Imaging performance comparison between a LaBr3:Ce scintillator based and a CdTe semiconductor based photon counting compact gamma camera

Medical Physics

Volumn 36, Issue 4, 2009, Pages 1298-1317

  Russo, P ^a   Mettivier, G ^b   Pani, R ^c   Pellegrini, R ^c   Cinti, M N ^c   Bennati, P ^c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b INFN SEZIONE DI NAPOLI   (Italy)

^c NONE

Author keywords

CdTe detector; compact gamma camera; Medipix2

Indexed keywords

BROMINE COMPOUNDS; CADMIUM TELLURIDE; CAMERAS; CERIUM COMPOUNDS; II-VI SEMICONDUCTORS; LANTHANUM COMPOUNDS; PARTICLE BEAMS; PHOTOMULTIPLIERS; PHOTONS; PIXELS; READOUT SYSTEMS; SCINTILLATION; SCINTILLATION COUNTERS; SEMICONDUCTING CADMIUM COMPOUNDS; SEMICONDUCTING CADMIUM TELLURIDE; SIGNAL TO NOISE RATIO;

CDTE DETECTOR; ENERGY DISCRIMINATIONS; GAMMA CAMERAS; HIGH RESOLUTION COLLIMATORS; HYBRID PIXEL DETECTORS; MEDIPIX2; MULTI-ANODE PHOTOMULTIPLIER TUBES; SINGLE PHOTON COUNTING;

SEMICONDUCTING TELLURIUM COMPOUNDS;

ARTICLE; CDTE SEMICONDUCTOR GAMMA CAMERA; CONTRAST; CONTROLLED STUDY; IMAGE QUALITY; LABR3:CE SCINTILLATOR GAMMA CAMERA; OPTICAL RESOLUTION; PHOTON; PRIORITY JOURNAL; SCINTILLATION CAMERA;

ALGORITHMS; CADMIUM COMPOUNDS; CRYSTALLIZATION; EQUIPMENT DESIGN; GAMMA CAMERAS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MODELS, STATISTICAL; PHOTONS; REPRODUCIBILITY OF RESULTS; SEMICONDUCTORS; SENSITIVITY AND SPECIFICITY; TELLURIUM; TOMOGRAPHY, EMISSION-COMPUTED, SINGLE-PHOTON;

EID: 63849193958     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.3081412     Document Type: Article

References (86)

