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Volumn 19, Issue 2, 2009, Pages 99-112

Effects of ionizing radiation sterilization on microparticulate drug delivery systems based on poly-α-hydroxyacids: An overview

Author keywords

Biodegradable polymers; Ionizing irradiation; Microspheres; Poly hydroxyacids

Indexed keywords

2 HYDROXYACID; ACICLOVIR; ARESTIN; BUPIVACAINE; BUSERELIN; CIPROFLOXACIN; CLONAZEPAM; DECAPEPTYL SR; ESTRADIOL; ETANIDAZOLE; FLUOROURACIL; GANCICLOVIR; HUMAN GROWTH HORMONE; IBUPROFEN; INDOMETACIN; LEUPRORELIN; MALARIA VACCINE; MICROSPHERE; MINOCYCLINE; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; OCTREOTIDE; OVALBUMIN; PACLITAXEL; POLYGLACTIN; POLYLACTIDE; POLYMER; PROGESTERONE; RECOMBINANT GROWTH FACTOR; RISPERIDONE; SOMATULINE LA; SUPRECUR MP; TETRACYCLINE; TRIPTORELIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 63649146823     PISSN: 17732247     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1773-2247(09)50017-2     Document Type: Review
Times cited : (8)

References (65)
  • 1
    • 85031361696 scopus 로고    scopus 로고
    • USP 31, 1211. - Sterilization and sterility assurance of compendial articles. - 2008, pp. 670-675.
    • USP 31, 1211. - Sterilization and sterility assurance of compendial articles. - 2008, pp. 670-675.
  • 2
    • 85031352854 scopus 로고    scopus 로고
    • Eur. Pharm. 6.0, 5.1.1. - Methods of preparation of sterile products. - 2008, pp. 525-527.
    • Eur. Pharm. 6.0, 5.1.1. - Methods of preparation of sterile products. - 2008, pp. 525-527.
  • 4
    • 0038445582 scopus 로고    scopus 로고
    • Biodegradable microspheres for protein delivery
    • Sinha V.R., Trehan A. - Biodegradable microspheres for protein delivery. - J Control Release, 90, 281-290, 2003.
    • (2003) J Control Release , vol.90 , pp. 281-290
    • Sinha, V.R.1    Trehan, A.2
  • 5
    • 0033985634 scopus 로고    scopus 로고
    • Branched biodegradable polyesters for parenteral drug delivery systems
    • Breitenbach A., Li Y., Kissel T. - Branched biodegradable polyesters for parenteral drug delivery systems. - J Control Release, 64, 167-178, 2000.
    • (2000) J Control Release , vol.64 , pp. 167-178
    • Breitenbach, A.1    Li, Y.2    Kissel, T.3
  • 6
    • 0032140213 scopus 로고    scopus 로고
    • Synthesis characteristics and in vitro degradation of star-block copolymers consisting of L-lactide glycolide and branched multi-arm poly(ethylene oxide)
    • Li Y., Kissel T. - Synthesis characteristics and in vitro degradation of star-block copolymers consisting of L-lactide glycolide and branched multi-arm poly(ethylene oxide). - Polymer, 39 (18), 4421-4427, 1998.
    • (1998) Polymer , vol.39 , Issue.18 , pp. 4421-4427
    • Li, Y.1    Kissel, T.2
  • 7
    • 10044290890 scopus 로고    scopus 로고
    • The role of branched polyesters and their modifications in the development of modern drug delivery vehicles
    • Dailey L.A., Wittmar M., Kissel T. - The role of branched polyesters and their modifications in the development of modern drug delivery vehicles. - J Control Release, 101, 137-149, 2005.
    • (2005) J Control Release , vol.101 , pp. 137-149
    • Dailey, L.A.1    Wittmar, M.2    Kissel, T.3
  • 8
    • 85031361953 scopus 로고    scopus 로고
    • Control Guidelines for radiation sterilization of medical devices No. RS-P 10/82, 1982.
    • Control Guidelines for radiation sterilization of medical devices No. RS-P 10/82, 1982.
  • 9
    • 85031365775 scopus 로고    scopus 로고
    • European Guideline 3AQ4A. - The use of ionizing radiation in the manufacture of medicinal products, 6/1992. - Official Publication of the European Community, 1992.
