Effect of γ-irradiation on peptide-containing hydrophilic poly (D,L- lactide-co-glycolide) microspheres

PDA Journal of Pharmaceutical Science and Technology

Volumn 53, Issue 6, 1999, Pages 309-313

  Shameem, Mohammed ^a   Lee, Heeyong ^a   Burton, Kevin ^a   Thanoo, B C ^a   Deluca, Patrick P ^a,b  

^a University of Kentucky   (United States)

^b Purdue Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSPHERE; POLYGLACTIN;

ARTICLE; DRUG FORMULATION; DRUG STABILITY; GAMMA IRRADIATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY;

GAMMA RAYS; LACTIC ACID; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS;

EID: 0033368407     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. D. H. Lewis, "Controlled Release of Bioactive Agents from Lactide/ Glycolide Polymers," In M. Chasin and R. Langer (eds.). Biodegradable Polymers as Drug Delivery Systems, Marcel Dekker Inc., New York. 1990, pp 1-41.
2. "Biodegradable Microspheres in Drug Delivery," H. Okada and H. Toguchi, Critical Reviews in Therapeutic Drug Carrier Systems, 12, 1-99 (1995).
3. S. Yolles and M. F. Sartori, "Degradable Polymers for Sustained Drug Release," In R. L. Juliano (ed.), Drug Delivery Systems, University Press, London. 1980, p. 84.
4. M. B. Sintzel, A. Merkli, C. Tabatabay, and R. Gurny, "Influence of irradiation sterilization on polymers used as drug carriers - a review," Drug. Develop. Indust. Pharm., 23, 857-878 (1997).
5. A. G. Hausberger, R. A. Kenley, and P. P. DeLuca, "Gamma irradiation effects on molecular weights and in vitro degradation of poly(d, 1-lactide-co-glycolide) microparticles," Pharm. Res., 12, 851-856 (1995).
6. C. C. Chu and N. D. Campbell, "Scanning electron microscopic study of the hydrolytic degradation of poly(glycolic acid) suture," J. Biomed. Mater. Res., 16, 417-430 (1982).
7. M. C. Gupta and V. G. Deshmukh, "Radiation effects on poly(lactic acid)," Polymer, 24, 827-830 (1983).
8. S. Yoshioka, Y. Aso, and S. Kojima, "Drug release from poly(dl-lactide) microspheres controlled by γ-Irradiation," J. Control. Rel., 37, 263-267 (1995).
9. D. L. Wise, (D. L. Wise ed.), Biopolymeric Controlled Release Systems, Vol I and II., Boca Raton, FL, CRC Press, 1984, p. 169.
10. C. Volland, M. Wolff, and T. Kissel, "The influence of terminal gamma-sterilization on captopril containing poly(dl-lactide-co-glycolide) microspheres, J. Control. Rel.," 31, 293-305 (1994).
11. J. K. Lalla and K. Sapna, "Biodegradable microspheres of poly (dl-lactic acid) containing paroxicam as model drug for controlled release via the parenteral route," J. Microencapsulation, 10, 449-460 (1993).
12. J. M. Ruiz, J. P. Busnel, and J. P. Benoit, "Influence of average molecular weights of poly (dl-lactic acid-co-glycolic acid) copolymers 50/50 on phase separation and in vitro drug release from microspheres," Pharm. Res., 7, 928-934 (1990).
13. Biodegradable Polyesters for Drug and Polypeptide Delivery, P. P. DeLuca, R. C. Metha, A. G. Hausberger, and B. C. Thanoo, in "Polymeric Delivery Systems, Properties and Applications," ACS Symposium Series 520, Eds. M. A. El-Nokaly, D. H. Piatt and B. A. Charpentier, pp. 53-79.
14. A. G. Hausberger and P. P. DeLuca, "Characterization of biodegradable poly-(dl-lactide-co-glycolide) polymers and microspheres," J. Pharm. Biomed. Anal., 13, 747-760 (1995).
15. A. L., Kraus, "Research Methodology", in The Laboratory Rat, Vol. 2, (H. J. Baker, J. R. Lindsey, and S. H. Weisbroth, eds.) Academic Press, New York, 1980, pp. 5-10.