메뉴 건너뛰기




Volumn 173, Issue 8, 2004, Pages 5046-5053

Sonic hedgehog regulates early human thymocyte differentiation by counteracting the IL-7-induced development of CD34+ precursor cells

Author keywords

[No Author keywords available]

Indexed keywords

CD34 ANTIGEN; CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 7; PROTEIN BAX; PROTEIN BCL 2; SONIC HEDGEHOG PROTEIN; STAT5 PROTEIN;

EID: 6344233198     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.8.5046     Document Type: Article
Times cited : (45)

References (53)
  • 2
    • 0036779662 scopus 로고    scopus 로고
    • Development of αβ T cells in the human thymus
    • Spits, H. 2002. Development of αβ T cells in the human thymus. Nat. Rev. Immunol. 2:760.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 760
    • Spits, H.1
  • 4
    • 0035577854 scopus 로고    scopus 로고
    • Hedgehog signaling in animal development: Paradigms and principles
    • Ingham, P. W., and A. P. McMahon. 2001. Hedgehog signaling in animal development: paradigms and principles. Genes Dev. 15:3059.
    • (2001) Genes Dev. , vol.15 , pp. 3059
    • Ingham, P.W.1    McMahon, A.P.2
  • 5
    • 0002452569 scopus 로고    scopus 로고
    • Developmental roles and clinical significance of hedgehog signaling
    • McMahon, A. P., P. W. Ingham, and C. J. Tabin. 2003. Developmental roles and clinical significance of hedgehog signaling. Curr. Top. Dev. Biol. 53:1.
    • (2003) Curr. Top. Dev. Biol. , vol.53 , pp. 1
    • McMahon, A.P.1    Ingham, P.W.2    Tabin, C.J.3
  • 6
    • 0036899614 scopus 로고    scopus 로고
    • Pathways and consequences: Hedgehog signaling in human disease
    • Mullor, J. L., P. Sanchez, and A. R. Altaba. 2002. Pathways and consequences: Hedgehog signaling in human disease. Trends Cell Biol. 12:562.
    • (2002) Trends Cell Biol. , vol.12 , pp. 562
    • Mullor, J.L.1    Sanchez, P.2    Altaba, A.R.3
  • 7
  • 8
    • 0019133661 scopus 로고
    • Mutations affecting segment number and polarity in Drosophila
    • Nusslein-Volhard, C., and E. Wieschaus. 1980. Mutations affecting segment number and polarity in Drosophila. Nature 287:795.
    • (1980) Nature , vol.287 , pp. 795
    • Nusslein-Volhard, C.1    Wieschaus, E.2
  • 9
    • 0036778132 scopus 로고    scopus 로고
    • Hedgehog signal transduction: Recent findings
    • Nybakken, K., and N. Perrimon. 2002. Hedgehog signal transduction: recent findings. Curr. Opin. Genet. Dev. 12:503.
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 503
    • Nybakken, K.1    Perrimon, N.2
  • 12
    • 0035901572 scopus 로고    scopus 로고
    • Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation
    • Strutt, H., C. Thomas, Y. Nakano, D. Stark, B. Neave, A. M. Taylor, and P. W. Ingham. 2001. Mutations in the sterol-sensing domain of Patched suggest a role for vesicular trafficking in Smoothened regulation. Curr. Biol. 11:608.
    • (2001) Curr. Biol. , vol.11 , pp. 608
    • Strutt, H.1    Thomas, C.2    Nakano, Y.3    Stark, D.4    Neave, B.5    Taylor, A.M.6    Ingham, P.W.7
  • 13
    • 0035901616 scopus 로고    scopus 로고
    • The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
    • Martin, V., G. Carrillo, C. Torroja, and I. Guerrero. 2001. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. Curr. Biol. 11:601.
    • (2001) Curr. Biol. , vol.11 , pp. 601
    • Martin, V.1    Carrillo, G.2    Torroja, C.3    Guerrero, I.4
  • 14
    • 0032808138 scopus 로고    scopus 로고
    • Gli proteins encode context-dependent positive and negative functions: Implications for development and disease
    • Ruiz i Altaba, A. 1999. Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 126:3205.
    • (1999) Development , vol.126 , pp. 3205
