Sterilized ibuprofen-loaded poly(D,L-lactide-co-glycolide) microspheres for intra-articular adminstration: Effect of γ-irradiation and storage

Journal of Microencapsulation

Volumn 21, Issue 6, 2004, Pages 653-665

  Fernandez Carballido A ^a   Herrero Vanrell, R ^a   Molina Martinez, I T ^a   Pastoriza, P ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Gamma irradiation; Ibuprofen microspheres; Intra articular; PLGA; Sterilization

Indexed keywords

IBUPROFEN; MICROSPHERE; NONSTEROID ANTIINFLAMMATORY AGENT; POLYGLACTIN; POLYMER; RESOMER; SOLVENT; WATER OIL CREAM;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BIOCOMPATIBILITY; BIODEGRADABILITY; CONTROLLED RELEASE FORMULATION; CONTROLLED STUDY; DEGRADATION KINETICS; DRUG SOLUBILITY; DRUG STABILITY; DRUG STERILITY; DRUG STORAGE; EVAPORATION; GAMMA IRRADIATION; GEL PERMEATION CHROMATOGRAPHY; JOINT CAVITY; LOW TEMPERATURE; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; RADIATION DOSE; RADIATION EXPOSURE; RHEUMATOID ARTHRITIS; STORAGE TEMPERATURE; VACUUM;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOCOMPATIBLE MATERIALS; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, GEL; DELAYED-ACTION PREPARATIONS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG STORAGE; GAMMA RAYS; HUMANS; IBUPROFEN; KNEE JOINT; LACTIC ACID; MICROSPHERES; POLYGLYCOLIC ACID; POLYMERS; STERILIZATION; SURFACE PROPERTIES; X-RAY DIFFRACTION;

EID: 11244322133     PISSN: 02652048     EISSN: None     Source Type: Journal    
DOI: 10.1080/09687860400008437     Document Type: Article

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