1. S. Majewski, V. Popov, R. Wojcik, and A. Weisenberger, " Optimization of a mini-gamma camera based on a 2×2 array of Hamamatsu H8500 PSPMTs.," Nucl. Instrum. Methods Phys. Res. A 569, 215-219 (2006). 0029-554X
2. J. Kim, Y. Choi, K. Joo, B. Sihn, J. Chong, S. E. Kim, K. H. Lee, Y. S. Choe, and B. Kim, " Development of a miniature scintillation camera using an NaI(Tl) scintillator and PSPMT for scintimammography.," Phys. Med. Biol. 0031-9155 10.1088/0031-9155/45/11/326 45, 3481-3488 (2000).
3. K. L. Matthews, " Development and application of a small gamma camera.," Med. Phys. 0094-2405 10.1118/1.597947 24, 1802-1802 (1997).
4. K. L. Matthews, Ph.D. thesis, University of Chicago, 1997.
5. M. N. Cinti, S. Majewski, M. B. Williams, C. Bachmann, F. Cominelli, B. K. Kundu, A. Stolin, V. Popov, B. L. Welch, G. De Vincentis, P. Bennati, M. Betti, S. Ridolfi, and R. Pani, " Iodine 125 imaging in mice using NaI(Tl)/flat panel PMT integral assembly.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2007.893324 54, 461-468 (2007).
6. R. Pani, A. Soluri, R. Scafe, A. Pergola, R. Pellegrini, G. De Vincentis, G. Trotta, and F. Scopinaro, " Multi-PSPMT scintillation camera.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/23.775602 46, 702-708 (1999).
7. F. Sanchez, J. M. Benlloch, B. Escat, N. Pavon, E. Porras, D. Kadi-Hanifi, J. A. Ruiz, F. J. Mora, and A. Sebastia, " Design and tests of a portable mini gamma camera.," Med. Phys. 0094-2405 10.1118/1.1755570 31, 1384-1397 (2004).
8. M. B. Williams, A. R. Goode, V. Galbis-Reig, S. Majewski, A. G. Weisenberger, and R. Wojcik, " Performance of a PSPMT based detector for scintimammography.," Phys. Med. Biol. 0031-9155 10.1088/0031-9155/45/3/315 45, 781-800 (2000).
9. F. Scopinaro, R. Pani, G. De Vincentis, A. Soluri, R. Pellegrini, and L. M. Porfiri, " High-resolution scintimammography improves the accuracy of technetium-99m methoxyisobutylisonitrile scintimammography: Use of a new dedicated gamma camera.," Eur. J. Nucl. Med. 0340-6997 10.1007/ s002590050584 26, 1279-1288 (1999).
10. R. Pani, M. N. Cinti, R. Pellegrini, F. De Notaristefani, P. Bennati, M. Betti, G. Trotta, M. Mattioli, F. Garibaldi, V. Orsolini Cencelli, G. Moschini, and F. Navarria, " LaBr3:Ce scintillation camera.," Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference, 2005 (unpublished), Vol. 4, pp. 2061-2065.
11. R. Pani, P. Bennati, M. Betti, M. N. Cinti, R. Pellegrini, M. Mattioli, V. Orsolini Cencelli, F. Navarria, D. Bollini, G. Moschini, F. Garibaldi, and F. De Notaristefani, " Lanthanum scintillation crystals for gamma ray imaging.," Nucl. Instrum. Methods Phys. Res. A 567, 294-297 (2006). 0029-554X
12. R. Pani, M. N. Cinti, R. Pellegrini, P. Bennati, M. Betti, F. Vittorini, M. Mattioli, G. Trotta, V. Orsolini Cencelli, R. Scafe, F. Navarria, D. Bollini, G. Baldazzi, G. Moschini, and F. de Notaristefani, " LaBr3:Ce scintillation gamma camera prototype for X and gamma ray imaging.," Nucl. Instrum. Methods Phys. Res. A 576, 15-18 (2007). 0029-554X
13. V. Popov and S. Majewski, " A compact high performance readout electronics solution for H9500 Hamamatsu 256 multianode photomultiplier tube for application in gamma cameras.," Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference, 2006 (unpublished), pp. 2981-2985.
14. R. Pani, " Compact large FoV gamma camera for breast molecular imaging.," Nucl. Instrum. Methods Phys. Res. A 569, 255-259 (2006). 0029-554X