    • Ruiz I Altaba, A.1
  • 15
    • 0036561818 scopus 로고    scopus 로고
    • Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling
    • Koebernick, K., and T. Pieler. 2002. Gli-type zinc finger proteins as bipotential transducers of Hedgehog signaling. Differentiation 70:69.
    • (2002) Differentiation , vol.70 , pp. 69
    • Koebernick, K.1    Pieler, T.2
  • 16
    • 0033712944 scopus 로고    scopus 로고
    • Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte
    • Outram, S. V., A. Varas, C. V. Pepicelli, and T. Crompton. 2000. Hedgehog signaling regulates differentiation from double-negative to double-positive thymocyte. Immunity 13:187.
    • (2000) Immunity , vol.13 , pp. 187
    • Outram, S.V.1    Varas, A.2    Pepicelli, C.V.3    Crompton, T.4
  • 22
    • 0030584081 scopus 로고    scopus 로고
    • Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
    • Ericson, J., S. Morton, A. Kawakami, H. Roelink, and T. M. Jessell. 1996. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity. Cell 87:661.
    • (1996) Cell , vol.87 , pp. 661
    • Ericson, J.1    Morton, S.2    Kawakami, A.3    Roelink, H.4    Jessell, T.M.5
  • 23
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
    • Oltvai, Z. N., C. L. Milliman, and S. J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609.
    • (1993) Cell , vol.74 , pp. 609
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmeyer, S.J.3
  • 24
    • 0033136288 scopus 로고    scopus 로고
    • Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors
    • Pallard, C., A. P. Stegmann, T. van Kleffens, F. Smart, A. Venkitaraman, and H. Spits. 1999. Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors. Immunity 10:525.
    • (1999) Immunity , vol.10 , pp. 525
    • Pallard, C.1    Stegmann, A.P.2    Van Kleffens, T.3    Smart, F.4    Venkitaraman, A.5    Spits, H.6
  • 25
    • 0029859982 scopus 로고    scopus 로고
    • Interleukin-7 is a critical growth factor in early human T-cell development
    • Plum, J., M. De Smedt, G. Leclercq, B. Verhasselt, and B. Vandekerckhove. 1996. Interleukin-7 is a critical growth factor in early human T-cell development. Blood 88:4239.
    • (1996) Blood , vol.88 , pp. 4239
    • Plum, J.1    De Smedt, M.2    Leclercq, G.3    Verhasselt, B.4    Vandekerckhove, B.5
  • 26
    • 0033918015 scopus 로고    scopus 로고
    • CD135 (Flk2/Flt3) expression by human thymocytes delineates a possible role of FLT3-ligand in T-cell precursor proliferation and differentiation
    • Bertho, J. M., A. Chapel, S. Loilleux, J. Frick, J. Aigueperse, N. C. Gorin, and P. Gourmelon. 2000. CD135 (Flk2/Flt3) expression by human thymocytes delineates a possible role of FLT3-ligand in T-cell precursor proliferation and differentiation. Scand. J. Immunol. 52:53.
    • (2000) Scand. J. Immunol. , vol.52 , pp. 53
    • Bertho, J.M.1    Chapel, A.2    Loilleux, S.3    Frick, J.4    Aigueperse, J.5    Gorin, N.C.6    Gourmelon, P.7
  • 29
    • 0027143182 scopus 로고
    • CD34-expressing human thymocyte precursors proliferate in response to interleukin-7 but have lost myeloid differentiation potential
    • Schmitt, C., S. Ktorza, S. Sarun, C. Blanc, R. De Jong, and P. Debre. 1993. CD34-expressing human thymocyte precursors proliferate in response to interleukin-7 but have lost myeloid differentiation potential. Blood 82:3675.
    • (1993) Blood , vol.82 , pp. 3675
    • Schmitt, C.1    Ktorza, S.2    Sarun, S.3    Blanc, C.4    De Jong, R.5    Debre, P.6
  • 30
    • 0033635292 scopus 로고    scopus 로고
    • Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system
