-
1
-
-
0022410582
-
Polyglutamation of methotrexate. Is methotrexate a prodrug?
-
Chabner BA, Allegra CJ, Curt GA, Clendeninn NJ, Baram J, Koizumi S, Drake JC, Jolivet J: Polyglutamation of methotrexate. Is methotrexate a prodrug? J Clin Invest 76:907, 1985
-
(1985)
J Clin Invest
, vol.76
, pp. 907
-
-
Chabner, B.A.1
Allegra, C.J.2
Curt, G.A.3
Clendeninn, N.J.4
Baram, J.5
Koizumi, S.6
Drake, J.C.7
Jolivet, J.8
-
2
-
-
0029846176
-
Intrinsic and acquired resistance to methotrexate in acute leukemia
-
Gorlick R, Goker E, Trippett T, Waltham M, Banerjee D, Bertino JR: Intrinsic and acquired resistance to methotrexate in acute leukemia. N Engl J Med 335:1041, 1996
-
(1996)
N Engl J Med
, vol.335
, pp. 1041
-
-
Gorlick, R.1
Goker, E.2
Trippett, T.3
Waltham, M.4
Banerjee, D.5
Bertino, J.R.6
-
3
-
-
0028063423
-
Blast cell methotrexatepolyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia
-
Synold TW, Relling MV, Boyett JM, Rivera GK, Sandlund JT, Mahmoud H, Crist WM, Pui CH, Evans WE: Blast cell methotrexatepolyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia. J Clin Invest 94:1996, 1994
-
(1994)
J Clin Invest
, vol.94
, pp. 1996
-
-
Synold, T.W.1
Relling, M.V.2
Boyett, J.M.3
Rivera, G.K.4
Sandlund, J.T.5
Mahmoud, H.6
Crist, W.M.7
Pui, C.H.8
Evans, W.E.9
-
4
-
-
0025302665
-
Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis
-
Whitehead VM, Rosenblatt DS, Vuchich MJ, Shuster JJ, Witte A, Beaulieu D: Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: A pilot prognostic factor analysis. Blood 76:44, 1990
-
(1990)
Blood
, vol.76
, pp. 44
-
-
Whitehead, V.M.1
Rosenblatt, D.S.2
Vuchich, M.J.3
Shuster, J.J.4
Witte, A.5
Beaulieu, D.6
-
5
-
-
0020554087
-
The pharmacology and clinical use of methotrexate
-
Jolivet J, Cowan KH, Curt GA, Clendeninn NJ, Chabner BA: The pharmacology and clinical use of methotrexate. N Engl J Med 309:1094, 1983
-
(1983)
N Engl J Med
, vol.309
, pp. 1094
-
-
Jolivet, J.1
Cowan, K.H.2
Curt, G.A.3
Clendeninn, N.J.4
Chabner, B.A.5
-
6
-
-
0028291535
-
Differences in constitutive and post-methotrexate folylpoly-glutamate synthetase activity in B-lineage and T-lineage leukemia
-
Barredo JC, Synold TW, Laver J, Relling MV, Pui CH, Priest DG, Evans WE: Differences in constitutive and post-methotrexate folylpoly-glutamate synthetase activity in B-lineage and T-lineage leukemia. Blood 84:564, 1994
-
(1994)
Blood
, vol.84
, pp. 564
-
-
Barredo, J.C.1
Synold, T.W.2
Laver, J.3
Relling, M.V.4
Pui, C.H.5
Priest, D.G.6
Evans, W.E.7
-
7
-
-
0029940952
-
Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia
-
Raimondi SC, Pui CH, Hancock ML, Behm FG, Filatov L, Rivera GK: Heterogeneity of hyperdiploid (51-67) childhood acute lymphoblastic leukemia. Leukemia 10:213, 1996
-
(1996)
Leukemia
, vol.10
, pp. 213
-
-
Raimondi, S.C.1
Pui, C.H.2
Hancock, M.L.3
Behm, F.G.4
Filatov, L.5
Rivera, G.K.6
-
8
-
-
0029147794
-
Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transportdeficient, methotrexate-resistant human breast cancer cells
-
Moscow JA, Gong M, He R, Sgagias MK, Dixon KH, Anzick SL, Meltzer PS, Cowan KH: Isolation of a gene encoding a human reduced folate carrier (RFC1) and analysis of its expression in transportdeficient, methotrexate-resistant human breast cancer cells. Cancer Res 55:3790, 1995
-
(1995)
Cancer Res
, vol.55
, pp. 3790
-
-
Moscow, J.A.1
Gong, M.2
He, R.3
Sgagias, M.K.4