15. E. L. Bradley, J. Cella, S. Majewski, V. Popov, J. Qian, M. S. Saha, M. F. Smith, A. G. Weisenberger, and R. E. Welsh, " A compact gamma camera for biological imaging.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2005.862977 53, 59-65 (2006).
16. W. S. Choong, W. W. Moses, C. S. Tindall, and P. N. Luke, " Design for a high-resolution small-animal SPECT system using pixellated Si(Li) detectors for in 125I imaging.," IEEE Trans. Nucl. Sci. 52, 174-180 (2005). 0018-9499
17. C. Scheiber, " CdTe and CdZnTe detectors in nuclear medicine.," Nucl. Instrum. Methods Phys. Res. A 448, 513-524 (2000). 0029-554X
18. C. Szeles, " Advances in the crystal growth and device fabrication technology of CdZnTe room temperature radiation detectors.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2004.829391 51, 1242-1249 (2004).
19. T. Takahashi and S. Watanabe, " Recent progress in CdTe and CdZnTe detectors.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/23.958705 48, 950-959 (2001).
20. O. T. Shi Yin Tuener, D. Maeding, J. Mainprize, G. Mawdsley, M. J. Yaffe, E. E. Gordon, and W. J. Hamilton, " Direct conversion CdZnTe and CdTe detectors for digital mammography.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2002.998748 49, 176-181 (2002).
21. C. Szeles, S. E. Cameron, J. O. Ndap, and W. C. Chalmers, " Advances in the crystal growth of semi-insulating CdZnTe for radiation detector applications.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2002.803882 49, 2535-2540 (2002).
22. D. Gagnon, G. L. Zeng, J. M. Links, J. J. Griesmer, and F. C. Valentino, " Design considerations for a new solid-state gamma-camera: SOLSTICE.," Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference, 2001 (unpublished), pp. 1156-1160.
23. J. J. Griesmer, B. Kline, J. Grosholz, K. Parnham, and D. Gagnon, " Performance evaluation of a new CZT detector for nuclear medicine: SOLSTICE.," Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference, 2001 (unpublished), pp. 1050-1054.
24. D. Gagnon, M. S. Penn, D. Lee, J. -L. Urbain, T. Chi-Hua, B. Kline, P. J. Bender, D. L. Mercer, and J. J. Griesmer, " Use of SOLSTICE rotating-slat solid-state camera for small animal imaging.," Proceedings of the IEEE Nuclear Science Symposium and Medical Imaging Conference, 2001 (unpublished), pp. 1367-1369.
25. M. Tsuchimochi, H. Sakahara, K. Hayama, M. Funaki, R. Ohno, T. Shirahata, T. Orskaug, G. Maehlum, K. Yoshioka, and E. Nygard, " A prototype small CdTe gamma camera for radioguided surgery and other imaging applications.," Eur. J. Nucl. Med. Mol. Imaging 30, 1605-1614 (2003).
26. D. J. Wagenaar, S. Chowdhury, J. C. Engdahl, and D. D. Burckhardt, " Planar image quality comparison between a CdZnTe prototype and a standard NaI(Tl) gamma camera.," Nucl. Instrum. Methods Phys. Res. A 0168-9002 10.1016/S0168-9002(03)01153-7 505, 586-589 (2003).
27. Y. Eisen, A. Shor, and I. Mardor, " CdTe and CdZnTe x-ray and gamma-ray detectors for imaging systems.," IEEE Trans. Nucl. Sci. 51, 1191-1198 (2004). 0018-9499
28. Y. Eisen, I. Mardor, A. Shor, Z. Baum, D. Bar, G. Feldman, H. Cohen, E. Issac, R. Haham-Zada, S. Blitz, Y. Cohen, B. Glick, R. Falk, S. Roudebush, and I. Blevis, " NUCAM3-A gamma camera based on segmented monolithic CdZnTe Detectors.," IEEE Trans. Nucl. Sci. 49, 1728-1732 (2002). 0018-9499
29. L. Verger, E. G. d'Aillon, O. Monnet, G. Mont́mont, and B. Pellicciari, " New trends in x-ray imaging with CdZnTe/CdTe at CEA-Leti.," Nucl. Instrum. Methods Phys. Res. A 571, 33-43 (2007). 0029-554X
