001) 8638-8643
19. Gao X., Ikuta K., Tajima M., and Sairenji T. 12-O-tetradecanoylphorbol-13-acetate induces Epstein-Barr virus reactivation via NF-kappaB and AP-1 as regulated by protein kinase C and mitogen-activated protein kinase. Virology 286 (2001) 91-99
20. Geller D.A., and Billiar T.R. Molecular biology of nitric oxide synthases. Cancer and Metastasis Reviews 17 (1998) 7-23
21. Ginnan R., Guikema B.J., Singer H.A., and Jourd'heuil D. PKC-delta mediates activation of ERK1/2 and induction of iNOS by IL-1beta in vascular smooth muscle cells. American Journal of Physiology-Cell Physiology 290 (2006) C1583-C1591
22. Giroux M., and Descoteaux A. Cyclooxygenase-2 expression in macrophages: modulation by protein kinase C-alpha. Journal of Immunology 165 (2000) 3985-3991
23. Gloire G., Legrand-Poels S., and Piette J. NF-kappaB activation by reactive oxygen species: fifteen years later. Biochemical Pharmacology 72 (2006) 1493-1505
24. Gui J., Song Y., Han N.L., and Sheu F.S. Characterization of transcriptional regulation of neurogranin by nitric oxide and the role of neurogranin in SNP-induced cell death: implication of neurogranin in an increased neuronal susceptibility to oxidative stress. International Journal of Biological Sciences 3 (2007) 12-224
25. Guix F.X., Uribesalgo I., Coma M., and Munoz F.J. The physiology and pathophysiology of nitric oxide in the brain. Progress in Neurobiology 76 (2005) 126-152
26. Han S., Lee K., Yeo J., Kweon H., Woo S., Lee M., Baek H., Kim S., and Park K. Effect of honey bee venom on microglial cells nitric oxide and tumor necrosis factor-alpha production stimulated by LPS. Journal of Ethnopharmacology 111 (2007) 176-181
27. Hong S., Park K.K., Magae J., Ando K., Lee T.S., Kwon T.K., Kwak J.Y., Kim C.H., and Chang Y.C. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion of renal carcinoma cells. Journal of Biological Chemistry 280 (2005) 25202-25209
28. Jang M.H., Shin M.C., Lim S., Han S.M., Park H.J., Shin I., Lee J.S., Kim K.A., Kim E.H., and Kim C.J. Bee venom induces apoptosis and inhibits expression of cyclooxygenase-2 mRNA in human lung cancer cell line NCI-H1299. Journal of Pharmacological Sciences 91 (2003) 95-104
29. Kato S., Esumi H., Hirano A., Kato M., Asayama K., and Ohama E. Immunohistochemical expression of inducible nitric oxide synthase (iNOS) in human brain tumors: relationships of iNOS to superoxide dismutase (SOD) proteins (SOD1 and SOD2), Ki-67 antigen (MIB-1) and p53 protein. Acta Neuropathological 105 (2003) 333-340
30. Kim W.K., Hwang S.Y., Oh E.S., Piao H.Z., Kim K.W., and Han I.O. TGF-beta1 represses activation and resultant death of microglia via inhibition of phosphatidylinositol 3-kinase activity. Journal of Immunology 172 (2004) 7015-7023
31. Knowles R.G., and Moncada S. Nitric oxide synthases in mammals. Biochemical Journal 298 (1994) 249-258
32. Lee S.J., and Lim K.T. Inhibitory effect of 30-kDa phytoglycoprotein on expression of TNF-alpha and COX-2 via activation of PKCalpha and ERK 1/2 in LPS-stimulated RAW 264.7 cells. Molecular and Cellular Biochemistry 317 (2008) 151-159
33. Li S., Huang F.L., Feng Q., Liu J., Fan S.X., and McKenna T.M. Overexpression of protein kinase C alpha enhances lipopolysaccharide-induced nitric oxide formation in vascular smooth muscle cells. Journal of Cellular Physiology 176 (1998) 402-411
34. Lidington D., Ouellette Y., and Tyml K. Endotoxin increases intercellular resistance in microvascular endothelial cells by a tyrosine kinase pathway. Journal of Cellular Physiology 185 (2000) 117-125
35. Lirk P., Hoffmann G., and Rieder J. Inducible nitric oxide synthase-time for reappraisal. Current Drug Targets Inflammation & Allergy 1 (2002) 89-108
36. Lowenstein C.J., Dinerman J.L., and Snyder S.H. Nitric oxide: a physiologic messenger. Annals of Internal Medicine 120 (1994) 227-237
37. Mellor H., and Parker P.J. The extended protein kinase C superfamily. Biochemical Journal 332 (1998) 281-292
38. Nadra I., Mason J.C., Philippidis P., Florey O., Smythe C.D., McCarthy G.M., Landis R.C., and Haskard D.O. Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: a vicious cycle of inflammation and arterial calcification?. Circulation Research 96 (2005) 1248-1256
39. Nakashima S. Protein kinase C alpha (PKC alpha): regulation and biological function. Journal of Biochemistry 132 (2002) 669-675
40. Park H.J., Lee H.J., Choi M.S., Son D.J., Song H.S., Song M.J., Lee J.M., Han S.B., Kim Y., and Hong J.T. JNK pathway is involved in the inhibition of inflammatory target gene expression and NF-kappaB activation by melittin. Journal of Inflammation 5 (2008) 7
41. Park H.J., Lee S.H., Son D.J., Oh K.W., Kim K.H., Song H.S., Kim G.J., Oh G.T., Yoon D.Y., and Hong J.T. Antiarthritic effect of bee venom: inhibition of inflammation mediator generation by suppression of NF-kappaB through interaction with the p50 subunit. Arthritis and Rheumatism 50 (2004) 3504-3515
42. Scherle P.A., Jones E.A., Favata M.F., Daulerio A.J., Covington M.B., Nurnberg S.A., Magolda R.L., and Trzaskos J.M. Inhibition of MAP kinase kinase prevents cytokine and prostaglandin E2 production in lipopolysaccharide-stimulated monocytes. Journal of Immunology 161 (1998) 5681-5686
43. Suh S.J., Kim K.S., Kim M.J., Chang Y.C., Lee S.D., Kim M.S., Kwon D.Y., and Kim C.H. Effects of bee venom on protease activities and free radical damages in synovial fluid from type II collagen-induced rheumatoid arthritis rats. Toxicology In Vitro 20 (2006) 1465-1471
44. Tao Z., Van Gool D., Lammens M., and Dom R. NADPH-diaphorase-containing neurons in cortex, subcortical white matter and neostriatum are selectively spared in Alzheimer's disease. Dementia and Geriatric Cognitive Disorders 10 (1999) 460-468
45. Velazquez K.T., Mohammad H., and Sweitzer S.M. Protein kinase C in pain: involvement of multiple isoforms. Pharmacological Research 55 (2007) 578-589
46. Wallis S., Lloyd S., Wise I., Ireland G., Fleming T.P., and Garrod D. The alpha isoform of protein kinase C is involved in signaling the response of desmosomes to wounding in cultured epithelial cells. Molecular Biologicy of the Cell 11 (2000) 1077-1092
47. Wei G., Dawson V.L., and Zweier J.L. Role of neuronal and endothelial nitric oxide synthase in nitric oxide generation in the brain following cerebral ischemia. Biochimical et Biophysica Acta 1455 (1999) 23-34