Acidic region tyrosines provide access points for allosteric activation of the autoinhibited Vav1 Db1 homology domain

Biochemistry

Volumn 44, Issue 46, 2005, Pages 15257-15268

  Amarasinghe, Gaya K ^a   Rosen, Michael K ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; CHEMICAL ACTIVATION; ENZYME INHIBITION; ENZYME KINETICS; NITROGEN COMPOUNDS; THERMODYNAMICS;

ACIDIC REGION TRYOSINES; CELLULAR FUNCTIONS; GUANINE NUCLEOTIDE EXCHANGE FACTORS (GEF); KINASES;

PROTEINS;

GUANINE NUCLEOTIDE EXCHANGE FACTOR; PROTEIN KINASE LCK; PROTEIN SH2; PROTEIN TYROSINE KINASE; PROTEIN VAV1; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; TYROSINE; UNCLASSIFIED DRUG; VAV PROTEIN;

ALLOSTERISM; ALPHA HELIX; ARTICLE; CATALYSIS; CELL FUNCTION; ENZYME BINDING; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTO ONCOGENE; QUANTITATIVE ANALYSIS; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; THERMODYNAMICS;

ALLOSTERIC REGULATION; AMINO ACID MOTIFS; KINETICS; LYMPHOCYTE SPECIFIC PROTEIN TYROSINE KINASE P56(LCK); NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-VAV; TYROSINE;

EID: 27944475226     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051126h     Document Type: Article

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