    • European Guideline 3AQ4A. - The use of ionizing radiation in the manufacture of medicinal products, 6/1992. - Official Publication of the European Community, 1992.
  • 10
    • 85031368287 scopus 로고    scopus 로고
    • European Guidelines CPMP/QWP/054/98 CORR. - Decision trees for the selection of the sterilization method, 4/2000. - Official Publications of the European Community, 2000.
    • European Guidelines CPMP/QWP/054/98 CORR. - Decision trees for the selection of the sterilization method, 4/2000. - Official Publications of the European Community, 2000.
  • 11
    • 85031353596 scopus 로고    scopus 로고
    • Guidance For Industry: Q3C impurities: residual solvents. - Tripartite harmonized ICH Guideline, 1997.
    • Guidance For Industry: Q3C impurities: residual solvents. - Tripartite harmonized ICH Guideline, 1997.
  • 12
    • 63649156645 scopus 로고    scopus 로고
    • EMEA/CVMP/511/03. - Annex I: Specifications for class 1, class 2 residual solvents in active substances; Annex II: residues of solvents used in the manufacture of finished products
    • European Guideline CPMP/QWP/450/03
    • European Guideline CPMP/QWP/450/03, EMEA/CVMP/511/03. - Annex I: specifications for class 1, class 2 residual solvents in active substances; Annex II: residues of solvents used in the manufacture of finished products. - Official Publications of the European Community, 2005.
    • (2005) Official Publications of the European Community
  • 13
    • 0018737940 scopus 로고
    • Biodegradable polymers for use in surgery: Poly(glycolic)/poly(lactic acid) homo and copolymers: 1
    • Gilding D.K., Reed A.M. - Biodegradable polymers for use in surgery: poly(glycolic)/poly(lactic acid) homo and copolymers: 1.- Polymer, 20, 1459-1464, 1979.
    • (1979) Polymer , vol.20 , pp. 1459-1464
    • Gilding, D.K.1    Reed, A.M.2
  • 14
    • 0033151448 scopus 로고    scopus 로고
    • Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro
    • Tracy M.A., Ward K.L., Firouzabadian L., Wang Y., Dong N., Qian R., Zhang Y. - Factors affecting the degradation rate of poly(lactide-co-glycolide) microspheres in vivo and in vitro. - Biomaterials, 20, 1057-62, 1999.
    • (1999) Biomaterials , vol.20 , pp. 1057-1062
    • Tracy, M.A.1    Ward, K.L.2    Firouzabadian, L.3    Wang, Y.4    Dong, N.5    Qian, R.6    Zhang, Y.7
  • 15
    • 0029878717 scopus 로고    scopus 로고
    • Polymer degradation and erosion: Mechanisms and applications
    • Gopferich A. - Polymer degradation and erosion: mechanisms and applications. - Eur J Pharm Biopharm, 42 (1), 1-11, 1996.
    • (1996) Eur J Pharm Biopharm , vol.42 , Issue.1 , pp. 1-11
    • Gopferich, A.1
  • 16
    • 0022975567 scopus 로고
    • Polymers for biodegradable medical devices. I. The potential of polyesters as controlled macromolecular release systems
    • Holland S.J., Tighe B.J., Gould P.L. - Polymers for biodegradable medical devices. I. The potential of polyesters as controlled macromolecular release systems. - J Control Release, 4, 155-180, 1986.
    • (1986) J Control Release , vol.4 , pp. 155-180
    • Holland, S.J.1    Tighe, B.J.2    Gould, P.L.3
  • 17
    • 0001855042 scopus 로고
    • Controlled release of bioactive agents from lactide/ glycolide polymers
    • Chasin M, Langer R. Eds, Marcel Dekker, New York
    • Lewis D.H. - Controlled release of bioactive agents from lactide/ glycolide polymers, - In: Biodegradable Polymers as Drug Delivery Systems, Chasin M, Langer R. Eds., Marcel Dekker, New York, 1990, pp. 2-41.
