Vav1 and PI3K are required for phagocytosis of β-glucan and subsequent superoxide generation by microglia

Molecular Immunology

Volumn 46, Issue 8-9, 2009, Pages 1845-1853

  Shah, Vaibhav B ^a   Ozment Skelton, Tammy R ^b   Williams, David L ^b   Keshvara, Lakhu ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b East Tennessee State University   (United States)

Author keywords

Cell surface molecules; Fungal; Microglia; Neuroimmunology; Phagocytosis; Reactive oxygen species; Signal transduction

Indexed keywords

BETA GLUCAN; DECTIN 1; GUANINE NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN VAV1; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNOPRECIPITATION; MICROGLIA; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA ISOLATION; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BETA-GLUCANS; CELLS, CULTURED; HUMANS; MICE; MICE, INBRED C57BL; MICROGLIA; PHAGOCYTOSIS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-VAV; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SUPEROXIDES;

EID: 64149122005     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2009.01.014     Document Type: Article

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