Examination of the role of DNA polymerase proofreading in the mutator effect of miscoding tRNAs

Journal of Bacteriology

Volumn 180, Issue 21, 1998, Pages 5712-5717

  Slupska, Malgorzata M ^a   King, Angela G ^a   Lu, Louise I ^a   Lin, Rose H ^a   Mao, Emily F ^a   Lackey, Chantal A ^a   Chiang, Ju Huei ^a   Baikalov, Claudia ^a   Miller, Jeffrey H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA POLYMERASE; TRANSFER RNA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CODON; DNA SYNTHESIS; ESCHERICHIA COLI; GENE MUTATION; MUTATOR GENE; NONHUMAN; PRIORITY JOURNAL;

ESCHERICHIA COLI;

EID: 0031771946     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/jb.180.21.5712-5717.1998     Document Type: Article

References (33)

1. Barnes, M. H., P. Spacciapoli, D. H. Li, and N. C. Brown. 1995. The 3′-5′ exonuclease site of DNA polymerase III from Gram-positive bacteria: definition of a novel motif structure. Gene 165:45-50,
2. Beese, L. S., and T. A. Steitz. 1991. Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism. EMBO J. 10:25-33.
3. Bernad, A, L. Blanco, J. M. Lazaro, G. Martin, and M. Salas. 1989. A conserved 3′-5′ exonuclease active site in prokaiyotic and eukaryotic DNA polymerases. Cell 59:219-228.
4. Bianco, L., A. Bernad, and M. Salas. 1992. Evidence favouring the hypothesis of a conserved 3′-5′ exonuclease active site in DNA-dependent DNA polymerases. Gene 112:139-144.
5. Bronner, C. E., S. M. Baker, P. T. Morrison, G. Warren, L. G. Smith, M. K. Lescoe, M. Kane, C. Earibino, J. Lipford, A. Linblom, P. Tannergard, R. J. Bollag, A. J. Godwin, D. C. Ward, M. Nordenskjold, R. Fishel, R. D. Kolodner, and R. M. Liskay. 1994. Mutation in the DNA mismatch repair gene homologue hMLH1 is associated with hereditary nonpolyposis colon cancer. Nature 368:258-261.
6. Cox, E. C., and D. L. Homer. 1982. Dominant mutators in Escherichia coli. Genetics 100:7-18.
7. Cupples, C. G., and J. H. Miller. 1989. A set of lacZ mutations in Escherichia coli that allow rapid detection of each of the six base substitutions. Proc. Natl. Acad. Sci. USA 86:5345-5349.
8. Derbyshire, V., N. D. F. Grindley, and C. M. Joyce. 1991. The 3′-5′ exonuclease of DNA polymerase I of Escherichia coli: contribution of amino acid at the active site to the reaction. EMBO J. 10:17-24.
9. Degnen, G. E., and E. C. Cox. 1974. Conditional mutator gene in Escherichia coli: isolation, mapping, and effector studies. J. Bacteriol. 117:477-487.
10. Echols, H., C. Lu, and P. M. Burges. 1983. Mutator strains of Escherichia coli, mutD and dnaQ, with defective exonucleolytic editing by DNA polymerase II holoenzyme. Proc. Natl. Acad. Sci. USA 80:2189-2192.
11. Fijalkowska, I. J., and R. M. Schaaper. 1996. Mutants in the Exo I motif of Escherichia coli dnaQ: defective proofreading and inviability due to error catastrophe. Proc. Natl. Acad. Sci. USA 93:2856-2861.
12. Fishel, R., M. K. Lescoe, M. R. S. Rao, N. G. Copeland, N. A. Jenkins, J. Garber, M. Kane, and R. Kolodner. 1993. The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer. Cell 75: 1027-1038.
13. Freemont, P. S., J. M. Friedman, L. S. Beese, M. R. Sanderson, and T. A. Steitz. 1988. Cocrystal structure of an editing complex of Klenow fragment with DNA. Proc. Natl. Acad. Sci. USA 85:8924-8928.
14. Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
15. Homer, D. L., and E. C. Cox. Personal communication.
16. Joyce, C. M., and T. A. Steitz. 1994. Function and structure relationships in DNA polymerases. Annu. Rev. Biochem. 63:777-822.