    • (1990) Biodegradable Polymers as Drug Delivery Systems , pp. 2-41
    • Lewis, D.H.1
  • 18
    • 34548415663 scopus 로고    scopus 로고
    • Microencapsulation techniques for parenteral depot systems and their application in the pharmaceutical industry
    • Benita S. Ed, 2nd ed, Taylor & Francis, New York
    • Kissel T., Maretschek S., Packhauser C., Schnieders J., Seidel N. - Microencapsulation techniques for parenteral depot systems and their application in the pharmaceutical industry. - In: Microencapsulation Methods and industrial Applications, Benita S. Ed., 2nd ed., Taylor & Francis, New York, 2006, pp. 99-119.
    • (2006) Microencapsulation Methods and industrial Applications , pp. 99-119
    • Kissel, T.1    Maretschek, S.2    Packhauser, C.3    Schnieders, J.4    Seidel, N.5
  • 19
    • 34250674670 scopus 로고    scopus 로고
    • Biodegradable microspheres advances in production
    • Benita S. Ed, 2nd ed, Taylor & Francis, New York
    • Tewes F., Boury F., Benoit J.R - Biodegradable microspheres advances in production. - In: Microencapsulation Methods and Industrial Applications, Benita S. Ed., 2nd ed., Taylor & Francis, New York, 2006, pp. 1-53.
    • (2006) Microencapsulation Methods and Industrial Applications , pp. 1-53
    • Tewes, F.1    Boury, F.2    Benoit, J.R.3
  • 20
    • 85031367148 scopus 로고    scopus 로고
    • Puel F., Briancon S., Fessi H. - industrial technologies and scale-up. - In: Microencapsulation Methods and industrial Applications, Benita S. Ed., 2nd ed., Taylor & Francis, New York, 2006, pp. 149-182.
    • Puel F., Briancon S., Fessi H. - industrial technologies and scale-up. - In: Microencapsulation Methods and industrial Applications, Benita S. Ed., 2nd ed., Taylor & Francis, New York, 2006, pp. 149-182.
  • 22
    • 11844259383 scopus 로고    scopus 로고
    • Microencapsulation by solvent extraction/evaporation: Reviewing the state of the art of microsphere preparation process technology
    • Freitas S., Merkle H.R, Gander B. - Microencapsulation by solvent extraction/evaporation: reviewing the state of the art of microsphere preparation process technology. - J. Control. Release, 102, 313-332, 2005.
    • (2005) J. Control. Release , vol.102 , pp. 313-332
    • Freitas, S.1    Merkle, H.R.2    Gander, B.3
  • 23
    • 0033635054 scopus 로고    scopus 로고
    • Protein instability in Poly(lactic-co-glycolic acid) microparticles
    • Vandeweert M., Hennink W.E., Jiskoot W. - Protein instability in Poly(lactic-co-glycolic acid) microparticles. - Pharma Res, 17 (10), 1159-1167, 2000.
    • (2000) Pharma Res , vol.17 , Issue.10 , pp. 1159-1167
    • Vandeweert, M.1    Hennink, W.E.2    Jiskoot, W.3
  • 24
    • 0036000111 scopus 로고    scopus 로고
    • Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems
    • Schwendeman S.P. - Recent advances in the stabilization of proteins encapsulated in injectable PLGA delivery systems. - Critical Reviews in Therapeutic Drug carrier Systems, 19 (1), 73-98, 2002.
    • (2002) Critical Reviews in Therapeutic Drug carrier Systems , vol.19 , Issue.1 , pp. 73-98
    • Schwendeman, S.P.1
  • 25
    • 0032863592 scopus 로고    scopus 로고
    • Why does PEG400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres?
    • Pean J.M., Boury F.P., Venier-Julienne M.C., Menei P., Proust J.E., Benoit J.P. - Why does PEG400 co-encapsulation improve NGF stability and release from PLGA biodegradable microspheres? - Pharma Res, 16 (8), 1294-1299,1999.
