Nicotinamide N-methyltransferase upregulation inversely correlates with lymph node metastasis in oral squamous cell carcinoma

Molecular Medicine

Volumn 13, Issue 7-8, 2007, Pages 415-421

  Sartini, Davide ^a   Santarelli, Andrea ^a   Rossi, Valentina ^a   Goteri, Gaia ^a   Rubini, Corrado ^a   Ciavarella, Domenico ^b   Lo Muzio, Lorenzo ^b   Emanuelli, Monica ^a  

^a UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

^b UNIVERSITY OF FOGGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; NICOTINAMIDE METHYLTRANSFERASE;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG TARGETING; DRUG TRANSFORMATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MOUTH CARCINOMA; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SQUAMOUS CELL CARCINOMA; UPREGULATION; WESTERN BLOTTING; XENOBIOTIC METABOLISM;

AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; FEMALE; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; MOUTH NEOPLASMS; NICOTINAMIDE N-METHYLTRANSFERASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR MARKERS, BIOLOGICAL; UP-REGULATION;

EID: 34548471787     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/2007-00035.Sartini     Document Type: Article

References (24)

1. Brinkman BM, Wong DT (2006) Disease mechanism and biomarkers of oral squamous cell carcinoma. Curr. Opin. Oncol. 18:228-33.
2. Carinci F et al. (2005) Potential markers of tongue tumor progression selected by cDNA microarray. Int. J. Immunopathol. Pharmacol. 18:513-24.
3. Tomioka H, Morita K, Hasegawa S, Omura K. (2006) Gene expression analysis by cDNA microarray in oral squamous cell carcinoma. J. Oral. Pathol. Med. 35:206-11.
4. Lo Muzio L et al. (2005) Survivin as prognostic factor in squamous cell carcinoma of the oral cavity. Cancer Lett. 225:27-33.
5. Lo Muzio L et al. (2006) Genetic analysis of oral squamous cell carcinoma by cDNA microarrays focused apoptotic pathway. Int. J. Immunopathol. Pharmacol. 19:675-82.
6. Li Y et al. (2006) Serum circulating human mRNA profiling and its utility for oral cancer detection. J. Clin. Oncol. 24:1754-60.
7. Rini J, Szumlanski C, Guerciolini R, Weinshilboum RM. (1989) Human liver nicotinamide N-methyltransferase, ion-pairing radiochemical assay, biochemical properties and individual variation. Clin. Chim. Acta. 186:359-74.
8. Aksoy S, Szumlanski CL, Weinshilboum RM. (1994) Human liver nicotinamide N-methyltransferase. cDNA cloning, expression, and biochemical characterization. J. Biol. Chem. 269:14835-40.
9. Aksoy S, Brandriff BF, Ward A, Little PF, Weinshilboum, RM. (1995) Human nicotinamide N-methyltransferase gene, molecular cloning, structural characterization and chromosomal localization. Genomics. 29:555-61.
10. Szakacs G et al. (2004) Predicting drug sensitivity and resistance, profiling ABC transporter genes in cancer cells. Cancer Cell. 6:129-37.
11. Xu J et al. (2003) Enhanced expression of nicotinamide N-methyltransferase in human papillary thyroid carcinoma cells. J. Clin. Endocrinol. Metab. 88:4990-6.
12. Myo K et al. (2005) Cyclin D1 gene numerical aberration is a predictive marker for occult cervical lymph node metastasis in TNM Stage I and II squamous cell carcinoma of the oral cavity Cancer. 104:2709-16.
13. Williams AC, Ramsden, DB. (2005) Autotoxicity, methylation and a road to the prevention of Parkinson's disease. J. Clin. Neurosci. 12:6-11.
14. Markert JM et al. (2001) Differential gene expression profiling in human brain tumors. Physiol. Genomics. 5:21-33.
15. Jang JS, Cho HY, Lee YJ, Ha WS, Kim, HW. (2004) The differential proteome profile of stomach cancer, identification of the biomarker candidates. Oncol. Res. 14:491-9.
16. Lim BH, Cho BI, Kim YN, Kim JW, Park ST, Lee, CW. (2006) Overexpression of nicotinamide N-methyltransferase in gastric cancer tissues and its potential post-translational modification. Exp. Mol. Med. 38:455-65.
17. Xu J, Capezzone M, Xu X, Hershman JM. (2005) Activation of nicotinamide N-methyltransferase gene promoter by hepatocyte nuclear factor-1beta in human papillary thyroid cancer cells. Mol. Endocrinol. 19:527-39.
18. Roessler M et al. (2005) Identification of nicotinamide N-methyltransferase as a novel serum tumor marker for colorectal cancer. Clin. Cancer Res. 11:6550-7.
19. Yao M et al. (2005) Gene expression analysis of renal carcinoma, adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. J. Pathol. 205:377-87.
20. Sartini D, Muzzonigro G, Milanese G, Pierella F, Rossi V, Emanuelli M. (2006) Identification of nicotinamide N-methyltransferase as a novel tumor marker for renal clear cell carcinoma. J. Urol. 176:2248-54.
21. Rogers CD et al. (2006) Differentiating pancreatic lesions by microarray and QPCR analysis of pancreatic juice RNAs. Cancer Biol. Ther. 5:1383-9.
22. Seifert R, Hoshino J, Kroger H. (1984) Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. Biochim. Biophys. Acta. 801:259-64.
23. Williams AC, Ramsden DB. (2005) Nicotinamide homeostasis, a xenobiotic pathway that is key to development and degenerative diseases. Med. Hypotheses. 65:353-62.
24. Zhang J. (2003) Are poly(ADP-ribosyl)ation by PARP-1 and deacetylation by Sir2 linked? Bioassays. 25:808-14.