Protein kinase C activation increases endothelial nitric oxide release in mesenteric arteries from orchidectomized rats

Journal of Endocrinology

Volumn 192, Issue 1, 2007, Pages 189-197

  Blanco Rivero, Javier ^a   Sagredo, Ana ^a   Balfagón, Gloria ^a   Ferrer, Mercedes ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; CALPHOSTIN C; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITROPRUSSIDE SODIUM; PHORBOL DIBUTYRATE; PROTEIN KINASE C; SUPEROXIDE; SUPEROXIDE DISMUTASE; TEMPOL; THROMBOXANE A2;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; MALE; MESENTERIC ARTERY; NONHUMAN; ORCHIECTOMY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RAT; VASODILATATION;

ACETYLCHOLINE; ANIMALS; BLOTTING, WESTERN; CARBAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; INDOLES; MALE; MESENTERIC ARTERIES; NAPHTHALENES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; ORCHIECTOMY; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; RATS; RATS, SPRAGUE-DAWLEY; STIMULATION, CHEMICAL; SUPEROXIDES; THROMBOXANE A2; VASODILATOR AGENTS;

EID: 33947361219     PISSN: 00220795     EISSN: None     Source Type: Journal    
DOI: 10.1677/joe.1.07079     Document Type: Article

References (55)