17. Komine, Y., T. Adachi, H. Inokuchi, and H. Ozeki. 1990. Genomic organization and physical mapping of the transfer RNA genes in Escherichia coli K12. J. Mol. Biol. 212:579-598.
18. Leach, F. S., N. C. Nicolaides, N. Papadopoulos, B. Liu, J. Jen, R. Parsons, P. Peltomaki, P. Sistonen, L. A. Aaltonen, and M. Nystrom-Lahti. 1993. Mutations of a mutS homolog in hereditary nonpolyposis colectoral cancer. Cell 75:1215-1225.
19. Maki, H., and M. Sekiguchi. 1992. MutT protein specifically hydrolyzes a potent mutagenic substrate for DNA synthesis. Nature 355:273-275.
20. Michaels, M. L., C. Cruz, A. P. Grollman, and J. H. Miller. 1992. Evidence that MutY and MutM combine to prevent mutations by an oxidatively damaged form of guanine in DNA. Proc. Natl. Acad. Sci. USA 89:7022-7025.
21. Michaels, M. L., C. Cruz, and J. H. Miller. 1990. mutA and mutC: two mutator loci in Escherichia coli that stimulate transversions. Proc. Natl. Acad. Sci. USA 87:9211-9215.
22. Michaels, M. L., and J. H. Miller. 1992. The GO system protects organisms from the mutagenic effect of the spontaneous lesion 8-hydroxyguanine (7,8-dihydro-8-oxoguanine). J. Bacteriol. 174:6321-6325.
23. Miller, J. H. 1992. A short course in bacterial genetics. A laboratory manual and handbook for Escherichia coli and related bacteria. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
24. Miller, J. H. 1996. Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repair. Annu. Rev. Microbiol. 50:625-643.
25. Modrich, P. 1991. Mechanisms and biological effects of mismatch repair. Annu. Rev. Genet. 25:229-253.
26. Moriya, M., W. Zhang, F. Johnson, and A. P. Grollman. 1994. Mutagenic potency of exocyclic DNA adducts: marked differences between Escherichia coli and simian kidney cells. Proc. Natl. Acad. Sci. USA 91:11899-11903.
27. Murphy, H. S., and M. Z. Humayun. 1997. Escherichia coli cells expressing a mutant glyV (glycine tRNA) gene have a UVM-constitutive phenotype: implications for mechanisms underlying the mutA or mutC mutator effect. J. Bacteriol. 179:7507-7514.
28. Nghiem, Y., M. Cabrera, C. G. Cupples, and J. H. Miller. 1988. The mutY gene: a mutator locus in Escherichia coli that generates GC→TA transversions. Proc. Natl. Acad. Sci. USA 85:2709-2713.
29. Ollis, D. L., P. Brick, R. Hamlin, N. G. Xuong, and T. A. Steitz. 1985. Structure of large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature 313:762-766.
30. Papadopoulos, N., N. C. Nicolaides, Y. F. Wei, S. M. Ruben, K. C. Carter, C. A. Rosen, W. A. Haseltine, R. D. Fleischmann, C. M. Fraser, M. D. Adams, J. C. Venter, S. R. Hamilton, G. M. Petersen, P. Watson, H. T. Lynch, P. Peltomaki, J.-P. Mecklin, A. de la Chapelle, K. W. Kinzler, and B. Vogelstein. 1994. Mutation of a mutL homolog in hereditary nonpolyposis colon cancer. Science 263:1625-1629.
31. Scheuermann, R., S. Tam, P. M. Burgers, C. Lu, and H. Echols. 1983. Identification of the epsilon-subunit of Escherichia coli DNA polymerase III holoenzyme as the dnaQ gene product: a fidelity subunit for DNA replication. Proc. Natl. Acad. Sci. USA 80:7085-7089.
32. Slupska, M. M., C. Baikalov, R. Lloyd, and J. H. Miller. 1996. Mutator tRNAs are encoded by the Escherichia coli mutator genes mutA and mutC: a novel pathway for mutagenesis. Proc. Natl. Acad. Sci. USA 93:4380-4385.
33. Takano, K., Y. Nakabeppu, H. Maki, T. Horiuchi, and M. Sekigucbi. 1986. Structure and function of dnaQ and mutD mutators of Escherichia coli. Mol. Gen. Genet. 205:9-13.