30. C. Mestais, N. Baert, J. P. Bonnefoy, A. Chapuis, A. Koenig, O. Monnet, P. Ouvrier Buet, J. P. Rostaing, F. Sauvage, and L. Verger, " A new design for a high resolution, high efficiency CZT gamma camera detector.," Nucl. Instrum. Methods Phys. Res. A 458, 62-67 (2001). 0029-554X
31. J. Chambron, Y. Arntz, B. Eclancher, Ch. Scheiber, P. Siert, M. Hage Hali, R. Regal, A. Kazandjian, V. Prat, S. Thomas, S. Warren, R. Matz, A. Jahnke, M. Karman, A. Pszota, and L. Nemet, " A pixellated γ-camera based on CdTe detectors clinical interests and performances.," Nucl. Instrum. Methods Phys. Res. A 448, 537-549 (2000). 0029-554X
32. N. Kubo, S. Zhao, Y. Fujiki, A. Kinda, N. Motomura, C. Katoh, T. Shiga, H. Kawashima, Y. Kuge, and N. Tamaki, " Evaluating performance of a pixel array semiconductor SPECT system for small animal imaging.," Ann. Nucl. Med. 19, 633-639 (2005). 0914-7187
33. K. Spartiotis, A. Leppänen, T. Pantsar, J. Pyyhtiä, P. Laukka, K. Muukkonen, O. Maännistö, J. Kinnari, and T. Schulman, " A photon counting CdTe gamma- and x-ray camera.," Nucl. Instrum. Methods Phys. Res. A 550, 267-277 (2005). 0029-554X
34. H. E. Nilsson, B. Norlin, C. Fröjdh, and L. Tlustos, " Charge sharing suppression using pixel-to-pixel communication in photon counting x-ray imaging systems.," Nucl. Instrum. Methods Phys. Res. A 576, 243-247 (2007). 0029-554X
35. D. G. Marks, H. B. Barber, B. A. Apotovsky, F. L. Augustine, H. H. Barrett, E. L. Dereniak, F. P. Doty, J. D. Eskin, W. J. Hamilton, K. J. Matherson, J. E. Venzon, J. M. Woolfenden, and E. T. Young, " A 48×48 CZT array with multiplexer readout.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/23.506673 43, 1253-1259 (1996).
36. K. J. Matherson, H. B. Barber, H. H. Barrel, J. D. Eskin, E. L. Dereniak, D. G. Marks, J. M. Woolfenden, E. T. Young, and F. L. Augustine, " Progress in the development of large-area modular 64×64. CdZnTe imaging arrays for nuclear medicine," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/23.682407 45, 354-358 (1998).
37. H. B. Barber, H. H. Barrett, F. L. Augustine, W. J. Hamilton, B. A. Apotovsky, E. L. Dereniak, F. P. Doty, J. D. Eskin, J. P. Garcia, D. G. Marks, K. J. Matherson, J. M. Woolfenden, and E. T. Young, " Development of a 64×64 CZT array and associated readout integrated circuit for use in nuclear medicine.," J. Electron. Mater. 0361-5235 10.1007/s11664-997-0229-y 26, 765-772 (1997).
38. G. A. Kastis, M. C. Wu, S. J. Balzer, D. W. Wilson, L. R. Furenlid, G. Stevenson, H. H. Barrett, H. B. Barber, J. M. Woolfenden, P. Kelly, and M. Appleby, " Tomographic small-animal imaging using a high-resolution semiconductor detector.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2002.998747 49, 172-175 (2002).
39. G. A. Kastis, L. R. Furenlid, D. W. Wilson, T. E. Peterson, H. B. Barber, and H. H. Barrett, " Compact CT/SPECT small-animal imaging system.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2004.823337 51, 63-67 (2004).
40. K. Spartiotis, J. Havulinna, A. Leppänen, T. Pantsar, K. Puhakka, J. Pyyhtiä, and T. Schulman, " A CdTe real time x-ray imaging sensor and system.," Nucl. Instrum. Methods Phys. Res. A 527, 478-486 (2004). 0029-554X
41. H. Kim, L. R. Furenlid, M. J. Crawford, D. W. Wilson, H. B. Barber, T. E. Peterson, W. C. J. Hunter, Z. Liu, J. M. Woolfenden, and H. H. Barrett, " SemiSPECT: A small-animal single-photon emission computed tomography (SPECT) imager based on eight cadmium zinc telluride (CZT) detector arrays.," Med. Phys. 0094-2405 10.1118/1.2164070 33, 465-474 (2006).