    • (1999) Pharma Res , vol.16 , Issue.8 , pp. 1294-1299
    • Pean, J.M.1    Boury, F.P.2    Venier-Julienne, M.C.3    Menei, P.4    Proust, J.E.5    Benoit, J.P.6
  • 26
    • 0031398790 scopus 로고    scopus 로고
    • Microencapsulation of rh-erythropoietin using biodegradable poly(D, L-lactide-coglycolide), protein stability and the effects of stabilizing excipients
    • Mordock M., Koll H., Winter G., Kissel T. - Microencapsulation of rh-erythropoietin using biodegradable poly(D, L-lactide-coglycolide), protein stability and the effects of stabilizing excipients. - Eur J Pharm Biopharm, 43, 29-36, 1997.
    • (1997) Eur J Pharm Biopharm , vol.43 , pp. 29-36
    • Mordock, M.1    Koll, H.2    Winter, G.3    Kissel, T.4
  • 28
    • 0033039914 scopus 로고    scopus 로고
    • Stabilization of proteins against methylen chloride/water interface-induced denaturation and aggregation
    • Sah H. - Stabilization of proteins against methylen chloride/water interface-induced denaturation and aggregation. - J Control Release, 58, 143-151, 1999.
    • (1999) J Control Release , vol.58 , pp. 143-151
    • Sah, H.1
  • 30
    • 23144467114 scopus 로고    scopus 로고
    • Effect of additives on the release of a model protein from PLGA microspheres
    • Kang E, Singh J. - Effect of additives on the release of a model protein from PLGA microspheres. - AAPS Pharm. Sci. Tech., 2 (4), 30, 2001.
    • (2001) AAPS Pharm. Sci. Tech , vol.2 , Issue.4 , pp. 30
    • Kang, E.1    Singh, J.2
  • 31
    • 11244322133 scopus 로고    scopus 로고
    • Sterilized ibuprofen-loaded poly(D, L-lactide-co-glycolide) microspheres for intra-articular administration: Effect of γ-irradiation and storage
    • Fernandez-Carballido A., Herrero-Vanrell R., Molina-Martinez, I.T., Pastoriza P. - Sterilized ibuprofen-loaded poly(D, L-lactide-co-glycolide) microspheres for intra-articular administration: effect of γ-irradiation and storage. - J Microencapsul, 21 (6), 653-665, 2004.
    • (2004) J Microencapsul , vol.21 , Issue.6 , pp. 653-665
    • Fernandez-Carballido, A.1    Herrero-Vanrell, R.2    Molina-Martinez, I.T.3    Pastoriza, P.4
  • 32
    • 3242798076 scopus 로고    scopus 로고
    • Biodegradable ibuprofen-loaded PLGA microspheres for intra-articular administration: Effect of Labrafil addition on release in vitro
    • Fernandez-Carballido A., Herrero-Vanrell R., Molina-Martinez It., Pastoriza P. - Biodegradable ibuprofen-loaded PLGA microspheres for intra-articular administration: effect of Labrafil addition on release in vitro. - Int J Pharma, 27, 33-41, 2004.
    • (2004) Int J Pharma , vol.27 , pp. 33-41
    • Fernandez-Carballido, A.1    Herrero-Vanrell, R.2    Molina-Martinez, I.3    Pastoriza, P.4
  • 33
    • 0037423784 scopus 로고    scopus 로고
    • POE/PLGA composite microspheres: Formation and in vitro behaviour of double walled microspheres
    • Yang Y.Y., Shi M., Goh S.H., Moochhala S.M., Ng S., Heller J. - POE/PLGA composite microspheres: formation and in vitro behaviour of double walled microspheres. - J Control Release, 88, 201-213, 2003.
    • (2003) J Control Release , vol.88 , pp. 201-213
    • Yang, Y.Y.1    Shi, M.2    Goh, S.H.3    Moochhala, S.M.4    Ng, S.5    Heller, J.6
  • 35
    • 0029075184 scopus 로고
    • Gamma irradiation effects on molecular weight and in vitro degradation of Poly(D, L-lactide-co-glycolide) microparticles
    • Hausberger A.G., Kenley R.A., Deluca P.R - Gamma irradiation effects on molecular weight and in vitro degradation of Poly(D, L-lactide-co-glycolide) microparticles. - Pharma Res, 12 (6), 851-856, 1995.