1. Ba ZF, Wang P, Koo DJ, Ornan DA, Bland KI & Chaudry IH 2001 Attenuation of vascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock. Archives of Surgery 136 1158-1163.
2. Békési G, Kakucs R, Várvíró S, Racz K, Sprintz D, Feher J & Szekacs B 2000 In vitro effects of different steroid hormones on superoxide anion production of human neutrophil granulocytes. Steroids 65 889-894.
3. Blanco-Rivero J, Balfagón G & Ferrer M 2005a Male castration increases neuronal nitric oxide synthase activity in the rat mesenteric artery through protein kinase C activation. Journal of Vascular Research 42 526-534.
4. 2 formation. Journal of Vascular Research 43 101-108.
5. Ceballos G, Figueroa L, Rubio I, Gallo G, García A, Martinez A, Yanez R, Perez J, Morato T & Chamorro G 1999 Acute and nongenomic effect of testosterone on isolate and perfused rat heart. Journal of Cardiovascular Pharmacology 33 691-697.
6. Chatrath R, Ronningen KL, Severson SR, LaBreche P, Jayachandran M, Bracamonte MP & Miller VM 2003 Endothelium-dependent responses in coronary arteries are changed with puberty in male pigs. American Journal of Physiology 285 H1168-H1176.
7. Chauhan S, Rahman A, Nilsson H, Clapp L, MacAllister R & Ahluwalia A 2003 NO contributes to EDHF-like responses in rat small arteries: a role for NO stores. Cardiovascular Research 57 207-216.
8. + channels and pulmonary vasoconstriction: role of protein kinase Czeta. Circulation Research 93 656-663.
9. Damron DS, Nadim HS, Hong SJ, Darvish A & Murray PA 1998 Intracellular translocation of PKC isoforms in canine pulmonary artery smooth muscle cells by ANG II. American Journal of Physiology 274 L278-L288.
10. De Witt BJ, Kaye AD, Ibrahim IN, Bivalacqua TJ, D'Souza FM, Banister RE, Arif AS & Nossaman BD 2001 Effects of PKC isozyme inhibitors on constrictor responses in the feline pulmonary vascular bed. American Journal of Physiology 280 L50-L57.
11. Dinerman JL, Steiner JP, Dawson TM, Dawson V & Snyder SH 1994 Cyclic nucleotide dependent phosphorylation of neuronal nitric oxide synthase inhibits catalytic activity. Neuropharmacology 33 1245-1251.
12. Eligini S, Barbieri SS, Cavalca V, Camera M, Brambilla M, Fanceschi MD, Tremoli E & Colli S 2005 Diversity and similarity in signalling events leading to rapid Cox-2 induction by tumor necrosis factor-alpha and phorbol ester in human endothelial cells. Cardiovascular Research 65 683-693.
13. Ferrer M, Encabo A, Marín J, Peiro C, Redondo J, de Sagarra MR & Balfagón G 1992 Comparison of the vasoconstrictor responses induced by endothelin and phorbol 12,13-dibutyrate in bovine cerebral arteries. Brain Research 599 186-196.
14. Ferrer M, Marín J & Balfagón G 2000 Diabetes alters neuronal nitric oxide release from rat mesenteric arteries. Role of protein kinase C. Life Sciences 66 337-345.
15. Ferrer M, Sánchez M, Martín MC, Márquez-Rodas I, Alonso MJ, Salaices M & Balfagón G 2004 Protein kinase A increases electrical stimulation-induced neuronal nitric oxide release in rat mesenteric artery. European Journal of Pharmacology 487 167-173.
16. Fleming I, Fisslthaler B, Dimmeler S, Kemp BE & Busse R 2001 Phosphorylation of Thr(495) regulates Ca(2+)/calmodulin-dependent endothelial nitric oxide synthase activity. Circulation Research 88 E68-E75.
17. Förstermann U, Pollock JS, Schmint HHHW, Heller M & Murad F 1991 Calmodulin-dependent endothelium-derived relaxing factor/nitric oxide synthase activity is present in the particulate and cytosolic fractions of bovine aortic endothelium cells. PNAS 88 1788-1792.
18. Furchgott RF & Zawadzki JV 1980 The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288 373-376.
19. Gonzales RJ, Krause DN & Duckles SP 2004 Testosterone suppresses endothelium-dependent dilation of rat middle cerebral arteries. American Journal of Physiology 286 H552-H560.
20. Hutchison SJ, Sudhir K, Chou TM, Sieves RE, Zhu BQ, Sun YP, Deedwania PC, Glantz SA, Parmley WW & Chatterjee K 1997 Testosterone worsens endothelial dysfunction associated with hypercholesterolemia and environmental tobacco smoke exposure in male rabbit aorta. Journal of American College of Cardiology 29 800-807.
21. Jones RD, Jones HT & Channer KS 2004 The influence of testosterone upon vascular reactivity. European Journal of Endocrinology 151 29-37.
22. Kobayashi E, Nakano H, Morimoto M & Tamaoki T 1989 Calphostin C (UCN-1028C), a novel microbial compound is a highly potent and specific inhibitor of protein kinase C. Biochemical and Biophysical Research Communications 159 548-553.
23. Li H, Oehrlein SA, Wallerath T, Ihrig-Biedert I, Wohlfart P, Ulshofer T, Jessen T, Herget T, Forstermann U & Kleinert H 1998 Activation of protein kinase C alpha and/or epsilon enhances transcription of the human endothelial nitric oxide synthase gene. Molecular Pharmacology 53 630-637.
24. Li H, Hergert SM, Schafer SC, Brausch I, Yao Y, Huang Q, Mang C, Lehr HA & Forstermann U 2005 Midostaurin upregulates eNOS gene expression and preserves eNOS function in the microcirculation of the mouse. Nitric Oxide: Biology and Chemistry 12 231-236.
25. Littleton-Kearney M & Hurn PD 2004 Testoterone as a modulator of vascular behavior. Biological Research for Nursing 5 276-285.
26. Liu D & Dillon JS 2002 Dehydroepiandrosterone activates endothelial cell nitric oxide synthase by a specific plasma membrane receptor coupled to G alpha (i2,3). Journal of Biological Chemistry 277 21379-21388.