42. M. Locker, P. Fischer, S. Krimmel, H. Krueger, M. Lindner, K. Nakazawua, T. Takahashi, and N. Wermes, " Single photon counting x ray imaging with Si and CdTe single chip pixel detectors and multichip pixel modules.," IEEE Trans. Nucl. Sci. 51, 1717-1723 (2004). 0018-9499
43. G. De Geronimo, P. O'Connor, A. Kandasamy, and J. Grosholz, " Advanced readout ASICs for multielement CZT detectors.," Proc. SPIE 0277-786X 10.1117/12.455775 4784, 105-118 (2003).
44. K. B. Parnham, J. Grosholz, R. K. Davis, S. Vydrin, and C. A. Cupec, " Development of a CdZnTe-based small field of view gamma camera.," Proc. SPIE 4508, 134-140 (2001). 0277-786X
45. C. Scheiber, B. Eclancher, J. Chambron, V. Prat, A. Kazandjan, A. Jahnke, R. Matz, S. Thomas, S. Warren, M. Hage-Hali, R. Regal, P. Siffert, and M. Karman, " Heart imaging by cadmium telluride gamma camera European Program BIOMED' consortium.," Nucl. Instrum. Methods Phys. Res. A 428, 138-149 (1999). 0029-554X
46. B. Mueller, M. K. O'Connor, I. Blevis, D. J. Rodhes, R. Smith, D. A. Collins, and S. W. Phillips, " Evaluation of a small cadmium zinc telluride detector for scintimammography.," J. Nucl. Med. 44, 602-609 (2003). 0161-5505
47. L. Verger, M. C. Gentet, L. Gerfault, R. Guillemaud, C. Mestais, O. Monnet, G. Montemont, G. Petroz, J. P. Rostaing, and J. Rustique, " Performance and perspectives of a CdZnTe-based gamma camera for medical imaging.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2004.839070 51, 3111-3117 (2004).
48. E. G. D'Aillon, M. C. Gentet, G. Montemont, J. Rustique, and L. Verger, " Simulation and experimental results on monolithic CdZnTe gamma-ray detectors.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2005.860176 52, 3096-3102 (2005).
49. R. Accorsi, " MediSPECT: Single photon emission computed tomography system for small field of view small animal imaging based on a CdTe hybrid pixel detector.," Nucl. Instrum. Methods Phys. Res. A 571, 44-47 (2007). 0029-554X
50. R. Accorsi, A. S. Curion, P. Frallicciardi, R. C. Lanza, A. Lauria, G. Mettivier, M. C. Montesi, and P. Russo, " Preliminary evaluation of the tomographic performance of the MediSPECT small animal imaging system.," Nucl. Instrum. Methods Phys. Res. A 571, 415-418 (2007). 0029-554X
51. R. Accorsi, L. Celentano, P. Laccetti, R. C. Lanza, M. Marotta, G. Mettivier, M. C. Montesi, G. Roberti, and P. Russo, " High resolution I-125 small animal imaging with a coded aperture and a hybrid pixel detector.," IEEE Trans. Nucl. Sci. 55, 481-490 (2008). 0018-9499
52. A. Syntfeld, R. Arlt, V. Gostilo, A. Loupilov, M. Moszyski, A. Nassalski, M. Swoboda, and D. Wolski, " Comparison of a LaBr3 (Ce) scintillation detector with a large volume CdZnTe detector.," IEEE Trans. Nucl. Sci. 53, 3938-3943 (2006). 0018-9499
53. Saint Gobain 2004, " BrilLanCe380 scintillation material.," Technical Data Sheet, 2007 (available online at http://www.detectors.saint- gobain.com/Media/Documents/S0000000000000001004/SGC-BrilLanCe-380-data-sheet. pdf).
54. W. J. Kernan, " Self-activity in lanthanum halides.," IEEE Trans. Nucl. Sci. 53, 395-400 (2006). 0018-9499
55. R. Pani, M. N. Cinti, R. Pellegrini, P. Bennati, S. Lo Meo, S. Ridolfi, F. Vittorini, F. de Notaristefani, and M. Mattioli, " Photodetector and scintillation crystals requirements for gamma-ray imaging.," Nuovo Cimento Soc. Ital. Fis., C 30, 435-448 (2007).
56. E. V. D. van Loef, P. Dorenbos, C. W. E. van Eijk, K. W. Kramer, and H. U. Gudel, " High-energy-resolution scintillator: Ce3+ activated LaBr3.," Appl. Phys. Lett. 0003-6951 10.1063/1.1385342 79, 1573-1575 (2001).
