Double-walled microspheres for the sustained release of a highly water soluble drug: Characterization and irradiation studies

Journal of Controlled Release

Volumn 83, Issue 3, 2002, Pages 437-452

  Lee, Teng Huar ^a   Wang, Jianjun ^a   Wang, Chi Hwa ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Double walled reservoir microspheres; Etanidazole; Irradiation; Poly(D,L lactic co glycolic acid); Poly(L lactic acid); Radiosensitizer

Indexed keywords

ACETIC ACID ETHYL ESTER; ETANIDAZOLE; MICROSPHERE; POLYGLACTIN; POLYLACTIC ACID; POLYMER;

ARTICLE; CRYSTAL; DRUG DELIVERY SYSTEM; DRUG MANUFACTURE; DRUG SOLUBILITY; GLASS TRANSITION TEMPERATURE; HYDROPHILICITY; IRRADIATION; MELTING POINT; MOLECULAR WEIGHT; PREDICTION; PRIORITY JOURNAL; PULSATILE DRUG RELEASE; RADIATION DOSE; SUSTAINED DRUG RELEASE;

DELAYED-ACTION PREPARATIONS; GAMMA RAYS; MICROSPHERES; SOLUBILITY; WATER;

EID: 0037202224     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(02)00235-3     Document Type: Article

References (23)

1. Jalil R., Nixon J.R. Microencapsulation using poly(L-lactic acid). IV. Release properties of microcapsules containing phenobarbitone. J. Microencapsul. 7:(1):1990;53-66.
2. Bodmeier R., McGinity J.W. The preparation and evaluation of drug containing poly (D,L-lactide) microspheres formed by the solvent evaporation. Pharm. Res. 4:1987;465-471.
3. Pekarek K.J., Jacob J.S., Mathiowitz E. One-step preparation of double-walled microspheres. Adv. Mater. 6:1994;684-686.
4. Lee H.K., Park J.H., Kwon K.C. Double-walled microparticles for single shot vaccine. J. Controlled Release. 44:1997;283-293.
5. Wang F.J., Wang C.H. Sustained release of etanidazole from spray dried microspheres prepared by nonhalogenated solvents. J. Controlled Release. 81:2002;263-280.
6. Coleman C.N., Halsey J., Cox R.S., Hirst V.K., Blaschke T., Howes A.E., H Wasserman T., C Urtasun R., Pajak T., Hancock S. Relationship between the neurotoxicity of the hypoxic cell radiosensitizer SR2508 and the pharmacokinetic profile. Cancer Res. 47:1987;319-322.
7. Coleman C.N., Buswell L., Noll L., Riese N., Rose M. The efficacy of pharmacokinetic monitoring and dose modification of etanidazole on the incidence of neurotoxicity - results from a phase II trial of etanidazole and radiation-therapy in locally advanced prostate cancer. Int J. Radiat Oncol. Biol. Phys. 22:1992;565-568.
8. E. Mathiowitz, R.S Langer, Preparation of multiwall polymeric microparticles, US Pat. No. 4861627 (1989).
9. Matsumoto A., Matsukawa Y., Suzuki T., Yoshino H., Kobayashi M. The polymer alloy method as a new preparation method of biodegradable microspheres: Principle and application to cisplatin-loaded microspheres. J. Controlled Release. 48:1997;19-27.
10. Brown J.M. Clinical trials of radiosensitizers: What should we expect? Int J. Radiat. Oncol. Bio. Phys. 10:1984;425-429.
11. Phan T.P., Crane C.H., Janjan N.A., Vrdoljak E., Milas L., Mason K.A. WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment. Int. J. Pancreatol. 29:2001;19-23.
12. Cerrotta A., Gardani G., Cavina R., Raspagliesi F., Stefanon B., Garassino I., Musumeci R., Tana S., De Palo G. Concurrent radiotherapy and weekly paclitaxel for locally advanced or recurrent squamous cell carcinoma of uterine cervix. A pilot study with intensification of dose. Eur. J. Gynaecol. Oncol. 23:2002;115-119.
13. Kinsella T.J., Schupp J.E., Davis T.W., Berry S.E., Hwang H.S., Warren K., Balis F., Barnett J., Sands H. Preclinical study of systemic toxicity and pharmacokinetics of 5-ido-2-deoxypyrimininone-2′-deoxyribose as a radiosensistizer prodrug in two nonrodent animal species: Implications for phase I study design. Clin. Cancer Res. 6:2000;3670-3679.
14. Eschwege F., G Garnier S., Chassagne D., Brisgand D., Guerra M., Malaise E.P., Bey P., Busutti L., Cionini L., Ngyuen T., Romanini A., Chavaudra J., Hill C. Results of a European randomized trial of etanidazole combined with radiotherapy in head and neck carcinomas. Intern. J. Radiat. Oncol. Biol. Phys. 39:1997;275-281.
15. Mohr D., Wolff M., Kissel T. Gamma irradiation for the sterilization of 17β-estradiol loaded poly-(D,L-lactide-co-glycolide) microparticels. J. Controlled Release. 61:1999;203-217.
16. Montanari L., Constantini M., Signoretti E.C., Valvo L., Santucci M., Bartolomei M., Fattibene P., Onori S., Faucitano A., Conti B., Genta I. Gamma irradiation effects on poly (D,L-lacticide-co-glycolide) microspheres. J. Controlled Release. 56:1998;219-229.
17. Cardinal J.R. Matrix systems. Langer R.S., Wise D.L., Medical Applications of Controlled Release. Vol. I:1984;41-67 CRC Press.
18. Nielsen L.E. Mechanical Properties of Polymers. 1962;11-46 Reinhold, New York.
19. Jamshidi K., Hyon S.H., Ikada Y. Thermal characterization of polylactides. Polymer. 29:1988;2229-2234.
20. E.Y. Yip, Sustained release system for highly water soluble radiosensitzer drug etanidazole: irradiation and degradation studies, B. Eng. Thesis, Department of Chemical and Environmental Engineering, National University of Singapore (2001).
21. Pekarek K.J., Jacob J.S., Mathiowitz E. Double-walled polymer microspheres for controlled drug release. Nature. 367:1994;258-260.
22. Leach K., Noh K., Mathiowitz E. Effects of manufacturing conditions on the formation of double-walled polymer microspheres. J. Microencapsul. 16:1999;153-167.
23. Snyder R.L. The role of the mobile phase in liquid chromatography. Kirkland J.J., Modern Practice of Liquid Chromatography. 1971;125-156 Wiley-Interscience, New York.