    • Alcedo, J., Y. Zou, and M. Noll. 2000. Posttranscriptional regulation of smoothened is part of a self-correcting mechanism in the Hedgehog signaling system. Mol. Cell 6:457.
    • (2000) Mol. Cell , vol.6 , pp. 457
    • Alcedo, J.1    Zou, Y.2    Noll, M.3
  • 31
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef, N., D. Neubuser, L. Perez, and S. M. Cohen. 2000. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102:521.
    • (2000) Cell , vol.102 , pp. 521
    • Denef, N.1    Neubuser, D.2    Perez, L.3    Cohen, S.M.4
  • 32
    • 0034687244 scopus 로고    scopus 로고
    • Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein
    • Ingham, P. W., S. Nystedt, Y. Nakano, W. Brown, D. Stark, M. van den Heuvel, and A. M. Taylor. 2000. Patched represses the Hedgehog signalling pathway by promoting modification of the Smoothened protein. Curr. Biol. 10:1315.
    • (2000) Curr. Biol. , vol.10 , pp. 1315
    • Ingham, P.W.1    Nystedt, S.2    Nakano, Y.3    Brown, W.4    Stark, D.5    Van Den Heuvel, M.6    Taylor, A.M.7
  • 33
    • 0038625111 scopus 로고    scopus 로고
    • Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
    • Zhu, A. J., L. Zheng, K. Suyama, and M. P. Scott. 2003. Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev. 17:1240.
    • (2003) Genes Dev. , vol.17 , pp. 1240
    • Zhu, A.J.1    Zheng, L.2    Suyama, K.3    Scott, M.P.4
  • 34
    • 0027170503 scopus 로고
    • + cells in the human thymus are defined by expression of CD34: Delineation of early events in human thymic development
    • + cells in the human thymus are defined by expression of CD34: delineation of early events in human thymic development. J. Exp. Med. 178:391.
    • (1993) J. Exp. Med. , vol.178 , pp. 391
    • Galy, A.1    Verma, S.2    Barcena, A.3    Spits, H.4
  • 35
    • 0034752055 scopus 로고    scopus 로고
    • Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis
    • Charrier, J. B., F. Lapointe, N. M. Le Douarin, and M. A. Teillet. 2001. Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis. Development 128:4011.
    • (2001) Development , vol.128 , pp. 4011
    • Charrier, J.B.1    Lapointe, F.2    Le Douarin, N.M.3    Teillet, M.A.4
  • 36
    • 0035735270 scopus 로고    scopus 로고
    • Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ
    • Cobourne, M. T., Z. Hardcastle, and P. T. Sharpe. 2001. Sonic hedgehog regulates epithelial proliferation and cell survival in the developing tooth germ. J. Dent. Res. 80:1974.
    • (2001) J. Dent. Res. , vol.80 , pp. 1974
    • Cobourne, M.T.1    Hardcastle, Z.2    Sharpe, P.T.3
  • 37
    • 0036086124 scopus 로고    scopus 로고
    • Sonic hedgehog signaling from the urethral epithelium controls external genital development
    • Perriton, C. L., N. Powles, C. Chiang, M. K. Maconochie, and M. J. Conn. 2002. Sonic hedgehog signaling from the urethral epithelium controls external genital development. Dev. Biol. 247:26.
    • (2002) Dev. Biol. , vol.247 , pp. 26
    • Perriton, C.L.1    Powles, N.2    Chiang, C.3    Maconochie, M.K.4    Conn, M.J.5
  • 38
    • 0032777606 scopus 로고    scopus 로고
    • Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm
    • Cann, G. M., J. W. Lee, and F. E. Stockdale. 1999. Sonic hedgehog enhances somite cell viability and formation of primary slow muscle fibers in avian segmented mesoderm. Anal. Embryol. (Berl.) 200:239.
    • (1999) Anal. Embryol. (Berl.) , vol.200 , pp. 239
    • Cann, G.M.1    Lee, J.W.2    Stockdale, F.E.3
  • 39
    • 0030793114 scopus 로고    scopus 로고
    • Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult in vitro
    • Miao, N., M. Wang, J. A. Ott, J. S. D'Alessandro, T. M. Woolf, D. A. Bumcrot, N. K. Mahanthappa, and K. Pang. 1997. Sonic hedgehog promotes the survival of specific CNS neuron populations and protects these cells from toxic insult In vitro. J. Neurosci. 17:5891.