57. A. Syntfeld-Kazuch,. Swiderski, W. Czarnacki, M. Gierlik, W. Klamra, M. Moszynski, and P. Schotanus, " Non-proportionality and energy resolution of CsI:Tl.," IEEE Trans. Nucl. Sci. 54, 1836-1841 (2007). 0018-9499
58. Hamamatsu Photonics, " Flat panel type, multianode photomultiplier tube assembly H8500.," Technical Data Sheet, 2006 (available online at http://sales.hamamatsu.com/assets/pdf/parts-H/H8500H8500B.pdf).
59. A. J. Bird, Z. He, and D. Ramsden, " Multi-channel readout of crossed-wire anode photomultipliers.," Nucl. Instrum. Methods Phys. Res. A 348, 668-672 (1994). 0029-554X
60. Rutherford Appleton Laboratories, Microelectronics Group HX2/RAL/SS, Technical Data Sheet, Chilton-Didcot, Oxfordshire UK, 1996 (available online at http://www.ins.clrc.ac.uk/INS/Electronic-Systems/Microelectronics-Design/ Projects/Other/Multiplexed-Amplifiers/HX2/files/hx2-user-guide.pdf).
61. National Instruments Corporation, " PCI-6110E/6111E user manual. Multifunction I/O boards for PCI bus computers.," 1998 (available online at http://www.ni.com/pdf/manuals/321759b.pdf).
62. R. Pani, R. Pellegrini, M. N. Cinti, C. Trotta, G. Trotta, R. Scafe, D. Addio, G. Iurlar o, L. Montani, P. Bennat i, S. Ridolfi, F. Cusanno, and F. Garibaldi, " Factors affecting Hamamatsu H8500 flat panel PMT calibration for gamma ray imaging.," IEEE Trans. Nucl. Sci. 54, 438-443 (2007). 0018-9499
63. H. O. Anger, " Scintillation camera.," Rev. Sci. Instrum. 0034-6748 10.1063/1.1715998 29, 27-33 (1958).
64. S. Basolo, J. F. Berar, N. Boudet, P. Breugnoa, B. Chantepia, J. C. Clemens, P. Delpierre, B. Dinkespiler, S. Hustache, K. Medjoubi, M. Menouni, C. Morel, P. Pangaud, and E. Vigeolas, " A 20 kpixels CdTe photon-counting imager using XPAD chip.," Nucl. Instrum. Methods Phys. Res. A 589, 268-274 (2008). 0029-554X
65. W. R. Cook, S. E. Boggs, A. E. Bolotnikov, J. A. Burnham, M. J. Fitzsimmons, F. A. Harrison, B. Kecman, B. Matthews, and S. M. Schindler, " High resolution CdZnTe pixel detectors with VLSI readout.," IEEE Trans. Nucl. Sci. 47, 1454-1457 (2000). 0018-9499
66. J. F. Butler, C. L. Lingren, S. J. Friesenhahn, F. P. Doty, W. L. Ashburn, R. L. Conwell, F. L. Augustine, B. Apotovsky, B. Pi, T. Collins, S. Zhao, and C. Isaacson, " CZT solid-state gamma camera.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/23.682408 45, 359-363 (1998).
67. R. Franchi, F. Glasser, A. Gasse, and J.-C. Clemens, " Photon counting X-ray imaging with CdTe pixel detectors based on XPAD2 circuit.," Nucl. Instrum. Methods Phys. Res. A 563, 249-253 (2006).
68. P. Russo, in Encyclopedia of Imaging Science and Technology, edited by, J. P. Hornak, (Wiley Interscience, John Wiley & Sons, Inc., New York, 2002).
69. X. Llopart, M. Campbell, R. Dinapoli, D. SanSegundo, and E. Pernigotti, " Medipix2, a 64k pixel read-out with 55 μm square elements working in single photon counting mode.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2002.803788 49, 2279-2283 (2002).
70. M. Chmeissani, C. Frojdh, O. Gal, X. Llopart, J. Ludwig, M. Maiorino, E. Manach, G. Mettivier, M. C. Montesi, C. Ponchut, P. Russo, L. Tlustos, and A. Zwerger, " First experimental tests with a CdTe photon counting pixel detector hybridized with a Medipix2 readout chip.," IEEE Trans. Nucl. Sci. 51, 2379-2385 (2004). 0018-9499
71. L. Tlustos, R. Ballabriga, M. Campbell, E. Heijne, K. Kincade, X. Llopart, and P. Stejskal, " Imaging properties of the Medipix2 system exploiting single and dual energy thresholds.," IEEE Trans. Nucl. Sci. 0018-9499 10.1109/TNS.2006.869844 53, 367-372 (2006).