Dixon, K.H.5
Anzick, S.L.6
Meltzer, P.S.7
Cowan, K.H.8
-
9
-
-
0025188811
-
Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia
-
Pui CH, Crist WM, Look AT: Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia. Blood 76:1449, 1990
-
(1990)
Blood
, vol.76
, pp. 1449
-
-
Pui, C.H.1
Crist, W.M.2
Look, A.T.3
-
10
-
-
0029084385
-
Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells
-
Wong SC, Proefke SA, Bhushan A, Matherly LH: Isolation of human cDNAs that restore methotrexate sensitivity and reduced folate carrier activity in methotrexate transport-defective Chinese hamster ovary cells. J Biol Chem 270:17468, 1995
-
(1995)
J Biol Chem
, vol.270
, pp. 17468
-
-
Wong, S.C.1
Proefke, S.A.2
Bhushan, A.3
Matherly, L.H.4
-
11
-
-
0026474761
-
Characterization of transport-mediated methotrexate resistance in human tumor cells with antibodies to the membrane carrier for methotrexate and tetrahydrofolate cofactors
-
Matherly LH, Angeles SM, Czajkowski CA: Characterization of transport-mediated methotrexate resistance in human tumor cells with antibodies to the membrane carrier for methotrexate and tetrahydrofolate cofactors. J Biol Chem 267:23253, 1992
-
(1992)
J Biol Chem
, vol.267
, pp. 23253
-
-
Matherly, L.H.1
Angeles, S.M.2
Czajkowski, C.A.3
-
12
-
-
0024804961
-
Carboxypeptidase G2 enhances trimetrexate cytotoxicity in CCRF-CEM cell lines sensitive and resistant to methotrexate
-
Romanini A, Chou TC, Bertino JR: Carboxypeptidase G2 enhances trimetrexate cytotoxicity in CCRF-CEM cell lines sensitive and resistant to methotrexate. Adv Enzyme Regul 28:323, 1989
-
(1989)
Adv Enzyme Regul
, vol.28
, pp. 323
-
-
Romanini, A.1
Chou, T.C.2
Bertino, J.R.3
-
13
-
-
0030948473
-
Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression
-
Gorlick R, Goker E, Trippett T, Steinherz P, Elisseyeff Y, Mazumdar M, Flintoff WF, Bertino JR: Defective transport is a common mechanism of acquired methotrexate resistance in acute lymphocytic leukemia and is associated with decreased reduced folate carrier expression. Blood 89:1013, 1997
-
(1997)
Blood
, vol.89
, pp. 1013
-
-
Gorlick, R.1
Goker, E.2
Trippett, T.3
Steinherz, P.4
Elisseyeff, Y.5
Mazumdar, M.6
Flintoff, W.F.7
Bertino, J.R.8
-
14
-
-
0027321073
-
Polymerase chain reaction-based mRNA quantification using an internal standard: Analysis of oncogene expression
-
Scheuermann RH, Bauer SR: Polymerase chain reaction-based mRNA quantification using an internal standard: Analysis of oncogene expression. Methods Enzymol 218:446, 1993
-
(1993)
Methods Enzymol
, vol.218
, pp. 446
-
-
Scheuermann, R.H.1
Bauer, S.R.2
-
15
-
-
0026560328
-
Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction
-
Horikoshi T, Danenberg KD, Stadibauer TH, Volkenandt M, Shea LC, Aigner K, Gustavsson B, Leichman L, Frosing R, Ray M, Gibson NW, Spears CP, Danenberg PV: Quantitation of thymidylate synthase, dihydrofolate reductase, and DT-diaphorase gene expression in human tumors using the polymerase chain reaction. Cancer Res 52:108, 1992
-
(1992)
Cancer Res
, vol.52
, pp. 108
-
-
Horikoshi, T.1
Danenberg, K.D.2
Stadibauer, T.H.3
Volkenandt, M.4
Shea, L.C.5
Aigner, K.6
Gustavsson, B.7
Leichman, L.8
Frosing, R.9
Ray, M.10
Gibson, N.W.11
Spears, C.P.12
Danenberg, P.V.13
-
16
-
-
0030034467
-
Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo
-