    • (1995) Pharma Res , vol.12 , Issue.6 , pp. 851-856
    • Hausberger, A.G.1    Kenley, R.A.2    Deluca, P.R.3
  • 36
    • 0032484048 scopus 로고    scopus 로고
    • Montanari L., Costantini M., Ciranni Signoretti E., Valvo L., Santucci M., Bartolomei M., Fattibene.P, Onori S., Faucitano A., Conti B., Genta I. - Gamma irradiation effects on poly(DL-lactide-co-glycolide) microspheres. - J Control Release, 56, 219-229, 1998.
    • Montanari L., Costantini M., Ciranni Signoretti E., Valvo L., Santucci M., Bartolomei M., Fattibene.P, Onori S., Faucitano A., Conti B., Genta I. - Gamma irradiation effects on poly(DL-lactide-co-glycolide) microspheres. - J Control Release, 56, 219-229, 1998.
  • 37
    • 0032817178 scopus 로고    scopus 로고
    • Gamma irradiation for terminal sterilization of 17β-estradiol loaded poly-(D,L-lactide-co-glycolide) microparticles
    • Mohr D., Wolff M., Kissel T. - Gamma irradiation for terminal sterilization of 17β-estradiol loaded poly-(D,L-lactide-co-glycolide) microparticles. - J Control Release, 61, 203-217, 1999.
    • (1999) J Control Release , vol.61 , pp. 203-217
    • Mohr, D.1    Wolff, M.2    Kissel, T.3
  • 38
    • 0036172460 scopus 로고    scopus 로고
    • Influence of irradiation sterilization on poly(lactide-co-glycolide) microspheres containing anti-inflammatory drugs
    • Calis S., Bozadag S., Kas H.S., Tuncay M., Hincal A.A. - Influence of irradiation sterilization on poly(lactide-co-glycolide) microspheres containing anti-inflammatory drugs. - II Farmaco, 57, 55-62, 2002.
    • (2002) II Farmaco , vol.57 , pp. 55-62
    • Calis, S.1    Bozadag, S.2    Kas, H.S.3    Tuncay, M.4    Hincal, A.A.5
  • 39
    • 0037151438 scopus 로고    scopus 로고
    • The effect of gamma-irradiation on drug release from bioerodible microparticles: A quantitative treatment
    • Faisant N., Siepman J., Oury P., Laffineur V., Bruna E., Haffner J., Benoit J.P - The effect of gamma-irradiation on drug release from bioerodible microparticles: a quantitative treatment. - Int J Pharma, 242, 281-284, 2002.
    • (2002) Int J Pharma , vol.242 , pp. 281-284
    • Faisant, N.1    Siepman, J.2    Oury, P.3    Laffineur, V.4    Bruna, E.5    Haffner, J.6    Benoit, J.P.7
  • 40
    • 0038446747 scopus 로고    scopus 로고
    • Release of paclitaxel from polylactide-coglycolide (PLGA) microparticles and discs under irradiation
    • Wang J.J., Ng C.W., Win K.Y., Shoemakers R, Lee T.K.Y., Feng S.S., Wang C.H. - Release of paclitaxel from polylactide-coglycolide (PLGA) microparticles and discs under irradiation. - J Microencapsul, 20 (3), 317-327, 2003.
    • (2003) J Microencapsul , vol.20 , Issue.3 , pp. 317-327
    • Wang, J.J.1    Ng, C.W.2    Win, K.Y.3    Shoemakers, R.4    Lee, T.K.Y.5    Feng, S.S.6    Wang, C.H.7
  • 41
    • 0037202224 scopus 로고    scopus 로고
    • Double walled microspheres for the sustained release of a highly water soluble drug: Characterization and irradiation studies
    • Lee T.H., Wang J., Wang C.H. - Double walled microspheres for the sustained release of a highly water soluble drug: characterization and irradiation studies. - J Control Release, 83 (3), 437-452, 2002.
    • (2002) J Control Release , vol.83 , Issue.3 , pp. 437-452
    • Lee, T.H.1    Wang, J.2    Wang, C.H.3
  • 42
    • 51449095186 scopus 로고    scopus 로고
    • Dorati R., Cofonna C., Serra M., Genta I., Modena T., Pavanetto E, Perugini P., Conti B. - γ-Irradiation of PEGd, IPLA and PEG-PLGA multi block copolymers. I. Effect of irradiation doses. - AAPS Pharm. Sci. Tech., 2008.