72. Acrorad Co. web site (http://www.acrorad.co.jp/us/detect.html).
73. D. San Segundo Bello, M. van Beuzekom, P. Jansweijer, H. Verkooijen, and J. Visschers, " Design of an interface board for the control and DAQ of the Medipix2 chip.," Nucl. Instrum. Methods Phys. Res. A 509, 164-170 (2003). 0029-554X
74. M. Conti, M. Maiorino, G. Mettivier, M. C. Montesi, and P. Russo, " Preliminary test of Medisoft 4: control software for the Medipix2 read-out chip.," IEEE Trans. Nucl. Sci. 50, 869-877 (2003). 0018-9499
75. C. Fröjdh, H. Graafsma, H. E. Nilsson, and C. Ponchut, " Characterization of a pixellated CdTe detector with single-photon processing readout.," Nucl. Instrum. Methods Phys. Res. A 563, 128-132 (2006).
76. G. Mettivier, M. C. Montesi, A. Sebastiano, and P. Russo, " High frame rate X-ray imaging with a 256×256 pixel single photon counting Medipix2 detector.," IEEE Trans. Nucl. Sci. 53, 1650-1655 (2006). 0018-9499
77. G. Mettivier, M. C. Montesi, and P. Russo, " Digital autoradiography with a Medipix2 hybrid silicon pixel detector.," IEEE Trans. Nucl. Sci. 52, 46-50 (2005). 0018-9499
78. D. Niederlöhner, F. Nachtrab, T. Michel, and G. Anton, " Using the Medipix2 detector for photon counting computed tomography.," in Proceedings of the Conference Records of the IEEE Nuclear Science Symposium and Medical Imaging Conference, 2005 (unpublished), pp. 2327-2331.
79. M. Autiero, L. Celentano, R. Cozzolino, P. Laccetti, M. Marotta, G. Mettivier, M. C. Montesi, P. Riccio, G. Roberti, and P. Russo, " Experimental study on in vivo optical and radionuclide imaging in small animals.," IEEE Trans. Nucl. Sci. 52, 205-209 (2005). 0018-9499
80. B. Norlin, C. Fröjdh, H. E. Nilsson, H. Graafsma, V. Vonk, and C. Ponchut, " Characterisation of the charge sharing in pixellated Si detectors with single-photon processing readout.," Nucl. Instrum. Methods Phys. Res. A 563, 133-136 (2006). 0029-554X
81. L. Tlustos, R. Ballabriga, M. Campbell, E. Heijne, and X. Llopart, in Proceedings of the Ninth ICATPP Conference on Astroparticle, Particle, Space Physics, Detectors and Medical Physics Applications, edited by, M. Barone, E. Borchi, A. Gaddi, C. Leroy, L. Price, P. Rancoita, and, R. Ruchti, (World Scientific, Singapore, 2006).
82. G. Pellegrini, M. Chmeissani, M. Maiorino, G. Blanchot, J. Garcia, M. Lozano, R. Martinez, C. Puigdengoles, M. Ullan, and P. Casado, " Performance limits of a 55-μm pixel CdTe detector.," IEEE Trans. Nucl. Sci. 53, 361-366 (2006). 0018-9499
83. M. Maiorino, G. Pellegrini, G. Blanchot, M. Chmeissani, J. Garcia, R. Martinez, M. Lozano, C. Puigdengoles, and M. Ullan, " Charge sharing observations with a CdTe pixel detector irradiated with a C 57 o source.," Nucl. Instrum. Methods Phys. Res. A 563, 177-181 (2006). 0029-554X
84. G. Pellegrini, M. Maiorino, G. Blanchot, M. Chmeissani, J. Garcia, M. Lozano, R. Martinez, C. Puigdengoles, and M. Ullan, " Direct charge sharing observation in single-photon-counting pixel detector.," Nucl. Instrum. Methods Phys. Res. A 573, 137-140 (2007). 0029-554X
85. E. Gros d' Aillon, J. Tabary, A. Glìre, and L. Verger, " Charge sharing on monolithic CdZnTe gamma-ray detectors: A simulation study.," Nucl. Instrum. Methods Phys. Res. A 563, 124-127 (2006).
86. E. J. Hoffman, M. P. Tornai, C. S. Levin, L. R. MacDonald, and S. Siegel, " Gamma and beta intra-operative imaging probes.," Nucl. Instrum. Methods Phys. Res. A 0168-9002 10.1016/S0168-9002(97)00247-7 392, 324-329 (1997).