27. Liu PY, Death AK & Handelsman DJ 2003 Androgens and cardiovascular disease. Endocrine Review 24 313-340.
28. Martín MC, Balfagón G, Minoves N, Blanco-Rivero J & Ferrer M 2005 Androgen deprivation increases neuronal nitric oxide metabolism and its vasodilator effect in rat mesenteric arteries. Nitric Oxide: Biology and Chemistry 12 163-176.
29. Martiny-Baron G, Kazanietz MG, Mischak H, Blumberg PM, Kochs G, Hug H, Marme D & Schachtele C 1993 Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976. Journal of Biological Chemistry 268 9194-9197.
30. McNeill AM, Kim N, Duckles SP, Krause DN & Kontos HA 1999 Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels. Stroke 30 2186-2190.
31. Michell BJ, Chen ZP, Tiganis T, Stapleton D, Katsis F, Power DA, Sin AT & Kemp BE 2001 Coordinated control of endothelial nitric-oxide synthase phosphorylation by protein kinase C and the cAMP-dependent protein kinase. Journal of Biological Chemistry 276 17625-17628.
32. Mukherjee S, Coaxum SD, Maleque M & Das SK 2001 Effects of oxidized low density lipoprotein on nitric oxide synthetase and protein kinase C activities in bovine endothelial cells. Cellular and Molecular Biology 47 1051-1058.
33. Nielsen KC & Owman C 1971 Contractile response and amine receptor mechanism in isolated middle cerebral artery of the cat. Brain Research 27 25-32.
34. Nishizuka Y 1984 The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature 308 693-698.
35. Orshal JM & Khalil RA 2004 Gender, sex hormones and vascular tone. American Journal of Physiology 286 R233-R249.
36. Perusquia M 2003 Androgen-induced vasorelaxation: a potential vascular protective effect. Experimental and Clinical Endocrinology and Diabetes 111 55-59.
37. Pollock JS, Förstermann U, Mitchell JA, Warner TD, Schmindt HHHW, Nakane M & Murad F 1991 Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. PNAS 88 10480-10484.
38. Pollock JS, Nakane M, Buttery LK, Martinez A, Springall D, Polar JM, Förstermann U & Murad F 1993 Characterization and localization of endothelial nitric oxide synthase using specific monoclonal antibodies. American Journal of Physiology 265 C1379-C1387.
39. Polytarchou C & Papadimitriou E 2005 Antioxidants inhibit human endothelial cell functions through down-regulation of endothelial nitric oxide synthase activity. European Journal of Pharmacology 510 1-38.
40. Sánchez-Ferrer CF & Marín J 1990 Endothelium-derived contractile factors. General Pharmacology 21 589-603.
41. Sader MA & Celermajer DS 2002 Endothelial function, vascular reactivy and gender differences in the cardiovascular system. Cardiovascular Research 53 579-604.
42. Schmeck B, Brunsch M, Seybold J, Krull M, Eichel-Streiber C, Suttorp N & Hippenstiel S 2003 Rho protein inhibition blocks cyclooxygenase-2 expression by proinflammatory mediators in endothelial cells. Inflammation 27 89-95.
43. Sekiguchi F, Nakahira T, Kawata K & Sunano S 2002 Responses to endothelium-derived factors and their interaction in mesenteric arteries from Wistar-Kyoto and stroke-prone spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology 29 1066-1075.
44. Shen GX 2003 Selective protein kinase C inhibitors and their applications. Current Drug Targets 3 301-307.
45. Simoncini T, Mannella P, Fornari L, Varone G, Caruso A & Genazzani AR 2003 Dehydroepiandrosterone modulates endothelial nitric oxide synthesis via direct genomic and nongenomic mechanisms. Endocrinology 144 3449-3455.
46. Spitales M & Cantrell DA 2004 Protein kinase C and beyond. Nature Immunology 5 785-790.
47. Sunano S, Nakahira T, Kawata K & Sekiguchi F 2001 Factors involved in the time course of response to acetylcholine in mesenteric arteries from spontaneously hypertensive rats. European Journal of Pharmacology 423 47-55.
48. Teoh H, Quan A & Man RY 2000 Acute impairment of relaxation by low levels of testosterone in porcine coronary arteries. Cardiovascular Research 45 1010-1018.
49. Tep-areenan P, Kendall DA & Randal MD 2003 Mechanisms of vasorelaxation to testosterone in the rat aorta. European Journal of Pharmacology 465 125-132.
50. Vanhoutte PM 1996 Endothelium-dependent responses in congestive heart failure. Journal of Molecular and Cellular Cardiology 28 2233-2240.
51. Ward JPT, Knock GA, Snetkov VA & Aaronson PI 2004 Protein kinase in vascular smooth muscle tone - role in the pulmonary vasculature and hypoxic pulmonary vasoconstriction. Pharmacoloy and Therapeutics 104 207-231.
52. Wedgwood S, Bekker JM & Black SM 2001 Shear stress regulation of endothelial NOS in fetal pulmonary arterial endothelial cells involves PKC. American Journal of Physiology 281 L490-L498.
53. Wynne FL & Khalil RA 2003 Testosterone and coronary vascular tone: implications in coronary artery disease. Journal of Endocrinological Investigation 26 181-186.
54. Yakubu MA, Sofola OA, Igbo I & Oyekan AO 2004 Link between free radicals and protein kinase C in glucose-induced alteration of vascular dilation. Life Sciences 75 2921-2932.
55. Yorek MA, Coppey LJ, Gellett JS, Davison EP, Bing X, Lund DD & Dillon JS 2002 Effect of treatment of diabetic rats with dehydroepiandrosterone on vascular and neural function. American Journal of Physiology 283 E1067-E1075.