    • Dorati R., Cofonna C., Serra M., Genta I., Modena T., Pavanetto E, Perugini P., Conti B. - γ-Irradiation of PEGd, IPLA and PEG-PLGA multi block copolymers. I. Effect of irradiation doses. - AAPS Pharm. Sci. Tech., 2008.
  • 43
    • 0035218387 scopus 로고    scopus 로고
    • PLGA miorosphere bioburden evaluation for radiosterilization dose selection
    • Geze A., Venier-Julienn M.C., Cottin J., Faisant N., Benoit J.P. - PLGA miorosphere bioburden evaluation for radiosterilization dose selection. - J Microencapsul, 18 (5), 627-636, 2001.
    • (2001) J Microencapsul , vol.18 , Issue.5 , pp. 627-636
    • Geze, A.1    Venier-Julienn, M.C.2    Cottin, J.3    Faisant, N.4    Benoit, J.P.5
  • 44
    • 85031359155 scopus 로고    scopus 로고
    • International Standard Organization. Sterilization Of Health Care Products. - Requirements for validation and routine control, radiation sterilization method. - B.3.4.1, ISO11137, 1995.
    • International Standard Organization. Sterilization Of Health Care Products. - Requirements for validation and routine control, radiation sterilization method. - B.3.4.1, ISO11137, 1995.
  • 45
    • 0344718438 scopus 로고    scopus 로고
    • Tetracycline-HCl-loaded poly(DL-lactide-co-glycolide) microspheres prepared by a spray drying technique:influence of γ-irradiation on radical formation and polymer degradation
    • Bittner B., Mader K., Kroll C., Borchert H.H., Kissel T. - Tetracycline-HCl-loaded poly(DL-lactide-co-glycolide) microspheres prepared by a spray drying technique:influence of γ-irradiation on radical formation and polymer degradation. - J Control Release, 59, 23-32, 1999.
    • (1999) J Control Release , vol.59 , pp. 23-32
    • Bittner, B.1    Mader, K.2    Kroll, C.3    Borchert, H.H.4    Kissel, T.5
  • 46
    • 0033634899 scopus 로고    scopus 로고
    • Biodegradable PLGA microspheres loaded with Ganciclovir for intraocular administration. Encapsulation technique, in vitro release profiles, and sterilization process
    • Herrero-Vanrell R., Ramirez L., Fernandez-Carballido A., Refojo M.F. - Biodegradable PLGA microspheres loaded with Ganciclovir for intraocular administration. Encapsulation technique, in vitro release profiles, and sterilization process. - Pharm Res, 17, 1323-1328, 2000.
    • (2000) Pharm Res , vol.17 , pp. 1323-1328
    • Herrero-Vanrell, R.1    Ramirez, L.2    Fernandez-Carballido, A.3    Refojo, M.F.4
  • 47
    • 4444286058 scopus 로고    scopus 로고
    • Study of gamma-irradiation effects on aciclovir poly(D,L-lactic-co-glycolic) acid microspheres for intravitreal administration
    • Martinez-Sancho C., Herrero-Vanrell R., Negro S. - Study of gamma-irradiation effects on aciclovir poly(D,L-lactic-co-glycolic) acid microspheres for intravitreal administration. - J Control Release, 99, 41-52, 2004.
    • (2004) J Control Release , vol.99 , pp. 41-52
    • Martinez-Sancho, C.1    Herrero-Vanrell, R.2    Negro, S.3
  • 49
    • 33645281131 scopus 로고    scopus 로고
    • Fernandez-Carballido A., Puebla P., Herrero-Vamrell R., Pastoriza R - Radiosterilisation of indomethacin PLGA/PEG-derivative microspheres: protective effects of low temperature during gamma irradiation. - Int J Pharma, 313, 129-135, 2006.
    • Fernandez-Carballido A., Puebla P., Herrero-Vamrell R., Pastoriza R - Radiosterilisation of indomethacin PLGA/PEG-derivative microspheres: protective effects of low temperature during gamma irradiation. - Int J Pharma, 313, 129-135, 2006.