    • (1997) J. Neurosci. , vol.17 , pp. 5891
    • Miao, N.1    Wang, M.2    Ott, J.A.3    D'Alessandro, J.S.4    Woolf, T.M.5    Bumcrot, D.A.6    Mahanthappa, N.K.7    Pang, K.8
  • 40
    • 0030802458 scopus 로고    scopus 로고
    • Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog
    • Fan, H., A. E. Oro, M. P. Scott, and P. A. Khavari. 1997. Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Nat. Med. 3:788.
    • (1997) Nat. Med. , vol.3 , pp. 788
    • Fan, H.1    Oro, A.E.2    Scott, M.P.3    Khavari, P.A.4
  • 43
    • 0038381478 scopus 로고    scopus 로고
    • Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells
    • Wang, B. E., J. Shou, S. Ross, H. Koeppen, F. J. De Sauvage, and W. Q. Gao. 2003. Inhibition of epithelial ductal branching in the prostate by sonic hedgehog is indirectly mediated by stromal cells. J. Biol. Chem. 278:18506.
    • (2003) J. Biol. Chem. , vol.278 , pp. 18506
    • Wang, B.E.1    Shou, J.2    Ross, S.3    Koeppen, H.4    De Sauvage, F.J.5    Gao, W.Q.6
  • 46
    • 2642589990 scopus 로고    scopus 로고
    • Notochord repression of endodermal Sonic hedgehog permits pancreas development
    • Hebrok, M., S. K. Kim, and D. A. Melton. 1998. Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 12:1705.
    • (1998) Genes Dev. , vol.12 , pp. 1705
    • Hebrok, M.1    Kim, S.K.2    Melton, D.A.3
  • 47
    • 0037083444 scopus 로고    scopus 로고
    • Sonic hedgehog inhibits the terminal differentiation of limb myoblasts committed to the slow muscle lineage
    • Bren-Mattison, Y., and B. B. Olwin. 2002. Sonic hedgehog inhibits the terminal differentiation of limb myoblasts committed to the slow muscle lineage. Dev. Biol. 242:130.
    • (2002) Dev. Biol. , vol.242 , pp. 130
    • Bren-Mattison, Y.1    Olwin, B.B.2
  • 48
    • 0034071348 scopus 로고    scopus 로고
    • The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium
    • Sukegawa, A., T. Narita, T. Kameda, K. Saitoh, T. Nohno, H. Iba, S. Yasugi, and K. Fukuda. 2000. The concentric structure of the developing gut is regulated by Sonic hedgehog derived from endodermal epithelium. Development 127:1971.
    • (2000) Development , vol.127 , pp. 1971
    • Sukegawa, A.1    Narita, T.2    Kameda, T.3    Saitoh, K.4    Nohno, T.5    Iba, H.6    Yasugi, S.7    Fukuda, K.8
  • 49
    • 0037089233 scopus 로고    scopus 로고
    • Effects of exogenous interleukin-7 on human thymus function
    • Okamoto, Y., D. C. Douek, R. D. McFarland, and R. A. Koup. 2002. Effects of exogenous interleukin-7 on human thymus function. Blood 99:2851.
    • (2002) Blood , vol.99 , pp. 2851
    • Okamoto, Y.1    Douek, D.C.2    McFarland, R.D.3    Koup, R.A.4
  • 50
    • 0029794831 scopus 로고    scopus 로고
    • Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7
    • Bolotin, E., M. Smogorzewska, S. Smith, M. Widmer, and K. Weinberg. 1996. Enhancement of thymopoiesis after bone marrow transplant by in vivo interleukin-7. Blood 88:1887.
    • (1996) Blood , vol.88 , pp. 1887
    • Bolotin, E.1    Smogorzewska, M.2    Smith, S.3    Widmer, M.4    Weinberg, K.5
  • 51
    • 0038784460 scopus 로고    scopus 로고
    • Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice
    • Napolitano, L. A., C. A. Stoddart, M. B. Hanley, E. Wieder, and J. M. McCune. 2003. Effects of IL-7 on early human thymocyte progenitor cells in vitro and in SCID-hu Thy/Liv mice. J. Immunol. 171:645.
    • (2003) J. Immunol. , vol.171 , pp. 645
    • Napolitano, L.A.1    Stoddart, C.A.2    Hanley, M.B.3    Wieder, E.4    McCune, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.