Masson E, Relling MV, Synold TW, Liu Q, Schuetz JD, Sandlund JT, Pui CH, Evans WE: Accumulation of methotrexate polyglutamates in lymphoblasts is a determinant of antileukemic effects in vivo. A rationale for high-dose methotrexate, J Clin Invest 97:73, 1996
-
(1996)
A Rationale for High-dose Methotrexate, J Clin Invest
, vol.97
, pp. 73
-
-
Masson, E.1
Relling, M.V.2
Synold, T.W.3
Liu, Q.4
Schuetz, J.D.5
Sandlund, J.T.6
Pui, C.H.7
Evans, W.E.8
-
17
-
-
0032545976
-
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia
-
Pui CH, Evans WE: Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med 338:499, 1998
-
(1998)
N Engl J Med
, vol.338
, pp. 499
-
-
Pui, C.H.1
Evans, W.E.2
-
18
-
-
0022376063
-
Cystathionine beta synthase: Gene dosage effect in trisomy 21
-
Chadefaux B, Rethore MO, Raoul O, Ceballos I, Poissonnier M, Gilgenkranz S, Allard D: Cystathionine beta synthase: Gene dosage effect in trisomy 21. Biochem Biophys Res Commun 128:40, 1985
-
(1985)
Biochem Biophys Res Commun
, vol.128
, pp. 40
-
-
Chadefaux, B.1
Rethore, M.O.2
Raoul, O.3
Ceballos, I.4
Poissonnier, M.5
Gilgenkranz, S.6
Allard, D.7
-
19
-
-
0027385417
-
Differences in purine metabolism in patients with down's syndrome
-
part 6
-
Peeters MA, Megarbane A, Cattaneo F, Rethore MO, Lejeune J: Differences in purine metabolism in patients with Down's syndrome. J Intellect Disabil Res 37:491, 1993 (part 6)
-
(1993)
J Intellect Disabil Res
, vol.37
, pp. 491
-
-
Peeters, M.A.1
Megarbane, A.2
Cattaneo, F.3
Rethore, M.O.4
Lejeune, J.5
-
20
-
-
0019498624
-
Demonstration, by somatic cell genetics, of coordinate regulation of genes for two enzymes of purine synthesis assigned to human chromosome 21
-
Patterson D, Graw S, Jones C: Demonstration, by somatic cell genetics, of coordinate regulation of genes for two enzymes of purine synthesis assigned to human chromosome 21. Proc Natl Acad Sci USA 78:405, 1981
-
(1981)
Proc Natl Acad Sci USA
, vol.78
, pp. 405
-
-
Patterson, D.1
Graw, S.2
Jones, C.3
-
21
-
-
0023200576
-
Pharmacokinetics and toxicity of methotrexate in children with down syndrome and acute lymphocytic leukemia
-
Garre ML, Relling MV, Kalwinsky D, Dodge R, Crom WR, Abromowitch M, Pui CH, Evans WE: Pharmacokinetics and toxicity of methotrexate in children with Down syndrome and acute lymphocytic leukemia. J Pediatr 111:506, 1987
-
(1987)
J Pediatr
, vol.111
, pp. 506
-
-
Garre, M.L.1
Relling, M.V.2
Kalwinsky, D.3
Dodge, R.4
Crom, W.R.5
Abromowitch, M.6
Pui, C.H.7
Evans, W.E.8
-
22
-
-
0030745895
-
Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines
-
Moscow JA, Connolly T, Myers TG, Cheng CC, Paull K, Cowan KH: Reduced folate carrier gene (RFC1) expression and anti-folate resistance in transfected and non-selected cell lines. Int J Cancer 72:184, 1997
-
(1997)
Int J Cancer
, vol.72
, pp. 184
-
-
Moscow, J.A.1
Connolly, T.2
Myers, T.G.3
Cheng, C.C.4
Paull, K.5
Cowan, K.H.6
-
24
-
-
0029151314
-
Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line
-
Brigle KE, Spinella MJ, Sierra EE, Goldman ID: Characterization of a mutation in the reduced folate carrier in a transport defective L1210 murine leukemia cell line. J Biol Chem 270:22974, 1995
-
(1995)
J Biol Chem
, vol.270
, pp. 22974
-
-
Brigle, K.E.1
Spinella, M.J.2
Sierra, E.E.3
Goldman, I.D.4
-
25
-
-
0030756226
-
Differences in folylpoly-glutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: Mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity
-
Galpin AJ, Schuetz JD, Masson E, Yanishevski Y, Synold TW, Barredo JC, Pui C-H, Relling MV, Evans WE: Differences in folylpoly-glutamate synthetase and dihydrofolate reductase expression in human B-lineage versus T-lineage leukemic lymphoblasts: Mechanisms for lineage differences in methotrexate polyglutamylation and cytotoxicity. Mol Pharmacol 52:155, 1997
-
(1997)
Mol Pharmacol
, vol.52
, pp. 155
-
-
Galpin, A.J.1
Schuetz, J.D.2
Masson, E.3
Yanishevski, Y.4
Synold, T.W.5
Barredo, J.C.6
Pui, C.-H.7
Relling, M.V.8
Evans, W.E.9
-
26
-
-
0030634067
-
Gamma-glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias
-
Longo GS, Gorlick R, Tong WP, Lin S, Steinherz P, Bertino JR: Gamma-glutamyl hydrolase and folylpolyglutamate synthetase activities predict polyglutamylation of methotrexate in acute leukemias. Oncol Res 9:259, 1997
-
(1997)
Oncol Res
, vol.9
, pp. 259
-
-
Longo, G.S.1
Gorlick, R.2
Tong, W.P.3
Lin, S.4
Steinherz, P.5
Bertino, J.R.6
-
27
-
-
0026686811
-
Expression cloning of a human cdna encoding folylpoly (gamma-glutamate) synthetase and determination of its primary structure
-
Garrow TA, Admon A, Shane B: Expression cloning of a human cDNA encoding folylpoly (gamma-glutamate) synthetase and determination of its primary structure. Proc Natl Acad Sci USA 89:9151, 1992
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9151
-
-
Garrow, T.A.1
Admon, A.2
Shane, B.3
-
28
-
-
0009675779
-
Studies of gamma-glutamyl hydrolase: Human tissue distribution and chromosome location
-
Pfleiderer H, Rokos H (eds): Berlin, Germany, Blackwell
-
Yao R: Studies of gamma-glutamyl hydrolase: Human tissue distribution and chromosome location, in Pfleiderer H, Rokos H (eds): Chemistry and Biology of Pteridines and Folates. Berlin, Germany, Blackwell, 1997, p 475
-
(1997)
Chemistry and Biology of Pteridines and Folates
, pp. 475
-
-
Yao, R.1
-
29
-
-
0008195538
-
Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects
-
Spinella MJ, Brigle KE, Freemantle SJ, Sierra EE, Goldman ID: Comparison of methotrexate polyglutamylation in L1210 leukemia cells when influx is mediated by the reduced folate carrier or the folate receptor. Lack of evidence for influx route-specific effects. Biochem Pharmacol 52:703, 1996
-
(1996)
Biochem Pharmacol
, vol.52
, pp. 703
-
-
Spinella, M.J.1
Brigle, K.E.2
Freemantle, S.J.3
Sierra, E.E.4
Goldman, I.D.5
-
30
-
-
24444469059
-
Evidence for a folate/antifolate influx process with optimal activity at low pH in an L1210 leukemia cell line lacking reduced folate carrier function
-
abstr
-
Sierra EE, Spinella MJ, Brigle KE, Goldman ID: Evidence for a folate/antifolate influx process with optimal activity at low pH in an L1210 leukemia cell line lacking reduced folate carrier function. Proc Annu Meet Am Assoc Cancer Res 37:2609a, 1996 (abstr)
-
(1996)
Proc Annu Meet Am Assoc Cancer Res
, vol.37
-
-
Sierra, E.E.1
Spinella, M.J.2
Brigle, K.E.3
Goldman, I.D.4
-
31
-
-
0032545976
-
Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia
-
Evans WE, Relling MV, Rodman JH, Crom WR, Boyett JM, Pui CH: Conventional compared with individualized chemotherapy for childhood acute lymphoblastic leukemia. N Engl J Med 338:499, 1998
-
(1998)
N Engl J Med
, vol.338
, pp. 499
-
-
Evans, W.E.1
Relling, M.V.2
Rodman, J.H.3
Crom, W.R.4
Boyett, J.M.5
Pui, C.H.6
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