  • 50
    • 0043158940 scopus 로고    scopus 로고
    • Claybourn M., Gray H., Murphy.D, Purnell I.J,. Rowlands C.C. - Electron paramagnetic resonance study of gamma-irradiated poly(lactide-co-glycolide) microspheres. - J Control Release, 91, 431-438, 2003.
    • Claybourn M., Gray H., Murphy.D, Purnell I.J,. Rowlands C.C. - Electron paramagnetic resonance study of gamma-irradiated poly(lactide-co-glycolide) microspheres. - J Control Release, 91, 431-438, 2003.
  • 51
    • 0037768717 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) microspheres containing bupivacaine: Comparison between gamma and beta irradiation effects
    • Montanari L., Cilurzo F., Selmin F., Conti B., Genta I., Poletti G., Orsini R, Valvo L. - Poly(lactide-co-glycolide) microspheres containing bupivacaine: comparison between gamma and beta irradiation effects. - J Control Release, 90, 281-290, 2003.
    • (2003) J Control Release , vol.90 , pp. 281-290
    • Montanari, L.1    Cilurzo, F.2    Selmin, F.3    Conti, B.4    Genta, I.5    Poletti, G.6    Orsini, R.7    Valvo, L.8
  • 53
    • 0037406071 scopus 로고    scopus 로고
    • Radiation induced free radical reactions in polymer/drug systems for controller release: An EPR investigation
    • Faucitano A., Buttafava A., Montanari L., Cilurzo F., Conti B., Genta I., Valvo L. - Radiation induced free radical reactions in polymer/drug systems for controller release: an EPR investigation. - Radiat Phys Chem, 67, 61-72, 2003.
    • (2003) Radiat Phys Chem , vol.67 , pp. 61-72
    • Faucitano, A.1    Buttafava, A.2    Montanari, L.3    Cilurzo, F.4    Conti, B.5    Genta, I.6    Valvo, L.7
  • 54
    • 28244495873 scopus 로고    scopus 로고
    • An EPR and ENDOR study of γ- and β-radiation sterilization in poly(lactide-co-glycolide) polymers and microspheres
    • Bushell J.A., Claybourn M., Williams H.E., Murphy D.M. - An EPR and ENDOR study of γ- and β-radiation sterilization in poly(lactide-co-glycolide) polymers and microspheres.-J Control Release, 110, 49-57, 2005.
    • (2005) J Control Release , vol.110 , pp. 49-57
    • Bushell, J.A.1    Claybourn, M.2    Williams, H.E.3    Murphy, D.M.4
  • 55
    • 63649132302 scopus 로고    scopus 로고
    • Dorati R., Colonna C., Tomasi C., Genta I., Modena T., Faucitano A., Buttafava A., Conti B. - γ-Irradiation of PEGd, IPLA and PEG-PLGA multi block copolymers. II. Effect of oxygen and EPR investigation. - AAPS Pharm Sci Tech, 2008.
    • Dorati R., Colonna C., Tomasi C., Genta I., Modena T., Faucitano A., Buttafava A., Conti B. - γ-Irradiation of PEGd, IPLA and PEG-PLGA multi block copolymers. II. Effect of oxygen and EPR investigation. - AAPS Pharm Sci Tech, 2008.
  • 56
    • 33744538612 scopus 로고    scopus 로고
    • The effect of γ-irradiation and polymer composition on the stability of PLG polymer and microspheres
    • Williams H.E., Huxley J., Claybourn M., Booth J., Hobbs M., Mcchan L., Clark B. - The effect of γ-irradiation and polymer composition on the stability of PLG polymer and microspheres. - Polym Degrad Stab, 91 (9), 2171-2181, 2006.
    • (2006) Polym Degrad Stab , vol.91 , Issue.9 , pp. 2171-2181
    • Williams, H.E.1    Huxley, J.2    Claybourn, M.3    Booth, J.4    Hobbs, M.5    Mcchan, L.6    Clark, B.7
  • 57
    • 0037400653 scopus 로고    scopus 로고
    • Sustained release system for highly water soluble radiosensitizer drug etanidazole: Irradiation and degradation studies
    • Yip E., Wang J.J., Wang C.H. - Sustained release system for highly water soluble radiosensitizer drug etanidazole: irradiation and degradation studies. - Biomaterials, 24, 1977-1987, 2003.
