Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: A vicious cycle of inflammation and arterial calcification?

Circulation Research

Volumn 96, Issue 12, 2005, Pages 1248-1256

  Nadra, Imad ^d   Mason, Justin C ^a   Philippidis, Pandelis ^a   Florey, Oliver ^a   Smythe, Cheryl D W ^a   McCarthy, Geraldine M ^b   Landis, Robert C ^a,c   Haskard, Dorian O ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c Tropical Medicine Research Institute   (Barbados)

^d NONE

Author keywords

Atherosclerosis pathophysiology; Calcification; Cell biology; Inflammation; Macrophage

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM PHOSPHATE; INTERLEUKIN 1BETA; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ARTERY CALCIFICATION; ARTICLE; ATHEROSCLEROSIS; CELL ACTIVATION; CELL VACUOLE; CHRONIC INFLAMMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CRYSTAL; CYTOKINE RELEASE; DISEASE COURSE; ENDOTHELIUM CELL; ENZYME ACTIVATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INFLAMMATION; INTERNALIZATION; LEUKOCYTE; MACROPHAGE ACTIVATION; MONOCYTE; POSITIVE FEEDBACK; PRIORITY JOURNAL; SHEAR FLOW; SIGNAL TRANSDUCTION;

ARTERIES; ARTERIOSCLEROSIS; CALCINOSIS; CALCIUM PHOSPHATES; CELLS, CULTURED; CRYSTALLIZATION; HUMANS; INFLAMMATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MACROPHAGE ACTIVATION; MACROPHAGES; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; TUMOR NECROSIS FACTOR-ALPHA; VASCULAR DISEASES;

EID: 21844438685     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000171451.88616.c2     Document Type: Article

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