    • (2003) Biomaterials , vol.24 , pp. 1977-1987
    • Yip, E.1    Wang, J.J.2    Wang, C.H.3
  • 58
    • 18844382150 scopus 로고    scopus 로고
    • The effect of freeze-drying with different cryoprotectants and gamma-irradiation sterilization on the characteristics of ciprofloxacin HCl-loaded poly(D, L-lactide-glycolide) nanoparticles
    • Bozdag S., Dillen K., Vandervoort J., Ludwig A. - The effect of freeze-drying with different cryoprotectants and gamma-irradiation sterilization on the characteristics of ciprofloxacin HCl-loaded poly(D, L-lactide-glycolide) nanoparticles. - J Pharm Pharmacol, 57, 699-707, 2005.
    • (2005) J Pharm Pharmacol , vol.57 , pp. 699-707
    • Bozdag, S.1    Dillen, K.2    Vandervoort, J.3    Ludwig, A.4
  • 59
    • 0033368407 scopus 로고    scopus 로고
    • Effect of gamma irradiation on peptide-containing hydrophilic poly(D, L-lactide-co-glycolide) microspheres
    • Shameem M., Lee H., Burton K., Thanoo B.C., Deluca RR - Effect of gamma irradiation on peptide-containing hydrophilic poly(D, L-lactide-co-glycolide) microspheres. - PDA J.Pharm. Sci. Technol., 53 (6), 309-313, 1999.
    • (1999) PDA J.Pharm. Sci. Technol , vol.53 , Issue.6 , pp. 309-313
    • Shameem, M.1    Lee, H.2    Burton, K.3    Thanoo, B.C.4    Deluca, R.R.5
  • 60
    • 0242365719 scopus 로고    scopus 로고
    • Effect of γ-sterilization process on PLGA microspheres loaded with insulin-like growth factor-I (IGF-I)
    • Carrascosa C., Espejo L., Torrado S., Torrado J.J. - Effect of γ-sterilization process on PLGA microspheres loaded with insulin-like growth factor-I (IGF-I). - J Biomater Appl, 18, 95-108, 2003.
    • (2003) J Biomater Appl , vol.18 , pp. 95-108
    • Carrascosa, C.1    Espejo, L.2    Torrado, S.3    Torrado, J.J.4
  • 61
    • 0030826511 scopus 로고    scopus 로고
    • Oxidation of human insulin-like growth factor I in formulation studies. 3. Factorial experiments of the effects of ferric ions, EDTA, and visible light on methionine oxidation and covalent aggregation in aqueous solution
    • Fransson J.R. - Oxidation of human insulin-like growth factor I in formulation studies. 3. Factorial experiments of the effects of ferric ions, EDTA, and visible light on methionine oxidation and covalent aggregation in aqueous solution. - J Pharma Sci, 86, 1046-1050, 1997.
    • (1997) J Pharma Sci , vol.86 , pp. 1046-1050
    • Fransson, J.R.1
  • 63
    • 0029044566 scopus 로고    scopus 로고
    • Yoshioka S., Aso Y., Otsuka T., Koima S.-The effect of γ-irradiation on drug release from poly(lactide) microspheres. - Radiat Phys Chem, 46 (2), 281-285, 1995.
    • Yoshioka S., Aso Y., Otsuka T., Koima S.-The effect of γ-irradiation on drug release from poly(lactide) microspheres. - Radiat Phys Chem, 46 (2), 281-285, 1995.
  • 64
    • 0031018099 scopus 로고    scopus 로고
    • Bovine serum albumin release from poly(α-hydroxy acid) microspheres: Effect of polymer molecular weight and surface properties
    • Boury F., Marchais H,, Proust J.E., Benoit J.P. - Bovine serum albumin release from poly(α-hydroxy acid) microspheres: effect of polymer molecular weight and surface properties. - J Control Release, 45, 75-86, 1997.
    • (1997) J Control Release , vol.45 , pp. 75-86
    • Boury, F.1    Marchais, H.2    Proust, J.E.3    Benoit, J.P.4


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